Gene Shk2 (Slime mold)

Shk2

Species: Slime mold
Alias: DdisK202, DDB0229941, shkB, Shk2
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4
Subfamily: Shk

Sequence

Name Sequence Type Origin Length Description Download
Shk2.AA Protein None 653 None Fasta, JSON
Shk2.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of Shk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Shk2.AA Shk 174-437 56 2e-211 708.64 In-house 1-269 (269) Show / Hide 
Range on Protein: 174-437
Range on HMM: 1-269/269
Sequence Identity: 56% (151 aa)

YNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACT-APEDLSIVTELMPKGSVHSLLRAKEDTSDFITF
.|||..||.|.||.||||..||||||.|......|.||||..|.|||..|.|...|...||||||| .|....|||||||||....||........||..
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

KRAILIARDTVLGMTWLHA--SNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDS--KDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWELL
|||....||..|||.|||.  .||.|.|||.|||||||||.|||.|||.|.|||...  |||..|..|.||.||||...|.||..|.||.||.|.|||.|
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILETILI
|.||||.|..|.|....|...|||.||.|||..|..||.|...||||.|.|||||.||...|||..|||
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase Shk2.AA Dicty4 174-434 51 1.7e-178 599.32 In-house 1-277 (277) Show / Hide 
Range on Protein: 174-434
Range on HMM: 1-277/277
Sequence Identity: 51% (143 aa)

YNREAKLGSGAFGSVYKGIVRGKEVAIKKL--TQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACT----APEDLSIVTELMPKGSVHSLLRA-----
.|.|...|.|.||.||||..||||||.|||  ....|.||..|||.|||..|.|.|.|...|||||||    .|....||||.||||...|||..     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-KEDTSDFITFKRAILIARDTVLGMTWLHASN--ILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDS--KDKLLGQAGSPLYMAPEMLVNQPYDGKVDV
 .....|....|||...|.|...||.|||..|  |.|.|||..|||||.||.|||.|||||.|||...  ||.. ...|.|..||||....|||..|.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

FSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILET
.||.|.|||.||.||||.|....|.|.|..|.|||.||.|||..|...|.|...||||.|..||||.||...||||.
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Shk2.AA TKL 180-430 28 2.6e-98 332.89 In-house 1-364 (364) Show / Hide 
Range on Protein: 180-430
Range on HMM: 1-364/364
Sequence Identity: 28% (107 aa)

LGSGAFGSVYKGIVRG----------KEVAIKKLTQTVFEENTMNE-----------------------FKKEVSLMAKLR--NPHLLLFMGACTAPED-
.|||.|| ||||. ||          |.||.||. ..   |.|.|.                       |..|. .| ..|   |....|||.|..|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LSIVTELMPKGS-VHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHASN--------ILHLDLKPANLLVDQNWV-----------
            | ||.|..|.||  | |.           . . . .|.|. .|| .||..|        |.| |||..|.|||.||            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---VKVADFGLSKYMKPDSKDKLLG------------------QAGSPLYMAPEMLVNQ----------------PYDGKVDVFSFSILLWELLTKQEPY
   .|..|||||. |.......  .                  | |.| .||||.| .|                .|. |.||.|| |.|||.|| ..||
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

NKLYSSYPQLV-------EGVVNKKNRPIIP------------DYFPTRLKDLLARCWDHYPSRRPSFAEISKQR
 .. .. ...        ..|..|..|| ||            ...|...|.|. .|||| |. |||| || |. 
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Shk2.AA TKL-Unique 178-430 33 1.6e-74 253.9 In-house 3-290 (290) Show / Hide 
Range on Protein: 178-430
Range on HMM: 3-290/290
Sequence Identity: 33% (98 aa)

AKLGSGAFGSVYKGIVRGKEVAIKKLT-QTVFEENTMNEFKKEVSLMAKLR-NPHLLLFMGACT----APEDLSIVTELMPKGSVHSLLR---------A
.|.|.|..|.||||. ||..||||..  .  ..   | ||..||..| ||.  | ....||.|.    .| ...||.| .| || ...|          .
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KEDTSDFITFKRAILIARDTVLGMTWLHASN--ILHLDLKPANLLVDQN-----WVVKVADFGLSKYMKPDSKDKLL--------GQAGSPLYMAPEMLV
.. .   ..... . .|.| ..||  || ..  |.|.|||. |.|||.|     | .|..||||||  . ..| ..         .  ||...||||.| 
NNCK---LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

N--QPYDGKVDVFSFSILLWELLTKQE------PYNKLYSS-YPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQR
.    |. |.||.||.| |||..| .       || .. .  . ..|  .  .. || ||.  | ...||. .||.| || |||| || .  
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Shk2.AA DRK 177-434 39 9.9e-71 238.77 In-house 4-258 (258) Show / Hide 
Range on Protein: 177-434
Range on HMM: 4-258/258
Sequence Identity: 39% (103 aa)

EAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFE-ENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRA
 .  | | .| |. |  || .||.|.|     . || .|||..|. || .|| |   .|||.|. | |  |..| ||.||  . |    | |  .   . 
GNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH---DESIEMDWPLM

ILIARDTVLGMTWLHASN--ILHLDLKPANLLVDQNWVVKVADFGLSK-YMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWELLTKQE
. .. |   ||. || .|  |.| |||  ||||| .| |||||||||  . |  ..       | |   ||| | ||.|  | ||.|| | |||..| | 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILET
||        | |  |   . ||..| . |     |. .||.  |. |||. |. .  .|| 
PYFGMPTF--QVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLE--RLEA
Kinase Shk2.AA MLK 174-430 26 4.5e-67 229.14 In-house 1-291 (291) Show / Hide 
Range on Protein: 174-430
Range on HMM: 1-291/291
Sequence Identity: 26% (79 aa)

YNREAKLGSGAFGSVYKGIVRGKE-----VAIKKLT-------QTVFEENTMNEFKKEVSLMAKLR-NPHLLLFMGACTAPED-LSIVTELMPKGSVHSL
 . . ..|||.||.|.||  |.|.     ||.|. .       .|  |   .... .... . ..  .|    |.|.|. |.  . ||.| ...|| ...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRAKEDTSD----------FITFKRAILIARDTVLGMTWLHASN---ILHLDLKPANLLVDQ------NWVVKVADFGLSKYMKPDSKDKLLGQAGSPLY
|..... ..           ...  |. .| .   ||  ||.     | | |||. |.|.|.      . ..|..|||.|. ..    .   ..||.. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEML---VNQPYDGKVDVFSFSILLWELLTKQEPYN-KLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQR
||||..    ...|. |.||.|. ..|||.||...||   .....     .|.....|| ||  .| ..| |. .||.  |..||||..| .. 
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAW--WVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Shk2.AA S_TKc 174-432 22 3.5e-61 210.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

YNREAKLGSGAFGSVYKGIVRG--KEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPK--GSVHSLLRAKED-TSD
|    |.|.||||.|||.. ..  ..||||..          . ...|.... | . |..  . ...   ..| .|.|...   |....... .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

F-ITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDG-KVDVFSFSILLWE
| ..  .|  ... .....  .|  .|.| ||||.|.|.|.  ..|..||||.. .          . |.| |||||.|   .|.. |.|. |. ..|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISK-------QRIL
.|. . |.      . .. . ..            .  .||.. .|..  |..||.  |. .          .
MLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shk2.AA LRRK 174-433 25 5.6e-57 195.61 In-house 1-351 (351) Show / Hide 
Range on Protein: 174-433
Range on HMM: 1-351/351
Sequence Identity: 25% (91 aa)

YNREAKLGSGAFG-SVYKGIVRG----------------------------KEVAIKKLTQT-----------------------------VFEENTM--
  .| ..|.|.|| .||....||                            ..|||||.. .                             . .|...  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-NEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKGSVHSLLRAKEDTS-DFIT--FKRAIL--IARDTVLGMTWLHASN--ILHLDLKPANLL
 .|| .||..| .|. |...  .| |  |  | .|.|..| |. ...|..|. ..  |.   ... ..  || .   ||  || .|  |.| |||. | |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---D---------QNWVVKVADFGLSK-YMKPDSKDKLLGQAGSPLYMAPEMLVNQ---PYDGKVDVFSFSILLWELLTKQ-EPYNKLY----SSYPQL
.   .         .. ..|.||||.|  . ... .  . |  | |..|||| . .     |. |||..|| ..|||||| |  |.  .     ..   .
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

VEGVVNKKNRPIIP-D-YFP----TRLKDLLARCWDHYPSRRPSFAEISKQRILE
.|  .... || || . . |    ....||.  ||.| | .||.| .|  .|. .
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQI-VKRLSQ
Kinase Shk2.AA Dicty5 182-436 36 1.6e-56 193.08 In-house 9-260 (260) Show / Hide 
Range on Protein: 182-436
Range on HMM: 9-260/260
Sequence Identity: 36% (94 aa)

SGAFGSVYKGIVRGKEVAIKKLTQTV-FEENTMNEFKKEVSLMAKLR--NPHLLLFMGACTAPEDL-SIVTELMPKGSVHSLLRAKED-TSDFITFKRAI
||| | ||.|| .|. |||| . | . .  . .|||..|| .|       | .  . || .  .    .|||.  .||. ..|. ..  |   | .   .
SGASGRVYNGIYKGMDVAIKVYSQENCMCFD-WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQL

LIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWELLTKQEPYNK
 .| |   .| .||  || | |||  | |.  || .|. ||| | .   | . .     | . .||.|.   |||. |.||.|| | |||..|. |||  
HMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFV--DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDN

LYS-SYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILETIL
. . . | .|     |  || ||   ||    |   ||   |..|||| || |  ..| | 
INNWNIPVMVM----KGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICK--YFESII
Kinase Shk2.AA Pkinase 174-432 21 1.9e-56 198.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

YNREAKLGSGAFGSVYKGIVRGKE--VAIKKLTQTVFEENTMNEFKK--EVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKG----SVHSLLRAKED
| .. |.|||.||.|||.. .| .  ||.|..     ...   .  .  |...|..|. |. . . .... . .. .|.|....|    . ......  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

TSDFI--TFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVV----KVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLV-NQPYDGKVDVF
 .  .  . . .. ... .. |.  .|. .|.| ||||.|.|.|.| ..    |..||||.| ..  ..  . . .|.| ||||| .  .|.|. |||..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFSILLWELLTKQEPYNKL-----YSSYPQLVEGVVNKKNRPIIPDYFP-------------------TRLKDLLARCWDHYPSRRPSFAEISKQRIL
|. ..|.|.|... |.        .. . |... .  ....  .|   .                     .||.. .|..  |..||....| .   .
SCGCILYEMLCGRPPFPGHCWHDNHDQM-QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Shk2.AA Dicty4-Unclassified 177-430 33 4.1e-54 183.73 In-house 4-263 (263) Show / Hide 
Range on Protein: 177-430
Range on HMM: 4-263/263
Sequence Identity: 33% (87 aa)

EAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFE--ENTMNEFKKEVSLMAKLRNPHLLLFMGACTAP----EDLSIVTELMPKGSVHSLLR-AKEDTSDF
   .| |.|  |.||. .||.||.||.    |   |  . .||||| ..  .  | |.   |.| .|      . ||.|.|.||    .      .    
DQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQP

ITFKR--AILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWEL
|       | .| |   || .||  |. | |.| .|.|.| .  .|.||||.|     |    .   || |   .|| |    |  | ||.|. ..|.||
IKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYEL

LTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQR
.|  |||    |    .   |  || || |||  .  .| |   ||   | .||.. .| .  
ATGDEPYQEIQSIM-NAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Shk2.AA Pkinase_Tyr 174-432 31 7.2e-53 179.67 Pfam 1-270 (270) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-270/270
Sequence Identity: 31% (87 aa)

YNREAKLGSGAFGSVYKGIVR------GKEVAIKKLTQTVFEEN-TMNEFKKEVSLMAKL-RNPHLLLFMGACT-APED--LSIVTELMPKGSVHSLLRA
     |||.||||.||||. .      . .||.|.| ..  .|.  . .| .|...| .| ..|... ..|.||   |   . ||.|.||.|. .. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

KEDTSDFITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKD-KLLGQAGSPL-YMAPEMLVNQPYDGKVDVFSF
. .  . .| |. . ....   || .|.. |. | ||   | ||. | |||..||||.... .|.   .  | .  |   |||| . .  .  | || ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

SILLWELLT-KQEP-YNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRIL
 .|.||..|  ..| |  .  |  ...| .  . .|  .|.. |  . ||. .||.. |..||.|.||  ...|
GVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase Shk2.AA RIPK 180-430 29 9.7e-53 178.04 In-house 1-290 (290) Show / Hide 
Range on Protein: 180-430
Range on HMM: 1-290/290
Sequence Identity: 29% (88 aa)

LGSGAFGSVYKGI--VRGKEVAIKKLT----QTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPED------LSIVTELMPKGSVHSLLRAKEDTS
.|.|.|| |.|    . | .||.|  .    .| ...   .. | |.  |.|||. | .   | |  .|.      ..||.| |..||   .| .| .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY-

DFITFKRAI-LIAR---DTVLGMTWLHASN--ILHLDLKPANLLVDQNWVVKVADFGLSKYMKPD--SKDKL-----LG-----QAGSPLYMAPEMLV--
    . ..  |  |    ...||  ||  |  |.|.||||.| ||| |  ||.|||||.. |      .|.      ..     . |   ||.||...  
--QHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

-NQP---YDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPI---IPDYFPTR-----LKDLLARCWDHYPSRRPSFAEISKQR
   |    . | || || |..||.||. .||  .    ..  . ......||    .|.|.|.      ...|. |||.  |  ||.| |.  . 
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHPY--EDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase Shk2.AA TyrKc 174-431 29 2.3e-50 174.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 174-431
Range on HMM: 1-280/280
Sequence Identity: 29% (85 aa)

YNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKL--RNPHLLLFMGACTAP-------EDLSIVTELMPKGSVHSLLRAKE
   . |||.|||| ||||. .  .||.|.|         . .| .| ..| ||  ..|... . |.|| .       | | ||.|.||.|. .. ||...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DTSDFITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPD------SKDKLLG---QAG--SPL-YMAPEMLVNQPYD
..   .. |  . .. .   ||  ||  |. | ||   | ||. | .||..|||||.. . |      .. .      ..    |.  |||| .    . 
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

GKVDVFSFSILLWELLTK-QEPYNKLYS--SYPQLVEGVVNKKNRPIIPDY--------FPTRLKDLLARCWDHYPSRRPSFAEISKQRI
 | ||.|| ...||..|  |.||         .| |   | . .|. .|..         |. . ..  .||.. |. ||.|.|| ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
SH2 Shk2.AA SH2 550-607 26 6.6e-07 22.1 Pfam 19-78 (81) Show / Hide 
Range on Protein: 550-607
Range on HMM: 19-78/81
Sequence Identity: 26% (16 aa)

GKKTGTYILRFSS-DPGSYAISYLNKN--KEIIHARVIYKQGSGYIHHGGQTHYATLDDLI
|.. ||...|.|.  ||.|..| . ..   .. | |.   .. ||   |... ...| .|.
GNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK-FCSLQELV