Gene SAPKalpha (Slime mold)

SAPKalpha

Species: Slime mold
Alias: DDB0185206, DdisK190, SAPKalpha, SpkA
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: ARK

Sequence

Name Sequence Type Origin Length Description Download
SAPKalpha.AA Protein None 638 None Fasta, JSON
SAPKalpha.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of SAPKalpha.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank SAPKalpha.AA Ank 150-184 37 6.2e-07 29.26 Pfam 1-33 (33) Show / Hide 
Range on Protein: 150-184
Range on HMM: 1-33/33
Sequence Identity: 37% (13 aa)

NGETPLHKAIFNNSVRLMMVGLLLKNGANVNLATQ
.|.|||| |....  .. .| .||..||.||. . 
DGFTPLHLACRCG--HTEVVKMLLQHGADVNAQDD
Ank SAPKalpha.AA Ank 185-217 39 6.5e-07 29.2 Pfam 1-33 (33) Show / Hide 
Range on Protein: 185-217
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

FQESPLHYAVRLGREDLVSVLLKAGADVDCVGT
  ..|||.|.| |... |. ||..||||. .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank SAPKalpha.AA Ank 43-79 29 8.5e-05 21.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 43-79
Range on HMM: 1-33/33
Sequence Identity: 29% (11 aa)

YGQSALTIALKNNNEEMVELLLSLCVTLKADINTFDK
.|...| .| .....|.|..||.      ||.|  |.
DGFTPLHLACRCGHTEVVKMLLQ----HGADVNAQDD
Ank SAPKalpha.AA Ank 113-149 32 0.00023 20.0 Pfam 1-33 (33) Show / Hide 
Range on Protein: 113-149
Range on HMM: 1-33/33
Sequence Identity: 32% (12 aa)

DLNTPIHYFCQKFRSPNCQEPFQLFIQKGVNVNAQNK
| .|| |. |..     . |  ....|.| .||||..
DGFTPLHLACRCG----HTEVVKMLLQHGADVNAQDD
Ank SAPKalpha.AA Ank 80-112 27 0.001257 17.34 Pfam 1-33 (33) Show / Hide 
Range on Protein: 80-112
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

NGFSALHQAVSSDDRILMRVLQYENINVDVQND
.||..|| |.....   .. | . . .|..|.|
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
SAM_1 SAPKalpha.AA SAM_1 238-301 30 3.2e-16 60.43 Pfam 1-66 (66) Show / Hide 
Range on Protein: 238-301
Range on HMM: 1-66/66
Sequence Identity: 30% (20 aa)

RIKKYKDLFDWLQKHGFEQYKDAF-LKEEMFLDELGEMSEDILNK-MGITSTGTRLRILKETSNLA
  . . |. .||.. |..||.|.|  .... .|.| .|... | | ||.|. | |..|...   | 
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM SAPKalpha.AA SAM 237-303 32 4.7e-16 60.58 SMART 1-67 (67) Show / Hide 
Range on Protein: 237-303
Range on HMM: 1-67/67
Sequence Identity: 32% (22 aa)

ARIKKYKDLFDWLQKHGFEQYKDAFLKEEMFLDELGEMS-EDILNKMGITSTGTRLRILKETSNLANE
.   . .|. |||.. |..||||.|.|..   ..| ... .. |..||||..| |..|||. . . ..
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 SAPKalpha.AA sam7 240-301 28 1.2e-15 53.48 In-house 1-70 (70) Show / Hide 
Range on Protein: 240-301
Range on HMM: 1-70/70
Sequence Identity: 28% (20 aa)

KKYKDLFDWLQKHGF---EQYKDAFLKEEM-----FLDELGEMSEDILNKMGITSTGTRLRILKETSNLA
   .|. .||.. |.   .||.|.|.....      .|.| .|.|. | .||||. | |..|...  .. 
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 SAPKalpha.AA SAM_2 237-301 28 2.6e-10 38.24 Pfam 1-71 (71) Show / Hide 
Range on Protein: 237-301
Range on HMM: 1-71/71
Sequence Identity: 28% (20 aa)

ARIKKYKDLFDWLQKHGF-EQYKDAFLKEEMFL-DEL-GEMSEDIL--N-KMGITSTGTRLRILKETSNLA
   .  .|. .||...|. .||||.|.. ..   . |   |..| |    .||||..| |..|...  .. 
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Kinase SAPKalpha.AA ARK 351-611 66 1.5e-218 732.33 In-house 1-280 (280) Show / Hide 
Range on Protein: 351-611
Range on HMM: 1-280/280
Sequence Identity: 66% (186 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVLKS-MTESKEIEEFKKEFQIMSAIRSKHVVHFYGAVLEP-----KLCMVMENCSRGSLYHVMDNNSLDIGW
||||.|.|.|||.|||||.||||||||||||| ||.|..||||||||||||.|||.|||.||||..||     |||||||.||||||||.|.||..|.||
LEYTCKIGSGSSCKVYKGKYRGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDFGW

ERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSRFNTGSNLETLVKMRGTFAYCAPEVYY-----------GEQFSGKSDVYS
.|.|......||||.|||.|.|.||||||||||||||..|..||||||||||||.||.|||.|||||||||||||||           |.....||||||
DRFFKWMMQMVRGINCLHNWTPQIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYS

IAVILWELVTRCINGRYERPFSEYKNLQ--HDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSR
...|.||.|.|||||.|.||.||||...  .||||.|||.|.|||||||..|||.|..|||.|||....|||.|..|.. 
MGIIMWEMVYRCINGCYMRPYSEYKHIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE
Kinase SAPKalpha.AA TKL 357-612 29 3.9e-106 358.89 In-house 1-364 (364) Show / Hide 
Range on Protein: 357-612
Range on HMM: 1-364/364
Sequence Identity: 29% (111 aa)

LGAGSSGKVYKGLYRG----------KEVAIKVLKSM--------------------------TESKEIEEFKKEFQIMSAIRSKHVVHFYGAVLEPK--
.| |..|.|||| .||          |.||.|..||.                          . |.. .....|  .|| .|  ..|.|.|....|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCMVMENCSRGSLYHVMDNNSLDIGWERTFRFAIETVRGIECLHKWD------PPIVHRDLKSLNLLVNDKWE--------------I
            ||.||| |..|||.|..        |....|.|... ||.. || ..      |||.|||||| |.||...|.              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVCDFGLSRFNTGS------------------NLETLVKMRGTFAYCAPEVYYGE----------------QFSGKSDVYSIAVILWELVTRCINGRYER
|.||||||||...|                  | .|. . .||....||||  |.                ..| |.|||| ...|||..|||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

PFSEYKNLQHDFQ-----IIIQTAKKNLRPTIP------------NACPESLVSLIQDCWDPNLENRPTCTDILSRL
|...|.. ...||     .... ..|.|||.||            . ||.|. .|.|||||.. |.||....||.||
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SAPKalpha.AA TKL-Unique 353-612 35 2.4e-90 306.48 In-house 1-290 (290) Show / Hide 
Range on Protein: 353-612
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

YTEKLGAGSSGKVYKGLYRGKEVAIKVLK--SMTESKEIEEFKKEFQIMSAIR-SKHVVHFYGAVL-----EPKLCMVMENCSRGSLYHVMD--------
  .|.|.|..|.|||| .||..||||...  .  ......||..|  .|. .. .. .||..|.       .|..|.||| |..|||| | .        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-NNSLDIGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDK-----WEIKVCDFGLSRFNTGSNLETLVKM--------RGTFAYCAPEVYYG
 ||.... ...  ..||  ..| . ||  .||| ||||||.|.||. .     | ||.||||||.||. .| .|.            |.| . ||||  .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--EQFSGKSDVYSIAVILWELVTRCINGRYERPFSEYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSRL
  .|.| |||||| ...|||..||.|   | .|.... . . ..... .. ..|.||.||| ||...  |||.||... ..||. ..|..||
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase SAPKalpha.AA Dicty4 351-614 35 1.9e-84 281.54 In-house 1-277 (277) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-277/277
Sequence Identity: 35% (102 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVL---KSMTESKEIEEFKKEFQIMSAIRSKHVVHFYGAVL----EP-KLCMVMENCSRGSLYHVMDN-----
.  ....| || |.||||  ||||||.|.|   .   ......||.||  ||. ||  ... |.|| .    .| |.| |.| ...|.|| .  .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-NSLDIGWERTFR---FAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSR-FNTGSNLET-LVKMRGTFAYCAPEVYYGEQFSGKSDV
  |  . |..  |    |. ..||.  ||  .| |.|||||| |||| . | .||||||||. . ..... . .  . || .. ||||  .. . .|.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSIAVILWELVTRCINGRYERPFS-EYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSR--LVT
|| . .|||..||      . |.. .....   .|...  . | ||| ||. || |. .|||.|||.. ..||.   |..|  | .
YSFGIVLWEILTR------QEPYQKHHMPY---MQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase SAPKalpha.AA MLK 351-612 31 2.8e-72 246.43 In-house 1-291 (291) Show / Hide 
Range on Protein: 351-612
Range on HMM: 1-291/291
Sequence Identity: 31% (95 aa)

LEYTEKLGAGSSGKVYKGLYRGKE-----VAIKVLKSMT-----ESKEIEEFKKEFQIMSAIRSKH----VVHFYGAVLEP-K-LCMVMENCSRGSLYHV
..  |..|.||.|||.|| .|.|.     ||.|  ....     .. |...|..|. . . .. .     .. |||. |.| . .| ||| |. ||||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

MDN-------------NSLDIGWERTFRFAIETVRGIECLHKWDP-PIVHRDLKSLNLLVND------KWEIKVCDFGLSRFNTGSNLETLVKMRGTFAY
  .             |.  .  .  ...|    ||.. ||. .| ||.|||||| |.|. .      .   |.||||.||. . .  ..  ...||.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

CAPEVY---YGEQFSGKSDVYSIAVILWELVTRCINGRYERPFS-EYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILS
 ||||     .|..| |.||.|..|.|||..||      | |.. .|...    .|... | ..|||.||. |||.. .|...||... ..||.   |..
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR------EVPYKQHYDPM----AIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQ

RL
 |
HL
Kinase SAPKalpha.AA LRRK 351-614 26 1.2e-62 214.41 In-house 1-351 (351) Show / Hide 
Range on Protein: 351-614
Range on HMM: 1-351/351
Sequence Identity: 26% (95 aa)

LEYTEKLGAGSSG-KVYKGLYRG----------------------------KEVAIKVLKS---------------------------------MTESKE
|.. |..| |..| .||.. .||                            ..||||...                                  .  .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IEEFKKEFQIMSAIRSKHVVHFYGAVLEPKLCMVMENCSRGSLYHVMDNNS---L-----DIGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLV
  || .|  |||  .  ..|  .|  ..| ||||||. . |.|||.. |..   .     .|.|  . . |..  .|.| ||. .|||.|||||| | |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

---N---------DKWEIKVCDFGLSR-FNTGSNLET-LVKMRGTFAYCAPEVYYGE---QFSGKSDVYSIAVILWELVTRCINGRYE-RPFSEYK-NLQ
   .         .   .|..|||.|| |   . ... . .. |.. ..|||.  ..   ... |.|.|| ..|||||.||      . .|| |..   .
WSSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR------QHHPFDEHDFFDH

HDFQIIIQT-AKKNLRPTIPNA-CPE-----SLVSLIQDCWDPNLENRPTCTDILSRLVT
  ....|.   .. ||||||.  ||.     .. .|||.||. . ..||. ..|..|| .
MQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase SAPKalpha.AA Shk 351-617 35 4.1e-58 199.38 In-house 1-269 (269) Show / Hide 
Range on Protein: 351-617
Range on HMM: 1-269/269
Sequence Identity: 35% (98 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVLKSM-TESKEIEEFKKEFQIMSAIRSKHVVHFYGAVL-EP-KLCMVMENCSRGSLYHVMDNNSLDIG---W
   ...|| || ||||||  ||||||.||..    . ..  .|.|| .||| |.  ... | ||    | |.  | | . .|.|   . .          
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

ERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSR-FNTGSNLET-LVKMRGTFAYCAPEVYYGEQFSGKSDVYSIAVILWELV
.|  | .  .. |.  ||   . |.|||||. ||||   |  ||||||.|    ....|   .    ||  . ||||  .  . .|.||||   ||||. 
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TRCINGRYERPFS-EYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSR--LVTIEN
|.      . |.. .....   .  |     | .|| ||. || ||  ||| |||.| ..||    |..|  | .|  
TC------QEPYPKHHSEYDKFYEAICN---KKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase SAPKalpha.AA TKL-ciliate2 351-613 35 9.2e-53 174.21 In-house 1-273 (273) Show / Hide 
Range on Protein: 351-613
Range on HMM: 1-273/273
Sequence Identity: 35% (101 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVLKSMTESK-EIEEFKKEFQIMSAIRSKHVVHFYGAVLE-PKLCMVMENCSRGSLYHVMDNNSLDIGWERTF
||  .|.  |  | .||  .|   ||.|  |   . . .| .|  | . | |.|   .| | ||  . |  |..|| | ||||. .. | .  . ||   
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

RFAIETVRGIECLHKWDPPIVHRDLK--------------------SLNLLVNDKWEIKVCDFGLSRFNTGSNLETLVKMRGTFAYCAPEVYYGEQFSGK
| |..  ||.  ||  .|||.|||||                    |||.|| |    |. |||  |     |  |  |. ||. . ||||     .  |
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMT-NKI-GTYQWMAPEVIKAFYYTEK

SDVYSIAVILWELVTRCINGRYERPFSEYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSRLV
 ||.| ..||||.  |      | |   |.| . |  .  .  ..|||||||  ||  .  |.| ||| | . ||.  .|.  | 
ADVFSYSIILWEIASR------EPP---YRNKKGDV-VAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase SAPKalpha.AA DRK 358-546 37 7.6e-50 167.0 In-house 8-200 (258) Show / Hide 
Range on Protein: 358-546
Range on HMM: 8-200/258
Sequence Identity: 37% (73 aa)

GAGSSGKVYKGLYRGKEVAIKVLKSMTES--KEIEEFKKEFQIMSAIRSKHVVHFYGAVLEP-KLCMVMENCSRGSLYHVMDNNSLDIGWERTFRFAIET
| |. | |. |  || .||.| |.   .   . . ||..|  .|.  |   .. | |. ..|   | .||  .||||| .  . |. . | .  . ..  
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDC

VRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLS-RFNTGSNLETLVKMRGTFAYCAPEVYYGEQFSGKSDVYSIAVILWELVTRCI
 .|.  ||  .| |.|||||| |||| . | .|| ||||| ||       .   | ||    ||||   . .  | |||| |..|||.||| .
AKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD
Kinase SAPKalpha.AA S_TKc 351-613 25 1.4e-48 168.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 351-613
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

LEYTEKLGAGSSGKVYKGLYRG--KEVAIKVLKSMTESKEIEEFKKEFQIMSAIRSKHVVHFYGAVLEPKLCMVMENCSR--GSLYHVMDNNS-------
 |  .|.| |. |||||.  ..  ..||||..|        | ...| ||..  . ...|..|..  . .|.|||| |.   |.|.......        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDIGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSRFNTGSNLETLVKMRGTFAYCAPEVYYGEQFSG-KSDVYSIAVIL
..  . |  ... ......| .|.    |.|||||  |.|...  .||.|||||.|.           . ||  |.||||    .... |.|..|. .||
FPE-HAR--FYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

WELVTRCINGRYERPFSEYKNLQHDFQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILS--------RLV
.|.....       ||.   ..|  |..|                .... ..|. |.. . |.|||. ..|           .
YEMLCGYP------PFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SAPKalpha.AA Pkinase 351-612 25 2.3e-47 168.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 351-612
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

LEYTEKLGAGSSGKVYKGLYRGKE--VAIKVLKSMTESKEI-EEFKK--EFQIMSAIRSKHVVHFYGAVL-EPKLCMVMENCSRG----SLYHVMD-NNS
..  .|.|.||.|.|||.  .| .  ||.|..|  .|...  ..  .  | |||  ......| .|...  .....|||| |  |    .|....   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LDI--GWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEI----KVCDFGLSR-FNTGSNLETLVKMRGTFAYCAPEVYY-GEQFSGKSDV
  .   ..   ... ...||.| .|.    |.|||||. |.|.... .|    |.|||||.. |.   | . .    ||  |.||||   |.  . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSIAVILWELVTRCINGRYERPFSEY---KNLQHDFQIIIQTAKKNLRPTIPNACP-------------------ESLVSLIQDCWDPNLENRPTCTDIL
.|. .||.|....        ||..    .|   . |.| .. .. |.  .|. |.                   |.. ..| .|.... . |||...||
WSCGCILYEMLCGR------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

SR--L
    .
QHPWF
Kinase SAPKalpha.AA Pkinase_Tyr 351-612 27 1.4e-45 154.98 Pfam 1-270 (270) Show / Hide 
Range on Protein: 351-612
Range on HMM: 1-270/270
Sequence Identity: 27% (77 aa)

LEYTEKLGAGSSGKVYKGLYR------GKEVAIKVLKSMTESKE--IEEFKKEFQIMSAI-RSKHVVHFYGAVL---EP-KLCMVMENCSRGSLYHVMDN
..  .|||.|. |.|||| ..      . .||.|.||  . ...  .|.| .| .||. . . ...| .||...   || ....||| .  |.|..   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---SLDIGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSRFN-TGSNL-ETLVKMRGTFAYCAPE-VYYGEQFSGKSDV
.      .  ..   ....  .| | |.     ..||||   | ||...  .|.|||||.|     ..   .  . .     .|||   ||. |. ||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDV

YSIAVILWELVTRCINGRYERP-FSEYKNLQHDFQIIIQTA-KKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSRL
.|  | .||..|..     | | . . .| .     ...   ... |  .|  ||. . .|...||... |.||| ..|...|
WSFGVLMWEIFTYG-----EQPTYPGMSNEE-----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SAPKalpha.AA Dicty5 351-544 34 1.6e-45 154.63 In-house 1-199 (260) Show / Hide 
Range on Protein: 351-544
Range on HMM: 1-199/260
Sequence Identity: 34% (70 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVLKSMT-ESKEIEEFKKEFQIMSAIRSKH--VVHFYGAVLEPKLC--MVMENCSRGSLYHVMDNNSL----D
    .   .|.||.||.| |.|. |||||. .      ...||..|  |||.. | |  .. .|||    .     | | |..|||              
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP

IGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSRFNTGSNLETL-VKMRGTFAYCAPEVYYGEQFSGKSDVYSIAVILWE
| .     .||   .... ||     |.||||||.| |..  |.||. ||| |||       |. |   || .. |.|.. |  .  | |||| ...|||
IAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHV---GTQCWMACELFNGQPYHQKCDVYSFGIVLWE

LVTR
. ||
MFTR
Kinase SAPKalpha.AA TyrKc 351-612 25 5.3e-44 153.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 351-612
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

LEYTEKLGAGSSGKVYKGLYRGKEVAIKVLKSMTESKEIEEFKKEFQIMSAI--RSKHVVHFYGAVLE--------PKLCMVMENCSRGSLYHVMDNNSL
..  .||| |  |.|||| ..  .||.|.||. .    .|.| .| .||. .  . ...| .||....        . |..||| .. |.| .   ..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

DIGWERTFRFAIETVRGIECLHKWDPPIVHRDLKSLNLLVNDKWEIKVCDFGLSRFNTGS-----NLETLVK-----MR--GTFAYCAPEVYYGEQFSGK
.. ..    |..   .| | ||.   ...||||   | ||...  .|..||||||. .       . .. .|      .       .|||.     |. |
KLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVYSIAVILWELVTRCINGRYERPFSE-YKNLQHDFQIIIQTAKKNLRPTIPNA--------CPESLVSLIQDCWDPNLENRPTCTDILSRL
|||.|  | .||. |..     . | ..  ..   . | .|.  |.  |. .|          ||. . .....||. . |.||| ..| ...
SDVWSFGVCMWEIFTYG-----QQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SAPKalpha.AA DRK 564-614 31 1.2e-09 28.93 In-house 208-258 (258) Show / Hide 
Range on Protein: 564-614
Range on HMM: 208-258/258
Sequence Identity: 31% (16 aa)

FQIIIQTAKKNLRPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSRLVT
||...   .  .|| .|  ||   . |..|||. .   ||.  ..| ||  
FQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase SAPKalpha.AA Dicty5 576-616 39 7.1e-08 23.18 In-house 220-260 (260) Show / Hide 
Range on Protein: 576-616
Range on HMM: 220-260/260
Sequence Identity: 39% (16 aa)

RPTIPNACPESLVSLIQDCWDPNLENRPTCTDILSRLVTIE
|||||  || .   ||  ||     |||. . |.  .  | 
RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII