Gene 24009 (Tetrahymena)

24009

Species: Tetrahymena
Alias: n.24009, 24009, 1152, 257.m00034, PreTt24009, TTHERM_01155730
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
24009.AA Protein None 697 None Fasta, JSON
24009.kin_dom Protein Kinase Domain None 187 None Fasta, JSON
24009.kin_dom2 Protein Kinase Domain None 187 None Fasta, JSON
24009.NA RNA None 3104 None Fasta, JSON

Protein domain

Protein domains of 24009.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24009.AA C2 48-349 40 7e-130 437.79 In-house 1-245 (245) Show / Hide 
Range on Protein: 48-349
Range on HMM: 1-245/245
Sequence Identity: 40% (124 aa)

GSFAIVLKAINKITGQTVALKVVECDESDFKGMEVIQNEYKMLEVFSGCKYIIKVFNSFYLTESNDSDSDEDDDQIPVGQNN--NQSNLIRVFYVMEQEL
|.|..||||.|| ....||||..||...|..||. .|.||.... .....|||||.|.||||.....|.|||.|.....|.|  .|.|. ..|.|.||| 
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CQTTLSSFIDTCKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLQIQLDHIQILKKIIKLFVQIVIFTEKLLDLIAK
||..| .....|...||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.||...  ..|  |                      
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQK-K----------------------

LQYIAKYIDSKQFKQIPQKQIYQIEKIFLNHKKNPPENGWACDLAFASALKNNETRLSISTFKGSQAY----TAPEVYYNVYKKLSDIFS-VGIVLLELD
                                         ||..|||.||.|..|...|.||..|.|    .||||| |.||| ||.|| ||.||||||
-----------------------------------------CDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELD

NIATFDVSK
|........
NMQQYTICC
Kinase 24009.AA Ciliate-C8 48-336 32 4.6e-89 302.21 In-house 1-238 (238) Show / Hide 
Range on Protein: 48-336
Range on HMM: 1-238/238
Sequence Identity: 32% (100 aa)

GSFAIVLKAINKITGQTVALKVVEC-DESDFKGMEVIQNEYKMLEVFSGCKYIIKVFNSFYLTESNDSDSDEDDDQIPVGQNN--NQSNLIRVFYVMEQE
|.|..||||.|| ....||||..|| .. . ..|| .. ||.|.  |. ......|...|||.| |... |...|.|...|..  .      .|.|||.|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK------SFFVMEME

LCQTT--LSSFIDTCKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLQIQLDHIQILKKIIKLFVQIVIFTEKLLDL
.||..  | ...|.|..|.||||||||||..||..|||..||.|...||||||.|||..|||...|| || .    .|                      
KCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-FK-KQ----------------------

IAKLQYIAKYIDSKQFKQIPQKQIYQIEKIFLNHKKNPPENGWACDLAFASALKNNETRLSISTFKGSQAY-----------TAPEVYYNVYKKLSDIFS
                                            ||..|||.|..|........|||...|           .||||....... |||||
--------------------------------------------CDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFS

-------VGIVL
       ||.||
KKSDSYSVGLVL
Kinase 24009.AA C8 36-212 31 5.1e-34 115.49 In-house 1-168 (226) Show / Hide 
Range on Protein: 36-212
Range on HMM: 1-168/226
Sequence Identity: 31% (56 aa)

QKHYQILQFAGNGSFAIVLKAINKITGQTVALKVVEC-DESDFKGMEVIQNEYKMLEVFSGCKYIIKVFNSFYLTESNDSDSDEDDDQIPVGQNNNQSNL
 . .|.| |   |....|||| |    ....||. .| ...| ...| |. ||.|..||.  . .. . . ||. ...    ... ..| . ..      
FNNFQYLSF---GAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEE------

IRVFYVMEQELCQTTLSSFIDTCKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKL
 . . ||| |||.  |  . | ...|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||
-KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKL
Kinase 24009.AA CMGC 39-201 16 1.3e-28 90.34 In-house 1-218 (513) Show / Hide 
Range on Protein: 39-201
Range on HMM: 1-218/513
Sequence Identity: 16% (38 aa)

YQILQFAGNGSFAIVLKAINKITG--------------QTVALKVVECDESDFKGME----------VIQNEYKMLEVFS----------------GCKY
|.|..  | |....| |...| |.              . ||.| .  .. .  ..            .. | |.|. ..                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKVFNSFYLTESNDSD-------SDEDDDQIPVGQNNNQSNLIRVFYVMEQELCQTTLSSFIDTCKQ-----KNSYPSQQM------------KEIMT-
|.| ...||  .|. ..       |              | ..  .. |.  |.....|  .|. ...     .. . |.              .  .. 
IVKLYDIFYHKNSDGNEYEDKHIIS--------------Q-HFNHLYLVF--EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI

-----IQILDSVA--FLHRFD--VVHRDIKPSNFLLN
      ||| ...  ..|. .  ..|||.||.| |.|
HIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILIN
Kinase 24009.AA Pkinase 39-212 20 4.1e-22 79.29 Pfam 1-153 (293) Show / Hide 
Range on Protein: 39-212
Range on HMM: 1-153/293
Sequence Identity: 20% (38 aa)

YQILQFAGNGSFAIVLKAINKITGQTVALKVVECDESDFKGMEVIQN--EYKMLEVFSGCKYIIKVFNSFYLTESNDSDSDEDDDQIPVGQNNNQSNLIR
|.|..  | |||. | |...| ||..||.|... .. . .  .   .  | ...  . ....|.. . .|.                            .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---------------------------K

VFYVMEQELCQTTLSSFIDTC-----KQKNSY--PSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKL
  . | .|.|. .|.  .| .     ......  . .. | .|. |||  ....|.  ..|||.||.|.|..  .||..  ..|.
DHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKI
Kinase 24009.AA STE 39-212 17 1.9e-17 58.28 In-house 1-188 (359) Show / Hide 
Range on Protein: 39-212
Range on HMM: 1-188/359
Sequence Identity: 17% (38 aa)

YQILQFAGNGSFAIVLKAINKI---------------TGQTVALKVVECDESDF---------------KGMEVIQNEYKMLEVFSG-CKYIIKVFNSFY
...... |.|.|  | ||.|.                ||. .| |... ....                . |. |..| |..  ..  ...|.| . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LTESNDSDSDEDDDQIPVGQNNNQSNLIRVFYVMEQELCQ-TTLSSFID---TCKQKNSYPS-------QQMKEIMTIQILDS-VAFLHRFDVVHRDIKP
    |                    .  .    .  |..   .|...|.    |.. .. ..        .   ... |||    ..||.  ..||||||
KEGHN--------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKP

SNFLLNFDQNGNPTLKL
.| ||          ||
ANILL---------VKL
Kinase 24009.AA S_TKc 39-401 16 4.9e-16 58.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-401
Range on HMM: 1-231/231
Sequence Identity: 16% (65 aa)

YQILQFAGNGSFAIVLKAINKITGQTVALKVVECDESDFKGMEVIQNEYKMLEVFSGCKYIIKVFNSFYLTESNDSDSDEDDDQIPVGQNNNQSNLIRVF
|.||.  | |.|. | |...| ||. ||.|..          | |..| ..|.   ....|.| . .|.                            ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD--------------------------DHLY

YVMEQELCQT---TLSSFIDTCKQKNS---YPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKL-------QIQLDHIQILKKI
 ||  |.| .   .| ..|. .. .     .|  . . .|  ||.. ....|.  ..|||.||.| ||.       ..|.       |.           
MVM--EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------

IKLFVQIVIFTEKLLDLIAKLQYIAKYIDSKQFKQIPQKQIYQIEKIFLNHKKNPPENGWACDLAFASALKNNETRLSISTFKGSQAYTAPEVYYNVYKK
                                                                               .|| |.  | ||||    | |
-------------------------------------------------------------------------------TTFCGTPWYMAPEVL--GYGK

-LSDIFSVGIVLLELDN-IATFDVSKTVIEQKFETKNGQIFQNFSIDRQSKIYQIAMQCLKYEVDQRKPAVELLI--------QFI
  .|. |.|..| |.      |.    .. .|                 .   .. ..||... ..|  | |.|         ...
CKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24009.AA Ciliate-E1 45-201 23 5.4e-16 48.91 In-house 1-143 (202) Show / Hide 
Range on Protein: 45-201
Range on HMM: 1-143/202
Sequence Identity: 23% (39 aa)

AGNGSFAIVLKAINKITG-QTVALKVVECD--ESDFKGMEVIQNEYKMLEVFSGCKYIIKVFNSFYLTES------NDSDSDEDDDQIPVGQNNNQSNLI
 |||||.||.||... .  . ||.|...|   ... .  ..|...||... | . .|||.... ... ..      ... .... |.. .          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

RVFYVMEQELCQTTLSSFIDTCKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLN
           .  |   .. |.|.. . ..| |. ...|..| .. || . . ||||||.| | |
-----------N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILIN
Kinase 24009.AA C8 287-336 36 2.5e-13 42.74 In-house 169-226 (226) Show / Hide 
Range on Protein: 287-336
Range on HMM: 169-226/226
Sequence Identity: 36% (21 aa)

CDLAFASALKNNETRLSISTF--KGSQAYTAPEVYYN------VYKKLSDIFSVGIVL
||..|||... |.    .  .   | .|| |||. .        |.. ||.||||.||
CDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 24009.AA CAMK 175-212 27 4.7e-11 31.14 In-house 187-237 (425) Show / Hide 
Range on Protein: 175-212
Range on HMM: 187-237/425
Sequence Identity: 27% (14 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKL
||.. |...|  ..||||.|| | ||. . ....             ..|.
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase 24009.AA CAMKL 175-200 53 1.8e-09 26.27 In-house 135-160 (297) Show / Hide 
Range on Protein: 175-200
Range on HMM: 135-160/297
Sequence Identity: 53% (14 aa)

QILDSVAFLHRFDVVHRDIKPSNFLL
||.. |...|. ..||||||| | ||
QIVSAVNYCHSHGIVHRDIKPENILL
Kinase 24009.AA CAMKL 39-71 38 7.8e-07 17.68 In-house 1-34 (297) Show / Hide 
Range on Protein: 39-71
Range on HMM: 1-34/297
Sequence Identity: 38% (13 aa)

YQILQFAGNGSFAIVLKAIN-KITGQTVALKVVE
|.|..  | |||. |  |.. ..||. || |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIID
Kinase 24009.AA CAMK 46-103 17 8.7e-07 17.13 In-house 3-104 (425) Show / Hide 
Range on Protein: 46-103
Range on HMM: 3-104/425
Sequence Identity: 17% (18 aa)

GNGSFAIVLKAINKITG------------QTVALKVVECDESDFK--------------------------GMEVIQNEYKMLEVFSG------CKYIIK
| |||..| ..|.| |.            | || |... .  . |                           .. ...|....   .|       . |||
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VF
 .
LY
Kinase 24009.AA ULK 39-103 23 3e-06 18.32 In-house 1-81 (324) Show / Hide 
Range on Protein: 39-103
Range on HMM: 1-81/324
Sequence Identity: 23% (19 aa)

YQILQFAGNGSFA-IVLKAINKIT---GQTVALKVVE-CDESDFKGM-------EVIQNEYKMLEVFS--GCKY--IIKVF
|.. .  | |||.  | |..||.|   .| || |... .  ...| .       . ..|| . .  .    ...  |.| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY
Kinase 24009.AA Ciliate-E2 158-212 22 3e-06 17.39 In-house 138-197 (365) Show / Hide 
Range on Protein: 158-212
Range on HMM: 138-197/365
Sequence Identity: 22% (16 aa)

KQKNSYPSQQMKEIMTIQILD---------------SVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKL
| .  |.. .    .. |||.                . .||    ..||||||.| |.         .|.
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKI
Kinase 24009.AA ULK 174-212 34 6e-06 17.18 In-house 133-179 (324) Show / Hide 
Range on Protein: 174-212
Range on HMM: 133-179/324
Sequence Identity: 34% (16 aa)

IQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKL
.||.    .||   ..||||||.| |.. .| .        |..||.
KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKI
Kinase 24009.AA TyrKc 39-400 11 1.6e-05 -133.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-400
Range on HMM: 1-280/280
Sequence Identity: 11% (47 aa)

YQILQFAGNGSFAIVLKAINKITGQTVALKVVECDESDFKGMEVIQNEYKMLEVF-SGCKYIIK----VFNSF-----------------------YLTE
 . ..  |.| | .| |.. |   ..|| |..  |      .| . .| ...  .    . |..    .  ..                       || .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SNDSDSDEDDDQIPVGQNNNQSNLIRVFYVMEQELCQTTLSSFIDTCKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTL
. .                                                   . . .  . .|| .  ..||.  ..|||.   | |.. ..      
HRPK-------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------

KLQIQLDHIQILKKIIKLFVQIVIFTEKLLDLIAKLQYIAKYIDSKQFKQIPQKQIYQIEKIFLNHKKNPPENGWACDLAFASALKNN------ETRLSI
                                                                            .|   . ....       .   . 
------------------------------------------------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRK

STFKGSQ-----AYTAPEVY-YNVYKKLSDIFSVGIVLLEL--------DN-----IATFDVSKTVIEQKFETKNGQ----IFQNFSIDRQSKIYQIAMQ
.. ||.        .|||.  |...   ||..| |... |.         .     .  ..| . | . .   .        |        ...|||  |
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQ

CLKYEVDQRKPAVELLIQF
| ... ..|    |.  .|
CWHEDPEDRPTFSEIHECF
Kinase 24009.AA STE 306-339 31 8.8e-05 12.95 In-house 222-261 (359) Show / Hide 
Range on Protein: 306-339
Range on HMM: 222-261/359
Sequence Identity: 31% (13 aa)

TFKGSQAYTAPEVYYN-------VYKKLSDIFSVGIVLLEL
|| |.. . ||||  .        |   .|| |.|....|.
TFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 24009.AA Ciliate-E2 39-112 14 0.000329 10.33 In-house 1-108 (365) Show / Hide 
Range on Protein: 39-112
Range on HMM: 1-108/365
Sequence Identity: 14% (16 aa)

YQILQFAGNGSFAIVLKAINKITGQ------------------TVALKVVECDESDFKGMEVIQNEYKML----------EV-----FSGCKYIIKVFNS
| ...  |.|.|..| |. .. ...                   |. | ..      .. | | .| ...          .      .  ...||| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYL-TESN
|.  ...|
FQEKDDNN
Kinase 24009.AA CAMK 287-336 19 0.000428 8.3 In-house 238-324 (425) Show / Hide 
Range on Protein: 287-336
Range on HMM: 238-324/425
Sequence Identity: 19% (17 aa)

CDLAFASALKNNETRL---------------------SISTFKGSQAYTA-PEVYYNV---------------YKKLSDIFSVGIVL
.|  ||  .. .|  .                       .|| |. .| | |||                   | . .|. |.|..|
IDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 24009.AA Ciliate-E2 304-339 28 0.000935 8.75 In-house 244-289 (365) Show / Hide 
Range on Protein: 304-339
Range on HMM: 244-289/365
Sequence Identity: 28% (13 aa)

ISTFKGSQAYTAPEVYYNV----------YKKLSDIFSVGIVLLEL
. |. |.  | |||.. .           | . .||.|.|..| |.
FNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 24009.AA ULK 306-336 23 0.001152 8.95 In-house 200-242 (324) Show / Hide 
Range on Protein: 306-336
Range on HMM: 200-242/324
Sequence Identity: 23% (10 aa)

TFK------GSQAYTAPEVYY------NVYKKLSDIFSVGIVL
|..      |.  | ||..        . | . .||.|.|...
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 24009.AA Pkinase 305-339 37 0.001339 13.81 Pfam 169-205 (293) Show / Hide 
Range on Protein: 305-339
Range on HMM: 169-205/293
Sequence Identity: 37% (14 aa)

STFKGSQAYTAPEV--YYNVYKKLSDIFSVGIVLLEL
.|| |.  | ||||   .. | . .|..|.|..| |.
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 24009.AA STE 381-401 33 0.015413 4.93 In-house 336-359 (359) Show / Hide 
Range on Protein: 381-401
Range on HMM: 336-359/359
Sequence Identity: 33% (8 aa)

QCLKYEVDQRKPAVELLI---QFI
.||... ..|  | .||     ||
KCLQKDPNKRPTASQLLKSEHPFI
Kinase 24009.AA CAMKL 305-336 38 0.075037 1.52 In-house 191-226 (297) Show / Hide 
Range on Protein: 305-336
Range on HMM: 191-226/297
Sequence Identity: 38% (14 aa)

STFKGSQAYTAPEVYYN--V-YK-KLSDIFSVGIVL
.|| || .| |||..      |  .  || | |..|
KTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVIL
Kinase 24009.AA C2 511-697 39 1.5e-106 360.29 In-house 1-245 (245) Show / Hide 
Range on Protein: 511-697
Range on HMM: 1-245/245
Sequence Identity: 39% (97 aa)

GATGLVLGVFNKAQNRYSALKIQRAK------KHEVVREVGIMKDCQ-MPLVIKFYDYFYLNVNNKED------------------------FVVYEIEK
||.||||..||| |||..|||||...      .|||..|.|||..|| ||..||.|.||||.||.|||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPAIKLAD----------FDQARKMPYDWSYIDGQN-VK
|.|||||..|...|||.......|...|||.||.|||||..||||||||..|.||......||.|||.|          ||.|.|..|..|.| ... ..
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

QYYPIEG----------------ACGTIGYCPPELVKDFLYSFNV
.......                ...|.||...||.....|... 
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 24009.AA Ciliate-C8 511-697 32 1.6e-81 277.1 In-house 1-234 (238) Show / Hide 
Range on Protein: 511-697
Range on HMM: 1-234/238
Sequence Identity: 32% (77 aa)

GATGLVLG-------VFNKAQNRYSALKIQRAK-KHEVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKED-----------------FVVYEIEKCS--G
||.|.||.        ... ..| ...|||... .||......||..||||.|...||.|||. .|.|||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPAIKLAD------FDQARKMPYDWS-YIDGQNVKQYYPIEG
||||......|.........|..||||..|..||||...|.|||||..|.|. ... ..| |||.|      |..|...|...| |.. . ......||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

A-CGTIGYCPPELVKD------FLYS-----FNV
. ||..||..||..|.       ..|     . |
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSV
Kinase 24009.AA C8 504-690 30 1.8e-40 138.17 In-house 3-205 (226) Show / Hide 
Range on Protein: 504-690
Range on HMM: 3-205/226
Sequence Identity: 30% (65 aa)

NFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYFYLN-VNNKEDFVVYEIEKCS--------------------
||...| || |.||   |  .||  .||.|  .   .   .  ||| ..||.|.. || .... .  .|...|.| ||||                    
NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC

-GNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPAIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTI
  ||||.   ............| .||||..| .||.|.. |.|||||..|.|  ..  ....|||.||. | . . . | |  .....       ||| 
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW

GYCPPELVKD
.|  ||  |.
AYFAPEIEKK
Kinase 24009.AA CAMK 507-689 17 8e-29 89.43 In-house 1-293 (425) Show / Hide 
Range on Protein: 507-689
Range on HMM: 1-293/425
Sequence Identity: 17% (51 aa)

FISVGATGLVLGVFNKAQN------------RYSALKI--------------------------------QRAKKHEVVREVGIMKDCQ-------MPLV
 .  |. | |  ...|  .            .  | ||                                .  ....| ||. ||| .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDYFYL-----------NVNN-----KEDFVVYE--IEKCSGN------LKQFLNN-----------LKKQNKELDENQKIKIAIQIMDVINYLHIH
||.|...             . ..     .....      | |||       .     .           .  ... ..| .  ..  || . ..|.| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

DIVHRDIKLENLLYVEQDPEIP------------A-IKLADFDQARKMP------YDWSYIDGQNVKQ-------YYPIEGACGTIGYCP-PELVK
.|||||.|.||.|... ... .            . ||..||  |.|..      .. .| .|. ...         . .  ||| .|.. ||...
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN
Kinase 24009.AA Pkinase 541-694 23 1.5e-17 63.1 Pfam 46-190 (293) Show / Hide 
Range on Protein: 541-694
Range on HMM: 46-190/293
Sequence Identity: 23% (39 aa)

VR--EVGIMKDCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-----NLKQFLNNLKKQNKEL--DENQKIKIAIQIMDVINYLHIHDIVHRDIKLEN
.|  |. ||| .. | ....||.|.      .| .    | | |      |. ..    .... .  .|.. .... ||   ..|.| . |.|||.|.||
RRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN

LLYVEQDPEI-PAIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGACGTIGYCPPELVK-DFLYS
.|.. ....| . .|..||  |...              .    . |||..|..||... .  |.
ILID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG
Kinase 24009.AA Ciliate-E2 522-689 21 2e-16 52.86 In-house 44-260 (365) Show / Hide 
Range on Protein: 522-689
Range on HMM: 44-260/365
Sequence Identity: 21% (50 aa)

KAQNRYSALKIQRAK-KHEVVREVGIMK----------------DCQMPLVIKFYDYFYLNVNNKEDFVVYEIEKCSG-NLKQFLNNL-KKQNKE-----
|... . |.||.. . . .. .|  ||.                  . | .||.|..|.   ..... . .  | |.| .|.....|  ||.|.|     
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

-LDENQKIKIAIQIMD---------------VINYLHIHD-IVHRDIKLENLLYVEQDPEIPAIKLADFDQARKMPYDWSYIDGQNVKQYYPIEGA----
 ..|.. ..|  || .                ..|||    |.|||||.||.|.         ||..||  ..|   |  .. . .. ..  ..      
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS

------------------CGTIGYCPPELVK
                  ||| || .|| ..
RTPGYMDQIIQQNMFNTICGTPGYMAPEILN
Kinase 24009.AA Ciliate-E1 508-634 21 1.3e-14 44.38 In-house 1-142 (202) Show / Hide 
Range on Protein: 508-634
Range on HMM: 1-142/202
Sequence Identity: 21% (30 aa)

ISVGATGLVLGVFNKAQN-RYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYF--YLNVNNKED--FVVYEIEKCSGNLKQFLN---------NLK
|. |  ..|.  ... .| .  |.||.  .   . . .  . | .. .. .|...|   ....  ...  . .  .|.|. .||. |.          ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLY
........ ||..|..|. | ...||.. | ||||| .|.|.
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI
Kinase 24009.AA CAMKL 592-690 27 5.8e-14 40.79 In-house 116-207 (297) Show / Hide 
Range on Protein: 592-690
Range on HMM: 116-207/297
Sequence Identity: 27% (28 aa)

KKQNKE--LDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPAIKLADFDQARKMP-YDWSYIDGQNVKQYYP-IEGACGTIGYCPPEL
|. ..   ..|..  ..  ||.. .||.| |.|||||||.||.|  |.. .   ||..||  . ..  .         ....    .  ||.  |..||.
KHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPC---------IFGPGQKLKTFCGSPPYMAPEI

VKD
...
FQG
Kinase 24009.AA CMGC 522-649 15 2.9e-13 39.02 In-house 17-248 (513) Show / Hide 
Range on Protein: 522-649
Range on HMM: 17-248/513
Sequence Identity: 15% (36 aa)

KAQN------------------RYSALKIQR-AKKHEVV---------------REVGIMKDCQ-----------------MPLVIKFYDYFYLNVNNKE
|...                  .. |.|. . .. .|                 ||. |.|  .                  . ..| ||.|| . ....
KCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGN

D------------FVVYEIEKCSGNLKQFLNNLKK-----QNKELDENQ------------KIKIA------IQIMDVIN--YLHIHD--IVHRDIKLEN
.             .    | .  .|.|.. | ..     ....|.| .            . ..        ||   ..  |.| |.  |.|||.| ||
EYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPEN

LLYVEQDPEI----------------PAIKLADF
.|  ..   |                  .|..||
ILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase 24009.AA STE 505-649 21 3.2e-13 43.13 In-house 1-191 (359) Show / Hide 
Range on Protein: 505-649
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

FEF---ISVGATGLVLGVFNK------AQNRY---------SALKIQR---------------------AKKHEVVREVGIMKDCQ--MPLVIKFYDYFY
.|.   |  ||.| |    |.        ..           | |. .                      .. .. .|. |||.|.   | ..|.|....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LN---VNNKEDFVVYEIEKCS-GNLKQFLNNLKKQNKELD----------ENQKIKIAIQIMDV-INYLHIHDIVHRDIKLENLLYVEQDPEIPAIKLAD
 .    .|...  ..  | .. | | ..... .. .|.|.          |.| ..|. ||     .||| | |.|||||  | |          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F
Kinase 24009.AA ULK 582-649 33 3.9e-11 35.83 In-house 102-182 (324) Show / Hide 
Range on Protein: 582-649
Range on HMM: 102-182/324
Sequence Identity: 33% (27 aa)

GNLKQFLNNLKK-----QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPAIKLADF
|.|.|.... ||      .| | |.. |.. .||.    .|| | |.|||||..|.|  . .|         .. .|.|||
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF