Gene 19025 (Tetrahymena)
19025
Sequence
Protein domains of 19025.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19025.AA | C2 | 37-78 | 55 | 1.9e-17 | 56.29 | In-house | 199-245 (245) | Show / Hide |
Range on Protein: 37-78 Range on HMM: 199-245/245 Sequence Identity: 55% (26 aa) KGTQSY----SAPEVDQGIFKKASDIFS-VGLVLLELDNIQTFDFTK |.||.| .||||.|.|.||.||.|| ||.|||||||.|.... . KWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | 19025.AA | C8 | 29-65 | 39 | 6.6e-11 | 34.21 | In-house | 184-226 (226) | Show / Hide |
Range on Protein: 29-65 Range on HMM: 184-226/226 Sequence Identity: 39% (17 aa) INQKNKFKKGTQSYSAPEVDQG------IFKKASDIFSVGLVL | .|. .. ||. |.|||. .. .... ||.||||||| IQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 19025.AA | Ciliate-C8 | 7-65 | 33 | 2.7e-10 | 33.4 | In-house | 179-238 (238) | Show / Hide |
Range on Protein: 7-65 Range on HMM: 179-238/238 Sequence Identity: 33% (23 aa) LGKNQI-LLFKKVKKNNNL-SFYLINQKNKFKKGTQSYSAPEVDQGIFKKASDIFS-------VGLVL | ||. ...||.|. .| |. |.|||| ... .. ||||| ||||| LPKNKSHYHSKKFKGTDQYIEMYF--------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 19025.AA | Ciliate-E2-Unclassified | 27-68 | 31 | 7.9e-05 | 12.71 | In-house | 213-263 (352) | Show / Hide |
Range on Protein: 27-68 Range on HMM: 213-263/352 Sequence Identity: 31% (16 aa) YLINQKNKFKKGTQSYS----APEVDQG-IFK----KASDIFSVGLVLLEL ....|. . . || .| |||| || ...||.|.| .| |. IWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM |
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| Kinase | 19025.AA | Ciliate-E2 | 14-68 | 20 | 0.003438 | 6.78 | In-house | 202-289 (365) | Show / Hide |
Range on Protein: 14-68 Range on HMM: 202-289/365 Sequence Identity: 20% (18 aa) LFKKVKKNNNLSFYLINQKNKFKK------------------------GTQSYSAPEVDQGIFK----------KASDIFSVGLVLLEL | ||....|. .. .| .... || | |||. .| ...||.|.| .| |. LSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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| Kinase | 19025.AA | Pkinase | 38-68 | 36 | 1.785493 | 2.76 | Pfam | 173-205 (293) | Show / Hide |
Range on Protein: 38-68 Range on HMM: 173-205/293 Sequence Identity: 36% (12 aa) GTQSYSAPEV--DQGIFKKASDIFSVGLVLLEL || | |||| .. ...|..|.|..| |. GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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| Kinase | 19025.AA | C2 | 230-366 | 47 | 8.1e-86 | 291.41 | In-house | 1-167 (245) | Show / Hide |
Range on Protein: 230-366 Range on HMM: 1-167/245 Sequence Identity: 47% (80 aa) GATGLILGVYNKSQKRHSALKIQRVSS-----KHEIVREIGIIRDCQ-MPLVIKFYGFFYLDVTKKED------------------------FVVYEIEK ||.||.|...||.|.||.|||||.. | .||...|.||.|.|| ||..||.|..|||.|.|||| |||||.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CSGNLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQSQVPIIKL |.|||||||||..|.........||..|||..|.|||||...|||||||..|.||...|...|.||| CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKL |
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| Kinase | 19025.AA | Ciliate-C8 | 230-366 | 38 | 1.4e-65 | 224.18 | In-house | 1-164 (238) | Show / Hide |
Range on Protein: 230-366 Range on HMM: 1-164/238 Sequence Identity: 38% (63 aa) GATGLILG-------VYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G ||.|..|. ......|....|||.. ..|||.....| ..||||.|...|..|||. ..|||| |.|.|.|||. . GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC NLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQSQVPIIKL ||||||.|..|.........|..||||.||..||||...|.|||||..|.|....|...|.||| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKL |
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| Kinase | 19025.AA | C8 | 222-366 | 32 | 1.1e-38 | 131.91 | In-house | 2-168 (226) | Show / Hide |
Range on Protein: 222-366 Range on HMM: 2-168/226 Sequence Identity: 32% (55 aa) SNFEFISVGATGLILGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKEDFVVYEIEKCS------------------- .||...| || |..| .| ..|. .||.| ...|..| .. | . ..||.|.. | |.... ....|...|.| |||| NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL --GNLKQYFNRLKKDKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQSQVPIIKL ||||.. ... . |...|.| .||||.|| .||.| |.|||||..|.| .|.....||| CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKL |
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| Kinase | 19025.AA | Ciliate-E1 | 227-416 | 19 | 9.9e-16 | 48.04 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 227-416 Range on HMM: 1-202/202 Sequence Identity: 19% (41 aa) ISVGATGLILGVYNKSQK-RHSALKIQRVS---SKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL |. | .... ...... .. |.||. . .. .. || . .. . ..| . ..|. |... . . .|.|. .||.|.. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC KKDKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQSQVPIIKLRVCLAVI-DNFETLEPSLKQKNLDSLHGFKIPFEPSHLVKNELIK .....|.....||||..| || ...||.. | ||||| .|||. .. .. . .. ... . . .. . .... . ..| | ||. |. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQ-EHNKNQKIN RNTKIY .. || YKSDIY |
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| Kinase | 19025.AA | Ciliate-E2 | 236-366 | 22 | 6.2e-14 | 44.2 | In-house | 36-197 (365) | Show / Hide |
Range on Protein: 236-366 Range on HMM: 36-197/365 Sequence Identity: 22% (39 aa) LGVYN----KSQKRHSALKIQRVSSKHEIVREIGIIR----------------DCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLK . ... | .. |.||.. . . .| .|| |.| . | .||.| .|. .|... . . | |.| .|..| . ..| Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKK KDKI-----QLNDEEKMQIAIQVID---------------VINYLHYNH-IVHRDIKLENILYIDNQSQVPIIKL .... .....| .| |... ..||| .. |.|||||.||||. ||. RNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKI |
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| Kinase | 19025.AA | Ciliate-E2a | 308-354 | 32 | 1e-13 | 36.76 | In-house | 87-135 (275) | Show / Hide |
Range on Protein: 308-354 Range on HMM: 87-135/275 Sequence Identity: 32% (16 aa) FNRLKKDK-IQLNDEEKMQIAIQVI-DVINYLHYNHIVHRDIKLENILY ....|..| .. ...| ..| | . . ..|.| ..|.|||.|.||||. YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILF |
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| Kinase | 19025.AA | CAMK | 226-366 | 17 | 7.5e-13 | 37.03 | In-house | 1-237 (425) | Show / Hide |
Range on Protein: 226-366 Range on HMM: 1-237/425 Sequence Identity: 17% (42 aa) FISVGATGLILGVYNKSQK------------RHSALKI-------------------------------QRVSSKHEIVREIGIIRDCQ-------MPLV . |. | ...|. . .. | || .| ...... ||| | . .| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKD--------------KIQLNDEEKMQIAIQVIDVINYLHYNH ||.| .. ||..... | ||| | .. |..... . .. .| .. |... ..|.| .. IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKLENILYIDNQSQVP-------------IIKL |||||.|.||||. || . . ||. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI |
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| Kinase | 19025.AA | CAMK-Unique | 308-354 | 34 | 1.1e-12 | 38.0 | In-house | 142-190 (363) | Show / Hide |
Range on Protein: 308-354 Range on HMM: 142-190/363 Sequence Identity: 34% (17 aa) FNRLKKDKIQLND--EEKMQIAIQVIDVINYLHYNHIVHRDIKLENILY || ||. ..... . .| .. ...|.| . |||||.|||||.. FNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMV |
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| Kinase | 19025.AA | Aur | 329-353 | 52 | 1.8e-11 | 26.04 | In-house | 109-133 (257) | Show / Hide |
Range on Protein: 329-353 Range on HMM: 109-133/257 Sequence Identity: 52% (13 aa) QVIDVINYLHYNHIVHRDIKLENIL |... ..|.| ..|.||||| |||| QICNALDYCHSKNIIHRDIKPENIL |
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| S_TKc | 19025.AA | S_TKc | 221-444 | 19 | 1.8e-10 | -23.28 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 221-444
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)
DSNFEFISVGATGLILGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKDK--
. | || | ...|. .|. |.|| . | ||| | . . | ..|.|..|. |.. | |.| .|..| . .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
IQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQSQVPIIKLRVCLAVIDNF---------ETLEPSLKQKNLDSLHGF------------
... . .. |... ..|.| ..|.|||.| |||| . .. |. .. . . | | | .|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL-----------GYGKCKCDWWSCGCIL
------KIPFEPSHLVKNELIKRNTKIYDIILNTVAFNQEKRKNLSSIIA-----DLHQKY
. ||. . . ..|. |.| . .. ||| . . .|.
YEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 19025.AA | Ciliate-E2-Unclassified | 302-364 | 26 | 2.2e-10 | 32.24 | In-house | 106-189 (352) | Show / Hide |
Range on Protein: 302-364 Range on HMM: 106-189/352 Sequence Identity: 26% (22 aa) GNLKQYFN-------------RLKKDKIQLNDEEKM-----QIAIQVIDVINYLHYNH-IVHRDIKLENILYIDNQS--QVPII |.|.|| . . .| . .. ... ... |... ..|||... |.|||||.||||. .|.. .. || GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII |
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| Kinase | 19025.AA | Pkinase | 248-354 | 22 | 4.6e-05 | 18.99 | Pfam | 28-141 (293) | Show / Hide |
Range on Protein: 248-354 Range on HMM: 28-141/293 Sequence Identity: 22% (27 aa) ALKIQRVSSKHEIVR-------EIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KDKIQL--NDEEKMQIAIQVIDVIN |.|| ....... .. || | . .. | ....|..|. .| . | | | . | ... ... . ..| .. |.. .. AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE YLHYNHIVHRDIKLENILY |.| . |.|||.|.||||. YCHSMGIIHRDLKPENILI |
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| TyrKc | 19025.AA | TyrKc | 221-440 | 13 | 5.9e-05 | -142.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 221-440
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)
DSNFEFISVGATGLI-LGVYNKSQKRHSALKIQRVSSKHEIVREIGIIRDC--QMPLVIKFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYFNRLKK
. . . || | . .|... . | | . ... .. ||. | . . | ....|| . . . ..| | . |.||.| . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP
DKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDIKLENILYIDNQ-------------SQV-------PIIKLRV--CLA-----------VIDNF----
. |. ... ....|. . .||| ....|||. |.|. .|. .. . . .|.
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT
------------------ETLEPS-----LKQKNL--DSLHGFKIPFEPSHLVKNELI---KRNTKIYDIILNTVAFNQEKRKNLSSIIADL
.. | .. . . . .|. | |... . . ...|.|.. ... |.| . | |. ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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