Gene 2605 (Tetrahymena)
2605
Sequence
Protein domains of 2605.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 2605.AA | C8 | 54-166 | 63 | 7.4e-65 | 221.79 | In-house | 103-226 (226) | Show / Hide |
Range on Protein: 54-166 Range on HMM: 103-226/226 Sequence Identity: 63% (79 aa) QDNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAPEV ..|||||.|..|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..||| ||.||||||. EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI EAG------QSRIQSDLFSLGLIL |.. |.||||||||.||.| EKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 2605.AA | Ciliate-C8 | 54-166 | 53 | 9.6e-64 | 218.09 | In-house | 97-238 (238) | Show / Hide |
Range on Protein: 54-166 Range on HMM: 97-238/238 Sequence Identity: 53% (76 aa) QDN--LKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDA |.| |||.||..||.|..| ..||||||||||...|.||..|||||||||.||||| ...|...||||| .||||...|.|| ..||| |||. QQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQ Y-----------FAPEVEAGQSRIQSDLFS-------LGLIL | ||||||..|||||||.|| .||.| YIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 2605.AA | C2 | 54-179 | 43 | 2.4e-36 | 121.75 | In-house | 102-245 (245) | Show / Hide |
Range on Protein: 54-179 Range on HMM: 102-245/245 Sequence Identity: 43% (62 aa) QDNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-KGT | |||| |. .|||. | ..||.|.||||. . | || ..| ||||||.|||. ... ||||| . |||.....|| .|| |.| QGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWT DAY----FAPEVEAGQSRIQSDLFS-LGLILLELDNLKTLNENW .| |||||. . . .||||| .|..|||||| .. . . QQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 2605.AA | TKL | 79-169 | 21 | 4.9e-20 | 68.83 | In-house | 137-282 (364) | Show / Hide |
Range on Protein: 79-169 Range on HMM: 137-282/364 Sequence Identity: 21% (31 aa) IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCASKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT .|... |.| || ..| |||.|..| || . . .|.||.|.. .|.|.. |.. || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT DAYFAPEV-----------------EAGQSRIQSDLFSLGLILLEL .. |||| . .. ..| .| |..| |. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
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Kinase | 2605.AA | Ciliate-E3 | 79-170 | 36 | 1.3e-18 | 54.95 | In-house | 108-202 (202) | Show / Hide |
Range on Protein: 79-170 Range on HMM: 108-202/202 Sequence Identity: 36% (35 aa) IAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYG-FSIKLCDLGFASAVSKSK--SFMSKKGTDAYFA-PEVEA-GQSRIQSDLFSLGLILLELD |.||.|.|. .| ||| | ||||.|.|| .|... || ||.| . .| | . |. ..| ||. .| ||. |.| ....| ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
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Kinase | 2605.AA | Ciliate-E2 | 1-169 | 22 | 1.9e-18 | 59.89 | In-house | 36-289 (365) | Show / Hide |
Range on Protein: 1-169 Range on HMM: 36-289/365 Sequence Identity: 22% (59 aa) MNKSH-----FKIFIFLSKFLKNKKYLQINQKKIIQKFRNKHF------------FNQNFNIKLIQFYNQQDN---------LKQ--LFDFLRKQQVPPP . .. .||.|. | .|... ||.|.. | . | | | .. ||.. .. .|. ... |||...... . Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRN KE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS----------KSFMS .| .||| | | .. .|. || || |.||||||.| |. ||..|.|.. .... | .| HEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF KK-----------------------GTDAYFAPEVEAGQSR----------IQSDLFSLGLILLEL | || | |||. |.. ..|..||| || |. -KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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Kinase | 2605.AA | Pkinase | 60-169 | 29 | 1.3e-17 | 63.36 | Pfam | 91-205 (293) | Show / Hide |
Range on Protein: 60-169 Range on HMM: 91-205/293 Sequence Identity: 29% (35 aa) LFDFLR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDAYFAPEV--EAG |||... .. . ...| | .. |...||. .| ..|.|||.||.|.|. . . ..|.|| |.| .. ... || | |||| .. LFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ QSRIQSDLFSLGLILLEL .| .|.|.|| |. YYGPKVDMWSCGCILYEM |
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Kinase | 2605.AA | Ciliate-A1 | 79-169 | 28 | 1.7e-17 | 56.1 | In-house | 106-221 (301) | Show / Hide |
Range on Protein: 79-169 Range on HMM: 106-221/301 Sequence Identity: 28% (34 aa) IAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSK-------------------SFMSKKGTDAYFAPEV----------E | |.|||. .| .||.|||.|||| |. . . |.|||| .. .| |. | .|| ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFI AGQSRIQSDLFSLGLILLEL . |||..|||.|...| ENKIYKQSDMYSLGCIICFL |
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Kinase | 2605.AA | CAMK | 82-166 | 21 | 1.7e-17 | 52.25 | In-house | 187-324 (425) | Show / Hide |
Range on Protein: 82-166 Range on HMM: 187-324/425 Sequence Identity: 21% (30 aa) QMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYF |...... .| .||.|||.|| | |.. ... . ||..| ||| . ... . || .| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM A-PEVEAG-------------QSRI--QSDLFSLGLIL | ||| | . . ..| |.| || AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 2605.AA | STE | 78-169 | 26 | 2.6e-17 | 57.78 | In-house | 155-261 (359) | Show / Hide |
Range on Protein: 78-169 Range on HMM: 155-261/359 Sequence Identity: 26% (31 aa) IIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEVEAG-QSR---- .|. | ..| |. || ..|.||||||.| |. .|||| |... ... .. . || . |||| . .. YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG --IQSDLFSLGLILLEL ...| |||. ..|. YDTKCDIWSLGCTIIEM |
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Kinase | 2605.AA | Ciliate-E2-Unclassified | 7-169 | 22 | 3.1e-16 | 52.81 | In-house | 34-263 (352) | Show / Hide |
Range on Protein: 7-169 Range on HMM: 34-263/352 Sequence Identity: 22% (53 aa) KIFIFLSKFLKNKKYLQINQKKIIQK-------------------------FRNKHFFNQNFNIKLIQFYNQQDNLKQ--------------LFDFLRKQ || |. .| .||. .|..|.... . . |.. .|| .. | .. .|.| ||. .... KIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQR QVPPPKEMK----EIIAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCASKEYGFSIKLCDLGFAS----------------AVSKSKSFMSKKGTDAYF-- . . ...| . .. | ..||. || || | ||||||.| |. ... . ||..|.|... .. |.. . .. || | KIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ --APEVEAG-QSR----IQSDLFSLGLILLEL |||| | . ...| .||| || |. YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM |
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Kinase | 2605.AA | S_TKc | 3-233 | 20 | 2.1e-10 | -24.45 | SMART | 17-231 (231) | Show / Hide |
Range on Protein: 3-233 Range on HMM: 17-231/231 Sequence Identity: 20% (54 aa) KSHFKI--FIFLSKFLKNKKYLQINQKKIIQKFRNKHFFNQNFNIKLIQFYNQQDNL--------K---QLFDFLRKQQVP------PPKEMKEIIAIQM | . | |. | .| .. .| .| . . .||. .. |.| |||...|.. . |. . . ... |. KCRHKKTGRIVAIKIIK---EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QI IEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFAPEVEAGQSRIQSDLFSLGLILLELDNLKTLNENWIDTN ...|. .| ..|.|||.||.| |.. ||.|| |.| . .. || | |||| | .. .| |.| || |. ... . . . CCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQ IKYYLFKGEEIPKEKYQIDKNSNIYKIAKICLKPWYLDRTTAGELLS--------QLI . . . . . . ||. .| || |.| . . MMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 2605.AA | TyrKc | 10-232 | 17 | 2e-06 | -118.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-232 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) IFLSKFL--------------------KNKKYLQINQKKIIQKFRN-KHFFNQN--FNIKLIQFY---NQQ-------DNLKQLF---------DFLRKQ | | | | . |.. .. |.. . . ....| || . | .. |.||| ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH QVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS-------KSFMSKK--GTD-----AYFAPEVE-AGQ . . . . ...| .| . || ||. |||. | || . . .| .| | . .. . ..|. |.. |||. | RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK SRIQSDLFSLGLILLELDNL-KTLNEN-----WIDTNIKYYLFKGEEIPKEKY-----QIDKNSNIYKIAKICLKPWYLDRTTAGELLSQL ..|| .| | . |. . .. .. .. . |. .|. |. .. . .|.| | | . || | |. ... FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 2605.AA | C8 | 259-332 | 51 | 1.9e-37 | 127.52 | In-house | 150-226 (226) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 150-226/226 Sequence Identity: 51% (40 aa) KPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKDLIQTIES--IGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLL ||.||||.||.... ||||||||...|...||. ||.... .|...|.||||..||||..|.|...||..||||.| KPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 2605.AA | Ciliate-C8 | 259-332 | 47 | 2.3e-33 | 116.96 | In-house | 146-238 (238) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 146-238/238 Sequence Identity: 47% (44 aa) KPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKD---------LIQTIES--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL ||.||||..| ..||.||||| ||...|.|.||. .|.||. .||.||.|||...| ......|.|||||||||||.| KPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 2605.AA | Ciliate-E2 | 259-332 | 26 | 5.3e-14 | 44.43 | In-house | 188-286 (365) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 188-286/365 Sequence Identity: 26% (29 aa) KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKD--------LIQTIES----------------------IGNLGYSAPEILNKQDNE----LKIYSKKSD |||| |. ||..||||| .. |. . . . . .|..|| ||||||..... | |..|.| KPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD SYSVGLLL .|.| .| IWSLGVIL |
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Kinase | 2605.AA | CAMK | 259-332 | 21 | 1.8e-13 | 39.09 | In-house | 206-324 (425) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 206-324/425 Sequence Identity: 21% (25 aa) KPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKDLI---------------------QTIESIGNLGYSA-PEILNKQ---------D |||| |. ... . ||..|||........... .. | ..| | ||.||.. | KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATD NELKIYSKKSDSYSVGLLL .| . |..|.| |.| .| EEKPYYGPKCDMWSCGVIL |
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Kinase | 2605.AA | TKL | 259-332 | 24 | 4.7e-11 | 36.06 | In-house | 167-279 (364) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 167-279/364 Sequence Identity: 24% (28 aa) KPENFLVYLDGKQPE-----------IKLCDFGLSAQIP---DNKDLI--------------QTIESIGNLGYSAPEILNKQDN-----------ELKIY |..| || ... .|.|||||| . ...| .|. .|.... |||.|..|.| . . | KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY SKKSDSYSVGLLL |.|.| || |..| SEKCDVYSFGIVL |
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Kinase | 2605.AA | Ciliate-A1 | 259-340 | 32 | 1.7e-10 | 31.92 | In-house | 128-226 (301) | Show / Hide |
Range on Protein: 259-340 Range on HMM: 128-226/301 Sequence Identity: 32% (33 aa) KPENFLVYLDGKQPEIKLCDFGLSAQIPDNK----------------DLIQTIESIGNLGYSAPEI----L-NKQDNELKIYSKKSDSYSVGLLLAFLDN ||.| |. | | .|.||.|.| | . |. .|.. ||| | .|| . .. | ||| |.|| ||.|. . || . KPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIY-KQSDMYSLGCIICFLCY YQD | KED |
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Kinase | 2605.AA | STE | 259-332 | 24 | 8.6e-10 | 30.88 | In-house | 179-258 (359) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 179-258/359 Sequence Identity: 24% (22 aa) KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKD--------------LIQTIESIGNLGYSAPEILNKQDNE-LKIYSKKSDSYSVGLLL || | |. .||||||...|. |. . .. .| . |||....... | |. |.| .|.|... KPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 2605.AA | Ciliate-E3 | 259-336 | 39 | 2.5e-07 | 19.24 | In-house | 130-202 (202) | Show / Hide |
Range on Protein: 259-336 Range on HMM: 130-202/202 Sequence Identity: 39% (31 aa) KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDLIQTIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLAFLD ||.|.|| | || ||||.| | || ...| |.|||.. .| || || |||| . | KPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQ-----ISKESDYYSVGAVFCQLC |
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Kinase | 2605.AA | Ciliate-E2-Unclassified | 259-332 | 28 | 8.8e-07 | 19.57 | In-house | 171-260 (352) | Show / Hide |
Range on Protein: 259-332 Range on HMM: 171-260/352 Sequence Identity: 28% (26 aa) KPENFLVYLDGKQPEIKLCDFGLSAQIPDN----------KDLIQTIES---IGNLGYS----APEILNKQDNELKIYSKKSDSYSVGLLL |||| |. .|| .||..|||.| .. .| .. .. .. .|...| |||.| .| .. . .|.| .|.| .| KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVIL |
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Kinase | 2605.AA | C2 | 259-345 | 32 | 6e-06 | 16.4 | In-house | 149-245 (245) | Show / Hide |
Range on Protein: 259-345 Range on HMM: 149-245/245 Sequence Identity: 32% (33 aa) KPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKDLIQTIESIGNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLAFLDNYQDLK ||.|||. .| .. | ||||| | . .. || | . . . | .|||. . .|| |.|| .| ||. | ||| | KPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYT KNA . ICC |
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Kinase | 2605.AA | Pkinase | 259-333 | 33 | 1.8e-05 | 20.44 | Pfam | 135-203 (293) | Show / Hide |
Range on Protein: 259-333 Range on HMM: 135-203/293 Sequence Identity: 33% (27 aa) KPENFLVYLDGKQPEI----KLCDFGLSAQI-PDNKDLIQTIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLA ||||.| .| ....| |.|||||..|. |. .|. | ..| |||... . . |..|.| .|.|..|. KPENIL--ID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY |