Gene Roco11 (Slime mold)

Roco11

Species: Slime mold
Alias: roco11, Roco11, DdisK231, DDB0191297
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco11.AA Protein None 1487 None Fasta, JSON
Roco11.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of Roco11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 Roco11.AA LRR_1 295-316 40 0.000412 18.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 295-316
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLAELDLSY-N--NI-KEIPKE-ICQL
|| .||||. |  |. ..||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco11.AA LRR_1 318-339 25 0.002707 15.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 318-339
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HLKILNMNN-N--QL-DDLPLE-LANL
.|..|.... |  .| ...| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco11.AA LRR_TYP 316-338 37 0.03229 12.07 SMART 1-24 (24) Show / Hide 
Range on Protein: 316-338
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LKHLKILNMNNNQLDDLPLEL-AN
| .|. |. .||||  || .. ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco11.AA LRR_TYP 339-362 29 0.057125 10.04 SMART 1-24 (24) Show / Hide 
Range on Protein: 339-362
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LTNLKYLAVQDNPLNKFPHHIIEQ
|.||. |  ..| |   |. . . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco11.AA LRR_TYP 295-315 40 0.304919 4.08 SMART 3-24 (24) Show / Hide 
Range on Protein: 295-315
Range on HMM: 3-24/24
Sequence Identity: 40% (9 aa)

NLAELDLSYNNIKEIPKEI-CQ
|| |||||.|.....| ..   
NLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco11.AA LRR_1 341-363 22 9.308186 3.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 341-363
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

NLKYLAVQD-N--PLN-KFPHHIIEQG
||..| ... |  .|  ..|. .. . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC Roco11.AA ROC 383-556 26 2.7e-43 142.83 In-house 1-215 (215) Show / Hide 
Range on Protein: 383-556
Range on HMM: 1-215/215
Sequence Identity: 26% (60 aa)

WNKVKLMFVGQEGVGKSSLCKALMGSRRRSSSSFAAELQKS---------GDTISTEGVK-IQSIK-----------GKKIDFYAWDFGGQQVFYPTHQF
 | .|||..||.||||.||||.||.             ..|         |.  .| |.  ||...            ..|.|  ||||||.....||||
CNEMKLMLCGQGGVGKTSLCKQLMH------------DKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQF

FLTN-QALYLLVFKLTD-----PNF----AER--VNYWTLQIKANSGLSV------PMIFLVGTHCDACTPEQ------LSSAEQILKENFVKYSRIRQ-
|||| ...||||... .      ..     ..  . ||   ||.... |.      ... .||||.| .  ..       ..  .. ..   |. .|.. 
FLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKLRNKFPNICHS

-------NAISFVSCTNG-TGIKELKKI
       ...  |.|. | .||..|.. 
WMQIEHYQGFFHVDCETGCKGIDKLRHH
Miro Roco11.AA Miro 387-510 23 1.7e-12 46.82 Pfam 1-140 (140) Show / Hide 
Range on Protein: 387-510
Range on HMM: 1-140/140
Sequence Identity: 23% (34 aa)

KLMFVGQEGVGKSSLCKALMGSRRR-------SSSSFAAELQKSGDTISTEGVKIQSIK-----GKKIDFYAWDFGGQQVFYPTHQFF--LTNQALYLLV
|.. .| .|.||||. ....|  .          ..   | ....  . |. |... ..      |   |  ||.||.  .. .|..|  ...   ...|
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADAICFV

FKLTDPN-FAERVNY--WTLQIKANSGLS-VPMIFLVGTHCD
. .||.. |.. .||  | |. . ..| . .|.| .||..||
YDCTDYESFNRVSNYMAW-LPHFRKWGKKAIPVI-VVGNKCD
RAB Roco11.AA RAB 386-564 22 0.000206 -87.56 SMART 1-172 (172) Show / Hide 
Range on Protein: 386-564
Range on HMM: 1-172/172
Sequence Identity: 22% (42 aa)

VKLMFVGQEGVGKSSLCKALMGSRRRSSSSFAAELQKSGDTISTE-GVKIQSIKGKKIDFYAWDFGGQQVFYP-THQFFLTNQALYLLVFKLTDPNFAER
 |.. .|  |||||.|    .      . .|  . .    ||  . ..|. .. ||..    ||  ||  |   |. .    ..  .||. .|...  |.
FKIILIGDSGVGKSCLLHRFT------DDKFSEQYK---HTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAHGC-ILVYDITNRESFEN

VNYWTLQIKANSGL--SVPMIFLVGTHCDACTPEQLSSAEQILKENFVKYSR--IRQNAISFV---SCTNGTGIKELKKILTNEAEKS
|  |  .|. ...   . . | |||  ||      |..  |. .|   |.     ... ..|    |  ..| ..|    |  .  . 
VKNWLKEIRMHANPPPENVVIMLVGNKCD------LEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR
COR Roco11.AA COR 679-1167 12 1.4e-48 155.52 In-house 45-434 (434) Show / Hide 
Range on Protein: 679-1167
Range on HMM: 45-434/434
Sequence Identity: 12% (74 aa)

NQKYIDYNDFERECKLSH-----------LAQEEIQGATEFLHNMGIILHYD----TPILRSLVVLDPQWLADVMSSLITFSHNW-----IKNGI-LNHS
....... .|   |. .            .  .|.. .. .||..|.|.|..     |.|. .|||||||....|.....  .        ..|| ..|.
EKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQ

ELVSIWSGK-----------YDQSIWPSLLKLLEKFEVSYELPN---EF----PSRSLIPSLLPEEPIDRI-QEIKEKLWIPLPEAIESKRVQIFGCQYN
.|  ||...           |...  . |..|.||||..|....   .|    ....|||.|||..  .   .. .   |         .  . ....|.
DLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQ-W-----ETNEHDCRYLRRHYH

F------DFMPLGFFPRLLLRILLIKGIDIKT----------YWANGILLDILTTE--------------DIKIQKLNHKKHSILPNNSSSTSSSTSSST
.      .|.| ||.||.. |.. .   . |.          || ||..|   . .              .|.|.    ... |                
YCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVLK-WEGHNKNEALVKCDNHDNKIYITVRGCQDCWID---------------

SSSTSSSSSSSTSSSSTSTTTTTVQIQSSPFGNSTTIVNKLTNIDNNNNNNNNNNNNNNNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIK
                                                                                                    
----------------------------------------------------------------------------------------------------

NIINNFENQNNLNNIITNNFGGKFEIIKKNDFESPLSSKKPKHQVLVTFKNQKSFESKDKDTYKLNVEIRSFNVSNNNDKDFLASLFFQQLLSTIDTLLS
                                                                                   .. ..|.. ..|. .. 
----------------------------------------------------------------------------------MCCQLWQIIRQHIQHIHN

GSY--GGLK-------VTRLIPCIHCIEKDPHSEPH--LFDINSCISQLLLGKSQLVCGKDST-----------------------TPV-RIDY
 ..   ||.       .  .||| |||....   ..   .  ..|| .   |.  ..|.|  .                        .. ||..
SWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
Kinase Roco11.AA LRRK 1185-1450 41 1.2e-152 513.41 In-house 1-351 (351) Show / Hide 
Range on Protein: 1185-1450
Range on HMM: 1-351/351
Sequence Identity: 41% (147 aa)

VVCEEQIGVGGFG-LVHKGKLILQ------------------------DKSLVVAIKSYIVG---------NSSA-------------------SDIIRK
...|||||.|||| .|...|.. |                        |..  ||||.....         ||..                   .| .|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQEFHHEMYIMSSLNHLNIVKLFGSMQNPPRMVMEFAPHGDLYHFLEKKK---------NIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLF
|.||.||..|||.||| |||.|.| . .|..||||.||||||||||..||         .|.|..| ...|.||||.|||...||||.||||.||||.|.
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

SLDEN-------APVCAKVADFGLSQ--QSLYS--VSGLLGNFQWMAPETIGAE--ESYTEKIDTYSFSMILFTILTGE-CPFDEFTSFGKMEFIRKIRE
|...|       |.||||.||||.|.  |....  ..|..||..|||||.....  |.||||.|.||| |||...||.. .||||...|..|... .|..
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

---EDLRPTIPSD-CPP-----TISNLIELCWSGDPKKRPHFSYIVKELTN
   | ||||||.. |||       ..||..||..|||||||||.||| |  
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Roco11.AA TKL 1191-1448 28 4.1e-92 312.33 In-house 1-364 (364) Show / Hide 
Range on Protein: 1191-1448
Range on HMM: 1-364/364
Sequence Identity: 28% (104 aa)

IGVGGFGLVHKGKLILQD------KSLVVAIKSYIVGNSSASDI--------------------IRKFQEFHHEMY-IMSSLNHLNIVKLFG--------
|| |||| |.|||.  ..      .. .||.| . . |.. ...                    ...|..|  |   .||.|.| |||.. |        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-SMQNP------PRMVMEFAPHGDLYHFLEKKKNIKWSFKVRLMLDIAKGIEYLQNQN------PPIVHRDLRSPNIFLFSL---------DENAPVCAK
  . .|      . .|||..|.|.|.|.|       |. ..|..||||.|..|| ..|      |||.|||| |.||....          ..||..|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VADFGLSQQSLYS----------------------VSGLLGNFQWMAPETIGAE---------------ESYTEKIDTYSFSMILFTILTGECPFDEFTS
..|||||.    |                       .   |...||||| .  .               ..|.||.| ||| ..|. |||.. |.... .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

FGKM------EFIRKIREEDLRPTIP------------SDCPPTISNLIELCWSGDPKKRPHFSYIVKEL
.  .      |.. .. .. |||.||            .|||| ...|.. ||. ||.||| |. |.|.|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Roco11.AA TKL-Unique 1187-1448 32 1.7e-61 210.6 In-house 1-290 (290) Show / Hide 
Range on Protein: 1187-1448
Range on HMM: 1-290/290
Sequence Identity: 32% (97 aa)

CEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSASDIIRKFQEFHHEMYIMSSLN-HLNIVKLFGSMQ----NPP--RMVMEFAPHGDLYHFLE-
  . || ||.| | |||     ..  ||||.  . |.. | ...  |||. |  .|. |. | |||...|        ||   .|||. |.| ||  |  
FWNKIGEGGYGQVYKGKW----RGYPVAIKQFHP-NEDSSNEMM--QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQ

---------KKKNIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLS----QQSLYSVS--------GLLGNFQWM
         ..... .. .|.. .|||.| .|| . .||| ||||.|.|. . .    |.. .|..|||||    . .  ...        . .|.|.||
NNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APETIGAE-ESYTEKIDTYSFSMILFTILTGEC------PFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVKEL
||| .  . . |.||.| |||...|  |.|..       |...... .  | ...  || .||.||..||. ...||. ||  || .|| |. |...|
APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Roco11.AA MLK 1185-1448 29 4.5e-61 209.21 In-house 1-291 (291) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-291/291
Sequence Identity: 29% (89 aa)

VVCEEQIGVGGFGLVHKGKLILQD-KSLVVAIKSYI---VGNSSASDIIRKFQEFHHEMYIMSSLNHLN-----IVKLFGSMQNPPR--MVMEFAPHGDL
   .| ||.|.|| |.||.   .|    .||.| .       .| .. ...  .|  | .. . |.|.|     |. . .. |.|.    |||....| |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQW--DFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL

YHFL---EKKKN-----------IKWSFKVRLMLDIAKGIEYLQNQNP-PIVHRDLRSPNIFLFSLDENAPVC---AKVADFGLSQ-QSLY-S-VSGLLG
|..|   ..| .           .. ..... .|..|.|..|| .. | ||.|||| |.|| .    .. . .   .|..|||.|   .   .   .  |
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAG

NFQWMAPETI--GAEESYTEKIDTYSFSMILFTILTGECPFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVKEL
.. ||||| |    .| |.|| | .|. ..|  .||.| |..       |. . .. .. |||.|||.||. ...|.. ||. ||.||| |..||..|
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK--QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Roco11.AA Dicty4 1185-1450 33 4.4e-57 189.0 In-house 1-277 (277) Show / Hide 
Range on Protein: 1185-1450
Range on HMM: 1-277/277
Sequence Identity: 33% (97 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSA-SDIIRKFQEFHHEMYIMSSLNHLNIVKLFGSMQ----NPPRM--VMEFAPHGDLYHFL
 . |. || |.|| |.||.   ..    ||.|     |  . ....   .||..|  ||... | ||... |.      .|..|  |.|. | |.||  |
INIEQRIGKGSFGEVYKGTWRGKE----VAVKKLNNHNQNFDENML---NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL

EK-------KKNIKWSFKVR---LMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQ-----QSLYS-VSGLLGNFQWMAPET
 .       .. . |.   |   ...|.|.|. .| . || |.|||| | |.     |.|  |  ||.||||||      ..    ..  |   ||||| 
HDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL---VDKNWRV--KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEV

IGAEESYTEKIDTYSFSMILFTILTGECPFD-EFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVKE--LTN
  ....|.|| | |||...|. |||.. |.  .. ..  |.|.| . .. ||| ||..||| .. ||. ||. ||..|| |. |...  |  
M-MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPY--MQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Roco11.AA Pkinase_Tyr 1185-1448 30 9.9e-50 169.05 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-270/270
Sequence Identity: 30% (87 aa)

VVCEEQIGVGGFGLVHKGKLI--LQDKSLVVAIKSYIVGNSSASDIIRKFQEFHHEMYIMSSL-NHLNIVKLFGSMQ---NP--PRMVMEFAPHGDLYHF
..  ...| | || |.||..    ... . ||.|.    ... ..   . ..| .|. ||..| .| |||.| |       |  . .|||..|||||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LEK----KKNIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQQS-----L-YSVSGLLGNFQWMAPETIGAEE
| |    |.... . ..   ..|||| ||| ..|  ..||||.  |. . .     . ..|..||||.          .. .|      ||||| |   .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

SYTEKIDTYSFSMILFTILT-GECPFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVKEL
 .|.| | .||   .. |.| || |  ..      |....| |.  |  .| .||. | .|. .||  ||..|| ||.|. .|
-FTTKSDVWSFGVLMWEIFTYGEQP--TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Roco11.AA TK 1185-1448 18 1.1e-49 164.3 In-house 1-486 (486) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-486/486
Sequence Identity: 18% (88 aa)

VVCEEQIGVGGFG---LVHKGKLILQD-----------------------KSLVVAIKSYIVG-NSSASDIIR----------KFQEFHHEMYIMSS--L
.. ....| | ||    |.||... ..                       .   ||.|    | ..|. . .           .| |. .|| .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHLNIVKLFG--------------SMQNPPRMVMEFAPHGD----LYHFLEKKKN---------------------------------------------
.| |||.|.|              . | |. .|||..||||    | ..| |...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IKWSFKVRLMLDIAKGIEYLQNQNP----PIVHRDLRSPNIFLFSLDE------NAPVCAKVADFGLS-
                               .    ..  ...||.| |||  .|      .|||||   |. ... .       . . ..|.|||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

------------QQSLYSVS------------------------GLLGNFQWMAPETIGAEE--------SYTEKIDTYSFSMILFTILT-G-ECPFDEF
             .  |..|                        |    . |||||..   .         .|.| | .||   .. |.| | | .  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TSFG------KMEFIRKIREE-------------DLRPTIPSDCP--------------PTISNLIELCWSGDPKKRPHFSYIVKEL
....        |.....|..              .|.  | .||              . .  |.  ||. ||..|| || ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Roco11.AA TyrKc 1185-1448 26 5.7e-46 159.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-280/280
Sequence Identity: 26% (82 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSASDIIRKFQEFHHEMYIMSSL--NHLNIVKLFGSMQ---------NPPRMVMEFAPHGDL
.. ....| | || |.||...     . ||.|.   .           ..|..|. ||..|  .| |||.|.|             |. .|||..|||||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

YHFLEKKKN-IKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQQS-----------LYSVS---GLL--GNFQW
 ..| |... .... ..  ...||.| |||  .  ...||||   |. . .       ..|..|||||               |...   |        |
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPETIGAEESYTEKIDTYSFSMILFTILT-GECPFDE-----FTSFGKMEFIRKIREEDLRPTIPSD-------CPPTISNLIELCWSGDPKKRPHFSY
||||.|  .  .|.| | .||   .. |.| |. |  .      . .   | |..... . .|  |.|       ||. . .... ||  ||..|| || 
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ---EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

IVKEL
|....
IHECF
Kinase Roco11.AA Gdt 1185-1448 30 1.3e-44 150.78 In-house 1-289 (289) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-289/289
Sequence Identity: 30% (91 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNS-SASDIIRKFQEFHHEMYIMSSLNHLNIVKLFGSMQNPPRM--VMEFAPHGDLYHFLEKKK
.. .| .. | || | ||.      |..||.|   .. .       . . |.  || |.| ..| ||| . |. ..      | |..| | |     .||
IDFKEYCSQGTFGMVYKGIW----RSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIGCVHFSSHHCIVTEYCPRGSLGYYIHQKK

---------------------------NIKWSF--KVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQQ--SLYSVSGL
                            || |.  |.|.|.||||| ..|.     |.||||.. ||..||..||..||||. ||| |     ... .  
NQKKSNTNTITNTITNTNTNTNTSTSTSIKMSMIQKIRIMIDIAKGCQFLHQNG--IIHRDLKPDNILIFSTNENSEVCAKICDFGTSKEINEFHCKNTN

LGNFQWMAPETIGAEESYTEKIDTYSFSMILFTILTGECPFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPT--ISNLIELCWSGDPKKRPHFSYIVKEL
 |    | .| |   |.|.. .|.||| . .. .. .. || |     . |  .... .  |||   |      |.|.|| ||. .|.||| |..|.| |
CGTMNYMSNE-IFEGENYQKSTDVYSFGILFYEMMIERIPFHEI---CHWEIPNFVQ-DGWRPTLDQDIFDDNDIRNIIECCWNKNPHKRPTFDEISKHL
Kinase Roco11.AA Dicty4-Unclassified 1185-1448 31 3.4e-44 149.24 In-house 1-263 (263) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-263/263
Sequence Identity: 31% (89 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSASDIIR--KFQEFHHEMYIMSSLNHLNIVKLFGSMQNP------PRMVMEFAPHGDLYHF
.     || | |  ||||      |   ||.|       . ..  |    |.|  |  |. |. | | ||. |   ||         |||| . | |   
IQIDQFIGKGHFSKVHKGNW----KGKDVAVKKF----NENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEV

LE-----KKKNIKWSF--KVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQ--QSLYSVSGLLGNFQWMAPETIGAEES
       ... ||      ..  .|||.|. .|   |  ..|||..| ||    .| .    .|.||||.|      .      |   | .|| .   ||
IHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNIL---MDKH--FNIKIADFGISRVIDFNFNMTTIAGTPKWESPE-CLMHES

YTEKIDTYSFSMILFTILTGECPFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVKEL
|. | | ||. |.|.  .||. |. |  |   |.  | . .  ||| ||. |.. .. ||  ||. ||.||| .  |.. |
YNQKSDVYSYAMMLYELATGDEPYQEIQSI--MNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Roco11.AA DRK 1233-1450 35 3.8e-42 140.55 In-house 42-258 (258) Show / Hide 
Range on Protein: 1233-1450
Range on HMM: 42-258/258
Sequence Identity: 35% (80 aa)

QEFHHEMYIMSSLNHLNIVKLFGSMQNPPRM--VMEFAPHGDLYHFLEKKK-NIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAP
.||| |  .|. | | ||.   |.  |||    .||. | | ||  |   .  . |.   ..|.|.|||. || . || |.|||| | |      ||.  
NEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLL---VDEHWQ

VCAKVADFGLSQ-----QSLYSVSGLLGNFQWMAPETIGAEESYTEKIDTYSFSMILFTILTGECPFDEFTSFGK--MEFIRKIREEDLRPTIPSDCPPT
|  ||||||||      ..        |   | |||   ... |||| | |||  .|  ..| . |.     ||.  .  .. .  . .|| .|  ||| 
V--KVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVL-RNQRYTEKADVYSFAIVLWECVTRQDPY-----FGMPTFQVVFSVGRHGMRPPMPQWCPPK

ISNLIELCWSGDPKKRPHFSYIVKELTN
   |.  ||. ||  || .  ... |  
YIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Roco11.AA S_TKc 1185-1452 25 5.7e-38 133.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 1185-1452
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSASDIIRKFQEFHHEMYIMSSLNHLNIVKLFGSMQ-NPPRMVMEFAPH--GDLYHFLEKKK
    ..|| |.|| |.|.. .      .||||                . .  |. |... .| |||||....| .   ||||....  |||.....|..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

N------IKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLSQQSLYSVSGLLGNFQWMAPETIGAEESYTE-KIDT
       .      ..|  |....||. ...  |.||||   ||.| .       . |..||||. |     . . |   .|||| .    .|.  |.| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDW

YSFSMILFTILTGECPFDEFTSFGKMEFIRKIREEDLRPTIPSDCPPTISNLIELCWSGDPKKRPHFSYIVK-----ELTNFY
.|.  ||.  |.|. ||.       .. ..||.            .|   ..|. |.  ||.|||    . .      .  . 
WSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Roco11.AA Pkinase 1185-1448 24 3.2e-34 122.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1185-1448
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

VVCEEQIGVGGFGLVHKGKLILQDKSLVVAIKSYIVGNSSASDIIRKFQEFHHEMYIMSSLNHLNIVKLFGSMQNPPRMV--MEFAPHG----DLYHFLE
 .....|| |.|| | |.. .   |  .||.|   . . . .  ....     | .|| .||| |||.|..........   ||....|    ||.....
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KKKNI--KWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLDENAPVCAKVADFGLS----QQSLYSVSGLLGNFQWMAPETIGAEESYTE
  .....   .    . |. |..|.||. ..   |.|||| . ||.. . ..... | |..||||.      .    ... |   .|||| |   . |. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KIDTYSFSMILFTILTGECPFDEF----TSFGKMEFIRKIREEDLRPTIPSDCP-------------------PTISNLIELCWSGDPKKRPHFSYIVKE
|.| .|.  ||.  |.|. ||..     .   .|. |..|.. .|.  .| .|.                   ..   .|. |.  |||||| .  |.. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase Roco11.AA Fer 1185-1314 33 1.4e-22 73.85 In-house 1-137 (283) Show / Hide 
Range on Protein: 1185-1314
Range on HMM: 1-137/283
Sequence Identity: 33% (47 aa)

VVCEEQIGVGGFGLVHKGK---LILQDKSLVV---AIKSYIVGNSSASDIIRKFQEFHHEMYIMSS-LNHLNIVKLFG-SMQNPPRM-VMEFAPHGDLYH
|. ....| | || |.||.    .. .|..||   |.|   . . .....  . .|| ||..|| . ..| |.||..| . .  | | ||||...|.|  
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVK--VKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDS

FLEKKKN--IKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDL
.| |.||  ..   |.|  ...|.|.|||  .|  ..|||.
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKN--CIHRDI
Kinase Roco11.AA Fer 1333-1449 26 1e-20 67.37 In-house 154-283 (283) Show / Hide 
Range on Protein: 1333-1449
Range on HMM: 154-283/283
Sequence Identity: 26% (35 aa)

KVADFGLSQQ-SLYSVSGLLG------NFQWMAPETIGAEESYTEKIDTYSFSMILFTILT-GECPFDE----FTSFGKM--EFIRKIREEDLRPTIPSD
|..|||.| | | | .. ...      .  |.||||.   . |..| | .||.  .. | | |..|. .    ..  . .  . ...|.... ....|. 
KISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMK-MTNVKKQARKWIIKKGYMMPMPNH

CPPTISNLIE-LCWSGDPKKRPHFSYIVKELT
.||.| ....  ||  ||..||... |...| 
MPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK