Gene 24007 (Tetrahymena)
24007
Sequence
Protein domains of 24007.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | 24007.AA | C2 | 48-275 | 51 | 3.1e-138 | 465.54 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 48-275 Range on HMM: 1-245/245 Sequence Identity: 51% (127 aa) GTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNN--NQSSLLRVFYVMEQEF | |.|||||.||.....|||| .||...|..||. .| ||.... .....|||||.|.||||.. ..|.|||.|.....|.| .|......|.|.|||| GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD----------LAFASALKNNETRLSISTFKG ||..| .....||..||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.|||| ..|||.||.|..|...|.||. CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW SQAY----TAPEVYQNVYKKLSDLFS-VGIVLLELDNIATFDISK .|.| .|||||||.||| ||||| ||.|||||||.....|.. TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
|||||||||
Kinase | 24007.AA | Ciliate-C8 | 48-262 | 40 | 7.5e-100 | 338.03 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 48-262 Range on HMM: 1-238/238 Sequence Identity: 40% (98 aa) GTFALVLKAINKNTGQTVALKAVEC-DESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNN--NQSSLLRVFYVMEQE | |..||||.||.....|||| .|| .. . ..|| .. ||.|. |. ......|...|||.| .... |...|.|...|.. . .|.|||.| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK------SFFVMEME FCQTT--LSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD------LAFASALKNNETRLSISTFKGS .||.. | ...|.||.|.||||||||||..||..|||..||.|...||||||.|||..|||...|| |||| ..|||.|..|........|||. KCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGT QAY-----------TAPEVYQNVYKKLSDLFS-------VGIVL ..| .||||....... ||.|| ||.|| DQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
|||||||||
Kinase | 24007.AA | C8 | 36-262 | 33 | 5.2e-54 | 185.76 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 36-262 Range on HMM: 1-226/226 Sequence Identity: 33% (78 aa) QKHYQILQFAGNGTFALVLKAINKNTGQTVALKAVEC-DESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSL . .|.| | | ...|||| | . ....|| .| ...| ...| |. ||.|..||. . .. . . ||. .. . . .... .. | .. FNNFQYLSF---GAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYE-VFEEEKCSNEKIVQTEE----- LRVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSISTF- . . ||| | |. | . | .|.|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||||..|||... |. . . -KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMN -KGSQAYTAPEVYQN------VYKKLSDLFSVGIVL | .|| |||. . |.. |||||||.|| TCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
Kinase | 24007.AA | Pkinase | 39-265 | 22 | 3.2e-31 | 111.48 | Pfam | 1-205 (293) | Show / Hide |
Range on Protein: 39-265 Range on HMM: 1-205/293 Sequence Identity: 22% (54 aa) YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQ---DEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSLL |.|.. | |.|. | |...|.||..||.| .. . .. ...... | ... . ....|.. . .|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------------- RVFYVMEQEFCQTTLSSFIDTC-----RQKNSY--PSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKLCDLAFASALKNNET . . | .|.|. .|. .| . ...... . .. | .|. ||| ....|. ..|||.||.|.|.. .||.. ..|.|| .| .. . KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-Y-N RLSISTFKGSQAYTAPEVYQ--NVYKKLSDLFSVGIVLLEL .|| |. | |||| . . | . .| .|.|..| |. NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
|||||||||
Kinase | 24007.AA | CMGC | 39-218 | 16 | 6.7e-30 | 94.71 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 39-218 Range on HMM: 1-251/513 Sequence Identity: 16% (45 aa) YQILQFAGNGTFALVLKAIN--------------KNTGQTVALKAVECDESDLKGME----------VIQDEYKMLEVFS----------------GCKY |.|.. | ||.. | |... ..|.. ||.| . .. . .. ...| |.|. .. .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIKVFNSFYLTES----------IDSDSDEDDDQIPVDQNNNQSSLLRVFYVMEQEFCQTTLSSFIDTCRQ-----KNSYPSQQM------------KEI |.| ...|| .| | | | .. .. |. |.....| .|. ... .. . |. . IVKLYDIFYHKNSDGNEYEDKHII-S----------------Q-HFNHLYLVF--EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKY MT------IQILDSVA--FLHRFD--VVHRDIKPSNFLLNFDQNG----------------NPTLKLCDLAFA .. ||| ... ..|. . ..|||.||.| |.| . | .||.|| .| FMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
|||||||||
Kinase | 24007.AA | S_TKc | 39-327 | 21 | 4.5e-29 | 103.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 39-327 Range on HMM: 1-231/231 Sequence Identity: 21% (67 aa) YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTESIDSDSDEDDDQIPVDQNNNQSSLLRVF |.||. | |.|. | |...|.||. ||.| . | |. | ..|. ....|.| . .|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----------------------------DH YVMEQEFCQT---TLSSFIDTCRQKNS---YPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSIST . | |.| . .| ..|. .. . .| . . .| ||.. ....|. ..|||.||.| ||. ..|.|| .| | .| LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TT FKGSQAYTAPEVYQNVYKK-LSDLFSVGIVLLELDN-IATFDISKTNLEQKFETKNGQIFQNFNIDKQSQIYKIVMQCLKYEVDQRKPAVELLI------ | |. | |||| | | .| |.|..| |. |. .... |. .. ....||... ..| | |.| FCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK --QFI ... CHPWF |
|||||||||
Kinase | 24007.AA | Ciliate-E1 | 45-256 | 19 | 2.5e-22 | 69.73 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 45-256 Range on HMM: 1-202/202 Sequence Identity: 19% (44 aa) AGNGTFALVLKAINKNTG-QTVALKAVECD--ESDLKGMEVIQDEYKMLEVFSGCKYIIKVFNSFYLTES------IDSDSDEDDDQIPVDQNNNQSSLL ||| |..|.||...|. . ||.| ..| ... . ..|. .||... | . .|||.... ... .. ... .... |.. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH--------- RVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPT-LKLCDLAFASALKNNETRLSISTFK . | .. |.|.. . ..| |. ...|..| .. || . . ||||||.| | | . |.. . . .... . ... . .. .. -----------N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYY GSQAYTAPEV---YQNVYKKLSDLF .. |. ||. ... ... ||.. PPEQYNCPEQEHNKNQKINYKSDIY |
|||||||||
Kinase | 24007.AA | CAMK | 175-262 | 22 | 2.6e-22 | 68.05 | In-house | 187-324 (425) | Show / Hide |
Range on Protein: 175-262 Range on HMM: 187-324/425 Sequence Identity: 22% (31 aa) QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKLCDLAFASALKNNETRL---------------------SISTFKGSQAYT ||.. |...| ..||||.|| | ||. . .... ..|..| || .. .| . .|| |. .| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM A-PEVYQNV---------------YKKLSDLFSVGIVL | ||| . | . .| |.|..| AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
|||||||||
Kinase | 24007.AA | STE | 171-265 | 29 | 2.3e-17 | 57.98 | In-house | 155-261 (359) | Show / Hide |
Range on Protein: 171-265 Range on HMM: 155-261/359 Sequence Identity: 29% (34 aa) IMTIQILDS-VAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNN-------------ETRLSIS-TFKGSQAYTAPEVYQN-------V ... ||| ..||. ..||||||.| || |||| ... | .. ||. . . || |.. . |||| |. YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG YKKLSDLFSVGIVLLEL | .| |.|....|. YDTKCDIWSLGCTIIEM |
|||||||||
Kinase | 24007.AA | ULK | 138-262 | 23 | 2.5e-16 | 53.56 | In-house | 92-246 (329) | Show / Hide |
Range on Protein: 138-262 Range on HMM: 92-246/329 Sequence Identity: 23% (37 aa) F--YVMEQEFCQT-TLSSFIDTCRQ-------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFAS . . . .|.|. .|...| . . |. . |. .... .||| .|| ..||||||.| |.. .| . |..||..| || HNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK ALKNN--ETRLSISTF-----KGSQAYTAPEVYQ------NVYKKLSDLFSVGIVL . |. | .. .. .|. | ||.. | . | . .|..|.|... HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
|||||||||
Kinase | 24007.AA | Ciliate-E2 | 175-265 | 19 | 2.5e-15 | 49.06 | In-house | 168-289 (365) | Show / Hide |
Range on Protein: 175-265 Range on HMM: 168-289/365 Sequence Identity: 19% (26 aa) QILDSVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKLCDLAFAS--ALKNNETRLSISTFK----------------------------GSQAYTAPE .|.. . .|| ..||||||.| |. .|..|. .. .|.... . | |. | ||| CIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE VYQNV----------YKKLSDLFSVGIVLLEL .... | . .|..|.|..| |. ILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
|||||||||
Kinase | 24007.AA | ULK | 174-262 | 28 | 3.1e-15 | 50.55 | In-house | 133-242 (324) | Show / Hide |
Range on Protein: 174-262 Range on HMM: 133-242/324 Sequence Identity: 28% (31 aa) IQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALKNNETRLSIS-TFK------GSQAYTAPEVYQ------NVYKKL .||. .|| ..||||||.| |.. .| . |..||..| || . ||. . |.. |. | ||.. | . | . KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYK SDLFSVGIVL .|..|.|... CDIWSLGCIF |
|||||||||
Kinase | 24007.AA | STE | 39-107 | 17 | 9.2e-09 | 27.2 | In-house | 1-100 (359) | Show / Hide |
Range on Protein: 39-107 Range on HMM: 1-100/359 Sequence Identity: 17% (17 aa) YQILQFAGNGTFALVLKAINKN---------------TGQTVALKAVECDESD---------------LKGMEVIQDEYKMLEVFSG-CKYIIKVFNSFY ...... |.|.| | ||.|.. ||. .| | .. .... . |. |. | |.. .. ...|.| . ... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF |
|||||||||
Kinase | 24007.AA | TyrKc | 39-326 | 14 | 1.6e-08 | -84.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-326 Range on HMM: 1-280/280 Sequence Identity: 14% (49 aa) YQILQFAGNGTFALVLKAINKNTGQTVALKAVECDESDLKGMEVIQDEYKMLEVF-SGCKYIIK----VFNSF-----------------------YLTE . .. |.| | | |.. | ..|| | . | .| . .| ... . . |.. . .. || . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK SIDSDSDEDDDQIPVDQNNNQSSLLRVFYVMEQEFCQTTLSSFIDTCRQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTL . . . . . . .|| . ..||. ..|||. | |.. .. | HRPK-------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TV KLCDLAFASALKNN------ETRLSISTFKGSQ-----AYTAPEVY-QNVYKKLSDLFSVGIVLLEL-DNIATFDIS-----KTNLEQKFETKNGQIFQN | .| . .... . . .. ||. .|||. ... || .| |... |. . .. ..| | |.| KISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ FNID-------KQSQIYKIVMQCLKYEVDQRKPAVELLIQF | . .|.| || ... ..| |. .| PPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
Kinase | 24007.AA | CAMK | 46-103 | 17 | 1.8e-05 | 12.8 | In-house | 3-104 (425) | Show / Hide |
Range on Protein: 46-103 Range on HMM: 3-104/425 Sequence Identity: 17% (18 aa) GNGTFALVLKAINKNTG------------QTVALKAVECDESD--------------------------LKGMEVIQDEYKMLEVFSG------CKYIIK | |.|. | ..|.|||. | || | .. . . | .. .. |.... .| . ||| GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK VF . LY |
|||||||||
Kinase | 24007.AA | ULK | 39-71 | 35 | 5.7e-05 | 13.65 | In-house | 1-37 (324) | Show / Hide |
Range on Protein: 39-71 Range on HMM: 1-37/324 Sequence Identity: 35% (13 aa) YQILQFAGNGTFA-LVLKAINKNT---GQTVALKAVE |.. . | |.|. | |..||.| .| || | .. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMID |
|||||||||
Kinase | 24007.AA | ULK | 39-71 | 32 | 0.00225 | 7.74 | In-house | 1-37 (329) | Show / Hide |
Range on Protein: 39-71 Range on HMM: 1-37/329 Sequence Identity: 32% (12 aa) YQILQFAGNGTFALVLKAINKNT----GQTVALKAVE |.. . | |.|. | |..||.| .. || | .. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMID |
|||||||||
Kinase | 24007.AA | Ciliate-E2 | 39-107 | 17 | 0.006659 | 5.78 | In-house | 1-102 (365) | Show / Hide |
Range on Protein: 39-107 Range on HMM: 1-102/365 Sequence Identity: 17% (18 aa) YQILQFAGNGTFALVLKAINKNTGQTVALK-------------AVECDESDLKGMEVIQDEYKMLEVFSG--------------------CKYIIKVFNS | ... |.|.|. | |. ...... .|.| | . .| |. | |... | ...||| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FY |. FQ |
|||||||||
Kinase | 24007.AA | STE | 305-327 | 30 | 0.00712 | 6.13 | In-house | 334-359 (359) | Show / Hide |
Range on Protein: 305-327 Range on HMM: 334-359/359 Sequence Identity: 30% (8 aa) VMQCLKYEVDQRKPAVELLI---QFI . .||... ..| | .|| || INKCLQKDPNKRPTASQLLKSEHPFI |
|||||||||
Kinase | 24007.AA | C2 | 424-610 | 39 | 4.2e-106 | 358.79 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 424-610 Range on HMM: 1-245/245 Sequence Identity: 39% (97 aa) GATGLVLGVFNKAQNRYSALKIQRAK------KHEVVREVGIMKDCQ-MPLVIKFYDYFYLNVNNKED------------------------FVVYEIEK ||.||||..||| |||..|||||... .|||..|.|||..|| ||..||.|.||||.||.||| |||||.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CSGNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD----------FDQARKMPYDWLYINEQY-VK |.|||||..|...|||.......|...|||.||.|||||..||||||||..|.||......||||||.| ||.|.|..|.. .|. . .. CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW QYYPIEG----------------ACGTIGYCPPELVKDFLYSFNS ....... ...|.||...||.....|.... TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
|||||||||
Kinase | 24007.AA | Ciliate-C8 | 424-619 | 34 | 2.9e-89 | 302.88 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 424-619 Range on HMM: 1-238/238 Sequence Identity: 34% (81 aa) GATGLVLG-------VFNKAQNRYSALKIQRAK-KHEVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKED-----------------FVVYEIEKCS--G ||.|.||. ... ..| ...|||... .||......||..||||.|...||.|||. .|.||| |.|.|.|||. . GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC NLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD------FDQARKMPYDWL-YINEQYVKQYYPIEG ||||......|.........|..||||..|..||||...|.|||||..|.|. ... ..|||||.| |..|...|... |. .........||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM A-CGTIGYCPPELVKD------FLYSFNSDIFQVGVCL . ||..||..||..|. ..|..||...||..| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
|||||||||
Kinase | 24007.AA | C8 | 417-619 | 30 | 7.9e-46 | 157.02 | In-house | 3-226 (226) | Show / Hide |
Range on Protein: 417-619 Range on HMM: 3-226/226 Sequence Identity: 30% (71 aa) NFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKEDFVVYEIEKCS-------------------- ||...| || |.|| | .|| .||.| . . . ||| ..||.|.. || .... . .|...|.| |||| NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC -GNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTI ||||. ............| .||||..| .||.|.. |.|||||..|.| .. ....|||.||. | . . . | . ... ||| EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW GYCPPELVKD-----FLYSFNSDIFQVGVCL .| || |. |. ||.|.||. | AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
Kinase | 24007.AA | CAMK | 420-612 | 16 | 2.7e-29 | 90.97 | In-house | 1-317 (425) | Show / Hide |
Range on Protein: 420-612 Range on HMM: 1-317/425 Sequence Identity: 16% (52 aa) FISVGATGLVLGVFNKAQN------------RYSALKI--------------------------------QRAKKHEVVREVGIMKDCQ-------MPLV . |. | | ...| . . | || . ....| ||. ||| .| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKFYDYFYL-----------NVNN-----KEDFVVYE--IEKCSGN------LKQFLNN-----------LKKQNKELDENQKIKIAIQIMDVINYLHIH ||.|... . .. ..... | ||| . . . ... ..| . .. || . ..|.| | IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH DIVHRDIKLENLLYVEQDPEIP-------------TIKLADFDQARKMP------YDWLYINEQYVKQ-------YYPIEGACGTIGYCP-PELVKDFL- .|||||.|.||.|... ... . .||..|| |.|.. .. | ... ... . . ||| .|.. ||... NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH -------------YSFNSDI |.. .|. CNMQNATDEEKPYYGPKCDM |
|||||||||
S_TKc | 24007.AA | S_TKc | 415-690 | 20 | 1.4e-20 | 75.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 415-690 Range on HMM: 1-231/231 Sequence Identity: 20% (61 aa) DPNFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKHEVVREVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG---NLKQFLNNLKKQNKE- . | || | | . .| .|. |.|| . . ||. |.| . | ..|.||.|. |.. | |.| .|.... . ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTIGYCPPELVKDFLYSF- ..| . ... || . ..|.| | |.|||.| ||.| | .||..|| ||.. ||| |..||.. |.. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKC NSDIFQVGVCLALIDN----FETLEPVLVNKSLDYLNNFSIPFEVKQHNEQEVVKRNTKIYDILLQTIVFKQHKRSNLSLILD--------GFS .|. .|..|. |. . .. .| . |.. . .. || .| . KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
Kinase | 24007.AA | Ciliate-E2 | 435-619 | 21 | 2.1e-20 | 66.74 | In-house | 44-286 (365) | Show / Hide |
Range on Protein: 435-619 Range on HMM: 44-286/365 Sequence Identity: 21% (56 aa) KAQNRYSALKIQRAK-KHEVVREVGIMK----------------DCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-NLKQFLNNL-KKQNKE----- |... . |.||.. . . .. .| ||. . | .||.|..|. ..... . . | |.| .|.....| ||.|.| KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK -LDENQKIKIAIQIMD---------------VINYLHIHD-IVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGA---- ..|.. ..| || . ..||| |.|||||.||.|. ||..|| ..| | .. . . .. .. YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS ------------------CGTIGYCPPELVK---------DFLYSFNSDIFQVGVCL ||| || .|| .. |.. .||. .||.| RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
|||||||||
Kinase | 24007.AA | Pkinase | 454-613 | 23 | 5.7e-19 | 68.16 | Pfam | 46-196 (293) | Show / Hide |
Range on Protein: 454-613 Range on HMM: 46-196/293 Sequence Identity: 23% (40 aa) VR--EVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-----NLKQFLNNLKKQNKEL--DENQKIKIAIQIMDVINYLHIHDIVHRDIKLEN .| |. ||| .. | ....||.|. .| . | | | |. .. .... . .|.. .... || ..|.| . |.|||.|.|| RRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN LLYVEQDPEI-PTIKLADFDQARKMPYDWLYINEQYVKQYYPIEGACGTIGYCPPELVK-DFLYSFNSDIF .|.. ....| ...|..|| |... . . |||..|..||... . |. .|.. ILID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW |
|||||||||
Kinase | 24007.AA | Ciliate-E1 | 421-547 | 21 | 1.3e-14 | 44.38 | In-house | 1-142 (202) | Show / Hide |
Range on Protein: 421-547 Range on HMM: 1-142/202 Sequence Identity: 21% (30 aa) ISVGATGLVLGVFNKAQN-RYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYF--YLNVNNKED--FVVYEIEKCSGNLKQFLN---------NLK |. | ..|. ... .| . |.||. . . . . . | .. .. .|...| .... ... . . .|.|. .||. |. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ KQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLY ........ ||..|..|. | ...||.. | ||||| .|.|. QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI |
|||||||||
Kinase | 24007.AA | CMGC | 435-562 | 15 | 1.4e-13 | 40.07 | In-house | 17-248 (513) | Show / Hide |
Range on Protein: 435-562 Range on HMM: 17-248/513 Sequence Identity: 15% (36 aa) KAQN------------------RYSALKIQR-AKKHEVV---------------REVGIMKDCQ-----------------MPLVIKFYDYFYLNVNNKE |... .. |.|. . .. .| ||. |.| . . ..| ||.|| . .... KCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGN D------------FVVYEIEKCSGNLKQFLNNLKK-----QNKELDENQ------------KIKIA------IQIMDVIN--YLHIHD--IVHRDIKLEN . . | . .|.|.. | .. ....|.| . . .. || .. |.| |. |.|||.| || EYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPEN LLYVEQDPEI----------------PTIKLADF .| .. | ..|..|| ILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
|||||||||
Kinase | 24007.AA | STE | 418-562 | 21 | 2.6e-13 | 43.48 | In-house | 1-191 (359) | Show / Hide |
Range on Protein: 418-562 Range on HMM: 1-191/359 Sequence Identity: 21% (44 aa) FEF---ISVGATGLVLGVFNK------AQNRY---------SALKIQR---------------------AKKHEVVREVGIMKDCQ--MPLVIKFYDYFY .|. | ||.| | |. .. | |. . .. .. .|. |||.|. | ..|.|.... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LN---VNNKEDFVVYEIEKCS-GNLKQFLNNLKKQNKELD----------ENQKIKIAIQIMDV-INYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD . .|... .. | .. | | ..... .. .|.|. |.| ..|. || .||| | |.||||| | | .||.| KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD F | F |
|||||||||
Kinase | 24007.AA | ULK | 495-562 | 32 | 8.2e-12 | 37.6 | In-house | 105-186 (329) | Show / Hide |
Range on Protein: 495-562 Range on HMM: 105-186/329 Sequence Identity: 32% (27 aa) GNLKQFLNNLKK------QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF |.|.|.... || .| | |.. |.. .||. .|| | |.|||||..| | . .| ....|.||| GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |
|||||||||
Kinase | 24007.AA | ULK | 495-562 | 33 | 9.6e-12 | 38.01 | In-house | 102-182 (324) | Show / Hide |
Range on Protein: 495-562 Range on HMM: 102-182/324 Sequence Identity: 33% (27 aa) GNLKQFLNNLKK-----QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF |.|.|.... || .| | |.. |.. .||. .|| | |.|||||..|.| . .| ....|.||| GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |