24007

Species: Tetrahymena
Alias: 780, TTHERM_01155710, 24007, PreTt24007, 257.m00032
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
24007.AA Protein None 975 None Fasta, JSON
24007.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
24007.kin_dom2 Protein Kinase Domain None 209 None Fasta, JSON
24007.NA RNA None 2928 None Fasta, JSON

Protein domain

Protein domains of 24007.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24007.AA C2 48-275 51 3.1e-138 465.54 In-house 1-245 (245) Show / Hide
Range on Protein: 48-275
Range on HMM: 1-245/245
Sequence Identity: 51% (127 aa)

GTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNN--NQSSLLRVFYVMEQEF
| |.|||||.||.....|||| .||...|..||. .| ||.... .....|||||.|.||||.. ..|.|||.|.....|.|  .|......|.|.||||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD----------LAFASALKNNETRLSISTFKG
||..| .....||..||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.||||          ..|||.||.|..|...|.||.
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

SQAY----TAPEVYQNVYKKLSDLFS-VGIVLLELDNIATFDISK
.|.|    .|||||||.||| ||||| ||.|||||||.....|..
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC

Kinase 24007.AA Ciliate-C8 48-262 40 7.5e-100 338.03 In-house 1-238 (238) Show / Hide
Range on Protein: 48-262
Range on HMM: 1-238/238
Sequence Identity: 40% (98 aa)

GTFALVLKAINKNTGQTVALKAVEC-DESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNN--NQSSLLRVFYVMEQE
| |..||||.||.....|||| .|| .. . ..|| .. ||.|.  |. ......|...|||.| .... |...|.|...|..  .      .|.|||.|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK------SFFVMEME

FCQTT--LSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD------LAFASALKNNETRLSISTFKGS
.||..  | ...|.||.|.||||||||||..||..|||..||.|...||||||.|||..|||...|| ||||      ..|||.|..|........|||.
KCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGT

QAY-----------TAPEVYQNVYKKLSDLFS-------VGIVL
..|           .||||....... ||.||       ||.||
DQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL

Kinase 24007.AA C8 36-262 33 5.2e-54 185.76 In-house 1-226 (226) Show / Hide
Range on Protein: 36-262
Range on HMM: 1-226/226
Sequence Identity: 33% (78 aa)

QKHYQILQFAGNGTFALVLKAINKNTGQTVALKAVEC-DESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSL
 . .|.| |   | ...|||| | .  ....||  .| ...| ...| |. ||.|..||.  . .. . . ||. .. . . .... .. |  ..     
FNNFQYLSF---GAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYE-VFEEEKCSNEKIVQTEE-----

LRVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSISTF-
 . . ||| | |.  |  . | .|.|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||||..|||... |.    .  . 
-KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMN

-KGSQAYTAPEVYQN------VYKKLSDLFSVGIVL
  | .|| |||. .        |.. |||||||.||
TCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 24007.AA Pkinase 39-265 22 3.2e-31 111.48 Pfam 1-205 (293) Show / Hide
Range on Protein: 39-265
Range on HMM: 1-205/293
Sequence Identity: 22% (54 aa)

YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQ---DEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSLL
|.|..  | |.|. | |...|.||..||.| .. . .. ......     | ...  . ....|.. . .|.                            
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---------------------------

RVFYVMEQEFCQTTLSSFIDTC-----RQKNSY--PSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKLCDLAFASALKNNET
.  . | .|.|. .|.  .| .     ......  . .. | .|. |||  ....|.  ..|||.||.|.|..  .||..  ..|.||  .|  .. .  
KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-Y-N

RLSISTFKGSQAYTAPEVYQ--NVYKKLSDLFSVGIVLLEL
    .|| |.  | |||| .  . | . .| .|.|..| |.
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

Kinase 24007.AA CMGC 39-218 16 6.7e-30 94.71 In-house 1-251 (513) Show / Hide
Range on Protein: 39-218
Range on HMM: 1-251/513
Sequence Identity: 16% (45 aa)

YQILQFAGNGTFALVLKAIN--------------KNTGQTVALKAVECDESDLKGME----------VIQDEYKMLEVFS----------------GCKY
|.|..  | ||.. | |...              ..|.. ||.| .  .. .  ..            ...| |.|. ..                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKVFNSFYLTES----------IDSDSDEDDDQIPVDQNNNQSSLLRVFYVMEQEFCQTTLSSFIDTCRQ-----KNSYPSQQM------------KEI
|.| ...||  .|          | |                | ..  .. |.  |.....|  .|. ...     .. . |.              .  
IVKLYDIFYHKNSDGNEYEDKHII-S----------------Q-HFNHLYLVF--EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKY

MT------IQILDSVA--FLHRFD--VVHRDIKPSNFLLNFDQNG----------------NPTLKLCDLAFA
..       ||| ...  ..|. .  ..|||.||.| |.| .                   | .||.||  .|
FMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA

Kinase 24007.AA S_TKc 39-327 21 4.5e-29 103.84 SMART 1-231 (231) Show / Hide
Range on Protein: 39-327
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSLLRVF
|.||.  | |.|. | |...|.||. ||.| .          | |. | ..|.   ....|.| . .|.                              .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----------------------------DH

YVMEQEFCQT---TLSSFIDTCRQKNS---YPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSIST
. |  |.| .   .| ..|. .. .     .|  . . .|  ||.. ....|.  ..|||.||.| ||.       ..|.||  .|  |         .|
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TT

FKGSQAYTAPEVYQNVYKK-LSDLFSVGIVLLELDN-IATFDISKTNLEQKFETKNGQIFQNFNIDKQSQIYKIVMQCLKYEVDQRKPAVELLI------
| |.  | ||||    | |  .|  |.|..| |.      |.    .... |.               ..   ....||... ..|  | |.|       
FCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

--QFI
  ...
CHPWF

Kinase 24007.AA Ciliate-E1 45-256 19 2.5e-22 69.73 In-house 1-202 (202) Show / Hide
Range on Protein: 45-256
Range on HMM: 1-202/202
Sequence Identity: 19% (44 aa)

AGNGTFALVLKAINKNTG-QTVALKAVECD--ESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTES------IDSDSDEDDDQIPVDQNNNQSSLL
 ||| |..|.||...|.  . ||.| ..|   ... .  ..|. .||... | . .|||.... ... ..      ... .... |.. .          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

RVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPT-LKLCDLAFASALKNNETRLSISTFK
           .  |   .. |.|.. . ..| |. ...|..| .. || . . ||||||.| | | . |.. . . ....   . ...   .  .. ..
-----------N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYY

GSQAYTAPEV---YQNVYKKLSDLF
 .. |. ||.   ... ... ||..
PPEQYNCPEQEHNKNQKINYKSDIY

Kinase 24007.AA CAMK 175-262 22 2.6e-22 68.05 In-house 187-324 (425) Show / Hide
Range on Protein: 175-262
Range on HMM: 187-324/425
Sequence Identity: 22% (31 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKLCDLAFASALKNNETRL---------------------SISTFKGSQAYT
||.. |...|  ..||||.|| | ||. . ....             ..|..|  ||  .. .|  .                       .|| |. .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVYQNV---------------YKKLSDLFSVGIVL
| ||| .                 | . .|  |.|..|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase 24007.AA STE 171-265 29 2.3e-17 57.98 In-house 155-261 (359) Show / Hide
Range on Protein: 171-265
Range on HMM: 155-261/359
Sequence Identity: 29% (34 aa)

IMTIQILDS-VAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNN-------------ETRLSIS-TFKGSQAYTAPEVYQN-------V
... |||    ..||.  ..||||||.| ||          ||||  ... | ..             ||. . . || |.. . |||| |.        
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

YKKLSDLFSVGIVLLEL
|   .|  |.|....|.
YDTKCDIWSLGCTIIEM

Kinase 24007.AA ULK 138-262 23 2.5e-16 53.56 In-house 92-246 (329) Show / Hide
Range on Protein: 138-262
Range on HMM: 92-246/329
Sequence Identity: 23% (37 aa)

F--YVMEQEFCQT-TLSSFIDTCRQ-------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFAS
.  . . .|.|.  .|...| . .        |.  . |. .... .|||    .||   ..||||||.| |.. .| .        |..||..|  || 
HNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

ALKNN--ETRLSISTF-----KGSQAYTAPEVYQ------NVYKKLSDLFSVGIVL
 . |.  | ..  ..      .|.  | ||.. |      . | . .|..|.|...
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF

Kinase 24007.AA Ciliate-E2 175-265 19 2.5e-15 49.06 In-house 168-289 (365) Show / Hide
Range on Protein: 175-265
Range on HMM: 168-289/365
Sequence Identity: 19% (26 aa)

QILDSVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKLCDLAFAS--ALKNNETRLSISTFK----------------------------GSQAYTAPE
.|.. . .||    ..||||||.| |.         .|..|. ..     .|....   .  |                            |.  | |||
CIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE

VYQNV----------YKKLSDLFSVGIVLLEL
....           | . .|..|.|..| |.
ILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

Kinase 24007.AA ULK 174-262 28 3.1e-15 50.55 In-house 133-242 (324) Show / Hide
Range on Protein: 174-262
Range on HMM: 133-242/324
Sequence Identity: 28% (31 aa)

IQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALKNNETRLSIS-TFK------GSQAYTAPEVYQ------NVYKKL
.||.    .||   ..||||||.| |.. .| .        |..||..|  ||  . ||.    .  |..      |.  | ||.. |      . | . 
KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYK

SDLFSVGIVL
.|..|.|...
CDIWSLGCIF

Kinase 24007.AA STE 39-107 17 9.2e-09 27.2 In-house 1-100 (359) Show / Hide
Range on Protein: 39-107
Range on HMM: 1-100/359
Sequence Identity: 17% (17 aa)

YQILQFAGNGTFALVLKAINKN---------------TGQTVALKAVECDESD---------------LKGMEVIQDEYKMLEVFSG-CKYIIKVFNSFY
...... |.|.|  | ||.|..               ||. .| | .. ....                . |. |. | |..  ..  ...|.| . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF





Kinase 24007.AA TyrKc 39-326 14 1.6e-08 -84.91 SMART 1-280 (280) Show / Hide
Range on Protein: 39-326
Range on HMM: 1-280/280
Sequence Identity: 14% (49 aa)

YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVF-SGCKYIIK----VFNSF-----------------------YLTE
 . ..  |.| |  | |.. |   ..|| | .  |      .| . .| ...  .    . |..    .  ..                       || .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SIDSDSDEDDDQIPVDQNNNQSSLLRVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTL
. .                                                   . . .  . .|| .  ..||.  ..|||.   | |.. ..    | 
HRPK-------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TV

KLCDLAFASALKNN------ETRLSISTFKGSQ-----AYTAPEVY-QNVYKKLSDLFSVGIVLLEL-DNIATFDIS-----KTNLEQKFETKNGQIFQN
| .|   . ....       .   . .. ||.        .|||.   ...   || .| |... |.  . ..         ..| |     |.|     
KISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ

FNID-------KQSQIYKIVMQCLKYEVDQRKPAVELLIQF
   |         . .|.|  || ... ..|    |.  .|
PPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 24007.AA CAMK 46-103 17 1.8e-05 12.8 In-house 3-104 (425) Show / Hide
Range on Protein: 46-103
Range on HMM: 3-104/425
Sequence Identity: 17% (18 aa)

GNGTFALVLKAINKNTG------------QTVALKAVECDESD--------------------------LKGMEVIQDEYKMLEVFSG------CKYIIK
| |.|. | ..|.|||.            | || | .. .  .                           | .. .. |....   .|       . |||
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VF
 .
LY

Kinase 24007.AA ULK 39-71 35 5.7e-05 13.65 In-house 1-37 (324) Show / Hide
Range on Protein: 39-71
Range on HMM: 1-37/324
Sequence Identity: 35% (13 aa)

YQILQFAGNGTFA-LVLKAINKNT---GQTVALKAVE
|.. .  | |.|.  | |..||.|   .| || | ..
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMID

Kinase 24007.AA ULK 39-71 32 0.00225 7.74 In-house 1-37 (329) Show / Hide
Range on Protein: 39-71
Range on HMM: 1-37/329
Sequence Identity: 32% (12 aa)

YQILQFAGNGTFALVLKAINKNT----GQTVALKAVE
|.. .  | |.|. | |..||.|    .. || | ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMID

Kinase 24007.AA Ciliate-E2 39-107 17 0.006659 5.78 In-house 1-102 (365) Show / Hide
Range on Protein: 39-107
Range on HMM: 1-102/365
Sequence Identity: 17% (18 aa)

YQILQFAGNGTFALVLKAINKNTGQTVALK-------------AVECDESDLKGMEVIQDEYKMLEVFSG--------------------CKYIIKVFNS
| ...  |.|.|. | |. ...... .|.|              |   .  .| |.  | |... |                        ...||| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY
|.
FQ

Kinase 24007.AA STE 305-327 30 0.00712 6.13 In-house 334-359 (359) Show / Hide
Range on Protein: 305-327
Range on HMM: 334-359/359
Sequence Identity: 30% (8 aa)

VMQCLKYEVDQRKPAVELLI---QFI
. .||... ..|  | .||     ||
INKCLQKDPNKRPTASQLLKSEHPFI

Kinase 24007.AA C2 424-610 39 4.2e-106 358.79 In-house 1-245 (245) Show / Hide
Range on Protein: 424-610
Range on HMM: 1-245/245
Sequence Identity: 39% (97 aa)

GATGLVLGVFNKAQNRYSALKIQRAK------KHEVVREVGIMKDCQ-MPLVIKFYDYFYLNVNNKED------------------------FVVYEIEK
||.||||..||| |||..|||||...      .|||..|.|||..|| ||..||.|.||||.||.|||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD----------FDQARKMPYDWLYINEQY-VK
|.|||||..|...|||.......|...|||.||.|||||..||||||||..|.||......||||||.|          ||.|.|..|.. .|. .  ..
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

QYYPIEG----------------ACGTIGYCPPELVKDFLYSFNS
.......                ...|.||...||.....|....
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC

Kinase 24007.AA Ciliate-C8 424-619 34 2.9e-89 302.88 In-house 1-238 (238) Show / Hide
Range on Protein: 424-619
Range on HMM: 1-238/238
Sequence Identity: 34% (81 aa)

GATGLVLG-------VFNKAQNRYSALKIQRAK-KHEVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKED-----------------FVVYEIEKCS--G
||.|.||.        ... ..| ...|||... .||......||..||||.|...||.|||. .|.|||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD------FDQARKMPYDWL-YINEQYVKQYYPIEG
||||......|.........|..||||..|..||||...|.|||||..|.|. ... ..|||||.|      |..|...|...  |. .........||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

A-CGTIGYCPPELVKD------FLYSFNSDIFQVGVCL
. ||..||..||..|.       ..|..||...||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL

Kinase 24007.AA C8 417-619 30 7.9e-46 157.02 In-house 3-226 (226) Show / Hide
Range on Protein: 417-619
Range on HMM: 3-226/226
Sequence Identity: 30% (71 aa)

NFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKEDFVVYEIEKCS--------------------
||...| || |.||   |  .||  .||.|  .   .   .  ||| ..||.|.. || .... .  .|...|.| ||||                    
NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC

-GNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTI
  ||||.   ............| .||||..| .||.|.. |.|||||..|.|  ..  ....|||.||. | . . .   |  . ...       ||| 
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW

GYCPPELVKD-----FLYSFNSDIFQVGVCL
.|  ||  |.       |.  ||.|.||. |
AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 24007.AA CAMK 420-612 16 2.7e-29 90.97 In-house 1-317 (425) Show / Hide
Range on Protein: 420-612
Range on HMM: 1-317/425
Sequence Identity: 16% (52 aa)

FISVGATGLVLGVFNKAQN------------RYSALKI--------------------------------QRAKKHEVVREVGIMKDCQ-------MPLV
 .  |. | |  ...|  .            .  | ||                                .  ....| ||. ||| .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDYFYL-----------NVNN-----KEDFVVYE--IEKCSGN------LKQFLNN-----------LKKQNKELDENQKIKIAIQIMDVINYLHIH
||.|...             . ..     .....      | |||       .     .           .  ... ..| .  ..  || . ..|.| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

DIVHRDIKLENLLYVEQDPEIP-------------TIKLADFDQARKMP------YDWLYINEQYVKQ-------YYPIEGACGTIGYCP-PELVKDFL-
.|||||.|.||.|... ... .             .||..||  |.|..      ..  | ... ...         . .  ||| .|.. ||...    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YSFNSDI
             |.. .|.
CNMQNATDEEKPYYGPKCDM

S_TKc 24007.AA S_TKc 415-690 20 1.4e-20 75.64 SMART 1-231 (231) Show / Hide
Range on Protein: 415-690
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

DPNFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKHEVVREVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG---NLKQFLNNLKKQNKE-
    . |  || | |  . .|  .|. |.|| .     . ||. |.|  . | ..|.||.|.       |..    | |.|   .|.... . ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTIGYCPPELVKDFLYSF-
 ..| .  ... || . ..|.| | |.|||.| ||.|  |      .||..||  ||..                     |||  |..||..    |.. 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKC

NSDIFQVGVCLALIDN----FETLEPVLVNKSLDYLNNFSIPFEVKQHNEQEVVKRNTKIYDILLQTIVFKQHKRSNLSLILD--------GFS
 .|.  .|..|.        |.  . .. .| .                            |.. .  ..   ||     .|          . 
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24007.AA Ciliate-E2 435-619 21 2.1e-20 66.74 In-house 44-286 (365) Show / Hide
Range on Protein: 435-619
Range on HMM: 44-286/365
Sequence Identity: 21% (56 aa)

KAQNRYSALKIQRAK-KHEVVREVGIMK----------------DCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-NLKQFLNNL-KKQNKE-----
|... . |.||.. . . .. .|  ||.                  . | .||.|..|.   ..... . .  | |.| .|.....|  ||.|.|     
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

-LDENQKIKIAIQIMD---------------VINYLHIHD-IVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGA----
 ..|.. ..|  || .                ..|||    |.|||||.||.|.         ||..||  ..|   |  .. .  . ..  ..      
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS

------------------CGTIGYCPPELVK---------DFLYSFNSDIFQVGVCL
                  ||| || .|| ..            |.. .||. .||.|
RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

Kinase 24007.AA Pkinase 454-613 23 5.7e-19 68.16 Pfam 46-196 (293) Show / Hide
Range on Protein: 454-613
Range on HMM: 46-196/293
Sequence Identity: 23% (40 aa)

VR--EVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-----NLKQFLNNLKKQNKEL--DENQKIKIAIQIMDVINYLHIHDIVHRDIKLEN
.|  |. ||| .. | ....||.|.      .| .    | | |      |. ..    .... .  .|.. .... ||   ..|.| . |.|||.|.||
RRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN

LLYVEQDPEI-PTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTIGYCPPELVK-DFLYSFNSDIF
.|.. ....| ...|..||  |...              .    . |||..|..||... .  |.  .|..
ILID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

Kinase 24007.AA Ciliate-E1 421-547 21 1.3e-14 44.38 In-house 1-142 (202) Show / Hide
Range on Protein: 421-547
Range on HMM: 1-142/202
Sequence Identity: 21% (30 aa)

ISVGATGLVLGVFNKAQN-RYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYF--YLNVNNKED--FVVYEIEKCSGNLKQFLN---------NLK
|. |  ..|.  ... .| .  |.||.  .   . . .  . | .. .. .|...|   ....  ...  . .  .|.|. .||. |.          ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLY
........ ||..|..|. | ...||.. | ||||| .|.|.
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI

Kinase 24007.AA CMGC 435-562 15 1.4e-13 40.07 In-house 17-248 (513) Show / Hide
Range on Protein: 435-562
Range on HMM: 17-248/513
Sequence Identity: 15% (36 aa)

KAQN------------------RYSALKIQR-AKKHEVV---------------REVGIMKDCQ-----------------MPLVIKFYDYFYLNVNNKE
|...                  .. |.|. . .. .|                 ||. |.|  .                  . ..| ||.|| . ....
KCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGN

D------------FVVYEIEKCSGNLKQFLNNLKK-----QNKELDENQ------------KIKIA------IQIMDVIN--YLHIHD--IVHRDIKLEN
.             .    | .  .|.|.. | ..     ....|.| .            . ..        ||   ..  |.| |.  |.|||.| ||
EYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPEN

LLYVEQDPEI----------------PTIKLADF
.|  ..   |                 ..|..||
ILINHNCELITRMMWKSEDWNPCQKNGRLKICDF

Kinase 24007.AA STE 418-562 21 2.6e-13 43.48 In-house 1-191 (359) Show / Hide
Range on Protein: 418-562
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

FEF---ISVGATGLVLGVFNK------AQNRY---------SALKIQR---------------------AKKHEVVREVGIMKDCQ--MPLVIKFYDYFY
.|.   |  ||.| |    |.        ..           | |. .                      .. .. .|. |||.|.   | ..|.|....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LN---VNNKEDFVVYEIEKCS-GNLKQFLNNLKKQNKELD----------ENQKIKIAIQIMDV-INYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD
 .    .|...  ..  | .. | | ..... .. .|.|.          |.| ..|. ||     .||| | |.|||||  | |          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F

Kinase 24007.AA ULK 495-562 32 8.2e-12 37.6 In-house 105-186 (329) Show / Hide
Range on Protein: 495-562
Range on HMM: 105-186/329
Sequence Identity: 32% (27 aa)

GNLKQFLNNLKK------QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||       .| | |.. |.. .||.    .|| | |.|||||..| |  . .|         ....|.|||
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF

Kinase 24007.AA ULK 495-562 33 9.6e-12 38.01 In-house 102-182 (324) Show / Hide
Range on Protein: 495-562
Range on HMM: 102-182/324
Sequence Identity: 33% (27 aa)

GNLKQFLNNLKK-----QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||      .| | |.. |.. .||.    .|| | |.|||||..|.|  . .|         ....|.|||
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF