Gene Shk3 (Slime mold)

Shk3

Species: Slime mold
Alias: DdisK203, shkC, DDB0230123, Shk3
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4
Subfamily: Shk

Sequence

Name Sequence Type Origin Length Description Download
Shk3.AA Protein None 506 None Fasta, JSON
Shk3.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of Shk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Shk3.AA Shk 24-284 66 4.7e-223 747.3 In-house 1-269 (269) Show / Hide 
Range on Protein: 24-284
Range on HMM: 1-269/269
Sequence Identity: 66% (179 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPNICLFMGACT-IPGRCVIVTELVPKGNLETLLHDQKIQLP--LY
||.|...|.||||||||||||.|.||||..||||||..|...||||||.||||.|||||||||||| .||.|.|||||.||||||.|||||....|  ||
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

LR-MRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKD-QSSAKGTPLYMAPEVMMFKEFNESSDVYSFGIVLWEIL
.| |||.||||||.||||.||....|||.|..|||||.|.|||.||||.|....||.|||| |..||||||.|||||||....||..|||||||.|||||
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TRKEPFS-HHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISA--LDHVII
|..||.. ||.|..||.||.|.|.||||||.||..||..||.||||..|..||||.|||..  |.|..|
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase Shk3.AA Dicty4 24-281 59 5.5e-192 644.09 In-house 1-277 (277) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-277/277
Sequence Identity: 59% (166 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLL--HKQNFDAATLSAFRKEVHLMSKIYHPNICLFMGACT----IPGRCVIVTELVPKGNLETLLHD-----
||.|..||.||||.||||..|.|.||||.|  |.||||...|..||||||.|.||.||||||||||||    .||...||||..|||||..||||     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QKIQLP--LYLR-MRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKD-QSSAKGTPLYMAPEVMMFKEFNESSDV
 |.|.|.  |..| ||||.|||.|.||||..|||..|||.||.|||||.|.|||.||||||....||...|| |..|.|||..|||||||....||..||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGIVLWEILTRKEPFS-HHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISA--LDH
|||||||||||||.||.. ||.....|..||| |..|||||..|..|...||..|||..|..||||.|||..  |.|
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Shk3.AA TKL 30-279 32 2e-107 363.19 In-house 1-364 (364) Show / Hide 
Range on Protein: 30-279
Range on HMM: 1-364/364
Sequence Identity: 32% (119 aa)

IGTGSFGKVYKGRCRQ----------KAVAVKLLHKQNFDAATL-------------------------SAFRKEVHLMSKIYHPNICLFMGACTIPGR-
|| |.||.||||..|.          | |||| ....| |  |.                           ...|. .||.. ||||..|||.|. |.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------CVIVTELVPKGNLETLLHDQKIQLPLYLRMRMARDAALGINWLHESN------PVFVHRDIKSSNLLVDENMR--------------V
            . ||.|..|.|.|. .||       . .|.|.|.|.|.|.|.|| .|      |  .|||.||.|.|||||..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KICDFGLSALKQKHKMLKDQSSA-----------------KGTPLYMAPEVMMFK----------------EFNESSDVYSFGIVLWEILTRKEPFS-HH
||||||||  .....  .|....                  ||| .|||||.. .                |..|..|||||||||||||||..|.. ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

RELEKFR-------EAVCVKHERPPIP------------NDCLDSLRRLIEKCWDKEPISRPSFKEIISAL
 . ..|.       . ||.| .|||||            .||..|...|...||| .| .||||.||.. |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Shk3.AA TKL-Unique 26-279 39 4e-96 325.64 In-house 1-290 (290) Show / Hide 
Range on Protein: 26-279
Range on HMM: 1-290/290
Sequence Identity: 39% (115 aa)

FEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSA-FRKEVHLMSKIY-HPNICLFMGACT----IPGRCVIVTELVPKGNLETLLH--------
| ..||.|..|.||||  |.. ||.| .|...    ...  |..|| .|.|.  |||| ..||.|.     |... ||.| .| |.|  .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-DQKIQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDEN-----MRVKICDFGLSALKQKH-KMLKDQS------SAKGTPLYMAPEVMMF
  ... |.. .|..||.|.|.| . || ..|   |||.||||.|||.|     ...|||||||| .. |  || .  .      . .|....|||||.. 
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--KEFNESSDVYSFGIVLWEILTRKE------PFSHHRELEKFREAVCV--KHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISAL
  . ..|.|||||||||||||.|||       |. .. . |. .|.| .  .  ||||||.|  ..| ||..||. .|  |||| |||. |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPY-QGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Shk3.AA MLK 24-279 33 8.1e-87 294.73 In-house 1-291 (291) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-291/291
Sequence Identity: 33% (100 aa)

INFEELIGTGSFGKVYKGRCRQKA-----VAVKLLHKQNFDAATLS-----AFRKEVHLMSKIYHPN----ICLFMGACTIPGR-CVIVTELVPKGNLET
|.|.| || ||||||.|||.| |      ||||  .   | ..  .     .|..|. . ... |||    |. |.|.|. |.   .||.| ...| | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHDQK-------------IQLPLYLRMRMARDAALGINWLHESNPV-FVHRDIKSSNLLVDE------NMRVKICDFGLSALKQKH---KMLKDQSSAK
.||...             .  .. . |. | . | |.. ||.  |.  .|||.||.|.|.||      .. .||||||.|  ....   .|     |..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM-----SNA

GTPLYMAPEVM---MFKEFNESSDVYSFGIVLWEILTRKEPFS-HHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISAL
||. .|||||        ..|..||.|.|.||||.|||..|.. |. ... . ... ....|||||..| ... .|...||. .| .||||..|.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVA-YNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Shk3.AA DRK 24-281 40 1.3e-85 289.93 In-house 1-258 (258) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-258/258
Sequence Identity: 40% (105 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFD-AATLSAFRKEVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPKGNLETLLHDQKIQLPLYLR
|     || |..| |. |  |   |||| |   | .    |. |..|. ||..  |||||.|||.|..|    |..|  |.| |   |||..|..   |.
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

MRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMMFKEFNESSDVYSFGIVLWEILTRKE
..|. |.| |.. || .||. .||| || ||||||. .||. |||||   .|||  |    . |||   ||||     . |  |||||.|||||..||. 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PFSHHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISALDH
|.     .   . .|    .|||.|  |     .|.  ||. .|  |||. |..  |. 
PYFGMPTFQVVF-SVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Shk3.AA LRRK 24-281 26 1.3e-78 267.45 In-house 1-351 (351) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-351/351
Sequence Identity: 26% (95 aa)

INFEELIGTGSFG-KVYKGRCRQ----------------------------KAVAVKLLHKQ---------NFDA-----------------------AT
. .||.|| |.|| .||....|.                            . ||.| ...          | ..                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LSAFRKEVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPKGNLETLLHDQK--------IQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLL
.. ||.||..||.  ||||   .| |  |  . .|.|..| |.| ..||. |        . ..  |. . | . | |.. || .|| ..||| || | |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---D---------ENMRVKICDFGLSA----LKQ--KHKMLKDQSSAKGTPLYMAPEVMMF---KEFNESSDVYSFGIVLWEILTRK-EPFSHHR----
.   .         ... .||.|||.|     ..     ...       |.|..||||.| .   .|..| .|.||||..|||.|||.  || .|     
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-------GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDH

-ELEKFREAVCVKHERPPIPND-CLD-----SLRRLIEKCWDKEPISRPSFKEIISALDH
 ... . |    .  ||.||.. |.      ..  ||..||. .| .||.| .|.. |  
MQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Shk3.AA Pkinase_Tyr 24-279 33 2.3e-72 245.69 Pfam 1-270 (270) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-270/270
Sequence Identity: 33% (93 aa)

INFEELIGTGSFGKVYKGRCR------QKAVAVKLLHKQNFDAAT--LSAFRKEVHLMSKI-YHPNICLFMGACTIPGRC---VIVTELVPKGNLETLLH
| | . .| |.||.||||...      .  |||| | |.. .     . .| .|. .|... .||||  ..|.||  |.     ||.|..|.|.| . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DQ---KIQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQS-SAKG---TPL-YMAPEVMMFKEFNE
..   | .|..     |... | | ..|.. |  ..|||.   | ||.||. ||||||||. .     . .|.   ..|    |   ||||......|..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

SSDVYSFGIVLWEILT-RKEP-FSHHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISAL
 |||.|||...|||.|  ..| .      | . |..  . .| |.| .| | . .|. .||...|  ||.|.||.. |
KSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Shk3.AA TyrKc 24-279 30 2.8e-66 227.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-280/280
Sequence Identity: 30% (87 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKI--YHPNICLFMGACTIP-------GRCVIVTELVPKGNLETLLHDQK
| ... .| | ||.||||. .   |||| |..       . .|..|  .|.|.   ||||  . |.|| .       .   ||.|..|.|.|   |.. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

IQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKH-------KMLKDQS--SAKG-TPL-YMAPEVMMFKEFNE
 .|..     .. ..| | . ||. |  ..|||.   | ||.|| .|||.|||||     .       .. . ..  ..|.  |.  ||||......|..
PKLCMKDLLSFCWQIACGMEYLHSKN--CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

SSDVYSFGIVLWEILTRKEPFSHH-----RELEKFREAVCVKHERPPIPND-------CLDSLRRLIEKCWDKEPISRPSFKEIISAL
 |||.|||...|||.|. ..          . .  .| |   . .|. |||       | | . .....||. .| .||.|.||.. .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Shk3.AA TK 24-279 18 1.5e-62 208.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-486/486
Sequence Identity: 18% (90 aa)

INFEELIGTGSFG---KVYKGRCRQK---------------------------AVAVKLLHKQ-NFDAATLSA--------------FRKEVHLMS--KI
| ... .| | ||   .||||. |..                            |||| |..  . ...   .              .  |  .|.  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHPNICLFMGACTIP------------GRCVIVTELVPKGN----LETLLHDQKI---------------------------------------------
 ||||  . |.|| .            . . ||.|..|.|.    | . |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLPLYLRMRMARDAALGINWLHESNP----VFVHRDIKSSNLLVDENMR-----------VKICDFGLSA
                              ||..  .. |....| |  .||. |      |||||.   | ||.||..           .||.||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LKQKHKMLKDQSSAK------------------------GTPL---YMAPEVMM---------FKEFNESSDVYSFGIVLWEILTRK-EPFSH--
     |  ..   .|  ...                        |. |   .||||...         .. | . |||.|||...|||.|.  ||.    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

--------HRELEKFREAVCVKH-------------ERPPIPNDCL--------------DSLRRLIEKCWDKEPISRPSFKEIISAL
        . ... . | ..  .              |.| | .|               . . .|. .||...|  ||.|... ..|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Shk3.AA Dicty5 24-283 36 3.6e-62 212.78 In-house 1-260 (260) Show / Hide 
Range on Protein: 24-283
Range on HMM: 1-260/260
Sequence Identity: 36% (99 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQN---FDAATLSAFRKEVHLMSKIY--HPNICLFMGACTIPGRC-VIVTELVPKGNLETLLHDQKI--
. | . |  |. |.||.|  . . ||.| .   |   ||   .  | .|| .|| .   |||.  . || .   .   .|||.. .| |  .| ||.   
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFD---WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTT

--QLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSA-LKQKHKMLKDQSSAKGTPLYMAPEVMMFKEFNESSDVYSFGI
   .   ... || |.| .. .||  |   .|||.|| | |. ||  .|| ||| |     . .|        ||. .||.|.   . . .  |||||||
GQPIAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHM----TMHVGTQCWMACELFNGQPYHQKCDVYSFGI

VLWEILTRKEPFSHHRELEKFREAVCV-KHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISALDHVI
||||..|||||.    .. .   .| | | ||| || ||  .   ||.|||   |  |||||||.  .. .|
VLWEMFTRKEPY---DNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase Shk3.AA Pkinase 24-279 22 1.6e-61 215.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

INFEELIGTGSFGKVYKGRCRQKA--VAVKLLHKQNFDAATLSAFRK--EVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPKG----NLETLLH-DQK
. ... || ||||.|||.. .     |||| . |.. .   . . |.  |...| .. ||||. . .... .... .|.|....|     | .... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IQL--PLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRV----KICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMM-FKEFNESSDV
  .  .     ....  . |.. .|. .  ..|||.|..|.|.|.|. .    |||||||..... .      ..  ||| |||||| .  ..   ..|.
GCFYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGIVLWEILTRKEPFSHH------RELEKFREAVCVKHERPPIPNDCL------------------DSLRRLIEKCWDKEPISRPSFKEIISA--L
.|.|..|.| |... ||..|      ........  . . ...    ..                   .... .|..|..| | .||....|     .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Shk3.AA S_TKc 24-284 24 2.4e-61 211.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-284
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

INFEELIGTGSFGKVYKGRCRQ--KAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPK--GNLETLLHDQKIQ---
  . ..|| |.||||||.| .   . ||.| ..           .|.|. ...|  ||||. . ...   ..  .|.|...   |.| ....... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMMFKEFNE-SSDVYSFGIV
  .|     ....  ..... .|. .  ..|||.| .|.|.||  ..|||||||...          ..  ||| ||||||.    ..  ..|..|.|..
FPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LWEILTRKEPFSHHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIIS----ALDHVII
|.| |... ||.   ....  . ..             .... .|.||..|.|  ||.  |.      .  |  .
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shk3.AA CZAK 24-279 36 1.5e-60 207.43 In-house 1-279 (279) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-279/279
Sequence Identity: 36% (105 aa)

INFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATL----SAFRKEVHLMSKIYHPNICLFMGACTIPG--RCVIVTELVPKGNLETLLHDQKIQL
  |.  || | ||.|||.. | | ||.| .|.  |   .       | |||  |||  |||.  |.|||.  |     ||.|    | |  || |    .
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

PL--YLRMRMARDAALGINWLHE---SNPVFVHRDIKSSNLLVDENMR-------------VKICDFGLS--ALKQKHKMLKDQSSAKGTPLYMAPEVMM
     |.. ||.| | | | ||     ||. .|||  |.| | |...               || |||||     |   |     .. |   .||||.  
KQNPHLQWNMAIDIARGMNYLHDNWKPNPI-LHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEM----TQTMGCLCWMAPECFK

FKEFNESSDVYSFGIVLWEILTRKEPFSHHRELEKFREAVCVKHE--RPPIPN--DCLDS-LRRLIEKCWDKEPISRPSFKEIISAL
   . | .||||||..||.|.|  .|     ...  . |     |  |||.|   |     |  |||.||.| | .|||||.|.  |
GENYTEKVDVYSFGMILWCIITCDQP---YQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
SH2 Shk3.AA SH2 396-468 32 1.2e-15 47.73 Pfam 1-79 (81) Show / Hide 
Range on Protein: 396-468
Range on HMM: 1-79/81
Sequence Identity: 32% (26 aa)

WFHGDLDTTEAASRLNG--QPIGSFLIRFSSTNAGCFTISQVVDGG---SIKHQRVSRQGVK--FNYQNVIYNSLIEIVS
|.||..   ||  .|.   .| |.||.|.|... |..|.| |.|.|   ..|| |. |.. .  . . .. ..|| |.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLS-VRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVE
SH2 Shk3.AA SH2 394-473 31 7.9e-14 53.19 SMART 1-87 (87) Show / Hide 
Range on Protein: 394-473
Range on HMM: 1-87/87
Sequence Identity: 31% (28 aa)

QKWFHGDLDTTEAASRLNG--QPIGSFLIRFSSTNAGCFTISQVVDGGSIKHQRVSRQG-VKFNYQN---VIYNSLIEIV---SKNGGG
| |.||...  || . |..  .| |.||.|.|..|.|....|  .. | .|| |. |..  |.  .    . ..|| |.|   ..| .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG