Gene 19028 (Tetrahymena)

19028

Species: Tetrahymena
Alias: 323.m00026, PreTt19028, TTHERM_01319530, 19028, 734
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
19028.AA Protein None 664 None Fasta, JSON
19028.kin_dom Protein Kinase Domain None 185 None Fasta, JSON
19028.kin_dom2 Protein Kinase Domain None 154 None Fasta, JSON
19028.NA RNA None 1995 None Fasta, JSON

Protein domain

Protein domains of 19028.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19028.AA C2 15-148 60 1.7e-74 253.79 In-house 109-245 (245) Show / Hide 
Range on Protein: 15-148
Range on HMM: 109-245/245
Sequence Identity: 60% (84 aa)

IEVIRKQNSYPNDQIKEIMMIQMLDSIAYLHRFDVVHRDIKPSNFLLSFNTQGYPLVKLCILYLQFLQKIKGDLAFASALEYNKSRISFSKFKGTQSY--
... |||||||..|.|.||.|||.|||.||||||.|||||||||||..|..||.|..|||....|. || |.|..|||.|.||||||.|||||.||.|  
FNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-KCDFDFASKLKYNKSRIHFSKFKWTQQYYQ

--SAPEVDQGIFKKASDIFS-LGLVLLELDNIDTFDFTK
  .||||.|.|.||.||.|| .|.|||||||. .... .
HIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 19028.AA Ciliate-C8 15-135 43 2.3e-53 183.59 In-house 106-238 (238) Show / Hide 
Range on Protein: 15-135
Range on HMM: 106-238/238
Sequence Identity: 43% (60 aa)

IEVIRKQNSYPNDQIKEIMMIQMLDSIAYLHRFDVVHRDIKPSNFLLSFNTQGYPLVKLCILYLQFLQKIKGDLAFASALEYNKSRISFSKFKGTQSY--
..  ||..|||..|.|||..|||.||..|||.|...||||||.|||..|..|..| .|||. .    . ...|..|||.|..|||.....|||||. |  
FDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F----K-KQCDFGFASQLPKNKSHYHSKKFKGTDQYIE

---------SAPEVDQGIFKKASDIFS-------LGLVL
         .|||| ... .. |||||       .||||
MYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 19028.AA C8 19-135 36 2.3e-35 120.2 In-house 114-226 (226) Show / Hide 
Range on Protein: 19-135
Range on HMM: 114-226/226
Sequence Identity: 36% (45 aa)

RKQNSYPNDQIKEIMMIQMLDSIAYLHRFDVVHRDIKPSNFLLSFNTQGYPLVKLCILYLQFLQKIKGDLAFASALEYNKSRISFSKF--KGTQSYSAPE
|... ......|||. |||.|.. |.| . ..||||||.|||. .. .  . .|||            |..|||... ||| |   |.   ||. |.|||
RNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC------------DFGFASQVSKNKSHIQSKKMNTCGTWAYFAPE

VDQG------IFKKASDIFSLGLVL
. ..      .... ||.||.||||
IEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 19028.AA CK1 34-65 46 4.5e-11 34.93 In-house 138-169 (339) Show / Hide 
Range on Protein: 34-65
Range on HMM: 138-169/339
Sequence Identity: 46% (15 aa)

MIQMLDSIAYLHRFDVVHRDIKPSNFLLSFNT
.||||... |.|.   .||||||.||... |.
AIQMLEALEYMHDCGFIHRDIKPDNFCMGRNE
Kinase 19028.AA CAMK 33-62 40 5.6e-10 27.59 In-house 184-213 (425) Show / Hide 
Range on Protein: 33-62
Range on HMM: 184-213/425
Sequence Identity: 40% (12 aa)

MMIQMLDSIAYLHRFDVVHRDIKPSNFLLS
.. |... ..|.|  ..||||.|| | ||.
YFRQICSAVHYCHSHNIVHRDLKPENILLD
Kinase 19028.AA Ciliate-E2 33-196 17 1.4e-09 29.09 In-house 150-360 (365) Show / Hide 
Range on Protein: 33-196
Range on HMM: 150-360/365
Sequence Identity: 17% (41 aa)

MMIQMLD---------------SIAYLHRFD-VVHRDIKPSNFLLSFNTQGYPLVKLCILYL-----QFLQKIKGDLAFASALEYNKSRISFSKF-----
.| | |.                . |||    ..||||||.| |.         .|.. . |     .. |.. . .  .  . . |...| .       
IMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQI

---------KGTQSYSAPEVDQGIFK----------KASDIFSLGLVLLELDNIDT-FDFTKTTNQQKLEIQTGNIFSSFQ----------------INR
          ||  | |||. .|             ...||.||| .| |.    . |           .|. ..|  ...                 . 
IQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKW

YSQIYKIAKQ----CIEFNPNNRIP-PVELL
  .   . |.    ... .|..||  . ..|
SQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 19028.AA Ciliate-E2a 33-75 28 7e-09 22.3 In-house 106-150 (275) Show / Hide 
Range on Protein: 33-75
Range on HMM: 106-150/275
Sequence Identity: 28% (13 aa)

MMIQML-DSIAYLHRFDVVHRDIKPSNFLLS-FNTQGYPLVKLCI
.| |.| . ..|.|   ..|||.|| |.|.   ....... ...|
IMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKI
Kinase 19028.AA Ciliate-E1 14-62 28 8.3e-09 25.26 In-house 95-143 (202) Show / Hide 
Range on Protein: 14-62
Range on HMM: 95-143/202
Sequence Identity: 28% (14 aa)

IIEVIRKQNSYPNDQIKEIMMIQMLDSIAYLHRFDVVHRDIKPSNFLLS
..  ..... . ..| |. ...|..| ...|| . . ||||||.| | .
YWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILIN
Kinase 19028.AA STE 32-74 40 2.1e-08 25.92 In-house 155-189 (359) Show / Hide 
Range on Protein: 32-74
Range on HMM: 155-189/359
Sequence Identity: 40% (18 aa)

IMMIQMLDS-IAYLHRFDVVHRDIKPSNFLLSFNTQGYPLVKLC
..  | |    .|||.  ..||||||.| ||         ||||
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLC
Kinase 19028.AA Pkinase 36-62 40 2.5e-08 30.5 Pfam 116-142 (293) Show / Hide 
Range on Protein: 36-62
Range on HMM: 116-142/293
Sequence Identity: 40% (11 aa)

QMLDSIAYLHRFDVVHRDIKPSNFLLS
|.|  ..|.|.  ..|||.||.|.|..
QILRGLEYCHSMGIIHRDLKPENILID
Kinase 19028.AA TKL 33-62 23 4.7e-07 21.45 In-house 137-174 (364) Show / Hide 
Range on Protein: 33-62
Range on HMM: 137-174/364
Sequence Identity: 23% (9 aa)

MMIQMLDSIAYLHRFD--------VVHRDIKPSNFLLS
.....   ..|||  .        ..|||.|..| |. 
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD
Kinase 19028.AA TKL 104-138 23 2.4e-05 15.22 In-house 231-282 (364) Show / Hide 
Range on Protein: 104-138
Range on HMM: 231-282/364
Sequence Identity: 23% (12 aa)

SKFKGTQSYSAPEV-----------------DQGIFKKASDIFSLGLVLLEL
..  ||  . ||||                  .. . ...|..| |.|| |.
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 19028.AA STE 106-138 35 0.012789 5.22 In-house 223-261 (359) Show / Hide 
Range on Protein: 106-138
Range on HMM: 223-261/359
Sequence Identity: 35% (14 aa)

FKGTQSYSAPEV-DQGIFK------KASDIFSLGLVLLEL
| ||. . |||| .|.  .        .|| |||....|.
FVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 19028.AA STE 179-200 32 0.045154 3.26 In-house 335-359 (359) Show / Hide 
Range on Protein: 179-200
Range on HMM: 335-359/359
Sequence Identity: 32% (8 aa)

KQCIEFNPNNRIPPVELLI---QFI
..| . .||.|  . .||     ||
NKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19028.AA Pkinase 106-138 37 0.4234 4.97 Pfam 171-205 (293) Show / Hide 
Range on Protein: 106-138
Range on HMM: 171-205/293
Sequence Identity: 37% (13 aa)

FKGTQSYSAPEV--DQGIFKKASDIFSLGLVLLEL
| ||  | ||||  ..    ...|..|.|..| |.
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 19028.AA C2 275-411 47 1.5e-85 290.51 In-house 1-167 (245) Show / Hide 
Range on Protein: 275-411
Range on HMM: 1-167/245
Sequence Identity: 47% (80 aa)

GATGLILGVYNKSQKRHSALKIQRVSS-----KHEIVREIGIIRDCQ-MPLVIKFYGFFYLDVTKKED------------------------FVVYEIEK
||.||.|...||.|.||.|||||.. |     .||...|.||.|.|| ||..||.|..|||.|.||||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKL
|.|||||||||..|.........||..|||..|.|||||...|||||||..|.|| ..|...|.|||
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKL
Kinase 19028.AA Ciliate-C8 275-411 38 1.2e-65 224.35 In-house 1-164 (238) Show / Hide 
Range on Protein: 275-411
Range on HMM: 1-164/238
Sequence Identity: 38% (63 aa)

GATGLILG-------VYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G
||.|..|.        ......|....|||.. ..|||.....| ..||||.|...|..|||. ..||||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKL
||||||.|..|.........|..||||.||..||||...|.|||||..|.|. ..|...|.|||
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKL
Kinase 19028.AA C8 267-411 32 3e-39 133.91 In-house 2-168 (226) Show / Hide 
Range on Protein: 267-411
Range on HMM: 2-168/226
Sequence Identity: 32% (55 aa)

SNFEFISVGATGLILGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKEDFVVYEIEKCS-------------------
.||...| || |..|  .|  ..|. .||.| ...|..|  .. | . ..||.|.. | |.... ....|...|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKL
   ||||..  ... . |...|.| .||||.|| .||.|  .|.|||||..|.|   .|.....|||
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKL
Kinase 19028.AA Ciliate-E1 272-461 20 8.8e-16 48.21 In-house 1-202 (202) Show / Hide 
Range on Protein: 272-461
Range on HMM: 1-202/202
Sequence Identity: 20% (42 aa)

ISVGATGLILGVYNKSQK-RHSALKIQRVS---SKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL
|. |  ....  ...... .. |.||. .    .. ..  ||  .   .. .  ..| . ..|. |...  . .  .|.|. .||.|..          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KKDKIQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKLRVCLAVI-DNFETLEPSLKQKNLDYPHGFKIPFEPSYLVKNELIK
.....|.....||||..| || ...||.. | ||||| .|||. .. ..  . .. ...  .  . ..   .  .... .|   ..| |  .  ||. |.
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQ-EHNKNQKIN

RNTKIY
 .. ||
YKSDIY
Kinase 19028.AA Ciliate-E2 281-411 22 1.1e-13 43.28 In-house 36-197 (365) Show / Hide 
Range on Protein: 281-411
Range on HMM: 36-197/365
Sequence Identity: 22% (39 aa)

LGVYN----KSQKRHSALKIQRVSSKHEIVREIGIIR----------------DCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLK
. ...    | ..   |.||.. . . .| .|| |.|                  . | .||.| .|.   .|... . .  | |.| .|..| .  ..|
Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKK

KDKI-----QLNDEEKMQIAIQVID---------------VINYLHYNE-IVHRDIKLENILYLDSQSQVPIIKL
....     .....|  .|  |...                ..||| .  |.|||||.||||.         ||.
RNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKI
Kinase 19028.AA Ciliate-E2a 353-411 31 5.2e-13 34.66 In-house 87-150 (275) Show / Hide 
Range on Protein: 353-411
Range on HMM: 87-150/275
Sequence Identity: 31% (20 aa)

FNRLKKDK-IQLNDEEKMQIAIQVI-DVINYLHYNEIVHRDIKLENILYL--DSQS-QVPIIKL
....|..| .. ...| ..|  | . . ..|.| . |.|||.|.||||.   ...| |   ||.
YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKI
Kinase 19028.AA CAMK 271-411 17 6.7e-12 33.91 In-house 1-237 (425) Show / Hide 
Range on Protein: 271-411
Range on HMM: 1-237/425
Sequence Identity: 17% (41 aa)

FISVGATGLILGVYNKSQK------------RHSALKI-------------------------------QRVSSKHEIVREIGIIRDCQ-------MPLV
 .  |. |    ...|. .            .. | ||                               .| ...... ||| | . .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKD--------------KIQLNDEEKMQIAIQVIDVINYLHYNE
||.| ..                    ||.....      | |||  | .. |.....               .  .. .|  ..  |... ..|.| . 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKLENILYLDSQSQVP-------------IIKL
|||||.|.||||. |. .  .              ||.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
S_TKc 19028.AA S_TKc 266-489 19 1.5e-10 -22.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 266-489
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)

DSNFEFISVGATGLILGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKDK--
    . |  || |    ...|. .|. |.|| .      | ||| | .  . | ..|.|..|.       |..    | |.|   .|..|  . .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKLRVCLAVIDNF---------ETLEPSLKQKNLDYPHGF------------
 ...  .   .. |... ..|.| . |.|||.| ||||  .   .. |.   ..  . . |         | |           ..|.            
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL-----------GYGKCKCDWWSCGCIL

------KIPFEPSYLVKNELIKRNTKIYDIILNTVTFNQEKRKNLSYIIA-----DLHQKY
      . ||.  . .  ..|.      |.| .  ... |||     . .      .|.  
YEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19028.AA CK1 369-398 40 3.9e-08 24.55 In-house 135-164 (339) Show / Hide 
Range on Protein: 369-398
Range on HMM: 135-164/339
Sequence Identity: 40% (12 aa)

MQIAIQVIDVINYLHYNEIVHRDIKLENIL
..|||| .... |.| . ..||||| .|..
LMIAIQMLEALEYMHDCGFIHRDIKPDNFC
Kinase 19028.AA TKL 368-398 33 5.7e-08 24.79 In-house 134-172 (364) Show / Hide 
Range on Protein: 368-398
Range on HMM: 134-172/364
Sequence Identity: 33% (13 aa)

KMQIAIQVIDVINYLHYNE--------IVHRDIKLENIL
....|...   .|||| ..        |.|||.| .|||
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNIL
Kinase 19028.AA STE 269-411 20 8.7e-08 23.71 In-house 1-188 (359) Show / Hide 
Range on Protein: 269-411
Range on HMM: 1-188/359
Sequence Identity: 20% (40 aa)

FEF---ISVGATG-LILGVYNK-----SQKRH---------SALKIQRVSS--------------------KHEIVREIGIIRDCQ--MPLVIKFYGFFY
.|.   |  ||.|   .....|     . ..           | |. ....                    . .| .|| | ..|.   | ..|.|| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LDV--TKKEDFVVYEIEKCS-GNLKQYFNRLKKDKIQLN----------DEEKMQIAIQVIDV-INYLHYNEIVHRDIKLENILYLDSQSQVPIIKL
 .   .| .| .    | .. | | .  .. .. . .||           ..   |. |..    .||| . |.|||||  |||          .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKL
Kinase 19028.AA Pkinase 293-399 22 0.0001 17.8 Pfam 28-141 (293) Show / Hide 
Range on Protein: 293-399
Range on HMM: 28-141/293
Sequence Identity: 22% (27 aa)

ALKIQRVSSKHEIVR-------EIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KDKIQL--NDEEKMQIAIQVIDVIN
|.|| ....... ..       || | . .. | ....|..|.      .| .    | | |   .   | ... ...  .   ..|   .. |..  ..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YLHYNEIVHRDIKLENILY
|.| . |.|||.|.||||.
YCHSMGIIHRDLKPENILI
TyrKc 19028.AA TyrKc 266-485 13 0.000134 -148.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 266-485
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

DSNFEFISVGATGLI-LGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDC--QMPLVIKFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYFNRLKK
 .  . .  || | . .|...    .  | |  . ... .. ||. | .    . | ....||    .    .  .  ..| |  .  |.||.|  . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP

DKIQLNDEEKMQIAIQVIDVINYLHYNEIVHRDIKLENILYLDSQSQVPIIKLRVC-------LAVI-------DNFET----LEP-----------SLK
.   |. ... ....|. .  .||| . ..|||.   |.|. . .        ...       .          |   .     .            ...
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

QK----------------------NLDYPH---GFKIPFEPSYLVKNE--LIKRNT-----------KIYDIILNTVTFNQEKRKNLSYIIADL
 .                         ||     .. ..|   .||.   . .              ..|.|..    .. |.| . | |. ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF