Gene Shk1 (Slime mold)

Shk1

Species: Slime mold
Alias: DDB0191149, DdisK201, Shk1, shkA
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4
Subfamily: Shk

Sequence

Name Sequence Type Origin Length Description Download
Shk1.AA Protein None 527 None Fasta, JSON
Shk1.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of Shk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Shk1.AA Shk 45-305 65 4.6e-222 744.0 In-house 1-269 (269) Show / Hide 
Range on Protein: 45-305
Range on HMM: 1-269/269
Sequence Identity: 65% (177 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQ-VDQKTLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELM-KGNLESLLLDPMVKLP--LI
|..|..||.||||.|||||||.|.||||||.|| .|..|.|.|||||.||||||||||.||.|||||.|||.||.|||| |||||.||.|.|||.|  |.
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

TR-MRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADVYSFGLVLWQIF
.| |||..|||||..|||.||...|||||||.|||||.|..|||||||.||.....|.|||.|.|||||||||||||......||||||||||..||.|.
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TRQELFP-EFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSE--LEEIII
|.||..| ......||..|||.|..||.||||||||||.|||||||.||..||||..|...  |..|.|
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase Shk1.AA Dicty4 45-302 57 3.4e-190 638.14 In-house 1-277 (277) Show / Hide 
Range on Protein: 45-302
Range on HMM: 1-277/277
Sequence Identity: 57% (158 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVKVM--LKQ-VDQKTLTDFRKEVAIMSKIFHPNIVLFLGACT---STPGKLMICTELM-KGNLESLLLD-----
|..|...|.||||.||||..| |.||||..  ..| .|...|..|||||.||.||.||||.||.||||   |.|||..|.||.| ||||.|||.|     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-PMVKLP--LITR-MRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADV
 ...||.  ||.| ||||.|||.|. |||..|||.||||||..|||||.|..||||||||||.....|..||.|..|.|||.||||||.... .||||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGLVLWQIFTRQELFP-EFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSE--LEE
||||.|||.|.||||... .......||.|.|.|.|||.|||.||.|.|.|||.|||..|..|||||.|...  ||.
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Shk1.AA TKL 51-300 31 1.7e-106 360.1 In-house 1-364 (364) Show / Hide 
Range on Protein: 51-300
Range on HMM: 1-364/364
Sequence Identity: 31% (118 aa)

LGDGSFGTVYKGRCRL----------KDVAVKVMLKQV-DQKTLTD-----------------------FRKEVAIMSKIF--HPNIVLFLGACTSTPG-
.| |.||.||||..|           ||||||.. ..  | .|...                       |..|. ||...   |||||.|.|.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KLMICTELM-KGNLESLLLDPMVKLPLITRMRMAKDAALGVLWLHSSN------PVFIHRDLKTSNLLVDANLT--------------V
           .|.| .|.. .|.|...|.       .  |.|.|.|.|.|. .|||.|      |  ||||||..|.||| |.|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVCDFGLSQIKQRGENLKDGQDG----------------AKGTPLWMAPEVLQGR----------------LFNEKADVYSFGLVLWQIFTRQELFPEFD
|.||||||. ... .| .|.. .                  ||| |||||||.|                  ..||.||||||.||| |.||.. . ...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NFF--------KFVAAICEKQLRPSIP------------DDCPKSLKELIQKCWDPNPEVRPSFEGIVSEL
..          . . .|.|.||| ||            .|||.|.|.|.|.|||..|| ||||. |...|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Shk1.AA TKL-Unique 47-300 35 7.7e-82 278.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 47-300
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

TESILGDGSFGTVYKGRCRLKDVAVKVMLKQVDQKTL--TDFRKEVAIMSKIF-HPNIVLFLGACT---STPGKLMICTE-LMKGNLESLLL--------
  . .| |..|.||||  | ..||.|.  .. |.      .|..|| .|.|.  |||||.. |.|.    .|... | .| .  |.| ..|         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-DPMVKLPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDAN-----LTVKVCDFGLSQIKQRG-ENLKDGQ-----DGAKGTPLWMAPEVLQG
  .  ||..  |..||.|.|.|   ||...|  ||||||.||.||| |     . .|.|||||| .. .  .. . .      .. .|...||||||| .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--RLFNEKADVYSFGLVLWQIFTRQE------LFPEFDNF--FKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSEL
   ...||.|||||| ||| |.||.        . ..|    .. |.   |. .|| ||..|||....|||.||...|. ||||. |...|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Shk1.AA DRK 45-302 37 3.1e-76 257.69 In-house 1-258 (258) Show / Hide 
Range on Protein: 45-302
Range on HMM: 1-258/258
Sequence Identity: 37% (99 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVK-VMLKQVD-QKTLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELM-KGNLESLLLDPMVKLPLIT
|      | |..| |. |  |   ||||   .  ..  . | .|..|. .|..  ||||..|.|.|.  |    ||.| | .| | . |.|. ...    
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP-DICICMEYMPRGSLYNILHDESIEMDWPL

RMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQ----IKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADVYSFGLVLWQ
...|. |.| |.  ||..||. ||||||. ||||| .  ||| |||||     .||..         . ||| | |||||    . ||||||||. ||| 
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAM-----TMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

IFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSELEE
. |||  .    . |  | ..    .|| .|  ||     |.. ||. .|  |||.. ..  || 
CVTRQDPYFGM-PTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Shk1.AA LRRK 45-302 27 2e-75 256.9 In-house 1-351 (351) Show / Hide 
Range on Protein: 45-302
Range on HMM: 1-351/351
Sequence Identity: 27% (99 aa)

ITTESILGDGSFG-TVYKGRCRL----------------------------KDVAVKVMLK------------------------QVDQKT---------
.  |. .|.|.|| .||....|                             ..||.|....                        ||.            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

-LTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELM-KGNLESLLLDPM-VK-------LPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSN
 .  ||.||.|||.  |||||  .| | . |  |.. .|..  |.| ..| ..   .       ..  .. . | . | |.  |||.|| .||||||. |
AFREFRHEVWIMSHLNHPNIVSLKGFCIH-P--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

LLV---D---------ANLTVKVCDFGLSQIKQRGENLKDG-QDGAKGTPLWMAPEVLQGR---LFNEKADVYSFGLVLWQIFTRQ-ELFPEFD--NFFK
 |.   .         |. ..|..|||.|.       .. |   |  |.|.|||||....     ..||.|.||||..|| . |||   | |.|   ...
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQ

FVAAICE---KQLRPSIPDD-CPK-----SLKELIQKCWDPNPEVRPSFEGIVSELEE
.   | .   ..|||.|| . ||      ....|||.||. .|. ||.|. ||. |..
WMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Shk1.AA MLK 45-300 33 6.6e-75 255.17 In-house 1-291 (291) Show / Hide 
Range on Protein: 45-300
Range on HMM: 1-291/291
Sequence Identity: 33% (100 aa)

ITTESILGDGSFGTVYKGRCRLKD-----VAVKVML-----KQVDQKTLTDFRKEVAIMSKIFHPN----IVLFLGACTSTPGKLMICTELM-KGNLESL
|... ..| |||| |.|||.| ||     ||||        |..      ||..|. . ... |||    |. |.|.|...| .. | .| . .| | ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LLD----PM---------VKLPLITRMRMAKDAALGVLWLHSSNPV-FIHRDLKTSNLLVDA------NLTVKVCDFGLSQ-IKQRGENLKDGQDGAKGT
| .    .|         .  ..   |. |.. | |.  |||  |.  |||||| .|.|.|.      ..|.|.||||.|  ..|...|      ...||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN----MMSNAGT

PLWMAPEVL---QGRLFNEKADVYSFGLVLWQIFTRQELFP-EFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSEL
. ||||||.   ..  ..||.||.|.|.|||...||.. .  . |... . . . .. ||| || .||...|.|...||...|. ||||  ||..|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIA-WWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Shk1.AA Pkinase_Tyr 45-300 33 5.4e-68 230.9 Pfam 1-270 (270) Show / Hide 
Range on Protein: 45-300
Range on HMM: 1-270/270
Sequence Identity: 33% (91 aa)

ITTESILGDGSFGTVYKGRCR------LKDVAVKVMLKQVDQKT--LTDFRKEVAIMSKI-FHPNIVLFLGACTSTPGK--LMICTELMKG-NLESLLLD
||    || |.||.||||...        .||||..  . ...   . || .|..||...  ||||| ..|.||.  .   ..| .|.|.. .| . | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P---MVKLPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENL-KDGQDGAKGTPL-WMAPEVLQGRLFNEKAD
.     .|.. .   |. . | |  .|.| |  .||||| . | ||. |..||.|||||.   .  ..  . ...|    |  |||||... . |..| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTKSD

VYSFGLVLWQIFT-RQEL-FPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSEL
|.||| ..| |||  ..  .|.    . ....| |.  |  .|..||. . .|...||...|| ||.|. |...|
VWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Shk1.AA TK 45-300 19 3.3e-65 217.25 In-house 1-486 (486) Show / Hide 
Range on Protein: 45-300
Range on HMM: 1-486/486
Sequence Identity: 19% (95 aa)

ITTESILGDGSFG---TVYKGRCRLK---------------------------DVAVKVMLKQVDQKTLTDFR-------------KEVAIMSKIF----
|| .  || | ||   .||||. | .                           .||||.. .  ..     |              .|...|..      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVLFLGACTSTPGK-----------LMICTELMK-GN----LESLLLDPMVK--------------------------------------------
 ||||| ..|.||   .|           .|| .|.|. |.    | . | .   |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPLITRMRMAKDAALGVLWLHSSNP----VFIHRDLKTSNLLVDANLT-----------VKVCDFGLS-
                               |.. ... |. ..| |  .||| |      |.|||| . | ||. |..           .|..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----QIKQRGENLKDGQDGAKGTPL-------------------------WMAPEVLQGRL---------FNEKADVYSFGLVLWQIFTRQ-ELFPE-F
       .  ...     .. .||..                         |||||.|..|          | .| ||.||| ..| |||.  | ...  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DN--------FFKFVAAICEKQ-------------LRPSIPDDCP--------------KSLKELIQKCWDPNPEVRPSFEGIVSEL
.|           ..  ... .             .|.  |..||              . . .|.|.||...|| ||.|. ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Shk1.AA TKL-ciliate2 45-301 37 5.1e-63 209.03 In-house 1-273 (273) Show / Hide 
Range on Protein: 45-301
Range on HMM: 1-273/273
Sequence Identity: 37% (105 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQVDQK-TLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELMKGNLESLLLDPMVKLPLITRM
....  . .| .| .|| . |   ||||    . |.. .. ||  |   |  . |||||.||||||  |   .|     .| | ||| .  |.|    | 
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

RMAKDAALGVLWLHSSNPVFIHRDLK--------------------TSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAK-GTPLWMAPEVLQGRLF
|.| |.| || .||||||  ||||||                      |.||| |.  |. |||   .|      .|    .| ||  ||||||..  ..
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKP-----QDNYMTNKIGTYQWMAPEVIKAFYY

NEKADVYSFGLVLWQIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSELE
 |||||.|....|| |  |   . .       .  .|.  |||.|| .||  . .|.|.||| | ..||||. |. |||
TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCN-NLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase Shk1.AA TyrKc 45-300 33 1.5e-61 211.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-300
Range on HMM: 1-280/280
Sequence Identity: 33% (96 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQVDQKTLTDFRKEVAIMSKI--FHPNIVLFLGACTSTP------GKLMICTELMK-GNLESLLLDPMV
|| . .|| | ||.||||. .  .||||.. .      . ||..|  ||.|.   ||||| ..|.||.        . ||| .|.|. |.| . | ..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KLPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRG-------ENLKDGQ-DGAKG-TPL-WMAPEVLQGRLFNEK
||.. .   .. ..| |   ||| |  .||||| . | ||..|.|||..|||||     .       .  .  . .|.|.  |. |||||... . |..|
KLCMKDLLSFCWQIACGMEYLHSKN--CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADVYSFGLVLWQIFTR-QELFPE----FDNFFKFVAAICEKQLRPSIPDD-------CPKSLKELIQKCWDPNPEVRPSFEGIVSEL
 ||.||| ..| |||. |.  |.    . . .  .. . .   .|  |.|       ||. . .....||. .|| ||.|. |....
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Shk1.AA Dicty5 45-304 35 4.1e-60 205.59 In-house 1-260 (260) Show / Hide 
Range on Protein: 45-304
Range on HMM: 1-260/260
Sequence Identity: 35% (94 aa)

ITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQV-DQKTLTDFRKEVAIMSKIF--HPNIVLFLGACTSTPGKLMICTELMK-GNLESLLLDPMV----K
.    .   |. |.||.|  . .|||.||    .     . .| .||.||| .   |||.. ..|| .    .. . ||. . | | ..|.|        
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP

LPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADVYSFGLVLW
.   ... || |.| .  .||| |   ||||||  | |.  |...|. ||| |    |   .. .     ||. |||.|. .|. . .|.|||||| |||
IAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFGTS----RFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW

QIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSELEEII
 .||| | . .  |     . .  |  || || ||| .   || |||   |  ||||  |.  .| ||
EMFTRKEPYDNINNW--NIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase Shk1.AA S_TKc 45-304 24 7.9e-52 179.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-304
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

ITTESILGDGSFGTVYKGRCRL--KDVAVKVMLKQVDQKTLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELMKG---NLESLLLDPMVK---
 .   ..| |.||.|||.| .   . ||.|..          ..|.|..|..|  ||||| ..... .  ..| ...|.. |   .| ... .   .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNE-KADVYSFGL
  .|  .  ....  ....  .|| .  .|||||| .|.|.|   ..|.|||||. .           .   ||| .||||||    ..  |.|..|.| 
FPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLWQIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVS-----ELEEII
.|.  .... .||        .... .| .        ....|..|.||.. .|| ||.   .        . . .
ILYEMLCGYPPFP-------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shk1.AA Pkinase 45-300 24 3.1e-50 177.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 45-300
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

ITTESILGDGSFGTVYKGRCRLKD--VAVKVMLKQVDQKTL--TDFR-KEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELMKG-----NLESLLL-DP
.......| ||||.|||.. .     ||||.. |. . .    |..|  |..|| .. ||||| ....... .... ...|.. |      | ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

MVKL--PLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTV----KVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQ-GRLFNEKA
  ..  .  .  ....  . |.  .|| .  .|||||| .|.|.| | ..    |.|||||.  ..  .  .   ..  ||| .|||||.. |.    |.
HGCFYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGLVLWQIFTRQELFP------EFDNFFKFVAAICEKQLRPSIPDDCP-------------------KSLKELIQKCWDPNPEVRPSFEGIVSE--
|..|.|..|.. .... .||      . ..  . .. | ...|. ..| .|.                   ...|..| .|....|. ||..| |.    
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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SH2 Shk1.AA SH2 424-495 39 3.6e-18 55.16 Pfam 1-78 (81) Show / Hide 
Range on Protein: 424-495
Range on HMM: 1-78/81
Sequence Identity: 39% (31 aa)

WFHGDISTSESENRLRQ--KPEGTFLVRFSTSEYGAYTISKVSKNG---GISHQRIHRPQGK--FQVNNSKYLSVKELI
|.||.|| .| |..|..  .|.||||||.| |. | ||.| |  .|    . | ||.| ...  .   . |. |. ||.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLS-VRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELV
SH2 Shk1.AA SH2 422-503 37 4.9e-18 67.15 SMART 1-87 (87) Show / Hide 
Range on Protein: 422-503
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

CAWFHGDISTSESENRLRQ--KPEGTFLVRFSTSEYGAYTISKVSKNGGISHQRIHRPQ-GKFQVNN---SKYLSVKELITG-EAQALG
. |.||.|| .| |. |..  .|.|.||||.| |. |.|..|  .| |.. | ||.| . ||. .      |. |. ||.      .||
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG