Gene Roco7 (Slime mold)
Roco7
Sequence
Protein domains of Roco7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| COR | Roco7.AA | COR | 1468-1746 | 18 | 9.6e-26 | 80.2 | In-house | 74-434 (434) | Show / Hide |
Range on Protein: 1468-1746
Range on HMM: 74-434/434
Sequence Identity: 18% (69 aa)
IEPRDSEAAIKYLYEIGEVLYYR-YEANDQLLNELVFLDSMWMSKLISAVLALKT--------QNGM-TVVDQITQAWAS-----------LFPHCKTSS
|.. .....|| . |..... .. ...| ...|.|| |... .. .. |. ..| .......| .|.
IDEDELHTVAMYLHDLGHIIHFKIWDHDPML-KDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEY
LLFLLEKFELVYISAED---------SSVIIPQLFGGERPMVM-RDLWSP---TAHANNEYLRIYEF------QFLPKGFFSRLSVRV--LQHYDPLC--
|. |.||||| | ..| . ..|||| .|| . |.. . | .. |.|.. .||| ||..|. || ..|... |
LVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFY
--------IWQNGMVLQPAGQLWGGAAKSFDSQCLIEYDSVNFILKVSIRDDNK-----QQQLLKSIVDLVSSFILWYF--PGRL-------SNVRVACT
.|.|||||. |.|. | ..|...| . ... .| . . ||. .| ... .. .. || .. . |
ERSCCEWMYWRNGMVLK-----WEGHNK---NEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCP
HCTNQHIE-NPT--MYTLDYLENQASLGQTNVICKAQL------------------------GGIIHETLSP
|| | . .. .| .|....... |.....|. . | .|
HCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWI-Q-RISD
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| Kinase | Roco7.AA | LRRK | 1775-2037 | 35 | 5.3e-152 | 511.28 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 1775-2037 Range on HMM: 1-351/351 Sequence Identity: 35% (125 aa) LKFGPQLGSGSYA-NVYRGIWNG----------------------------SEVAIKVLNFD-----------DG------------------HANTTEK ||...|.|.|... .|||..|.| ..||||..|.| .. |...... LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA YREFRNEAHITGELRHANTVSLMGVSLSPFCLVTELLQYGDLAKFIRNTAET--------FSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLG .||||.|..|. .|.| | |||.|....|.|.|.|....||| .|..|.... .||...||.|...||||..|||..|.|.|||||| |||| FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW GSSMD--------NLVAKVGDFGLSI--KPIGKEVKGRKVWNWRWLAPECMGDG---QYTEKIDIYSYAIVLWEIITRD-LPFEEYV--DQLKWNSIIED .|... . .||..|||.| ......| ..|.|..|.|||.|... .||||.|.||....|||..||. .||.|.. |...|...||| SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED KIMKGLRPTIPNE-CPP-----DMKQLITDCWSGDPKKRPSFNSILERLST ||..|||||||.. ||| ....||..||..||||||.|..|..|||. KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | Roco7.AA | TKL | 1781-2035 | 27 | 2e-101 | 343.26 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 1781-2035 Range on HMM: 1-364/364 Sequence Identity: 27% (103 aa) LGSGSYANVYRGIWNG----------SEVAIKVLNFDDG---------------------HANTTEKYREFRNEAH-ITGELRHANTVSLMG-------- .|||... ||.|.|.| .||.|... .. ........|.|..| . ||| | |..|| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -VSLSP------FCLVTELLQYGDLAKFIRNTAETFSWGTVLKLAIDVAKGMNFLHSCK------PMIVHRDLKSANILLGGSSM----------DNLVA |...| .|.|.|. . |.| .. | ...|.|.|.|||.|||.. | |.||||||.|||. .. .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KVGDFGLSI---------------------KPIGKEVKGRKVWNWRWLAPECMGDG----------------QYTEKIDIYSYAIVLWEIITRDLPFEEY |..||||| . ... ..... . ||.|||.. . .|.||.|.||..||||||.|| .|...| KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY V-DQLKWN----SIIEDKIMKGLRPTIP------------NECPPDMKQLITDCWSGDPKKRPSFNSILERL .. ... ... . |||||.|| . |||.||.|..|||. ||.|||||. ||.|| PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | Roco7.AA | TKL-Unique | 1777-2035 | 35 | 9e-81 | 274.65 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1777-2035
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)
FGPQLGSGSYANVYRGIWNGSEVAIKVLNF-DDGHANTTEKYREFRNEAHITGELR-HANTVSLMGVSL----SPF--CLVTELLQYGDLAKFIR-----
|. .|.|.|..||.|.|.|..||||.... | . |. .||.|| . |. |.| | .||.. .| |.|.| .. | | . .
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSN---EMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN
----NTAETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGS-SMDNLVAKVGDFGLSI--KPIGKEVKGRK--------VWNWRWLAPEC
| .... ..|.|||.|.||..||.|.| | |||||| |.|. . .|. |||||. . | |. .... . . ||.|||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV
MGD--GQYTEKIDIYSYAIVLWEIITRDL------PFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
. . ||.||.|.||..||||||.||.. |.... || .| ... . ...||.|||.||.. . ||..|| || .||||..|..||
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
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| Kinase | Roco7.AA | MLK | 1775-2035 | 30 | 8.5e-73 | 248.15 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-291/291 Sequence Identity: 30% (90 aa) LKFGPQLGSGSYANVYRGIWNGSE-----VAIKVLN--FDDGHANTTEKYREFRNEAHITGELRHAN----TVSLMGVSLSP---FCLVTELLQYGDLAK ..| .||||. |..| | . . ||.| . .. . | . ..|. |. . |.| | . ..||.|.| ||.|.| ...| |. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN FIRN-TAETF------------SWGTVLKLAIDVAKGMNFLHSCKP-MIVHRDLKSANILLG---GSSMDNLVAKVGDFGLSIKPIGK-EVKGRKVWNWR .... . . . . . ... | ..|.||..||| .| .|.|||||| |||. . |.....|. |||.| . . . . . . . VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA WLAPECM---GDGQYTEKIDIYSYAIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL | ||| ..|.|| |..|...||||..|| .|.....|.. |. ...||||.||..||. .|.|...||. ||.||||| .|.. | WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM---AIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | Roco7.AA | Pkinase_Tyr | 1775-2035 | 29 | 3.2e-69 | 235.07 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-270/270 Sequence Identity: 29% (84 aa) LKFGPQLGSGSYANVYRGIWN------GSEVAIKVLNFDDGHANTTEKY---REFRNEAHITGEL-RHANTVSLMGVSL---SP--FCLVTELLQYGDLA ..|| .||.|.. .||.|.|. . .||.|.|. ..... ..| .|| | .| .| | |.|.|| . | ..|.|. ..||| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL KFIRNT---AETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI--KPIGKE--VKGRKVWNWRWLAPECMGDG .. |. . .. . |. ....||||..|.| . ..|||| |.|.. |.|.|..||||. . . ..| . .|.||||. .| DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG QYTEKIDIYSYAIVLWEIIT-RDLP-FEEYVDQLKWNSIIEDKI-MKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL .|.| |..|. ...|||.| . | ... .. . ..| .| | .| ||... .|...|| ||..||.| |.|.| KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Roco7.AA | TK | 1775-2035 | 17 | 1.7e-65 | 218.27 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1775-2035
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)
LKFGPQLGSGSYA---NVYRGIWNG---------------------------SEVAIKVLNFDDGHANTTEKYREFR---------NEAHITGELR----
...| .||.| . ||.|.|.| .||.|.| .|... . .. .|.. .||.. ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HANTVSLMGVSLSP--------------FCLVTELLQYGD----LAKFIRNTAET--------------------------------------------
| | |.| ||.. . ...|.|. ..|| | .. |. ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------FSWGTVLKLAIDVAKGMNFLHSCKP----MIVHRDLKSANILLGGSS-------MDNLVAKVGDFGLS-
.. . | . ..|.|| .|||.. .||||| |.|.| . .. .|.|..|||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
------IKPIGK----EVKG------------------------RKVWNWRWLAPECMG---------DGQYTEKIDIYSYAIVLWEIITRD-LPFEE-Y
. |.. .|. . . ||.||||. .| .|.| |..|. ...||| |. |. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
VDQLKWN----SIIEDKIMKG--------------LRPTIPNECP--------------PDMKQLITDCWSGDPKKRPSFNSILERL
.| |. . ... .| .|. | || ... .|...||. ||..||.| ..|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Roco7.AA | Dicty4-Unclassified | 1775-2035 | 32 | 7.7e-64 | 217.51 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 1775-2035
Range on HMM: 1-263/263
Sequence Identity: 32% (88 aa)
LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSLSP------FCLVTELLQYGDLAKFIR----N
.. .| | . |..|.| | .||.| .| . | .|. | | | . | | | . | .. | .| |.|.. | | |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFR-EEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE
TAETFSWGT--VLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMD-NLVAKVGDFGLSIKPIGKEVKGRKVW-NWRWLAPECMGDGQYTEKIDI
. ..| |.|.|.|| .||. ..|||.||.||| || . .|..|||.| | . .| .|||. |. | |.
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNIL-----MDKHFNIKIADFGIS-RVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDV
YSYAIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
||||..|.| .| | |. | . . | |.||| || |.. .|.|| .||. ||.|||..| | ..|
YSYAMMLYELATGDEPYQEIQSIMNAARSVCD---KKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
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| Kinase | Roco7.AA | TyrKc | 1775-2035 | 29 | 1.9e-61 | 211.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-280/280 Sequence Identity: 29% (87 aa) LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTTEKYREFRNEAHITGEL--RHANTVSLMGVSL---------SPFCLVTELLQYGDLAKFIR ...| .||.| . ||.|.|. .||.|.|. | ..|..|| | .| .| | | | || . | ..|.|. .||| ...| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR NTAETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSIKPIGK-------EVK-------GRKVWNWRWLAPECM .. ..... . |. ....|.||..||| ..|||| |.|.| .|...|..||||| . . ... |. .. ||.||||. KHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVG----ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI GDGQYTEKIDIYSYAIVLWEIITR-DLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNE--------CPPDMKQLITDCWSGDPKKRPSFNSILERL .| .|.| |..|. ...||| |. . | .. . | . |. . ....| |. .| . ||..| |....|| ||..||.|. | |.. NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Roco7.AA | TK-Unique | 1775-2035 | 26 | 1.6e-54 | 186.4 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-294/294 Sequence Identity: 26% (83 aa) LKFGPQLGSGSYANVYRGIWNG--------SEVAIKVLNFDDGHANTTEKYREFRNEAHITGELR-HANTVSLMGVSL---SPFCLVTELLQYGDLAKFI |..| ..|.|.. |.|| | . ||.| |. .| .. ..| .|. . || | | |...|.. |.... | ...|.| ... LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK----DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL RNTAET-------------------------FSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI-----KPIGKE |... . | .... |...|.||..|.| . .|||||| . |.||.. ..|.|..|||.. ... .. RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMM VK-GRKVWNWRWLAPECMG--DGQY-TEKIDIYSYAIVLWEIIT--RDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNEC-PPDMKQLITDCWSGDPKKR . || ||.||| . .|.| |.| |..|.....||| | |. .. . |...| .| |. |..| ...| .|. ||. .|..| CSQGRIP--IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKD-----IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEER PSFNSILERL ||| .|. || PSFRQIKHRL |
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| Kinase | Roco7.AA | DRK | 1775-1977 | 36 | 4.7e-51 | 171.15 | In-house | 1-202 (258) | Show / Hide |
Range on Protein: 1775-1977 Range on HMM: 1-202/258 Sequence Identity: 36% (77 aa) LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTT-EKY-REFRNEAHITGELRHANTVSLMGVSLSP--FCLVTELLQYGDLAKFIRNTAETFS | | | |.|. |.|| | |..||.| | . | |. ||. |. . ||| | . || . | | ..| . | |.. . . . IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNH----NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMD WGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI---KPIGKEVKGRKVWNWRWLAPECMGDGQYTEKIDIYSYAIVL |. ......|.||||..||.| | |.|||||| | | .. || ||||| | . . | ||| . |||| |.||.|||| WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD----EHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVL WEIITRDLPF ||..|| |. WECVTRQDPY |
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| Kinase | Roco7.AA | Dicty4 | 1775-1925 | 35 | 8.4e-50 | 164.35 | In-house | 1-161 (277) | Show / Hide |
Range on Protein: 1775-1925
Range on HMM: 1-161/277
Sequence Identity: 35% (60 aa)
LKFGPQLGSGSYANVYRGIWNGSEVAIKVL--NFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSL----SP--FCLVTELLQYGDLAKFIRN--
.... .|.||.. ||.|.| |.|||.|.| . .. .|. . |||.|.|| . .|| | . .|| .. | .| |||.. |.|.. ...
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLN---EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP
----TAETFSWGTVLK---LAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLS
. .|..... .|.|.|.||| ||.| | |.||||||.|.| .|...||.|||||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVD----KNWRVKVCDFGLS
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| Kinase | Roco7.AA | UTK | 1775-2035 | 27 | 2.5e-49 | 166.91 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-296/296 Sequence Identity: 27% (85 aa) LKFGPQLGSGSYANVYRGIWNG-------SEVAIKVLNFDDGHANTTEKYR---EFRNEAH---ITGELR-HANTVSLMGVSLS--PFCLVTELLQYGDL ...| |||.| . .|... .. . ||.||.. ||... . . .|..|| . . .. | | . | || .. |...|||. . ||| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL AKFIRNTAETFS-------WGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDN----LVAKVGDFG---LSIKPIGK--------EV--- ... |. ..|. . |. | |.| ||..||||. .||||| |.|.. ..| .|.|..||| .| . .. | RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG--FVHRDLAARNCLVHMHRM-MWHCMMVCKIADFGRGGMS-RRVNTFHFSNRYWESYYY --KGRKVWNWRWLAPECMGDG-QYTEKIDIYSYAIVLWEIITR-DLPFEEYVDQLKWNSIIEDKIMKG--LRPTIPNECPPDMKQLITDCWSGDPKKRPS ... | .|| |||.. .. ..|.| |..|. .|.||| |. ||.... .| . ...| .|. | .|| .. .| ..|| || .||. MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-----SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD FNSILERL | ..... FEDLVQQM |
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| Kinase | Roco7.AA | Pkinase | 1775-2035 | 24 | 2.5e-44 | 157.79 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1775-2035 Range on HMM: 1-293/293 Sequence Identity: 24% (75 aa) LKFGPQLGSGSYANVYRGIWNGSE--VAIKVLNFDDGHANTTEKYREFR-NEAHITGELRHANTVSLMGVSL--SPFCLVTELLQYG----DLAKFIR-N ...| ..||||.. ||.... |.. ||.|... . |.. .... .| .|..| .|.| | | | .. . ..|.|... | ||. .|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW TAETF--SWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVA----KVGDFGLSI---KPIGKEVKGRKVWNWRWLAPECMG-DGQY .| |. .. . . ...|....||. |.|||||..|||. .| . |..||||. . ... . | ..||| . | RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILI----DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW-YMAPEVIRGGQYY TEKIDIYSYAIVLWEIITRDLPFE------EYVDQLKWNSIIEDKIMKGLRPTIPNECP-------------------PDMKQLITDCWSGDPKKRPSFN . |.|..|. ..|.| ... .|| . .||.. .|. . .. |. .|..|. ...|..|..|. ||||||.. GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQ---MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE SILER--L ||. . QILQHPWF |
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| Kinase | Roco7.AA | S_TKc | 1775-2042 | 22 | 2e-39 | 138.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1775-2042
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)
LKFGPQLGSGSYANVYRGIWNG--SEVAIKVLNFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSL-SPFCLVTELLQY--GDLAKFIRNTAE--
... ..|.|... ||...... .||||... . .|.| | . .| | | | .| . ...|.|.. ||| ..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG
---TFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSIKPIGKEVKGRKVWNWRWLAPECMGDGQYTE-KIDIYSY
|. .. ... ........|| |.||||| .|||| . |..||||. . . ..||| . .|. |.|..|
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC
AIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILE--RLSTMQKTF
..|.| ... ||. .....| .. .|..|..| |. ||.|||. .|. .. . |
GCILYEMLCGYPPFP-----------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Roco7.AA | Dicty4 | 1943-2037 | 43 | 2.8e-35 | 115.25 | In-house | 183-277 (277) | Show / Hide |
Range on Protein: 1943-2037 Range on HMM: 183-277/277 Sequence Identity: 43% (43 aa) WLAPECMGDGQYTEKIDIYSYAIVLWEIITRDLPFE-EYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILER--LST | |||.| |.|| | ||..|||||| ||. |. .. . . ... |.||| ||. ||| |.||..||. ||..||||. |..| | . WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQ---FVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | Roco7.AA | DRK | 1997-2037 | 51 | 1.4e-16 | 52.75 | In-house | 218-258 (258) | Show / Hide |
Range on Protein: 1997-2037 Range on HMM: 218-258/258 Sequence Identity: 51% (21 aa) GLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERLST |.|| .| ||| ||..|||. || |||. .|||| GMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| WD40 | Roco7.AA | WD40 | 2472-2488 | 27 | 6.401916 | 2.39 | Pfam | 22-39 (39) | Show / Hide |
Range on Protein: 2472-2488 Range on HMM: 22-39/39 Sequence Identity: 27% (5 aa) MDRFVITCSE-RVICIFD | ......|. . |.|.| MGHYLASGSRDGTIRIWD |
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| WD40 | Roco7.AA | WD40 | 2491-2527 | 22 | 6.2e-05 | 16.82 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 2491-2527 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) GIIKKRLDGLASRVLSLLILDT---YIIGACYDSTILVWD . |. . | . | .. . . |.. .. |.|| .|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | Roco7.AA | WD40 | 2532-2574 | 16 | 0.01237 | 10.2 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 2532-2574 Range on HMM: 1-39/39 Sequence Identity: 16% (7 aa) FRMVQSLKKKHTDAISSLAFALSPQGKPQLWVGGWDKKITTYS .... ||......|.. . . . | |..|..| .. WKCKHTF--GHTHWVTCCAWHPD--MGHYLASGSRDGTIRIWD |
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