Gene 13371 (Tetrahymena)

13371

Species: Tetrahymena
Alias: PreTt13371, TTHERM_00361560, 38.m00206, 13371, 264
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
13371.AA Protein None 859 None Fasta, JSON
13371.kin_dom Protein Kinase Domain None 122 None Fasta, JSON
13371.kin_dom2 Protein Kinase Domain None 122 None Fasta, JSON
13371.NA RNA None 2580 None Fasta, JSON

Protein domain

Protein domains of 13371.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13371.AA C2 47-285 48 9.5e-130 437.35 In-house 1-245 (245) Show / Hide 
Range on Protein: 47-285
Range on HMM: 1-245/245
Sequence Identity: 48% (124 aa)

GAFSFVLKSTNKKTGQIVALKVTECDDNDINGMKQVDEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEESSNDDSEE----IKKQKKEKNLFFVVEQEF
|||..|||..|||....||||..||..||||||..| .||...||..|..||..|.|.|.||.....||...||..|.    |||||.||..|.|.||||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CQTNLENFFTQCRLKKSYPCQQQKEVMAIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD----------LSFASALKNNKSRITVSKIV-
||.||...|..|| ..||||||.|..|||||.|||.||||||..||||||||||...|...|||.|.||          ..|||.||.|||||..||.. 
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

TQTFNKHLIQLQSNKILKERNLSLFCSRSRKRHLQKRGIVLLELDNMAIFNFNE
||. ..|.............|..||.         ..|.||||||||.......
TQQYYQHIFAPEVYQNIYKKNSDLFS---------TVGYVLLELDNMQQYTICC
Kinase 13371.AA Ciliate-C8 47-272 38 4.6e-89 302.2 In-house 1-238 (238) Show / Hide 
Range on Protein: 47-272
Range on HMM: 1-238/238
Sequence Identity: 38% (93 aa)

GAFSFVLKSTNKKTGQIVALKVTEC-DDNDINGMKQVDEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEESSNDDSEEIKKQKKEKNLFFVVEQEFCQT
|||..|||..|||....||||..|| .....|.|... .||....||......|||..||.|.||........||  .... |.| |..|||.|.|.||.
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGND--KIVQTQEKIKKSFFVMEMEKCQQ

N--LENFFTQCRLKKSYPCQQQKEVMAIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD------LSFASALKNNKSRITVSKIV-TQTFN
|  |...|..|| |.|||.||.||..||||.||..|||.|. .||||||.|||...|....||.|.||      . |||.|..|||.....|.. |.. .
NCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYI

KHL-------IQLQSNKILKERNLSLFCSRSRKRHLQKRGIVL
...       .  .  |  ..... .|...   ..... |.||
EMYFCGNWGYFAPEVEKKQSRIQSDIFSKK---SDSYSVGLVL
Kinase 13371.AA C8 38-232 35 3.5e-42 144.19 In-house 1-191 (226) Show / Hide 
Range on Protein: 38-232
Range on HMM: 1-191/226
Sequence Identity: 35% (69 aa)

YTDFSYSGNGAFSFVLKSTNKKTGQIVALKVTECDDN-DINGMKQVDEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEESSNDDSEEIKKQKKEKNLFF
  .| |  .||.. |||  | |  . ..||. .| .. ||... ..  ||...  |.  . .| . .|| . .|.   |. ||    |.  | .||  .|
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSN----EKIVQTEEKS-CF

VVEQEFCQTNLENFFTQCRLKKSYPCQQQKEVMAIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKNNKSRITVSKIVT
| | | |. ||.... ..| |. .. ...|| .||||.|.. |.| .  .||||||.|||. ||.......|.||. |||... ||| |   |..|
VMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT
Kinase 13371.AA CMGC 38-232 15 4e-27 85.41 In-house 1-288 (513) Show / Hide 
Range on Protein: 38-232
Range on HMM: 1-288/513
Sequence Identity: 15% (46 aa)

YTDFSYSGNGAFSFVLKSTN--------------KKTGQIVALKVTECDDNDINGMK----------QVDEEYRLLRQFS----------------NCKY
|.  .. | |... | | ..              ..|..|||.|    .  . ...|              | ..|....                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQVFNCFFLTEEESSDEESSNDDSEEIKKQKKEKNLFFVVEQEFCQTNLENFFTQCR--------LKKSYPC----------QQQKEVM-----AIQML
||. ...|   .......|...     | .| ....|..|   |.....| ..  ...        .. |             .. |  |     . |.|
IVKLYDIFYHKNSDGNEYEDKHI----I-SQ-HFNHLYLV--FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQIL

DSIA--YLHRFD--LLHRDIKPSNFLLSLDEKEI----------------PTVKICDLSFASALKNNK--------------------SRITVSKIVT
 ...  |.|. .   .|||.||.| |.. . . |                 ..||||  .| .. ...                    .|   . .||
RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVT
Kinase 13371.AA Ciliate-E1 123-235 25 7.5e-13 38.56 In-house 59-176 (202) Show / Hide 
Range on Protein: 123-235
Range on HMM: 59-176/202
Sequence Identity: 25% (31 aa)

EEIKKQKKEKNLFFVVEQEFCQTNLENFFT---------QCRLKKSYPCQQQKEVMAIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLS
. |. .|...|....  .|.|. .|.. ..         ||. .. .  .|||. ...|..| ...|| . ..||||||.| | . . ..    ..||..
QIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY---VYCDFG

FASALKNNKSRITVSKIVTQTF
 .. ||||.   .. |  |. .
ISKFLKNNQNQQCQYKGYTHYY
Kinase 13371.AA CAMK 172-211 26 1.4e-11 32.87 In-house 187-239 (425) Show / Hide 
Range on Protein: 172-211
Range on HMM: 187-239/425
Sequence Identity: 26% (14 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIP-------------TVKICD
|... ..|.|  .  |||.|| | ||. .... .             ..||.|
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID
Kinase 13371.AA CAMKL 172-211 37 4e-10 28.34 In-house 135-172 (297) Show / Hide 
Range on Protein: 172-211
Range on HMM: 135-172/297
Sequence Identity: 37% (15 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD
|... ..|.|. .  |||||| | ||. . ..  ..||.|
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIID
Kinase 13371.AA Pkinase 172-211 41 1.5e-09 34.82 Pfam 116-155 (293) Show / Hide 
Range on Protein: 172-211
Range on HMM: 116-155/293
Sequence Identity: 41% (17 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEI-PTVKICD
|.|  ..|.|.   .|||.||.|.|.. .. .| ..|||||
QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICD
Kinase 13371.AA Ciliate-E2 167-215 30 2.4e-09 28.23 In-house 163-203 (365) Show / Hide 
Range on Protein: 167-215
Range on HMM: 163-203/365
Sequence Identity: 30% (15 aa)

EVMAIQMLDSIAYLHRFD-LLHRDIKPSNFLLSLDEKEIPTVKICDLSFA
| .. .... . |||     .||||||.| |.         .||.|. ..
EFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS
Kinase 13371.AA STE 38-106 20 6.9e-09 27.64 In-house 1-100 (359) Show / Hide 
Range on Protein: 38-106
Range on HMM: 1-100/359
Sequence Identity: 20% (20 aa)

YTDFSYSGNGAFSFVLKSTNKK---------------TGQIVALKVTECDDND---------------INGMKQVDEEYRLLRQFSN-CKYIVQVFNCFF
... .  |.|||  | |  |.|               ||.|.| |. . ....               .. |.|. .| ........ ...||. . |.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase 13371.AA STE 168-227 26 1.2e-08 26.76 In-house 155-223 (359) Show / Hide 
Range on Protein: 168-227
Range on HMM: 155-223/359
Sequence Identity: 26% (21 aa)

VMAIQMLDS-IAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKNN-----------------KSRITV
... | |    .|||.    ||||||.| ||         ||.||  ... | ..                 . | |.
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTF
Kinase 13371.AA ULK 179-215 31 2e-06 18.73 In-house 141-185 (324) Show / Hide 
Range on Protein: 179-215
Range on HMM: 141-185/324
Sequence Identity: 31% (15 aa)

YLHRFDLLHRDIKPSNFLLS----------LDEKEIPTVKICDLSFA
.||     ||||||.| |..          .  . ....||.|  ||
ELHKHNIIHRDIKPQNILIHNGQPKTDSKKV-HP-NGVLKIADFGFA
Kinase 13371.AA Ciliate-E1 45-109 26 1.1e-05 15.04 In-house 2-68 (202) Show / Hide 
Range on Protein: 45-109
Range on HMM: 2-68/202
Sequence Identity: 26% (18 aa)

GNGAFSFVLKSTNKKTG-QIVALKVTECDDN--DINGMKQVDEEYRLLRQFSNCKYIVQVFNCFFLTE
||| ||.|.|  ....  . ||.|. .| .|  ...  ..  |.| ..  | . .||.|....... .
GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQ
Kinase 13371.AA Pkinase 45-105 26 0.000193 16.78 Pfam 8-69 (293) Show / Hide 
Range on Protein: 45-105
Range on HMM: 8-69/293
Sequence Identity: 26% (17 aa)

GNGAFSFVLKSTNKKTGQIVALKVTECDDNDINGMKQVDE--EYRLLRQFSNCKYIVQVFNCF
| |.|. | | ..|.||.|||.|. . .... .  ..     | .... . |...||. . .|
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWF
Kinase 13371.AA ULK 45-105 23 0.00035 10.81 In-house 8-84 (324) Show / Hide 
Range on Protein: 45-105
Range on HMM: 8-84/324
Sequence Identity: 23% (18 aa)

GNGAFS-FVLKSTNKKT---GQIVALKVTE-CDDNDINGM-------KQVDEEYRLLRQFS--NCKY--IVQVFNCF
| |.|   | | .||||   .|.|| |. . .  |... .       .. . | ......   ....  ||. . .|
GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWF
Kinase 13371.AA CAMK 45-105 14 0.000486 8.12 In-house 3-107 (425) Show / Hide 
Range on Protein: 45-105
Range on HMM: 3-107/425
Sequence Identity: 14% (15 aa)

GNGAFSFVLKSTNKKTG------------QIVALKV----TECDDN----------------------DINGMKQVDEEYRLLRQFS------NCKYIVQ
| |.|. | . ..|.|.            | || |.       |..                      . . .|.|  |...... .      . . |..
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VFNCF
 .  .
LYEVY
Kinase 13371.AA Ciliate-E2 45-105 17 0.123706 1.36 In-house 8-101 (365) Show / Hide 
Range on Protein: 45-105
Range on HMM: 8-101/365
Sequence Identity: 17% (17 aa)

GNGAFSFVLKSTNKKTGQIVALKVTECDD----------------------NDINGMKQVDEEYRLLR------------QFSNCKYIVQVFNCF
|.|.|. | | ...|... .|.|. . .                       |.|. .||.. ..| ..            .. |...|.. . ||
GQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECF
Kinase 13371.AA C2 433-609 39 1.1e-92 314.19 In-house 1-232 (245) Show / Hide 
Range on Protein: 433-609
Range on HMM: 1-232/245
Sequence Identity: 39% (91 aa)

GAKGLVLGTFNKTLGFKTVLKIQQVQS-----KHEVVQEVGIMRDCQ-MPLVIKFYGYFYLSVNKNDD------------------------FVVYEIEK
||.||||..|||. . ...||||..||     .|||..|.||||.|| ||..||.|.||||.|||..|                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYLTRLQKENIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLAD----------FDQSRKLPYELYYRDD-ELVK
|.||||||..|..|.|. .....||..|.|..|..|||....|||||||..|.||...|...|||||.|          ||...||.|. ..  . ....
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

DYFPVQGI-------------CEVFS-VGVCL
.. ..|.|             ...|| || .|
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVL
Kinase 13371.AA Ciliate-C8 433-609 30 1e-69 237.89 In-house 1-238 (238) Show / Hide 
Range on Protein: 433-609
Range on HMM: 1-238/238
Sequence Identity: 30% (73 aa)

GAKGLVLG-------TFNKTLGFKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKNDD-----------------FVVYEIEKCS--G
||.|.||.        ...    . |.|||..|..||......||..||||.|...|..|||. .|| .|                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYLTRLQKENIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLAD------FDQSRKLPYELY-YRDDELVKDYFP---
|||||..|..|... .....|..||.|.||.||||... |.|||||..|.|....|...|||||.|      |.....||..   | . . .. . .   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

-------------VQG----ICEVFS-------VGVCL
             ...       .||       ||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13371.AA C8 425-579 30 1.1e-35 121.36 In-house 2-178 (226) Show / Hide 
Range on Protein: 425-579
Range on HMM: 2-178/226
Sequence Identity: 30% (54 aa)

SNFEFISVGAKGLVLGTFNKTLGFKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKNDDFVVYEIEKCS-------------------
.||...| ||.|.|| . |     . |||.|..|.|..  ..  ||. ..||.|.. |  ...  . . ....|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYLTRLQKENIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLADFDQSRKLP
   ||||.   .....  .....| .||.|.|| |||..   |.|||||..|.|  ..|. ...|||.||. . ...
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVS
Kinase 13371.AA Ciliate-E2 452-572 23 2.1e-16 52.82 In-house 52-200 (365) Show / Hide 
Range on Protein: 452-572
Range on HMM: 52-200/365
Sequence Identity: 23% (38 aa)

LKIQQVQSKHEVVQEVGIMR----------------DCQMPLVIKFYGYFYLSVNKNDDFVVYEIEKCSG-NLKQYLT--RLQKENI-----ALTDNQKM
.||.. . . .. ||  |||                  . | .||.| .|.   .|.|. . .  | |.| .|..|.   .... ..      .|...  
MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIK

QIAVQIID---------------VVNYLNYNG-IVHRDIKLDNILYIESQSDVPTIKLADF
.|  ||..                ..||  .. |.|||||..|||.         ||..||
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDF
Kinase 13371.AA Ciliate-E1 430-575 22 1.7e-14 44.01 In-house 1-161 (202) Show / Hide 
Range on Protein: 430-575
Range on HMM: 1-161/202
Sequence Identity: 22% (37 aa)

ISVGAKGLVLGTFNKTLG-FKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYF--YLSVNKNDD--FVVYEIEKCSGNLKQYLT---------RLQ
|. |  ..|.  ...     .  .||.... . . ...  . . .. .. .|.. |   .. . | |.  . .  .|.|. .||.||.          .|
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KENIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPT-IKLADFDQS
.... .|. |||||..|.|| ...| ...| ||||| .|||.  .   | . . ...| ..
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKN
Kinase 13371.AA CAMK 458-579 19 3.2e-14 41.52 In-house 73-247 (425) Show / Hide 
Range on Protein: 458-579
Range on HMM: 73-247/425
Sequence Identity: 19% (35 aa)

QSKHEVVQEVGIMRDCQ-------MPLVIKFYGYFYL-----------SVNK-----NDDFVVYE--IEKCSG-NLKQY-LTRLQKE-------------
.....| .|. ||. .|        | .||.| ..             . .|     .....      | |||  | .. . ....              
KDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV

-NIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVP-------------TIKLADFDQSRKLP
 .  .|  .  ..  ||.. |.|.  ..|||||.|..|||. .. .| .             .||..||  ..|..
ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
S_TKc 13371.AA S_TKc 424-678 18 1.6e-12 6.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 424-678
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

DSNFEFISVGAKGLVLGTFNKTLGFKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLSVNKNDDFVVYEIEKCSG---NLKQYLTRLQKEN--
    . |  || | |    .|  | .  .||        . .|. |..  . | ..|.|..|.       |..    | |.|   .|..|. . ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLADFDQSRKLPYELYYRDD----------ELVKDYFPVQG-ICEVFSVGV
  ..  .   .. ||.. ..|.  .||.|||.| .|||  |      .||..||  .|.|       .           |..    .  .  | . |.|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

CLALLDN----FEKLEPVILKKAQDYFFGFKIPFEQNFHVKEELINRKSQIYDILLKTVVFQPN---QISYSLH-------FKPL
.|. .      |.  . ...||                          ..  |.. |  .. |.    .   |.          .
ILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13371.AA STE 452-572 23 1.6e-12 40.63 In-house 64-191 (359) Show / Hide 
Range on Protein: 452-572
Range on HMM: 64-191/359
Sequence Identity: 23% (33 aa)

LKIQQVQSKHEVVQEVGIMRDCQ--MPLVIKFYGYFYLS---VNKNDDFVVYEIEKCS-GNLKQYLTRLQKENIALT----------DNQKMQIAVQIID
|.. . . . .. .|. ||..|.   | ..|.||...      . .|.  ..  | .. | | . . .  . .  |.           .|   |..||. 
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILK

V-VNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLADF
   .||  ..|.||||| .|||          .||.||
GLLYYLHSHHIIHRDIKPANILL---------VKLCDF
Kinase 13371.AA CAMKL 532-572 51 1.1e-11 33.39 In-house 135-173 (297) Show / Hide 
Range on Protein: 532-572
Range on HMM: 135-173/297
Sequence Identity: 51% (21 aa)

QIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLADF
||.. |||.  .||||||||..|||  |...   .||..||
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDF
Kinase 13371.AA CMGC 501-572 17 1.3e-10 30.15 In-house 135-248 (513) Show / Hide 
Range on Protein: 501-572
Range on HMM: 135-248/513
Sequence Identity: 17% (20 aa)

EKCSGNLKQYLTRLQK-----ENIALTDNQ------------KMQIA------VQIIDVVN--YLNYNG--IVHRDIKLDNILYIESQSDV---------
| .  .|.||. . |.      .. |.. .            .  .        ||.  ..  |.  ..  |.|||.|  |||  .    .         
EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED

-------PTIKLADF
        ..|..||
WNPCQKNGRLKICDF
Kinase 13371.AA ULK 505-572 30 3.8e-10 32.25 In-house 102-182 (324) Show / Hide 
Range on Protein: 505-572
Range on HMM: 102-182/324
Sequence Identity: 30% (25 aa)

GNLKQYLTRLQK-----ENIALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQ---------SDVPTIKLADF
|.|.||. . .|     |.  |. ..  |.  ||.    .|. ..|.|||||..|||  . |         .  ...|.|||
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADF
Kinase 13371.AA Pkinase 465-584 20 6.5e-09 32.6 Pfam 49-169 (293) Show / Hide 
Range on Protein: 465-584
Range on HMM: 49-169/293
Sequence Identity: 20% (27 aa)

QEVGIMRDCQMPLVIKFYGYFYLSVNKNDDFVVYEIEKCSG-----NLKQYLTRLQKENIAL--TDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILY
.|. ||. .. | ....|..|.      .| .    | | |      |. |...  ... ..  ....   .. ||.  ..|.  .||.|||.|..|||.
SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI

IESQSDV-PTIKLADFDQSR---KLPYELYY
  .. .. ...|..||  ..     ... ..
D-NNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase 13371.AA TyrKc 440-658 17 2e-06 -119.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 440-658
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

GTFNKTLG---FKTVLK-----------IQQVQSKHEVVQEVGIMRDC--QMPLVIKFYGYFYLS----VNKNDDFVVYEIEKCSGNLKQYLTRLQKENI
 |..|.||   | .| |           ..    . .  .|  ||.    . | ....||.   .    .     ..| |  .  |.||.|| . ...  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK--

ALTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLADFDQSRKLPYE-------LYYRDDE--LVKDYFPV---------QGIC-
 |.  .. ....|| .  .||  ....|||.   |.|. | .    |.| .||  ||..  .        |||  |    |. .|.          |.. 
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-------------EVFSVGVCLALL-----DNFEKLEPVILKKAQDYFFGFKIPFEQN------FHVKEELIN--------------RKSQIYDIL
             |.|. |            . . .   . .       |.  |  .|       .  .|. .              . |.|....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-------GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF