Gene 30140 (Tetrahymena)
30140
Sequence
Protein domains of 30140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 30140.AA | C8 | 50-199 | 48 | 3.3e-70 | 239.55 | In-house | 1-172 (226) | Show / Hide |
Range on Protein: 50-199 Range on HMM: 1-172/226 Sequence Identity: 48% (84 aa) TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCS-----------CSLDE- .||||.||||..||||..|..| |..|||||.||....|.|||..|||.....|.|.|.||.|..|.......|.|||.|||| |...| FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM ----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQP-EIKLCNLG |..|.||..||....| .||||.||.|||||..||.||||||.||||.||.... ||||| .| ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFG |
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Kinase | 30140.AA | Ciliate-C8 | 59-196 | 41 | 9.1e-70 | 238.09 | In-house | 1-165 (238) | Show / Hide |
Range on Protein: 59-196 Range on HMM: 1-165/238 Sequence Identity: 41% (68 aa) GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDR-----------------YSVFELEKCS--C |.|||||.. .| .|...|.|.||||...|. |.....|||....|.|||.||........ ... ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQPEIKLC .|..|.|| ..|........| .||||.||||||.| |||.||||||.||||..| ..||.|||| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLC |
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Kinase | 30140.AA | C2 | 59-242 | 27 | 1.3e-39 | 132.99 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 59-242 Range on HMM: 1-245/245 Sequence Identity: 27% (67 aa) GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQHIQNEISIMQKLK-EPLVVQLYDSYIIENKIGPD-------------R----------YSVFELE |.||.|| . | ......||||.... .. .|.|..||.... |.....|... . | . |.|.| GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCN----------------LGYSAPEILNKQ-- .|.. | |..|. |. ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | ||||. | |. .| .. FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK ------------DNELKIYSKKSDSYS-VGLLLAFLDNYQDLKKNA .. .|| |.|| .| ||. | ||| | . WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 30140.AA | Ciliate-E1 | 56-223 | 24 | 8.4e-24 | 74.59 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 56-223 Range on HMM: 1-202/202 Sequence Identity: 24% (51 aa) LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQH-------IQNEISIMQKLKEPL-VVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLD------- .. |||..|. |. . .... .||..... . |.....||. .|. ..|..| ..|.. .. ... .|.|.||| .||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY ---RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIK-------------------LCNLGYSAPEILNK---QDNELKI |....||... | ||..|.|| ....|..|||||||||.| |.. . .. . |. || .| . |. .. WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQK YSKKSDSY ...||| | INYKSDIY |
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Kinase | 30140.AA | Ciliate-B2 | 54-184 | 30 | 9.2e-23 | 50.28 | In-house | 5-137 (197) | Show / Hide |
Range on Protein: 54-184 Range on HMM: 5-137/197 Sequence Identity: 30% (42 aa) QILSFGSFGMVLATKKAKL--DKKEIVLKIQKI---EDEQHIQNEISIMQKL-KEPLVVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLDRQNKDG- ... | .|.. | . ......||. |.. ||.||.||. . .. ||.. |. |...| |. .||| ||| . |.. .| KYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETI-----DVLIMEKCECSLKQELQKIQKQQK QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV .|| ||. | || ... ||.| ||||.| |. CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF |
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Kinase | 30140.AA | CAMK | 55-229 | 18 | 5.3e-21 | 63.78 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 55-229 Range on HMM: 1-324/425 Sequence Identity: 18% (61 aa) ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQHIQNEISIMQK-------LKEPLV .| |||| | . . . .. || .|. |.. ...||.||.| |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQLYDSYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYIHSF ..||. | .| . |.. .. . | || | .|. .. . .| |. .. .. ||.. |.|.|| IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH NIIHRDIKPENFLVYLDGKQPE--------------IKLCNLGYS-------------------------------------------A-PEILNKQ--- ||.|||.|||| |. ... . ||.. | . | ||.||.. NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ------DNELKIYSKKSDSYSVGLLL |.| . |..|.| |.| .| NMQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 30140.AA | Ciliate-E2 | 50-229 | 20 | 6e-20 | 65.16 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 50-229 Range on HMM: 1-286/365 Sequence Identity: 20% (62 aa) TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQK------IEDEQHIQNEIS----------IMQKLKEPLVVQLYDS . ... .|.|| | ..| | ..|.. .||.| |. |.|| .|| |...|. | ....|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YI--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFL .. .|.| . .| |. .| .|. ... . ..|.. .| ||.. ..|.|| | |||||||||| | FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL VYLDGKQPEIKLCNLG---------------------------------------------------YSAPEILNKQDNE----LKIYSKKSDSYSVGLL . ||.. .| | ||||||..... | |..|.| .|.| . F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI L | L |
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Kinase | 30140.AA | CMGC | 53-199 | 15 | 9.9e-20 | 60.67 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 53-199 Range on HMM: 1-249/513 Sequence Identity: 15% (38 aa) FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIEDEQHIQ---------------NEISIMQKLK-----------------EPL ..|.. |..|.| . . . .... .|. | . ..| ||.|...|. .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVQLYDSYIIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YI .|.|||.. .| . .. ... . | . ..| .|..... . | ... . . ||. ... |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCNLG || . |||||.|||| |. ... ..|.| | HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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Kinase | 30140.AA | S_TKc | 50-301 | 24 | 4.2e-19 | 70.69 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 50-301 Range on HMM: 1-231/231 Sequence Identity: 24% (68 aa) TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG ... |.|| | .. | .... .|| | .||..||.|..| . | .|.|||.. . . .| |. .| .|...... | YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG Q---FNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLG-------------YSAPEILNKQDNELKIYSK-KSDSYSVGLLL |. . .. ||.. ..|.|| .|||||.|||| |. .||.| | | |||.| |.| |.| .|.| .| LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQLTTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL AFLDNYQDLKKNAPFTFLLMTKKQLDKPFEKSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVE-QSD---TKFL . . | || |... |.| . .| ||. . . | .| . .. . ..| .. YEM-----LCGYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 30140.AA | Pkinase | 50-184 | 27 | 9.5e-16 | 56.77 | Pfam | 1-141 (293) | Show / Hide |
Range on Protein: 50-184 Range on HMM: 1-141/293 Sequence Identity: 27% (41 aa) TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQHIQN-------EISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC-----SL ... |||| | .|.. . . ..|| | ..| . .. ||.||..|. | .|.|||.. ... . .| | . .| YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV .|. . ..| | ... .. ||. ..|.|| .|||||.||||.|. FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI |
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Kinase | 30140.AA | Ciliate-C8 | 197-229 | 58 | 1.6e-15 | 52.35 | In-house | 205-238 (238) | Show / Hide |
Range on Protein: 197-229 Range on HMM: 205-238/238 Sequence Identity: 58% (20 aa) NLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL |.||.|||...| ......|.|||||||||||.| NWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 30140.AA | CK1 | 59-184 | 19 | 2.1e-15 | 50.25 | In-house | 10-165 (339) | Show / Hide |
Range on Protein: 59-184 Range on HMM: 10-165/339 Sequence Identity: 19% (32 aa) GSFG-MVLAT-----KKAKLDK----KEIVLKIQKI-EDEQH--IQNEISIMQKLK---------------------EPLVVQLYDSYIIENKIGPDRYS |.|| .. | | .| .| ..|. .. . || . |. ...||. .| ....... ... | GGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDY-----YN VFELEKCSCSLDEYLD-RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV . .. . .|..... ... .. |.. ..||||..... |.|. ..|||||||.||.. YMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM |
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Kinase | 30140.AA | C8 | 200-229 | 60 | 5.6e-15 | 48.53 | In-house | 197-226 (226) | Show / Hide |
Range on Protein: 200-229 Range on HMM: 197-226/226 Sequence Identity: 60% (18 aa) YSAPEILNKQDNELKIYSKKSDSYSVGLLL |.||||..||||..|.|...||..||||.| YFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 30140.AA | STE | 156-229 | 25 | 2.4e-13 | 43.59 | In-house | 156-258 (359) | Show / Hide |
Range on Protein: 156-229 Range on HMM: 156-258/359 Sequence Identity: 25% (28 aa) IAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLGYSA-----------------------------------PEILNKQDNE-LKIYSK |. ||. .|.|| .|||||||| | |. .|||. | .. ||....... | |. ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDT KSDSYSVGLLL |.| .|.|... KCDIWSLGCTI |
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Kinase | 30140.AA | TyrKc | 50-296 | 18 | 3.1e-08 | -89.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 50-296 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKL--KEPLVVQLYDSYIIENKIG-----PDRYSVFELEKCSCSLDEYL-DR ..| | || | |.... . | | . .. . .|..|| || . | .|.|| .. . . . . |.|. . .|..|| .. ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLG-----YSA------PEILNK----QDN-------------EL ..| .. .|. ....|| . .|.|| |.||||. | || .. .| . | |. . | . . RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY KIYSKKSDSYSVGLLL----AFLDNYQDL-----KKNAPFTFLLMTKKQLDKPFE----KSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVEQS .... ||| .| | .. . . ..|. .... . ...| . . .|.|. . | .| . .|.|. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 30140.AA | STE | 50-118 | 16 | 2.3e-05 | 15.04 | In-house | 1-112 (359) | Show / Hide |
Range on Protein: 50-118 Range on HMM: 1-112/359 Sequence Identity: 16% (18 aa) TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQHIQNEISIMQKLK--EPLVVQLYDSYI . ... |.|| ..| .. . .. . |. .. |..| |..||.||.|.. | .|. |..|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF IE-------NKI | ... KEGHNHKNDDEL |
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Kinase | 30140.AA | Pkinase | 198-230 | 30 | 2.073966 | 2.53 | Pfam | 175-203 (293) | Show / Hide |
Range on Protein: 198-230 Range on HMM: 175-203/293 Sequence Identity: 30% (10 aa) LGYSAPEILNKQDNELKIYSKKSDSYSVGLLLA ..| |||... . . |..|.| .|.|..|. PWYMAPEVIR----GGQYYGPKVDMWSCGCILY |