Gene 13323 (Tetrahymena)

13323

Species: Tetrahymena
Alias: 777, TTHERM_01174650, 263.m00037, PreTt13323, 13323
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
13323.AA Protein None 1132 None Fasta, JSON
13323.kin_dom Protein Kinase Domain None 287 None Fasta, JSON
13323.kin_dom2 Protein Kinase Domain None 209 None Fasta, JSON
13323.NA RNA None 3399 None Fasta, JSON

Protein domain

Protein domains of 13323.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13323.AA C2 48-273 50 6.8e-135 454.45 In-house 1-245 (245) Show / Hide 
Range on Protein: 48-273
Range on HMM: 1-245/245
Sequence Identity: 50% (124 aa)

GSFALVLKAINKNTGQTVALKVVECDENDLKGIQAIQEEYKMLEIFTGCKYVVKVLNNFFLTESSDSD--EDDDQIPVGQNN--NQSNLLRVFYVMEQEF
|.|.|||||.||.....||||..||..||..| . .|.||.... . ...|..|| | |.||.. ..|  ||.|.....|.|  .|.|....|.|.||||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CQTTLQSFIETCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD----------LAFASALKNNETRLSISTFKG
||..|......||..||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.||||          ..|||.||.|..|...|.||.
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

SQAY----TAPEVYQNVYKKLSDLFS-VGIVLLELDNIATFDISK
.|.|    .|||||||.||| ||||| ||.|||||||.....|..
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13323.AA Ciliate-C8 48-260 38 2.7e-96 326.21 In-house 1-238 (238) Show / Hide 
Range on Protein: 48-260
Range on HMM: 1-238/238
Sequence Identity: 38% (95 aa)

GSFALVLKAINKNTGQTVALKVVEC-DENDLKGIQAIQEEYKMLEIFTGCKYVVKVLNNFFLT--ESSDSDEDDDQIPVGQNN--NQSNLLRVFYVMEQE
|.|..||||.||.....||||..|| .... ...  ...||.|.  |  ...||.| ..|.|.  .... |...|.|...|..  .      .|.|||.|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK------SFFVMEME

FCQTT--LQSFIETCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD------LAFASALKNNETRLSISTFKGS
.||..  |......||.|.||||||||||..||..|||..||.|...||||||.|||..|||...|| ||||      ..|||.|..|........|||.
KCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGT

QAY-----------TAPEVYQNVYKKLSDLFS-------VGIVL
..|           .||||....... ||.||       ||.||
DQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13323.AA C8 36-260 33 2e-54 187.13 In-house 1-226 (226) Show / Hide 
Range on Protein: 36-260
Range on HMM: 1-226/226
Sequence Identity: 33% (78 aa)

QKHYQILEFAGNGSFALVLKAINKNTGQTVALKVVECDEN-DLKGIQAIQEEYKMLEIFTGCKYVVKVLNNFFLTESSDSDEDDDQIPVGQNNNQSNLLR
 . .|.| |   |....|||| | .  ....||. .| .. | ..|. |. ||.|...|   . .| . . | . ..    |....  . |... |    
FNNFQYLSF---GAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKS----

VFYVMEQEFCQTTLQSFIETCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSISTF--K
 . ||| | |.  |. . . .|.|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||||..|||... |.    .  .   
-CFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTC

GSQAYTAPEVYQN------VYKKLSDLFSVGIVL
| .|| |||. .        |.. |||||||.||
GTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13323.AA Pkinase 39-263 23 3.3e-29 104.34 Pfam 1-205 (293) Show / Hide 
Range on Protein: 39-263
Range on HMM: 1-205/293
Sequence Identity: 23% (57 aa)

YQILEFAGNGSFALVLKAINKNTGQTVALKVVECDENDLKGIQAIQE--EYKMLEIFTGCKYVVKVLNNFFLTESSDSDEDDDQIPVGQNNNQSNLLRVF
|.|..  | |||. | |...|.||..||.|... .... .  |.     | ...  . .....|. .  .| .                        .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLY-DWFED------------------------KDH

YVMEQEFCQT-----TLQSFIETCRQKNSY--PSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKLCDLAFASALKNNETRLS
. | .|.|.       | ..|.| ......  . .. | .|. |||  ....|.  ..|||.||.|.|..  .||..  ..|.||  .|  .. .     
IYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-Y-NNS-

ISTFKGSQAYTAPEVYQ--NVYKKLSDLFSVGIVLLEL
 .|| |.  | |||| .  . | . .| .|.|..| |.
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 13323.AA CMGC 39-216 16 9.4e-29 90.86 In-house 1-251 (513) Show / Hide 
Range on Protein: 39-216
Range on HMM: 1-251/513
Sequence Identity: 16% (43 aa)

YQILEFAGNGSFALVLKAIN--------------KNTGQTVALKVVECDENDLKGIQ----------AIQEEYKMLEIF----------------TGCKY
|.|..  | |... | |...              ..|.. ||.| .  .. .  . .           .. | |.|. .                   ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVKVLNNFFLTESSDSDEDDDQIPVGQNNNQSNLLRVFYVMEQEFCQTTLQSFIETCRQ-----KNSYPSQQM------------KEIMT------IQIL
.|| .. |   .|  ....| .|.  .   | ..  .. |.  |.....|  .|. ...     .. . |.              .  ..       |||
IVKLYDIFYHKNSDGNEYEDKHII--S---Q-HFNHLYLVF--EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQIL

DSVA--FLHRFD--VVHRDIKPSNFLLNFDQNG----------------NPTLKLCDLAFA
 ...  ..|. .  ..|||.||.| |.| .                   | .||.||  .|
RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 13323.AA S_TKc 39-325 21 5e-28 100.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

YQILEFAGNGSFALVLKAINKNTGQTVALKVVECDENDLKGIQAIQEEYKMLEIFTGCKYVVKVLNNFFLTESSDSDEDDDQIPVGQNNNQSNLLRVFYV
|.||.  | |.|. | |...|.||. ||.|..          . |. | ..|.   .....|| .  |                             .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD--------------------------DHLY

MEQEFCQT---TLQSFIETCRQKNS---YPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSISTFK
|  |.| .   .| ..|. .. .     .|  . . .|  ||.. ....|.  ..|||.||.| ||.       ..|.||  .|  |         .|| 
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TTFC

GSQAYTAPEVYQNVYKK-LSDLFSVGIVLLELDN-IATFDISKTNLEQKFETKNGQIFQNFNIDRQSQIYKIVMQCLKYEVDQRKPAVELLI--------
|.  | ||||    | |  .|  |.|..| |.      |.    .... |.               ..   ....||... ..|  | |.|         
GTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

QFI
...
PWF
Kinase 13323.AA CAMK 173-260 22 2.6e-22 68.05 In-house 187-324 (425) Show / Hide 
Range on Protein: 173-260
Range on HMM: 187-324/425
Sequence Identity: 22% (31 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKLCDLAFASALKNNETRL---------------------SISTFKGSQAYT
||.. |...|  ..||||.|| | ||. . ....             ..|..|  ||  .. .|  .                       .|| |. .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVYQNV---------------YKKLSDLFSVGIVL
| ||| .                 | . .|  |.|..|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 13323.AA Ciliate-E1 45-254 20 2.9e-21 66.25 In-house 1-202 (202) Show / Hide 
Range on Protein: 45-254
Range on HMM: 1-202/202
Sequence Identity: 20% (45 aa)

AGNGSFALVLKAINKNTG-QTVALKVVECD--ENDLKGIQAIQEEYKMLEIFTGCKYVVKVLNNFFLTES--------SDSDEDDDQIPVGQNNNQSNLL
 |||||..|.||...|.  . ||.|...|   .|. .  . |.|.||... | . .|...... ... ..        . .... |.. .          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

RVFYVMEQEFCQTTLQSFIETCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPT-LKLCDLAFASALKNNETRLSISTFK
           .  |   .  |.|.. . ..| |. ...|..| .. || . . ||||||.| | | . |.. . . ....   . ...   .  .. ..
-----------N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYY

GSQAYTAPEV---YQNVYKKLSDLF
 .. |. ||.   ... ... ||..
PPEQYNCPEQEHNKNQKINYKSDIY
Kinase 13323.AA Ciliate-E2 39-263 14 5.4e-20 65.3 In-house 1-289 (365) Show / Hide 
Range on Protein: 39-263
Range on HMM: 1-289/365
Sequence Identity: 14% (49 aa)

YQILEFAGNGSFALVLKAINKNTGQ------------------TVALKVVECDENDLKGIQAIQEEYKML----EIFTGCKYVVKVLNNFFLTESSDSDE
| ...  |.|.|. | |. ......                   |. | ..   .  ..|..|  | ...    . |                       
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F-----------------------

DDDQIPVGQN----------NNQSNLLRVFYVME----------QEFCQT-TLQSFIE---TCRQKN----SYPSQQMKEIMTIQILD------------
        .           .|  |... ... .           |.||  .|...|.   ..|...     |.. .    .. |||.            
--------YKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIAC

---SVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKLCDLAFAS--ALKNNETRLSISTFK----------------------------GSQAYTAPEV
    . .||    ..||||||.| |.         .|..|. ..     .|....   .  |                            |.  | |||.
IILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

YQNV----------YKKLSDLFSVGIVLLEL
...           | . .|..|.|..| |.
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 13323.AA STE 169-263 29 2.3e-17 57.98 In-house 155-261 (359) Show / Hide 
Range on Protein: 169-263
Range on HMM: 155-261/359
Sequence Identity: 29% (34 aa)

IMTIQILDS-VAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNN-------------ETRLSIS-TFKGSQAYTAPEVYQN-------V
... |||    ..||.  ..||||||.| ||          ||||  ... | ..             ||. . . || |.. . |||| |.        
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

YKKLSDLFSVGIVLLEL
|   .|  |.|....|.
YDTKCDIWSLGCTIIEM
Kinase 13323.AA ULK 136-260 23 5.1e-17 56.02 In-house 92-246 (329) Show / Hide 
Range on Protein: 136-260
Range on HMM: 92-246/329
Sequence Identity: 23% (37 aa)

F--YVMEQEFCQT-TLQSFIETCRQ-------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFAS
.  . . .|.|.  .|...|.. .        |.  . |. .... .|||    .||   ..||||||.| |.. .| .        |..||..|  || 
HNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

ALKNN--ETRLSISTF-----KGSQAYTAPEVYQ------NVYKKLSDLFSVGIVL
 . |.  | ..  ..      .|.  | ||.. |      . | . .|..|.|...
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 13323.AA ULK 141-260 25 1.6e-15 51.62 In-house 96-242 (324) Show / Hide 
Range on Protein: 141-260
Range on HMM: 96-242/324
Sequence Identity: 25% (37 aa)

QEFCQT-TLQSFIETCRQ------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALKNNETR
.|.|.  .|...|.. .       |.  . |. .... .||.    .||   ..||||||.| |.. .| .        |..||..|  ||  . ||.  
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFF-KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

LSIS-TFK------GSQAYTAPEVYQ------NVYKKLSDLFSVGIVL
  .  |..      |.  | ||.. |      . | . .|..|.|...
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 13323.AA STE 39-101 19 2.7e-10 32.67 In-house 1-94 (359) Show / Hide 
Range on Protein: 39-101
Range on HMM: 1-94/359
Sequence Identity: 19% (18 aa)

YQILEFAGNGSFALVLKAINKN---------------TGQTVALKVVECDEND---------------LKGIQAIQEEYKMLEIFTG-CKYVVK
....|. |.|.|  | ||.|..               ||. .| |... ....                . .| |..| |..  .   ....||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase 13323.AA TyrKc 39-324 13 1.1e-08 -81.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-324
Range on HMM: 1-280/280
Sequence Identity: 13% (47 aa)

YQILEFAGNGSFALVLKAINKNTGQTVALKVVECDENDLKGIQAIQEEYKMLEIF-TGCKYVVK----VLNNF-----------------------FLTE
 . ..  |.| |  | |.. |   ..|| |..  |      .... .| ...  .    . .|.    ..  .                       .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SSDSDEDDDQIPVGQNNNQSNLLRVFYVMEQEFCQTTLQSFIETCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKL
. .                                                 . . .  . .|| .  ..||.  ..|||.   | |.. ..    | | 
HRPK-----------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKI

CDLAFASALKNN------ETRLSISTFKGSQ-----AYTAPEVY-QNVYKKLSDLFSVGIVLLEL-DNIATFDIS-----KTNLEQKFETKNGQIFQNFN
.|   . ....       .   . .. ||.        .|||.   ...   || .| |... |.  . ..         ..| |     |.|       
SDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPP

ID-------RQSQIYKIVMQCLKYEVDQRKPAVELLIQF
 |         . .|.|  || ... ..|    |.  .|
NDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 13323.AA ULK 39-106 22 1e-06 19.75 In-house 1-84 (324) Show / Hide 
Range on Protein: 39-106
Range on HMM: 1-84/324
Sequence Identity: 22% (19 aa)

YQILEFAGNGSFA-LVLKAINKNT---GQTVALKVVE----CDENDLKG----IQAIQEEYKMLEIFT--GCKY--VVKVLNNF
|.. .  | |||.  | |..||.|   .| || |...     . . .      .| .. | . . ..    ...  .|| .  |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWF
Kinase 13323.AA CAMK 46-90 18 3.2e-05 11.99 In-house 3-85 (425) Show / Hide 
Range on Protein: 46-90
Range on HMM: 3-85/425
Sequence Identity: 18% (15 aa)

GNGSFALVLKAINKNTG------------QTVALKVVECDEND--------------------------LKGIQAIQEEYKML
| |||. | ..|.|||.            | || |... .  .                           |  . .. |....
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIM
Kinase 13323.AA ULK 39-106 24 0.000223 11.29 In-house 1-87 (329) Show / Hide 
Range on Protein: 39-106
Range on HMM: 1-87/329
Sequence Identity: 24% (21 aa)

YQILEFAGNGSFALVLKAINKNT----GQTVALKVVECDENDLKG--------IQAIQEEYKMLEIFT---GCKY----VVKVLNNF
|.. .  | |||. | |..||.|    .. || |... .. . |         .| .. | | .       ..|.    .|| .  |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF
Kinase 13323.AA STE 303-325 30 0.00712 6.13 In-house 334-359 (359) Show / Hide 
Range on Protein: 303-325
Range on HMM: 334-359/359
Sequence Identity: 30% (8 aa)

VMQCLKYEVDQRKPAVELLI---QFI
. .||... ..|  | .||     ||
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase 13323.AA C2 390-576 40 6.5e-108 364.82 In-house 1-245 (245) Show / Hide 
Range on Protein: 390-576
Range on HMM: 1-245/245
Sequence Identity: 40% (98 aa)

GATGLVLGVFNKTQNRYSALKIQRAK------KHEVVREVGIMKDCQ-MPLVIKFYDYFYLNVNNKED------------------------FVVYEIEK
||.||||..|||.|||..|||||...      .|||..|.|||..|| ||..||.|.||||.||.|||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD----------FDQARKMPYDWSYIDGQN-VK
|.|||||..|...|||.......|...|||.||.|||||..||||||||..|.||......||||||.|          ||.|.|..|..|.| ... ..
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

QYYPIEG----------------ACGTIGYCPPELVKDFLYSFNS
.......                ...|.||...||.....|....
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13323.AA Ciliate-C8 390-585 34 1.1e-90 307.57 In-house 1-238 (238) Show / Hide 
Range on Protein: 390-585
Range on HMM: 1-238/238
Sequence Identity: 34% (82 aa)

GATGLVLG-------VFNKTQNRYSALKIQRAK-KHEVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKED-----------------FVVYEIEKCS--G
||.|.||.        ... ..| ...|||... .||......||..||||.|...||.|||. .|.|||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD------FDQARKMPYDWS-YIDGQNVKQYYPIEG
||||......|.........|..||||..|..||||...|.|||||..|.|. ... ..|||||.|      |..|...|...| |.. . ......||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

A-CGTIGYCPPELVKD------FLYSFNSDIFQVGVCL
. ||..||..||..|.       ..|..||...||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13323.AA C8 383-585 31 4.4e-47 161.45 In-house 3-226 (226) Show / Hide 
Range on Protein: 383-585
Range on HMM: 3-226/226
Sequence Identity: 31% (72 aa)

NFEFISVGATGLVLGVFNKTQNRYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKEDFVVYEIEKCS--------------------
||...| || |.||   |  .||  .||.|  .   .   .  ||| ..||.|.. || .... .  .|...|.| ||||                    
NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC

-GNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTI
  ||||.   ............| .||||..| .||.|.. |.|||||..|.|  ..  ....|||.||. | . . . | |  .....       ||| 
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW

GYCPPELVKD-----FLYSFNSDIFQVGVCL
.|  ||  |.       |.  ||.|.||. |
AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13323.AA CAMK 386-578 16 2.4e-30 94.41 In-house 1-317 (425) Show / Hide 
Range on Protein: 386-578
Range on HMM: 1-317/425
Sequence Identity: 16% (54 aa)

FISVGATGLVLGVFNK-TQN-----------RYSALKI--------------------------------QRAKKHEVVREVGIMKDCQ-------MPLV
 .  |. | |  ...| |..           .  | ||                                .  ....| ||. ||| .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDYFYL-----------NVNN-----KEDFVVYE--IEKCSGN------LKQFLNN-----------LKKQNKELDENQKIKIAIQIMDVINYLHIH
||.|...             . ..     .....      | |||       .     .           .  ... ..| .  ..  || . ..|.| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

DIVHRDIKLENLLYVEQDPEIP-------------TIKLADFDQARKMP------YDWSYIDGQNVKQ-------YYPIEGACGTIGYCP-PELVKDFL-
.|||||.|.||.|... ... .             .||..||  |.|..      .. .| .|. ...         . .  ||| .|.. ||...    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YSFNSDI
             |.. .|.
CNMQNATDEEKPYYGPKCDM
S_TKc 13323.AA S_TKc 381-656 20 2.4e-21 78.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 381-656
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

DPNFEFISVGATGLVLGVFNKTQNRYSALKIQRAKKHEVVREVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG---NLKQFLNNLKKQNKE-
    . |  || | |  . .|  .|. |.|| .     . ||. |.|  . | ..|.||.|.       |..    | |.|   .|.... . ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTIGYCPPELVKDFLYSF-
 ..| .  ... || . ..|.| | |.|||.| ||.|  |      .||..||  ||..                     |||  |..||..    |.. 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKC

NSDIFQVGVCLALIDN----FETLEPVLVNKSLDYLNNFSIPFEVKQHNEQEVVKRNTKIYDILLQTIVFKQHKRSNLSLILD--------GFS
 .|.  .|..|.        |.  . .. .| .                            |.. .  ..   ||     .|          . 
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13323.AA Ciliate-E2 401-585 21 3.6e-21 69.39 In-house 44-286 (365) Show / Hide 
Range on Protein: 401-585
Range on HMM: 44-286/365
Sequence Identity: 21% (56 aa)

KTQNRYSALKIQRAK-KHEVVREVGIMK----------------DCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-NLKQFLNNL-KKQNKE-----
|... . |.||.. . . .. .|  ||.                  . | .||.|..|.   ..... . .  | |.| .|.....|  ||.|.|     
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

-LDENQKIKIAIQIMD---------------VINYLHIHD-IVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGA----
 ..|.. ..|  || .                ..|||    |.|||||.||.|.         ||..||  ..|   |  .. . .. ..  ..      
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS

------------------CGTIGYCPPELVK---------DFLYSFNSDIFQVGVCL
                  ||| || .|| ..            |.. .||. .||.|
RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 13323.AA Pkinase 420-579 23 1.4e-19 70.35 Pfam 46-196 (293) Show / Hide 
Range on Protein: 420-579
Range on HMM: 46-196/293
Sequence Identity: 23% (40 aa)

VR--EVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-----NLKQFLNNLKKQNKEL--DENQKIKIAIQIMDVINYLHIHDIVHRDIKLEN
.|  |. ||| .. | ....||.|.      .| .    | | |      |. ..    .... .  .|.. .... ||   ..|.| . |.|||.|.||
RRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN

LLYVEQDPEI-PTIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTIGYCPPELVK-DFLYSFNSDIF
.|.. ....| ...|..||  |...              .    . |||..|..||... .  |.  .|..
ILID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW
Kinase 13323.AA Ciliate-E1 387-579 18 2.1e-16 50.23 In-house 1-202 (202) Show / Hide 
Range on Protein: 387-579
Range on HMM: 1-202/202
Sequence Identity: 18% (41 aa)

ISVGATGLVLGVFNKTQN-RYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYF--YLNVNNKED--FVVYEIEKCSGNLKQFLN---------NLK
|. |  ..|.  ... .| .  |.||.  .   . . .  . | .. .. .|...|   ....  ...  . .  .|.|. .||. |.          ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTIGYCPPELVK---
........ ||..|..|. | ...||.. | ||||| .|.|.  |.  . .              | .  . .. .|.. .   . |  |.||| ..   
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPE

---DFL--YSFNSDIF
   .    ....|||.
QEHNKNQKINYKSDIY
Kinase 13323.AA STE 384-528 21 7.9e-14 45.32 In-house 1-191 (359) Show / Hide 
Range on Protein: 384-528
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

FEF---ISVGATGLVLGVFNKT---------------QNRYSALKIQR---------------------AKKHEVVREVGIMKDCQ--MPLVIKFYDYFY
.|.   |  ||.| |    |.                .... | |. .                      .. .. .|. |||.|.   | ..|.|....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LN---VNNKEDFVVYEIEKCS-GNLKQFLNNLKKQNKELD----------ENQKIKIAIQIMDV-INYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD
 .    .|...  ..  | .. | | ..... .. .|.|.          |.| ..|. ||     .||| | |.|||||  | |          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F
Kinase 13323.AA CMGC 400-528 16 2.7e-13 39.11 In-house 34-248 (513) Show / Hide 
Range on Protein: 400-528
Range on HMM: 34-248/513
Sequence Identity: 16% (36 aa)

NKTQNRYSALKIQR-AKKHEVV---------------REVGIMKDCQ-----------------MPLVIKFYDYFYLNVNNKED------------FVVY
..  |.. |.|. . .. .|                 ||. |.|  .                  . ..| ||.|| . .....             .  
HHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYL

EIEKCSGNLKQFLNNLKK-----QNKELDENQ------------KIKIA------IQIMDVIN--YLHIHD--IVHRDIKLENLLYVEQDPEI-------
  | .  .|.|.. | ..     ....|.| .            . ..        ||   ..  |.| |.  |.|||.| ||.|  ..   |       
VFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS

---------PTIKLADF
          ..|..||
EDWNPCQKNGRLKICDF
Kinase 13323.AA ULK 461-528 32 8.2e-12 37.6 In-house 105-186 (329) Show / Hide 
Range on Protein: 461-528
Range on HMM: 105-186/329
Sequence Identity: 32% (27 aa)

GNLKQFLNNLKK------QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||       .| | |.. |.. .||.    .|| | |.|||||..| |  . .|         ....|.|||
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF
Kinase 13323.AA ULK 461-528 33 9.6e-12 38.01 In-house 102-182 (324) Show / Hide 
Range on Protein: 461-528
Range on HMM: 102-182/324
Sequence Identity: 33% (27 aa)

GNLKQFLNNLKK-----QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||      .| | |.. |.. .||.    .|| | |.|||||..|.|  . .|         ....|.|||
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF