Gene Shk5 (Slime mold)

Shk5

Species: Slime mold
Alias: Shk5, DDB0230104, DdisK205, shkE
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4
Subfamily: Shk

Sequence

Name Sequence Type Origin Length Description Download
Shk5.AA Protein None 710 None Fasta, JSON
Shk5.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of Shk5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Shk5.AA Shk 238-496 61 1.7e-217 728.83 In-house 2-269 (269) Show / Hide 
Range on Protein: 238-496
Range on HMM: 2-269/269
Sequence Identity: 61% (165 aa)

VKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACT-KPGKVMIVSELM-QTDLEKLIHSSEVEPP-PLYE
...|.||.|..|||||..||||.|||||..||...|....||..||.||..|||||..|..|||| .|||.|||.||| ...||||.|...|..| .||.
NREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILYK

R-MKMCLDAALGINWLHG-ICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEVMMKHEFNEKADVYSFGLILYEMAT
| |.||.|||||.||||| .|||||||||.|||.......||..||||||..|....|.| |||.|||.|.|||||||.|..||||||||||.||.|..|
RAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEILT

CEELFP-EYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQR--MNEVLT
|.|..| ..||.|.||.||||||.||||||..|||||.||||||||.|..||||||..||  .|..|.
CQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase Shk5.AA Dicty4 238-493 46 6.8e-182 610.56 In-house 2-277 (277) Show / Hide 
Range on Protein: 238-493
Range on HMM: 2-277/277
Sequence Identity: 46% (129 aa)

VKTDLLGGGAYGKVYKATCRGKKVAVKVP--KKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACT----KPGKVMIVSELM-QTDLEKLIHS------
......|.|..|.|||.|.|||.||||..  ..|...|..|..|..||.||..|.|||..|..||||    .|||..||.|.| ...|..|.|.      
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

SEVEPP-PLYER-MKMCLDAALGINWLHG-ICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEVMMKHEFNEKADVY
...... ||..| |.|..|||.|.||||. ...||||||| .||...|...||..|||.||..|......| |....||...|||||||....|||||||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVY

SFGLILYEMATCEELFP-EYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQR--MNE
|||..|.|..|..|... .......|..|.|||||||||||..|.|.|.|||.||||||..||||.|..||  ...
SFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Shk5.AA TKL 243-491 27 3.8e-93 315.74 In-house 1-364 (364) Show / Hide 
Range on Protein: 243-491
Range on HMM: 1-364/364
Sequence Identity: 27% (103 aa)

LGGGAYGKVYKATCRG----------KKVAVKVPKKQTLSESELKS-----------------------FKNEVEIMKQIF--HPNVVLCLGACTKPGK-
.| |..|.|||...||          | ||||. |..  .|....|                       |. |.|||  .   |||.|...|.|. |.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VMIVSELM-QTDLEKLIHSSEVEPPPLYERMKMCLDAALGINWLHG-------ICNIIHRDLKLANLMISKDKT--------------
             .|| |..   .|. ..|        .  |....||.|.|.|.||         ..||||||| .|... .. |              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VKIGDFGFSQVIKTGTTLSD-----------------QKGPKGTALYMAPEVMMKH----------------EFNEKADVYSFGLILYEMATCEELFPEY
.||.|||.|..... .  .|                    . ||  .|||||....                |..||.||||||..|.|..|... . .|
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

SEIDP--------FYDAICNKKLRPPIP------------DSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
 ....        .   .|.|.||||||            ...|.|.| |.|.||||||.|||||.|...|.
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Shk5.AA TKL-Unique 239-491 32 2.1e-72 246.85 In-house 1-290 (290) Show / Hide 
Range on Protein: 239-491
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

KTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSE-SELKSFKNEVEIMKQIF-HPNVVLCLGACT----KPGKVMIVSELMQTD-LEKLIHS-------
   ..|.|.||.|||.. ||..||.|. ... .|. .... |.||| .|| .  |||.|.. |.|.    .|..  ||.| ..   | ...|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-SEVEPPPLYERMKMCLDAALGINWLHGICN-IIHRDLKLANLMISKD-----KTVKIGDFGFSQVIK--TGTTLSDQ-----KGPKGTALYMAPEVMMK
 ..  ....  |.|| .|.|.| . ||     |||||||  |. .. .       .|| |||.| . .  . .|..        ...|....|||||.. 
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--HEFNEKADVYSFGLILYEMATCEE----LFPEYSEIDPF--YDAICN--KKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
    ..||.|||||| .|.|.|| .       | |...|.   . ..    ...|||||.. ||... |||.||.||| .||||.|.  | 
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP-YQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Shk5.AA Dicty4-Unclassified 234-491 38 2e-62 212.63 In-house 1-263 (263) Show / Hide 
Range on Protein: 234-491
Range on HMM: 1-263/263
Sequence Identity: 38% (105 aa)

IKFDVKTDLLGGGAYGKVYKATCRGKKVAVKV--PKKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACTKP----GKVMIVSELMQT-DLEKLIH--S
|. |     .| |.  ||.|   .|| ||||     |    |  .. || ||||.  | ||| | | |.|  |       .|| |.|    |  .||   
IQID---QFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

SEVEPPPLYER---MKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIK---TGTTLSDQKGPKGTALYMAPEVMMKHEFNEKAD
|| . |   .    .|. .| | |. .||   |.||||.| .|... |.  .||.||| | ||    . ||        ||    .||..|   .| |.|
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTR-NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIA------GTPKWESPECLMHESYNQKSD

VYSFGLILYEMATCEELFPEYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
|||....|||.|| .| . |   |      .| ||||| |||. .  .| ||  ||  ||||||..|...|..
VYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Shk5.AA Pkinase_Tyr 234-491 31 2.2e-62 211.92 Pfam 1-270 (270) Show / Hide 
Range on Protein: 234-491
Range on HMM: 1-270/270
Sequence Identity: 31% (87 aa)

IKFDVKTDLLGGGAYGKVYKATCR------GKKVAVKVPKKQTLSESE--LKSFKNEVEIMKQI-FHPNVVLCLGACT-KPGK--VMIVSELMQT-DLEK
|.|. |   || ||.|.|||.|..      . .||||.  |.. ....  ...| .|..||||.  |||.| ..|.|| . .   ..|| |.|.  || .
ITFGKK---LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LIHSS--EVEPPPLYERMKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFSQVI-KTGTT-LSDQKGPKGTALYMAPEVMMKHEFNEK
  ..   . .|... .  .||.. | | ..|. .  .|||||   | .......|||.||| .  | ....   . ..|.      ||||...  .|..|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTK

ADVYSFGLILYEMAT-CEEL-FPEYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
 ||.|||  ..|. | .|.  .|. |  . .|..|  .  | |.|.  |. . .|...||..||..||.| |. ...
SDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Shk5.AA MLK 236-491 29 4.5e-62 212.52 In-house 1-291 (291) Show / Hide 
Range on Protein: 236-491
Range on HMM: 1-291/291
Sequence Identity: 29% (87 aa)

FDVKTDLLGGGAYGKVYKATCRGKK-----VAVKVPKKQT----LSESELKSFKNEVEIMKQIFHPN----VVLCLGACTKPGK-VMIVSELMQT-DLEK
.....  .| |..|||.|...|.|      ||||  .  .     ...| . |. |... . . |||    ..  .|.|..|.. . ||.| ..   |  
IQFHE-WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LIHSSEVEPP------------PLYERMKMCLDAALGINWLHGICN--IIHRDLKLANLMIS------KDKTVKIGDFGFSQVIKTG-TTLSDQKGPKGT
..|. . ..             ..   |. .|. | |.. ||      |||||||  |..|.      ...|.|| ||| |  ...  |.  ..   .||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN---AGT

ALYMAPEVM---MKHEFNEKADVYSFGLILYEMATCEELFP-EYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
. .|||||        ..||.||.|.|..|.|| |.|. .  .|...  .. .. ...|||||| ..|...| |...||. ||.||||| .. |  
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVA-YNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Shk5.AA S_TKc 237-495 25 1.1e-59 205.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 237-495
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

DVKTDLLGGGAYGKVYKATCRG--KKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPNVVLCLGACTKPGKVMIVSELMQT---DLEKLIHSSEVEPP-
  . ...| ||.|||||.. ..  ..||.|. |         .....|..|.|.  |||.| .....   ... .| |.. .   || ..|..   ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

---PLYERMKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSDQKGPKGTALYMAPEVMMKHEFNE-KADVYSFGLIL
   |  .  ...   ..... .|   .||||||| .|.....  ..||.|||.. ..         .   ||  ||||||.    ..  |.|..|.| ||
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YEMATCEELFPEYSEIDPFYDAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQ-----RMNEVL
|||.. . .||   ...  .. |.            ....| .|.||.. ||.|||.  |. |     .. . .
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shk5.AA TK 237-491 17 1.5e-57 191.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 237-491
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

DVKTDLLGGGAYG---KVYKATCRGK---------------------------KVAVKVPKKQ-TLSESELKS-FKN----------EVEIMKQIF----
 .  . || |..|   .|||.. ||.                           .||||. |.  . |. | .  . .          |.|.||.      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVVLCLGACTKP------------GKVMIVSELMQ-TD----LEKLIHSSEVE--------------------------------------------
 |||.| ..|.||..            . .||| |.|.  |    | .  ...  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PPPLYERMKMCLDAALGINWLHGI-C----NIIHRDLKLANLMISKDKT-----------VKIGDFG---
                              .... ... ||...| |  .||   |    |..||||   | .......           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FSQVI---KTGTTLSDQKGPK------------------GTAL---YMAPEVMMKHE---------FNEKADVYSFGLILYEMAT-CEELFPEYS
      .  |   .  .. |......                  |. |   .||||......         | .| ||.|||  ..|. | ..| .... 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EI---------DPFYDAICN-------------KKLRPPIPDSFP--------------KSLKTLIQKCWDHDPNKRPSFNEVTQRM
           . ... ...              ..|.| |.  |              . .  |.|.||..||..||.| .. ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Shk5.AA TyrKc 237-491 27 3.9e-55 190.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 237-491
Range on HMM: 1-280/280
Sequence Identity: 27% (79 aa)

DVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQI--FHPNVVLCLGACTKP-------GKVMIVSELMQT-DLEKLIHSSE
 .. . || ||.|.|||.| .  .||||. |. .     .. | .| .||...   |||.| ..|.||..       . .||| |.|   || . .....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

VEPPPLYERMKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFSQVIKTG-------TTLSDQK--GPK--GTALYMAPEVMMKHEFNE
 .  .. .  ..|...| | . ||   |.|||||   | ......||||.||| |  |. .        . . ..  | |       ||||......|..
PK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KADVYSFGLILYEMATCEELFPEY-----SEIDPFYDAICNKKLRPPIPD-------SFPKSLKTLIQKCWDHDPNKRPSFNEVTQRM
| ||.|||  ..|. |  .  ..       . .  .  . . . .|. |.         |. . .....||..||..||.|.|. ...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Shk5.AA Pkinase 238-491 24 4.5e-53 187.43 Pfam 2-293 (293) Show / Hide 
Range on Protein: 238-491
Range on HMM: 2-293/293
Sequence Identity: 24% (74 aa)

VKTDLLGGGAYGKVYKATCRGKK--VAVKVPKKQTLSESELKSFKN--EVEIMKQIFHPNVVLCLGACTKPGKVMIVSELMQTDLEKLIHSS------EV
..   .| |..|.|||.. .|    ||||. ||.. .......  .  |..||| . |||.| ...... .... .| |... .|. ..  .      . 
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRH

EPP--PLYERMKMCLDAALGINWLHGICNIIHRDLKLANLMISKDKTV----KIGDFGFSQVIKTGTTLSDQKGPKGTALYMAPEVMM-KHEFNEKADVY
 .   .  |  ....  . |.. .|  ..|||||||..|..|... ..    ||.|||.. ...     |  ... ||  |||||| .   .   |.|..
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGLILYEMATCEELFPEY----SEIDPFYDAICNKKLRPPIPDSFP-----------------------KSLKTLIQKCWDHDPNKRPSFNEVTQR--M
|.|.|||||.. . .||.     . .|. .  . .....||.. ..|                       ...| .| .|.. ||.|||.. .. |   .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQ--MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Shk5.AA LRRK 238-493 25 2.8e-52 180.0 In-house 2-351 (351) Show / Hide 
Range on Protein: 238-493
Range on HMM: 2-351/351
Sequence Identity: 25% (92 aa)

VKTDLLGGGAYG-KVYKATCRG----------------------------KKVAVKVPKKQ---------------------------------TLSESE
..  ..| |..| .||.|..||                            ..||.|. ..                                   .... 
KIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA-

LKSFKNEVEIMKQIFHPNVVLCLGACTKPGKVMIVSELMQT-DLEKLIHSSE-VE-----PP-PLYERMKMCLDAALGINWLHGICN--IIHRDLKLANL
. .| .|| ||    |||.|  .| | .|   ..| |...  || ...|...  .     .  .   . |  |. | |.. ||  .|  |||||||  | 
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNI

MISKDK------------TVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEVMMKH---EFNEKADVYSFGLILYEMATCE-ELFPEYSEIDPF--Y
 . . .            ..||.||| |. .   ....   ||  |. ..||||.| .    |..||.|.||||.||.|  | .   | |..  | .   
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWM

DAICN---KKLRPPIPDS-FPK-----SLKTLIQKCWDHDPNKRPSFNEVTQRMNE
  | .   ..|||.|| .  |      ....|||.||.|||.|||.|.....|. .
EQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Shk5.AA STE 238-486 21 1.2e-48 167.91 In-house 1-350 (359) Show / Hide 
Range on Protein: 238-486
Range on HMM: 1-350/359
Sequence Identity: 21% (79 aa)

VKT-DLLGGGAYGKVYKATCR-----------------GKKVAVKVPKKQTLS---------------ESELKSFKNEVEIMKQIF--HPNVVLCLGACT
 .  . .| ||.|.|||| ..                 |. .|.|. .... .               ..|......|..|||.    |||.| ..|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KPG-------KVMIVSELMQ-TDLEKLIHS--SEVEPPP----------LYERMKMCLDAALG-INWLHGICNIIHRDLKLANLMISKDKTVKIGDFGFS
| |       .. |. |.|    |...|..  .  .| .            .  ..| .   |  . ||    |||||.| || ..     ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

Q-VIKTGT------------TLS-DQKGPKGTALYMAPEVMMK------HEFNEKADVYSFGLILYEMATCEELFPEYSEIDPFYD--AICNK-------
  ......            | .   .   ||  .|||||...      .. ..|.|..|.|. . |||| .   |....  |..   .| ..       
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK---PPWHDMHPMRAMFMIPFNYHMQQQF

-------KLRPPIPD-------------------SFPKSLKTLIQKCWDHDPNKRPSFNE
       .  ||.||                   .. ...|  |.|| . ||||||. ..
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase Shk5.AA DRK 335-493 34 1.7e-32 107.38 In-house 100-258 (258) Show / Hide 
Range on Protein: 335-493
Range on HMM: 100-258/258
Sequence Identity: 34% (58 aa)

RMKMCLDAALGINWLHGICN--IIHRDLKLANLMISKDKTVKIGDFGFSQ----VIKTGTTLSDQKGPKGTALYMAPEVMMKHEFNEKADVYSFGLILYE
...| .|.| |.. ||. ||  |||||||  || .     ||. ||| |     .   ...    . . ||    ||||     . ||||||||. .| |
MKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFA----MTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

MATCEELFPEYSEIDPFY--DAICNKKLRPPIPDSFPKSLKTLIQKCWDHDPNKRPSFNEVTQRMNE
..| .   | |  . .|    ..   ..|||.|   |     |.. ||. ||  |||. |. .|.  
CVTRQD--P-YFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Shk5.AA DRK 234-314 35 3.2e-18 58.34 In-house 1-79 (258) Show / Hide 
Range on Protein: 234-314
Range on HMM: 1-79/258
Sequence Identity: 35% (29 aa)

IKFDVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLS-ESELKSFKNEVEIMKQIFHPNVVLCLGACTKPGKVMIVSELM
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IKIGNR---IGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYM
SH2 Shk5.AA SH2 597-628 41 8e-06 18.96 Pfam 1-34 (81) Show / Hide 
Range on Protein: 597-628
Range on HMM: 1-34/81
Sequence Identity: 41% (14 aa)

WFHFDISRDISEKRLRG--RPENTFLLRLSANDP
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WYHGKISRQEAERLLMNPGNPDGTFLVRESESTP
SH2 Shk5.AA SH2 595-694 21 5.1e-05 19.2 SMART 1-87 (87) Show / Hide 
Range on Protein: 595-694
Range on HMM: 1-87/87
Sequence Identity: 21% (22 aa)

KRWFHFDISRDISEKRLRG--RPENTFLLRLSANDPIKTPFTISKTKGSKPTHKRVSREDVQINEIKQFPMGYKFTVPLDGNELVFGSITQMVEELHRIG
  |.| .|||.  |. |..   |. .||.| | .   .  ...|   ..|  | |. |.|           .| ..     ..  | |. ..|.  ..  
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWKGKVKHYRIRRNDD---------GKYYIDET---WRRKFPSL-ELVNHYQHNP

NL
  
LG