Gene Roco10 (Slime mold)
Roco10
Sequence
Protein domains of Roco10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RhoGAP | Roco10.AA | RhoGAP | 663-748 | 25 | 3.2e-10 | 36.2 | Pfam | 28-124 (156) | Show / Hide |
Range on Protein: 663-748 Range on HMM: 28-124/156 Sequence Identity: 25% (25 aa) KLEVENICNQYDQGIEV---SLKKCNVHVVSEILIEFFNRLPEPIISVEFYETLLN--YYQT------ETLLHLMIRKMNNPNKSILCRLMKYLKDI | ... .....|.| .| .. .||.|. .| ..| ||||... |.||.... ... ....|||. || ..|..||. |. . KSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMRELIRKLPPPNYDTLRYLMRHLHRV |
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| RhoGAP | Roco10.AA | RhoGAP | 624-804 | 15 | 3.1e-07 | 11.55 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 624-804 Range on HMM: 1-193/193 Sequence Identity: 15% (34 aa) NSSPNIINQLQQQQQPQPTTTTTTNTNTSPHQYLSQKS-IKLEVENICNQYDQGIEVS--------------LKKCNVHVVSEILIEFFNRLPEPIISVE | |. .. . . . .| . .|. . ... ..|..|.| . . . . .||.|. .| .|. ||||.| | SHIPIIVRKCIEYIEKHGMDTE----------GIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFE FYETLLNYYQT--------------------ETLLHLMIRKMNNPNKSILCRLMKYLKDIMVYTNFNDVTLELLVERFHKFILRPTIGTIAQSKEISESH || ... .. ||. |.. .... | .|| |. . . .| ... | | ...| ... LYEEFIEAMKCYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP-----------MMD LKTIKDIVTMFIQQAD . .. .| ..|...| MRHQNKCVEFLIEHYD |
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| LRR_1 | Roco10.AA | LRR_1 | 989-1010 | 25 | 0.05162 | 11.31 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 989-1010 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) DLQELNLNR-N--KF-KLLPGD-LARL ||.|.|.. | .. . .| . . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco10.AA | LRR_TYP | 987-1009 | 33 | 0.052951 | 10.31 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 987-1009 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) LKDLQELNLNRNKFKLLPGDL-AR | |.||.|..|... || .. . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1010-1033 | 25 | 0.12442 | 7.27 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1010-1033 Range on HMM: 1-24/24 Sequence Identity: 25% (6 aa) LTSLRTICIEENNLTEISSEMADF |..||. . |.||.. ... . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco10.AA | LRR_1 | 1012-1034 | 25 | 2.491584 | 5.34 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1012-1034 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) SLRTICIEE-N--NLT-EISSEMADFL .|... . | ||| .|... | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco10.AA | LRR_1 | 1062-1083 | 25 | 0.010934 | 13.7 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1062-1083 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) KLKTLNISN-N--YLT-KLPID-IFQI .|..|..|. | || ..| . . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1038-1061 | 41 | 0.102489 | 7.96 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1038-1061 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) LSNLENVTLSSNRLVVLPPLYTWL |.||. ||.|.| ||| . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1062-1083 | 50 | 0.102778 | 7.95 | SMART | 3-24 (24) | Show / Hide |
Range on Protein: 1062-1083 Range on HMM: 3-24/24 Sequence Identity: 50% (11 aa) KLKTLNISNNYLTKLPIDIFQI .|..|. ||| || || ..|| NLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco10.AA | LRR_1 | 1040-1060 | 29 | 0.231366 | 9.0 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1040-1060 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) NLENVTLSS-N--RLV-VLPP--LYTW ||. ||. | .|. .|| . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco10.AA | LRR_1 | 1109-1130 | 40 | 0.000139 | 20.42 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1109-1130 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) KLRSLDLRK-N--HLT-SIPEG-IINL .|..|||. | .|| .||.. . || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1199-1222 | 41 | 0.000192 | 22.01 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1199-1222 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) MQSLIELRLTNNNISRLPPGIVAL . .| ||.| ||....||||. . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1153-1175 | 41 | 0.000856 | 19.85 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1153-1175 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) LTSLTELNLNGNQIQSLPPQL-LL |..|.||.|..||...|||.. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1176-1198 | 37 | 0.002064 | 18.58 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1176-1198 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) LTNLKKLYLDNNQLQSISSAI-HR |.||..|.|.||||... . . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco10.AA | LRR_1 | 1155-1176 | 29 | 0.002984 | 15.7 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1155-1176 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) SLTELNLNG-N--QIQ-SLPPQ-LLLL .|..|.|.| | ... ..|| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco10.AA | LRR_1 | 1178-1199 | 25 | 0.004182 | 15.18 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1178-1199 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) NLKKLYLDN-N--QLQ-SISSA-IHRM ||..|.|.. | .|. .|.. . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco10.AA | LRR_1 | 1201-1222 | 29 | 0.004182 | 15.18 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1201-1222 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) SLIELRLTN-N--NIS-RLPPG-IVAL .| .| | . | |.. .||. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1130-1152 | 37 | 0.007289 | 16.76 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1130-1152 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) LVELQVLTLADNQISHLTSDI-QK |..|..| | .||..|| ... | LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco10.AA | LRR_1 | 1132-1153 | 25 | 0.056902 | 11.16 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1132-1153 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) ELQVLTLAD-N--QIS-HLTSD-IQKL ||.| | . | ... |. .. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco10.AA | LRR_TYP | 1108-1129 | 43 | 0.065743 | 9.54 | SMART | 2-24 (24) | Show / Hide |
Range on Protein: 1108-1129 Range on HMM: 2-24/24 Sequence Identity: 43% (10 aa) TKLRSLDLRKNHLTSIPEGI-IN ..||.||| |.||..|.|. . PNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco10.AA | LRR_1 | 1085-1107 | 24 | 1.687619 | 5.94 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1085-1107 Range on HMM: 1-26/26 Sequence Identity: 24% (7 aa) TLEVLRVSN-N--DL-DDNGIPK--ICTS .|..| .|. | | .. ||. . NLQHLDLSGCNCCNLTGH--IPPSCF-NL |
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| LRR_1 | Roco10.AA | LRR_1 | 1224-1242 | 38 | 32.354535 | 1.39 | Pfam | 1-21 (26) | Show / Hide |
Range on Protein: 1224-1242 Range on HMM: 1-21/26 Sequence Identity: 38% (8 aa) KLNSLELTG-N-KPLKDNIPE .| .| | | | .| ..||. NLQHLDLSGCNCCNLTGHIPP |
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| ROC | Roco10.AA | ROC | 1266-1354 | 20 | 1.6e-07 | 21.87 | In-house | 192-267 (215) | Show / Hide |
Range on Protein: 1266-1354 Range on HMM: 192-267/215 Sequence Identity: 20% (19 aa) CYRTRIIMLGDKSTGKSNLIKCLKKLPKSSFSSSSSNLPSLNNLNSNNSNNSGNSKTNILD-IQDWQCPIN---VDGPDGKKKKTITIHLWEF |.. .....|. ||. |.|.|.. ..| |..| . ...|. . ||.| ... ||.. |....|.| CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC-------------DKGNHPTTHGIEPIQQWVLDCKDMMF----RKKEDEIKFNVWDF |
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| COR | Roco10.AA | COR | 1460-1573 | 17 | 3e-05 | 12.6 | In-house | 313-435 (434) | Show / Hide |
Range on Protein: 1460-1573 Range on HMM: 313-435/434 Sequence Identity: 17% (23 aa) IRKLRRDIKQ--MIAKNPILKQTYPASFMFLEDYLKEESNLM----SPPLVTKKTLQQMARTME----------LHNEPHFTQLKSLFNSLGSIALFE-- ||| .. ||. | . ..| | |.. ....|.|....| . |. ..| ..|... . .. | . .. . ..||.| |. IRKTAKKIKHKQMFED--YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIW -QFIRMEPGSTPQKTEMIALNPIWIAKAIASLV .. . . |.| |......... DHDPML--------KDFVVLDPQWFCQMMYHIF |
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| ROC | Roco10.AA | ROC | 1403-1463 | 20 | 0.0002 | 11.43 | In-house | 143-215 (215) | Show / Hide |
Range on Protein: 1403-1463 Range on HMM: 143-215/215 Sequence Identity: 20% (15 aa) KKATIIIIGTHLDEISSNSKK--QVDKVFDCLSLKYKQLFPTL----------NLVFHAVSTLK-SDADGIRKL ... .||.|||.|... . .| |... . |... || . .||. .. .. |..|. QPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKLRNKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH |
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| COR | Roco10.AA | COR | 1783-1814 | 16 | 0.090599 | 1.14 | In-house | 235-284 (434) | Show / Hide |
Range on Protein: 1783-1814 Range on HMM: 235-284/434 Sequence Identity: 16% (8 aa) RRFSL------DVIPNGLFGRLLSRLMQHAHLYK------------CWKD |.. . ...|.|.. |.. || .| . .|.. RHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRN |
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| COR | Roco10.AA | COR | 1863-1963 | 13 | 1.3e-09 | 27.06 | In-house | 289-434 (434) | Show / Hide |
Range on Protein: 1863-1963 Range on HMM: 289-434/434 Sequence Identity: 13% (20 aa) QFREE---RILVNVDHDSNTIEITIRFIR------PSTLSSQVYSIFESLVSKW---YKVS-------FKTFIPCSHCIEKKIV-TPH--LFKLEECEAQ ..... .|| |.. | | ||.| . .. | ..... ..... | .. .. .||| |||... .. .....|... KWEGHNKNEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRA IFKGELGIYCQYKP----------------------NNNNS-SNDT .|.. ..|. . |.... . .. EEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD |
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| Kinase | Roco10.AA | LRRK | 2108-2342 | 31 | 5.70000000001e-105 | 355.04 | In-house | 96-351 (351) | Show / Hide |
Range on Protein: 2108-2342
Range on HMM: 96-351/351
Sequence Identity: 31% (82 aa)
NCARILSSFRHEALSLYNFRHSNVLSIIGISMNPIAIITENPTFGSKGSTTLSEYIQDRQKHP------EIPWNIKLKIALDIARAMDKLNSHSPPFLLT
.|.|....||||. .....|.|..|..|....|.....|....|. |........... .|.|..||||||.||..|..|.||.||.. .
DCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGD-----LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHR
NLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSS----FLPSLFPTSTTPKSYHSPEVLQK---LNYHENSDVYSFGIILYELLTRS-IAFQDHD
.|.| .|.|..|....|.. .....|.|||.||..|. |............ ...||.... .|.|..|.||||.||.|||||. ..|..||
DLKSPNILLWSSPQNHSPN---YPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD
---------RFSNIVISGQRPSIPLD-CLP-----SFADLIKDCWSGEPLNRPSPSKIISQLYT
......|.|.||.|| . |.| .. |||..||...|..||..|.|...| .
FFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
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| Kinase | Roco10.AA | TKL | 2116-2340 | 22 | 1.6e-51 | 177.48 | In-house | 72-364 (364) | Show / Hide |
Range on Protein: 2116-2340
Range on HMM: 72-364/364
Sequence Identity: 22% (69 aa)
FRHEALSLYNFRHSNVLSIIG---------ISMNP------IAIITENPTFGSKGSTTLSEYIQDRQKHPEIPWNIKLKIALDIARAMDKLNSHS-----
.. |.... ..|| |.....| ..|.| ..|..| || .. . |. ....||||||.|. | |.
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT
-PPFLLTNLTSSGIILEKSNDHQS-------SGNGLEIEPFVNAKIIDFSQSSFLPS--------------LFPTSTTPKSYHSPEVLQKL---------
|| . .|.|. | . . . ..| . . | | .. .. |... . | . . .||||..
KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI
-------NYHENSDVYSFGIILYELLTRSIAFQDHDRF------------SNIVISGQRPSIP------------LDCLPSFADLIKDCWSGEPLNRPSP
| | .|||||||.|.|.||| . ..|.. . . .. |.|| || ||.||...|..|||. .| .|||
DEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSF
SKIISQL
..|...|
QEILKRL
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| Kinase | Roco10.AA | TKL-Unique | 2116-2340 | 27 | 1.4e-34 | 119.44 | In-house | 42-290 (290) | Show / Hide |
Range on Protein: 2116-2340 Range on HMM: 42-290/290 Sequence Identity: 27% (72 aa) FRHEALSLYNFR-HSNVLSIIGISM----NPI--AIITENPTFGSKGSTTLSEYIQD--------RQKHPEIPWNIKLKIALDIARAMDKLNSHSPPFLL |. | . ... | |.. ..|..| |. |..| . . || | ..... ..... .... ..|.|.|||..|. | . .|| . FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME---YCPGGS--LYDVLHQNNNNNNNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIH TNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSSFLPSLFPTSTTPK------------SYHSPEVLQK--LNYHENSDVYSFGIILYELLTRS ..|.|| . . |.. | . .|.||.||. | |. . .... . . .|||| | | ||||||||.|.|..|| RDLKSSNFLVD---------NNSNIAE-WNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK I------AFQDHDRF--SNIVIS---GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL | .|. |. .| . ..|| || .| ... |||..|| .| .||| . ||. | ITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | Roco10.AA | Dicty4 | 2255-2342 | 40 | 6.3e-32 | 103.89 | In-house | 183-277 (277) | Show / Hide |
Range on Protein: 2255-2342 Range on HMM: 183-277/277 Sequence Identity: 40% (38 aa) YHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQ-DHDRFSNIVIS----GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQ--LYT . .|||... | | .|||||||.|.|.||| . .| |. . ..|.. . ||.|| .|.||...||..||. .| .||| . ||.. | . WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | Roco10.AA | MLK | 2257-2340 | 34 | 1.1e-25 | 86.2 | In-house | 201-291 (291) | Show / Hide |
Range on Protein: 2257-2340 Range on HMM: 201-291/291 Sequence Identity: 34% (31 aa) SPEVL---QKLNYHENSDVYSFGIILYELLTRSIAFQ-DHD---RFSNIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL .|||. . | | .||.|.|..|.|.||| . .. ..| .. .. |.|| || .| .... |.|.||. .| .||| . |...| APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | Roco10.AA | Dicty5 | 2255-2344 | 36 | 4.9e-25 | 83.1 | In-house | 169-260 (260) | Show / Hide |
Range on Protein: 2255-2344 Range on HMM: 169-260/260 Sequence Identity: 36% (34 aa) YHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFS--NIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQLYTIK . ..|. . ||. |||||||.|.|..|| .. . . . ..| .| || || || ... ||| || | |||| .|. . | WMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | Roco10.AA | Shk | 2258-2345 | 41 | 1.5e-22 | 77.74 | In-house | 175-269 (269) | Show / Hide |
Range on Protein: 2258-2345 Range on HMM: 175-269/269 Sequence Identity: 41% (39 aa) PEVLQKLNYHENSDVYSFGIILYELLTRSIAFQ----DHDRFSN-IVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQ--LYTIKK |||... | | .|||||||||.|.||. . . | | . |. ||.|| ||..| .|| || .| .||| . ||.. | .| PEVMMNHPYNEKADVYSFGIILWEILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI |
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| Kinase | Roco10.AA | DRK | 2257-2342 | 37 | 5.9e-21 | 67.75 | In-house | 170-258 (258) | Show / Hide |
Range on Protein: 2257-2342 Range on HMM: 170-258/258 Sequence Identity: 37% (34 aa) SPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFSNIVIS-GQ---RPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQLYT .|||| | | |||||.|.| |..|| . .. | .|.| |. || .| | | .. |..|||. .| ||| .. | APEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTF-QVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | Roco10.AA | MLK | 2258-2340 | 33 | 2.7e-20 | 63.6 | In-house | 195-280 (280) | Show / Hide |
Range on Protein: 2258-2340 Range on HMM: 195-280/280 Sequence Identity: 33% (29 aa) PEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDRFS---NIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL |||... . . ||| |.|..| ||||. .. .| . . . .. .|| | .| |..||| .| ||. |.|. || PEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL |
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| Kinase | Roco10.AA | Dicty4-Unclassified | 2110-2340 | 30 | 3.7e-20 | 65.69 | In-house | 37-263 (263) | Show / Hide |
Range on Protein: 2110-2340 Range on HMM: 37-263/263 Sequence Identity: 30% (75 aa) AR--ILSSFRHEALSLYNFRHSNVLSIIGISMNP------IAIITENPTFGSKGSTTLSEYIQ----DRQKHPEIPWNIKLKIALDIARAMDKLNSHSPP .| .. |. | | | | . . | ..|| . |..| | || .| | | ..|. . .|.|.|||. | | |. FREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVME---FMHKG--NLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHL--HTRN FLLTNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQS---SFLPSLFPTSTTPKSYHSPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDHDR | . || | . | . |.|| || | .| . ||| |||.| | |||||....||||.| .|. FIHRDIKSSNILMDKHF---------------NIKIADFGISRVIDFNFNMTTIAGTPK-WESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQS FSNIVIS----GQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL |. .| . || || | . . |||.||. .| ||. .|| | IMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| TyrKc | Roco10.AA | TyrKc | 2082-2340 | 15 | 5.1e-13 | -12.22 | SMART | 16-280 (280) | Show / Hide |
Range on Protein: 2082-2340 Range on HMM: 16-280/280 Sequence Identity: 15% (50 aa) MMGMYGKQFVNIKVFNAPLLGADFQNNCARILSSFRHEALSLYNF--RHSNVLSIIGISM---------NPIAIITENPTFGSKGSTTLSEYIQDRQKHP . |.. . | .|. .. . |..|| . .. .| |.. ..|. . |. |..| . ..|. | .|....... YKGTWK-IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME---YMPHGD--LKDYLRKHRPK- EIPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSSGNGLEIEPFV---------------NAKIIDFSQSSFLPSL----FPTSTT ... .|.....||. |. | |. ... .|| || | .. . ... -LCMKDLLSFCWQIACGMEYLHSK--------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYY PK----SYH--------SPEVLQKLNYHENSDVYSFGIILYELLTRSIAFQDH--------DRFSNIVISGQRPSIPLD--------CLPSFADLIKDCW | . . .||.... . . |||.|||. ..|..|. .. . | .| |. .| . | . ...|.|| RKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW SGEPLNRPSPSKIISQL .| .||. | |.... HEDPEDRPTFSEIHECF |
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| Kinase | Roco10.AA | Pkinase_Tyr | 2257-2340 | 29 | 1.8e-12 | 42.88 | Pfam | 182-270 (270) | Show / Hide |
Range on Protein: 2257-2340 Range on HMM: 182-270/270 Sequence Identity: 29% (26 aa) SPEVLQKLNYHENSDVYSFGIILYELLT---RS-IAFQDHDRFSNIV-ISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIISQL .||... . . |||.|||. ..|..| . . .. . . .|.| .| .| . ||.|.|| .| .||. | |..|| APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Roco10.AA | Pkinase | 2255-2340 | 23 | 8.5e-11 | 39.25 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 2255-2340 Range on HMM: 177-293/293 Sequence Identity: 23% (27 aa) YHSPEVLQ-KLNYHENSDVYSFGIILYELLTRSIAFQDH------DRFSNIVISGQ---RPSIPLDCL-------------------PSFADLIKDCWSG | .|||.. | .|..|.|.||||.|.. |..| | |. .. . ..| .| ... |.||.|. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK EPLNRPSPSKIISQ--L | ||.. | . DPKKRPTAEQILQHPWF |
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| S_TKc | Roco10.AA | S_TKc | 2060-2342 | 17 | 3.8e-10 | -28.04 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2060-2342
Range on HMM: 1-231/231
Sequence Identity: 17% (53 aa)
YREIEVLPDHSNQNENGTSTQSMMGMYGK--QFVNIKVFNAPLLGADFQNNCARILSSFRHEALSLYNFRHSNVLSIIGISM-NPIAIITENPTFGSKGS
|. .... |. . . . | . | ||. . ..| | | . .| |. .... . . ...| .
YEILRKI-------GKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVME------YCD
T---TLSEYIQDRQKHPE---IPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSSGNGLEIEPFVNAKIIDFSQSSFLPSLFPTST
. .| .||..|..|. .| ... |..|.. . || .. | . | | . . ||.|| . .| |
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----------------HIKICDFGLARQL----TTFC
TPKSYHSPEVLQKLNYHE-NSDVYSFGIILYELLTRSIAFQDHDRFSNIVISGQRPSIPLDCLPSFADLIKDCWSGEPLNRPSPSKIIS-------QLYT
| .|||| | .|..|.|.||||.|.. |..... ... |.. |.|. |. .| .||. .. .
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Roco10.AA | Pkinase_Tyr | 2112-2189 | 19 | 0.00032 | 14.92 | Pfam | 145-224 (270) | Show / Hide |
Range on Protein: 2112-2189 Range on HMM: 145-224/270 Sequence Identity: 19% (17 aa) ILSSFRHEALSLYNF-RHSNVLSIIGISM---NP--IAIITENPTFGSKGSTTLSEYIQDR---QKHPEIPWNIKLKIALDIARAMD .. .| .|| . .. .| |... .|. . | | |..| | | .| ... .... ... .|.....||..|. CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-----DLLDYLRKHREDKQPLTMKD--LLQMCWQIAKGME |
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| Kinase | Roco10.AA | MLK | 2116-2189 | 18 | 0.001339 | 8.51 | In-house | 52-138 (291) | Show / Hide |
Range on Protein: 2116-2189 Range on HMM: 52-138/291 Sequence Identity: 18% (17 aa) FRHEALSLYNFRHSN----VLSIIGISMNP---IAIITENPTFGSKGSTTLSEYIQDRQKHPE-----------IPWNIKLKIALDIARAMD |. |. | ..| | . . |.. .| .|..| . ..|| |.... ....... .. ....||..||.|. FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVME---YCEGGS--LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMH |
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| Kinase | Roco10.AA | Dicty5 | 2158-2188 | 28 | 0.028451 | 3.62 | In-house | 85-117 (260) | Show / Hide |
Range on Protein: 2158-2188 Range on HMM: 85-117/260 Sequence Identity: 28% (10 aa) TLSEYIQDRQK----HPEIPWNIKLKIALDIARAM .|..| |. | . .. .| .|.|||..| SLFNYLNDQRKTTGQPIAYF--QQLHMAIDIAQSM |
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| Kinase | Roco10.AA | Dicty4 | 2112-2186 | 25 | 0.268959 | 0.28 | In-house | 41-123 (277) | Show / Hide |
Range on Protein: 2112-2186 Range on HMM: 41-123/277 Sequence Identity: 25% (22 aa) ILSSFRHEALSLYNFRHSNVLSIIGISM----NP--IAIITENPTFGSKGSTTLSEYIQD----RQKHPEIPWNIKLK---IALDIAR .|..||.|. . . || |.. | . .| . | || . .||. | . . | |. ...| .. .|.|.|| MLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTE---YMPKGN--LYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAAR |
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| Kelch_1 | Roco10.AA | Kelch_1 | 2368-2404 | 18 | 0.982233 | 6.4 | Pfam | 1-35 (45) | Show / Hide |
Range on Protein: 2368-2404 Range on HMM: 1-35/45 Sequence Identity: 18% (7 aa) PLPSGGSIIYQDKIIHFGGWNNSSKPHSKVFALNLSS | . |. ...|| .||... . ..|....... PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPET |
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| RGS | Roco10.AA | RGS | 2430-2525 | 25 | 1.7e-10 | 36.69 | Pfam | 20-115 (124) | Show / Hide |
Range on Protein: 2430-2525 Range on HMM: 20-115/124 Sequence Identity: 25% (25 aa) MQSEFNE-ENLMFYEAIKTFKSLPNQTPDDREIIKIQ-SKKIYQVFIGENAPKEI-NLPFLLKKELKNKIDFPDGPSVTVFNDTLTFVISSIE-DSFHRF ..||| | ||. |..|.. || . .|..| .. . ..||. .| ...|.|. |... ......... . |. ..|.. . . . .| ||. || LESEFCEYENIEFWLACEDFKKMF---SDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQA-QPTPDCFDEAQRHIYTLMEKDSYPRF |
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| RGS | Roco10.AA | RGS | 2410-2528 | 19 | 3.2e-08 | 34.54 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 2410-2528 Range on HMM: 1-121/121 Sequence Identity: 19% (26 aa) KLMVVLNNKQSTTYKAFYTHMQSEFNE--ENLMFYEAIKTFKSLPNQTPDDREIIKIQSKKIYQVFIGENAPK--EINLPFLLKKELKNKIDFPDGPSVT . .. .. . |. ...|| | ||| |..|.. || ... | .. ..||. .| .|||. ..|... ....... .. |. . SFHHLCD-NDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED------EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN---PHPD VFNDTLTFVISSI-EDSFHRF-------KFT .|.. .. | . .||..|| .. CFDEAQRHVYQLMEKDSYPRFLRSDYYKRYL |
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| Kelch_1 | Roco10.AA | Kelch_1 | 2549-2595 | 27 | 0.000346 | 18.78 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 2549-2595 Range on HMM: 1-45/45 Sequence Identity: 27% (13 aa) PMVGHSSILWNNSLIVIGGWFNKARLLNQIHILNLETFEWNQFVCTG | .||.. |. . ||||. . . || . ....|| .| . . PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPETNQWTRCPPMP |
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| LRR_1 | Roco10.AA | LRR_1 | 2582-2605 | 33 | 28.052265 | 1.61 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 2582-2605 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) NLETFEWNQF---VCTGDIPPSSIAAL ||.. . . ||.||||.. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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