Gene 12233 (Tetrahymena)
12233
Sequence
Protein domains of 12233.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 12233.AA | C2 | 285-321 | 48 | 1.3e-10 | 32.56 | In-house | 199-245 (245) | Show / Hide |
Range on Protein: 285-321 Range on HMM: 199-245/245 Sequence Identity: 48% (23 aa) KGTQSY----CAPEVDS-----GSDIFS-VGLVLLELDNMQSFDFTK |.||.| ||||. ||.|| ||.||||||||| ... . KWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 12233.AA | PEK | 286-374 | 23 | 1e-09 | 29.26 | In-house | 551-655 (655) | Show / Hide |
Range on Protein: 286-374 Range on HMM: 551-655/655 Sequence Identity: 23% (25 aa) GTQSYCAPEVDSGS-----------DIFSVGLVLLELDNM---QSFDFTKTTNQQK-LEIQFGNIFS--SFQINRQSQIYRIVKQCLEFNPQNRTPAVDL ||..|..||. ||. |..| |....|. ......|| .. . ||| ..|. .|. |.. . . .....| .||.| | .. GTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFD-NKYPKQADFIQWMLSHDPQQRPSAQQI LIQFIV | . . LQHEFF |
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Kinase | 12233.AA | Ciliate-C8 | 286-308 | 45 | 9.5e-08 | 24.19 | In-house | 204-238 (238) | Show / Hide |
Range on Protein: 286-308 Range on HMM: 204-238/238 Sequence Identity: 45% (16 aa) GTQSYCAPEVDSG-----SDIFS-------VGLVL |. |.|||| . ||||| ||||| GNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 12233.AA | C8 | 282-308 | 42 | 3.1e-07 | 21.3 | In-house | 185-226 (226) | Show / Hide |
Range on Protein: 282-308 Range on HMM: 185-226/226 Sequence Identity: 42% (18 aa) QFKK----GTQSYCAPEVDSG-----------SDIFSVGLVL | || ||. | |||. .. ||.||||||| QSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 12233.AA | Pkinase | 286-311 | 36 | 2.638971 | 2.16 | Pfam | 173-205 (293) | Show / Hide |
Range on Protein: 286-311 Range on HMM: 173-205/293 Sequence Identity: 36% (12 aa) GTQSYCAPEV-------DSGSDIFSVGLVLLEL || |.|||| .. .|..|.|..| |. GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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Kinase | 12233.AA | C2 | 473-610 | 47 | 1.6e-81 | 277.13 | In-house | 1-167 (245) | Show / Hide |
Range on Protein: 473-610 Range on HMM: 1-167/245 Sequence Identity: 47% (79 aa) GATGLILGVYNISQKRHSALKIQRVSS-----KHEIVREIGIIRDCQ-MPLVIKFYGFFYLDVTKKED------------------------FVVYEIEK ||.||.|...| .|.||.|||||.. | .||...|.||.|.|| ||..||.|..|||.|.|||| |||||.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CSGNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL |.|||||||||..|.........||..|||..|.|||||..|||||||| .|.||...... .|.||| CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQG-IPTIKL |
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Kinase | 12233.AA | Ciliate-C8 | 473-610 | 37 | 3.4e-62 | 212.93 | In-house | 1-164 (238) | Show / Hide |
Range on Protein: 473-610 Range on HMM: 1-164/238 Sequence Identity: 37% (62 aa) GATGLILG-------VYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G ||.|..|. .. ...|....|||.. ..|||.....| ..||||.|...|..|||. ..|||| |.|.|.|||. . GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC NLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL ||||||.|..|.........|..||||.||..||||...|.||||| .|.|.... ....|.||| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD-QQYQPTIKL |
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Kinase | 12233.AA | C8 | 465-610 | 32 | 1e-36 | 124.95 | In-house | 2-168 (226) | Show / Hide |
Range on Protein: 465-610 Range on HMM: 2-168/226 Sequence Identity: 32% (54 aa) SNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKEDFVVYEIEKCS------------------- .||...| || |..| .|. ..|. .||.| ...|..| .. | . ..||.|.. | |.... ....|...|.| |||| NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL --GNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL ||||.. ... . |...|.| .||||.|| .||.| |.||||| .|.| ... ....||| CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQN-YGFEIKL |
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Kinase | 12233.AA | Ciliate-E1 | 470-604 | 22 | 6.4e-18 | 55.24 | In-house | 1-149 (202) | Show / Hide |
Range on Protein: 470-604 Range on HMM: 1-149/202 Sequence Identity: 22% (34 aa) ISVGATGLILGVYNISQK-RHSALKIQRVS---SKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL |. | .... ...... .. |.||. . .. .. || . .. . ..| . ..|. |... . . .|.|. .||.|.. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC KKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSK .....|.....||||..| || ...||.. | ||||| .|||. .... . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYV |
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Kinase | 12233.AA | CAMK-Unique | 551-597 | 36 | 5.9e-14 | 42.25 | In-house | 142-190 (363) | Show / Hide |
Range on Protein: 551-597 Range on HMM: 142-190/363 Sequence Identity: 36% (18 aa) FNRLKKDKIQLNE--EEKMQIAIQVIDVINYLHYNDIVHRDIKIENILY || ||. .....| . .| .. ...|.| .||||||.| |||.. FNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMV |
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Kinase | 12233.AA | CAMK | 469-610 | 18 | 3.5e-13 | 38.12 | In-house | 1-237 (425) | Show / Hide |
Range on Protein: 469-610 Range on HMM: 1-237/425 Sequence Identity: 18% (43 aa) FISVGATGLILGVYNISQK------------RHSALKI-------------------------------QRVSSKHEIVREIGIIRDCQ-------MPLV . |. | ..... . .. | || .| ...... ||| | . .| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKD--------------KIQLNEEEKMQIAIQVIDVINYLHYND ||.| .. ||..... | ||| | .. |..... . ..|.| .. |... ..|.| .. IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKIENILYIDSNKSKVP------------IIKL |||||.| ||||. |.|... | ||. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI |
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Kinase | 12233.AA | Ciliate-E2 | 491-610 | 24 | 8.6e-13 | 40.23 | In-house | 51-197 (365) | Show / Hide |
Range on Protein: 491-610 Range on HMM: 51-197/365 Sequence Identity: 24% (39 aa) ALKIQRVSSKHEIVREIGIIR----------------DCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLKKDKI-----QLNEEEK |.||.. . . .| .|| |.| . | .||.| .|. .|... . . | |.| .|..| . ..|.... ...|.| AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI MQIAIQVID---------------VINYLHYND-IVHRDIKIENILYIDSNKSKVPIIKL .| |... ..||| . |.||||| ||||. ||. KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKI |
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Kinase | 12233.AA | Ciliate-E2a | 551-608 | 32 | 6.2e-12 | 31.43 | In-house | 87-151 (275) | Show / Hide |
Range on Protein: 551-608 Range on HMM: 87-151/275 Sequence Identity: 32% (21 aa) FNRLKKDKIQLNE-EEKMQIAIQVI-DVINYLHYNDIVHRDIKIENILYI--DSNK---SKVPII ....|..| . | .| ..| | . . ..|.| . |.|||.| ||||. ..|. |.. || YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKII |
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Kinase | 12233.AA | CAMK1 | 572-605 | 45 | 1.1e-11 | 30.15 | In-house | 116-150 (276) | Show / Hide |
Range on Protein: 572-605 Range on HMM: 116-150/276 Sequence Identity: 45% (16 aa) QVIDVINYLHYNDIVHRDIKIENILYIDS-NKSKV |... ..|.|...|||||.| ||.|| | . ||. QILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKI |
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S_TKc | 12233.AA | S_TKc | 464-688 | 19 | 2.6e-10 | -25.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 464-688 Range on HMM: 1-231/231 Sequence Identity: 19% (52 aa) DSNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKDK-- . | || | ..... .|. |.|| . | ||| | . . | ..|.|..|. |.. | |.| .|..| . .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL------RVCLAVIDNF---------ETLEPSLKQKNLDC--------- ...| . .. |... ..|.| . |.|||.| |||| . ||. |. . | | | .. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG -----LHGFKIPFEPSYLVKNELIKRNTKIYDIILKTVAFNQEKRKNLSSIIA-----DLHQKY . . ||. . . ..|. |.| | .. ||| . . .|. CILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 12233.AA | Pkinase | 491-597 | 23 | 2.4e-05 | 19.96 | Pfam | 28-141 (293) | Show / Hide |
Range on Protein: 491-597 Range on HMM: 28-141/293 Sequence Identity: 23% (28 aa) ALKIQRVSSKHEIVR-------EIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KDKIQL--NEEEKMQIAIQVIDVIN |.|| ....... .. || | . .. | ....|..|. .| . | | | . | ... ... . |.| .. |.. .. AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE YLHYNDIVHRDIKIENILY |.| . |.|||.| ||||. YCHSMGIIHRDLKPENILI |
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TyrKc | 12233.AA | TyrKc | 464-684 | 14 | 0.000211 | -151.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 464-684 Range on HMM: 1-280/280 Sequence Identity: 14% (44 aa) DSNFEFISVGATGLI-LGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDC--QMPLVIKFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYFNRLKK . . . || | . .|... . | | . ... .. ||. | . . | ....|| . . . ..| | . |.||.| . .. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP DKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSN--------------------------------KSK--VPI-------IKLR---- . |. ... ....|. . .||| . ..|||. |.|. . . .| .|| |. . K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT --------VCL-----------AV-----IDNFETLEPSLKQKNLDCLHG-----FKIPFEPSYLVKNELIKRNTKIYDIILKTVAFNQEKRKNLSSIIA ||. ..|.| .| . . ... . | ...|.|... ... |.| . | |. KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--------------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHE DL .. CF |
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Kinase | 12233.AA | PEK | 543-596 | 13 | 0.00122 | 7.69 | In-house | 365-459 (655) | Show / Hide |
Range on Protein: 543-596 Range on HMM: 365-459/655 Sequence Identity: 13% (13 aa) CS-GNLKQYFNRLK----------------------------------------KDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENIL |. ..|... .. . .. ...... .|. |... ||.| . ..|||.| ||. CEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIF |