Gene 28099 (Tetrahymena)

28099

Species: Tetrahymena
Alias: 330.m00012, 28099, PreTt28099, 731, TTHERM_01331050
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
28099.AA Protein None 1089 None Fasta, JSON
28099.kin_dom Protein Kinase Domain None 366 None Fasta, JSON
28099.kin_dom2 Protein Kinase Domain None 111 None Fasta, JSON
28099.NA RNA None 3270 None Fasta, JSON

Protein domain

Protein domains of 28099.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28099.AA C8 51-284 58 1.3e-119 403.67 In-house 1-226 (226) Show / Hide 
Range on Protein: 51-284
Range on HMM: 1-226/226
Sequence Identity: 58% (143 aa)

FQNFEYLSSGAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEKSFFVMEME
|.||.|||.|||..||||||.|.||...|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.| |..| .|..||| ..|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSK
|||||||||.|..||.|.. |.|.||||||||..|.|..|.||||||||||||||||..|.|||.||.|                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYLSKK----GTDTYFAPEVEKG------QSRIQSDLFSLGLVL
||..|||    ||..|||||.||.      |.||||||||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 28099.AA Ciliate-C8 60-284 52 1.1e-117 397.24 In-house 1-238 (238) Show / Hide 
Range on Protein: 60-284
Range on HMM: 1-238/238
Sequence Identity: 52% (133 aa)

GAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEK---SFFVMEMELCEQN-
||...||||.|.|.||.|||||..|..|.  ...|...||||....|.|..|.|.|||||||| |... |..||.| . |.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSKSHYL
 |||.||..|..|.. ||..||||||||....|.||..||||||||||||||| .|.|..|||.|. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDTY-----------FAPEVEKGQSRIQSDLFS-------LGLVL
|||  |||.|           |||||||.|||||||.||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 28099.AA C2 60-297 37 9.2e-65 220.14 In-house 1-245 (245) Show / Hide 
Range on Protein: 60-297
Range on HMM: 1-245/245
Sequence Identity: 37% (96 aa)

GAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEK---------SFFVMEME
|| .||||| | |.|| ||||   | | . ..| ... |||....... . ....||..|||  .. | .   |.  . ..|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRNTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKIC-KKFRFLQNLSIQKIIDNQGDLGFASAVTKS
 |. |||| |. .|. .  |.|..|.|.||||. . | ||...| |||||| |||.  .|    |||.|    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYLSK-KGTDTY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLNVLXXLN
||  . || |.| .|    |||||...  . .||||| .|.||||||| .      
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 28099.AA C8 303-416 57 1.5e-61 210.84 In-house 110-226 (226) Show / Hide 
Range on Protein: 303-416
Range on HMM: 110-226/226
Sequence Identity: 57% (67 aa)

YLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL-EIKLCDFGLSTQLEKNCEQIEILDM--VGNWAYMAPEILTKNNDQ
|.||. |...||.|.|..||||.||.||||||.||.||||||.|||||| .|.. ||||||||...|..||...|.. .|  .|.|||.||||..|...|
YDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQ

NKIYSKKSDSYSVGLLL
.|.|...||..||||.|
YKQYRIQSDLFSVGLVL
Kinase 28099.AA Ciliate-C8 299-416 48 4.2e-61 209.3 In-house 101-238 (238) Show / Hide 
Range on Protein: 299-416
Range on HMM: 101-238/238
Sequence Identity: 48% (67 aa)

QLNEYLER-QGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLY-GNQLEIKLCD------FGLSTQLEKNCE---------QIEILDM
.|..|..| . |....|...|..||||.||||||.|||||.||||||.|||||.  ..|..|||||      ||...||.||..         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNWAYMAPEILTK-NNDQNKIYSKKSDSYSVGLLL
  .|||.|.|||...| . .|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 28099.AA C2 300-416 34 3.1e-28 93.64 In-house 105-232 (245) Show / Hide 
Range on Protein: 300-416
Range on HMM: 105-232/245
Sequence Identity: 34% (46 aa)

LNEYLERQGKEG-EFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL-EIKLCD----------FGLSTQLEKNCEQIEILDMVGNWAY
|  |..|. |.  ......|  .|||..||.||.|.|.|.||||||.|||. .  ...  |||||          |  .  |..| ..| .  ...  .|
LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQY

----MAPEILTKNNDQNKIYSKKSDSYS-VGLLL
    .|||.      . .|| |.|| .| ||. |
YQHIFAPEV------YQNIYKKNSDLFSTVGYVL
Kinase 28099.AA CAMK 300-416 21 9.5e-25 76.06 In-house 151-324 (425) Show / Hide 
Range on Protein: 300-416
Range on HMM: 151-324/425
Sequence Identity: 21% (38 aa)

LNEYLERQGK------------EGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYG--------------NQLEIKLCDFGLSTQLEKNC
| .|. ..|.            .| |. .|   .  |... |.|.|  ||.|||.||.| |..  .              |.  ||..|||........ 
LFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE

EQI---------------------EILDMVGNWAYMA-PEILTKNN---------DQNKIYSKKSDSYSVGLLL
..                         ...|  .||| ||.| ..          .... |..|.|  |.| .|
NNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 28099.AA TKL 318-416 23 1.7e-24 85.12 In-house 134-279 (364) Show / Hide 
Range on Protein: 318-416
Range on HMM: 134-279/364
Sequence Identity: 23% (35 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPDNFLVCLYGN-----------QLEIKLCDFGLSTQLEKNCEQIEILDM-----------------
....|...   .|| |  |        |||||.|..| ||   ..           .  .|.||||||. .... ..  .  .                 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGNWAYMAPEILTKNNDQNK-----------IYSKKSDSYSVGLLL
.|. ..||||.| .... ..            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 28099.AA CMGC 51-218 14 2.1e-23 72.98 In-house 1-246 (513) Show / Hide 
Range on Protein: 51-218
Range on HMM: 1-246/513
Sequence Identity: 14% (38 aa)

FQNFEYLSSGAYALVLKAKN--------------IKSNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
... ... .|.|. | |...              ...|..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMDEDVE-------VDKNGNEKPILTKEKSFFVMEMELCEQNLKQLFDYLR-------NTQLPSQE------------IKEII-----AIQ
.|. ||.||  ..| .       . .          .   . . .|.....|.|. .  .       .  |.  .            || ..     . |
IVKLYDIFYHKNSDGNEYEDKHII-S--------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQ

MLEGLN--TLHIKN--IMHRDIKPHNFLVCASQTY----------------GFTIKIC
.|.||.   .| ..  |.|||.|| | |..   ..                 ...|||
ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 28099.AA Pkinase 51-218 23 2.9e-23 83.36 Pfam 1-154 (293) Show / Hide 
Range on Protein: 51-218
Range on HMM: 1-154/293
Sequence Identity: 23% (41 aa)

FQNFEYLSSGAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEKSFFVMEM
..  . . ||... | |.........||.| .   ...  | .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEQN--LKQLFDYLR---NTQL--PSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKIC
|.||    .  ||||..   .. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|||
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 28099.AA STE 321-416 32 6.6e-23 77.8 In-house 156-258 (359) Show / Hide 
Range on Protein: 321-416
Range on HMM: 156-258/359
Sequence Identity: 32% (36 aa)

IAIQVIDS-VNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKNCE--------------QIEILDMVGNWAYMAPEILTKNNDQ-NKIYS
|. |..    .|.|  .||||||||.| |.        .||||||...||....               | .   .||   .||||....|.   .| |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 28099.AA Ciliate-E2 307-416 25 2.2e-22 73.66 In-house 138-286 (365) Show / Hide 
Range on Protein: 307-416
Range on HMM: 138-286/365
Sequence Identity: 25% (41 aa)

QGKEGEFSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKN---------CEQIEILD-
. . . |...| ..|  |...                ..|.|  | ||||||||.| |.        ||..|||||... ..         |. .     
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KN

--------------------MVGNWAYMAPEILTKNNDQN----KIYSKKSDSYSVGLLL
                     .|.  ||||||| . ...|    | |..|.| .|.| .|
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 28099.AA Pkinase 298-416 30 8.4e-21 74.64 Pfam 89-202 (293) Show / Hide 
Range on Protein: 298-416
Range on HMM: 89-202/293
Sequence Identity: 30% (37 aa)

IQLNEYLERQGKEGEF--SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL--EIKLCDFGLSTQLEKNCEQIEILDMVGNWAYMAPEIL
. | .|...  ..| |  |..|  ... |..  ..|.|  .|||||.||.|.|.    ...   .|.|||||. |.. .  .    . .|   |||||..
MDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVI

TKNNDQNKIYSKKSDSYSVGLLL
      .. |..|.| .|.|..|
R----GGQYYGPKVDMWSCGCIL
Kinase 28099.AA Ciliate-E1 299-410 26 1.6e-19 60.49 In-house 82-202 (202) Show / Hide 
Range on Protein: 299-410
Range on HMM: 82-202/202
Sequence Identity: 26% (34 aa)

QLNEYLE----------RQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLST--QLEKNCEQ---IEILDMVG
.|..||.           | ....|....|..|..| || ....| .|||||||||.| |.. . ... .   |||.|   ....| ..    ..  .  
SLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYP

NWAYMAPEILTKNNDQNKIYSKKSDSY
.. |. |  .  . ..|.....||| |
PEQYNCP--EQ-EHNKNQKINYKSDIY
Kinase 28099.AA CAMK 56-218 13 9.5e-19 56.37 In-house 1-238 (425) Show / Hide 
Range on Protein: 56-218
Range on HMM: 1-238/425
Sequence Identity: 13% (34 aa)

YLSSGAYALVLKAKNIKSN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | ........            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MDEDVEVDKNGNEKPILTKEKSFFVMEM---ELCEQN--LKQLFDYLR-NTQ---------------LPSQEIKEIIAIQ
.. |. .               ...          .  . .....| |   |.|.    .  ||||.. ...               .. .| . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNTLHIKNIMHRDIKPHNFLVCASQTYG-------------FTIKIC
...... .| .||.|||.|| | |.. . .               ..|||.
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 28099.AA Ciliate-A1 140-287 29 2.1e-16 52.31 In-house 73-221 (301) Show / Hide 
Range on Protein: 140-287
Range on HMM: 73-221/301
Sequence Identity: 29% (47 aa)

KEKSFFVMEMELCEQNLKQLFDYLRNTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVC-ASQTYGFTIKICKKFRFLQNLSIQK-IIDNQ
||  |..||   |. ..  ||.|  .   .   || ||   |. ||.  .| .||.|||.|| | |.    .     .|||  .   . |  ..   |. 
KECMFIIMEY--CQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILIHFDDK-----WKIC-DLGMSKQLEQNQDCCDDV

GDLGFASAVTKSKSHYLSKKGTDTYFAPEV----------EKGQSRIQSDLFSLGLVLLEL
    |.  | |  .|  .| |.  | .||            ..    |||..|||.....|
NGCSFSKQVNK-HYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
Kinase 28099.AA Ciliate-E1 147-278 20 3.7e-16 49.44 In-house 71-202 (202) Show / Hide 
Range on Protein: 147-278
Range on HMM: 71-202/202
Sequence Identity: 20% (32 aa)

MEMELCEQNLKQLFDYLR-------------NTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKICKKFRFLQNLSIQKII
......|   ..|.|||.             | .  ... |. |..|...||. ||..||.||||||.| |.. .  | ..                   
ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC-------------------

DNQGDLGFASAVTKSKSHYLSKKGTDTYFAPEVEKG----------QSRIQSDLF
    |.| ..   ... ..  .||  .|..|. ..           .  ..||..
----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 28099.AA STE 51-218 19 6.5e-16 52.78 In-house 1-189 (359) Show / Hide 
Range on Protein: 51-218
Range on HMM: 1-189/359
Sequence Identity: 19% (41 aa)

FQNFEYLSSGAYALVLKAKNIK---------------SNRMVALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
... | . .||.  | ||.|.|               .....| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMDEDVEVDKNGNEKPILTKEKSFFVMEMELCE-QNLKQLFDYLRNTQLPS-----------QEIKEIIAIQMLEG-LNTLHIKNIMHRDIKPHNFLVC
.  ...             .|...   . ||...   | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |. 
FKEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

ASQTYGFTIKIC
        .|.|
--------VKLC
Kinase 28099.AA S_TKc 51-488 13 5.5e-15 42.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-488
Range on HMM: 1-231/231
Sequence Identity: 13% (61 aa)

FQNFEYLSSGAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEKSFFVMEME
..  . . .||.. | |....|..| ||.| .                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

LCEQNLKQLFDYLRNTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSKS
                                                                                                    
----------------------------------------------------------------------------------------------------

HYLSKKGTDTYFAPEVEKGQSRIQSDLFSLGLVLLELDNLN-VLXXLNI---QLNEYLERQGKEGE---FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIK
           .  |..  ..     .  |  |  . |.|  |.  ..     | .|....|..|    |.  .   .. |... ..|.|  .|||||.|
---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLK

PDNFLVCLYGNQLEIKLCDFGLSTQLEKNCEQIEILDMVGNWAYMAPEILTKNNDQNKIYSK-KSDSYSVG-LLLSLLDNYLILKELTGATFMNMTLNQY
|.| |..      .||.|||||..||           ..|   |||||.|         |.| |.| .|.| .|  .|  |        ..| ..     
PENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----

EEPFKKQKIKIKQNTEIFKLIQQLVVWERVNRASLSIIVE----QNSNKFK
               |   .|... ...  .| .   . .     ..  . 
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28099.AA CMGC 300-372 18 6.3e-15 44.58 In-house 141-257 (513) Show / Hide 
Range on Protein: 300-372
Range on HMM: 141-257/513
Sequence Identity: 18% (22 aa)

LNEYLERQG--KEG----EFSDEE------------KLNIA------IQVIDSVN--YIHCFN--IIHRDIKPDNFLVCLYGNQ----------------
| .|....   . |    ..|. .            . ..        |.. ...  |.|  .  |||||.|| | |..  .                  
LYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQK

-LEIKLCDFGLSTQLEKN
  ..|.|||||.......
NGRLKICDFGLARWYHPH
Kinase 28099.AA Ciliate-A1 314-416 33 2e-14 45.43 In-house 99-218 (301) Show / Hide 
Range on Protein: 314-416
Range on HMM: 99-218/301
Sequence Identity: 33% (41 aa)

SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKNC----------------EQIEILDMVGNWAYMAPEI----L
. ||   |  | |  .  ||  ||.|||.||.| |.   ..   .|.||.|.|.||| |                    .     ||  ||.||     .
KKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI---HFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

-TKNNDQNKIYSKKSDSYSVGLLL
  .    |||| |.|| ||.|. .
RDQMFIENKIY-KQSDMYSLGCII
Kinase 28099.AA Ciliate-E2 149-287 23 2.5e-13 42.11 In-house 113-289 (365) Show / Hide 
Range on Protein: 149-287
Range on HMM: 113-289/365
Sequence Identity: 23% (48 aa)

MELCEQNLKQLFDYLRNTQLPSQEI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRDIKPHNFLVCASQTYGFTIKICKKF
||.|..  . ||||..| .. ....         |||  |  | |.               .|. || || |.|||||| | |.                
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------

RFLQNLSIQKIIDNQGDLGFASAVTKS---------KSHYLSKK-----------------------GTDTYFAPEVEKGQSR----------IQSDLFS
         |||    |.|..  ....            |.  |                       ||  | |||. .|..            ..|..|
--------IKII----DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGLVLLEL
|| .| |.
LGVILYEM
Kinase 28099.AA TKL 177-218 28 1.6e-08 26.82 In-house 137-196 (364) Show / Hide 
Range on Protein: 177-218
Range on HMM: 137-196/364
Sequence Identity: 28% (17 aa)

IAIQMLEGLNTLHI--------KNIMHRDIKPHNFLVCASQT----------YGFTIKIC
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase 28099.AA Ciliate-E1 57-121 22 2.2e-08 23.89 In-house 1-66 (202) Show / Hide 
Range on Protein: 57-121
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYALVLKAKNIKSN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYL
...| ...|.|||....| . ||.|.  |  ..    .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 28099.AA TyrKc 51-483 13 5.8e-08 -93.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-483
Range on HMM: 1-280/280
Sequence Identity: 13% (64 aa)

FQNFEYLSSGAYALVLKAKNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKF-SQSDFLVNVYDCFYLMDEDVEVDKNGNEKPILTKEKSFFVMEM
 .  . | .||.  | |.. .   ..|| | |   .      .| . .| ... |.  . . .|. | .     .             .  |  . ||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYIEPLMIVMEY

ELCEQNLKQLFDYLRNTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCASQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSK
  .  .||   ||||...                                                                                  
-MPHGDLK---DYLRKHRPK--------------------------------------------------------------------------------

SHYLSKKGTDTYFAPEVEKGQSRIQSDLFSLGLVLLELDNLNVLXXLNIQLNEYLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLV
                                                               .. ...|....|. .  .|.|  |.||||.   |   
---------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN---

CLYGNQLEIKLCDFGLSTQLEKN------CEQIEI-----LDMVGNWAYMAPEILTKNNDQNKIYSKKSDSYSVGLLL-----------SL-----LDNY
||.|... .| .|||||  ..         . .        ...     |||| .     . .... ||| .| | ..           .      ..|.
CLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ

LILKELTGATFMNMTLNQYEEP--FKKQKIKIKQNTEIFKLIQQLVVWERVNRASLSIIVEQN
 ... .     |    | |  |  |          .|......|    .  .| . | |.|. 
EVIEYVKQGYRMPQPPNDY--PMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 28099.AA Ciliate-E2 51-125 13 1e-06 18.7 In-house 1-107 (365) Show / Hide 
Range on Protein: 51-125
Range on HMM: 1-107/365
Sequence Identity: 13% (15 aa)

FQNFEYLSSGAYALVLKAKNIKSNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
.   . . .|... | |.|..| ....|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMDED
||. .|..
CFQEKDDN
Kinase 28099.AA TKL 237-287 17 0.000303 11.2 In-house 196-282 (364) Show / Hide 
Range on Protein: 237-287
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASAVTKSKS-------------------HYLSKKGTDTYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
.|.|..  ...|..                   .  .. ||  . ||||                 ....   ..| .| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 28099.AA Ciliate-A1 51-91 21 0.000509 9.5 In-house 1-42 (301) Show / Hide 
Range on Protein: 51-91
Range on HMM: 1-42/301
Sequence Identity: 21% (9 aa)

FQNFEYLSSGAYALVLKAKNIKSNR-MVALKFLTCTSKEGLK
.     . .| .  |..| .|  ..  ...| . || .| .|
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYK
Kinase 28099.AA STE 238-287 20 0.008692 5.82 In-house 190-261 (359) Show / Hide 
Range on Protein: 238-287
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYLSKKGTDTYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 28099.AA Pkinase 237-287 29 0.017529 9.86 Pfam 154-205 (293) Show / Hide 
Range on Protein: 237-287
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSHYLSKKGTDTYFAPEV--EKGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  .       .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM