Gene DDB0229848 (Slime mold)

DDB0229848

Species: Slime mold
Alias: DDB0229848, DdisK186
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: ARK

Sequence

Name Sequence Type Origin Length Description Download
DDB0229848.AA Protein None 986 None Fasta, JSON
DDB0229848.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of DDB0229848.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2 DDB0229848.AA C2 8-90 43 4.1e-24 84.72 Pfam 1-90 (90) Show / Hide 
Range on Protein: 8-90
Range on HMM: 1-90/90
Sequence Identity: 43% (40 aa)

VRIEVLEGRNLVPMD--SNGMSDPYGVVIVGD-----KKKKTKAIKHTLFPKWESDNCFEFDIDVNLLAI--TVEVYDWDRFSSDDRMGLTN
.|. |.|.||| |||  .|| |||| .| .|.     .|.||| || || |.|.    |.||.... |.   ...|.|||||..|| .| ..
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWN--ETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 DDB0229848.AA C2 7-105 23 1.3e-13 52.5 SMART 1-92 (92) Show / Hide 
Range on Protein: 7-105
Range on HMM: 1-92/92
Sequence Identity: 23% (28 aa)

SVRIEVLEGRNLVPMDSNGMSDPYGVVIVGDKKKKTKAIKHTL---FPKWESD-NCFEFDIDVNLLAITVEVYDWDRFSSDDRMGLTNIP----------
.... ..|.|||         ||| .|       ||| .|.||    |.|.     |.||..     ...||.|.      | .| ..||          
TLTVHIIEARNLP--------DPYVKVY------KTKVVKNTLSGFNPVWNEWMETFYFDVHP--Q-LRFEVWDH------DFIGHCCIPPNNPHWHQWD

----VSQIQEYIVDTTK
    .|.|.    .   
GCIHLSDIL-GYRH-WW
Ank DDB0229848.AA Ank 205-241 24 3e-06 27.04 Pfam 1-33 (33) Show / Hide 
Range on Protein: 205-241
Range on HMM: 1-33/33
Sequence Identity: 24% (9 aa)

HGNTPLHLFVQKNVSLNCEDIINKLIERGCGINDENN
.|.||||| ....    .....  |...|. .|  ..
DGFTPLHLACRCG----HTEVVKMLLQHGADVNAQDD
Ank DDB0229848.AA Ank 278-310 39 1.1e-05 24.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 278-310
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

TRDTPLHYAIKVGKVEFVRFFLQNGANVMIEGG
  .||||.|.. | .| |...||.||.| .   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank DDB0229848.AA Ank 242-277 41 8e-05 21.66 Pfam 1-33 (33) Show / Hide 
Range on Protein: 242-277
Range on HMM: 1-33/33
Sequence Identity: 41% (15 aa)

LGETALHKACLATVVQKTTIVEQLLQKGAIINHQTK
 |.|.|| ||.      | .|. |||.|| .|.|..
DGFTPLHLACRCG---HTEVVKMLLQHGADVNAQDD
Ank DDB0229848.AA Ank 171-204 26 0.005968 14.9 Pfam 1-33 (33) Show / Hide 
Range on Protein: 171-204
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

EGTPAIHIAAASNNIPLITMLLKGSDARVSIRDQ
.|  . |.|. ....  ..|||.   | | ..| 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Sam7 DDB0229848.AA sam7 333-394 15 1.2e-07 25.08 In-house 1-70 (70) Show / Hide 
Range on Protein: 333-394
Range on HMM: 1-70/70
Sequence Identity: 15% (11 aa)

EKVIEISDWLNELQL---ETLIPKFIKNEI-----YMDVITDINEGTLDLLNISVSGQRTKLLRAVRKIK
  . ....|| ....   .  ...| ...|      .|..  ..|  |  ..|.  | | |.........
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 DDB0229848.AA SAM_2 330-394 14 5.5e-05 19.96 Pfam 1-71 (71) Show / Hide 
Range on Protein: 330-394
Range on HMM: 1-71/71
Sequence Identity: 14% (10 aa)

SKVEKVIEISDWLNELQL-ETLIPKFIKNEIYM-DVI-TDINEGTL--D-LLNISVSGQRTKLLRAVRKIK
 ..  . ....|| .. . .   ..| ...|   ...   ... .|     ..|.  |.| |..... ..|
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM_1 DDB0229848.AA SAM_1 331-394 18 7.1e-05 20.27 Pfam 1-66 (66) Show / Hide 
Range on Protein: 331-394
Range on HMM: 1-66/66
Sequence Identity: 18% (12 aa)

KVEKVIEISDWLNELQLETLIPKF-IKNEIYMDVITDINEGTLDL-LNISVSGQRTKLLRAVRKIK
 .  .  ...||... ..  |. |  ...| || .... .  |   ...   | | |....... |
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Kinase DDB0229848.AA ARK 601-861 59 8.20000000001e-201 673.41 In-house 1-280 (280) Show / Hide 
Range on Protein: 601-861
Range on HMM: 1-280/280
Sequence Identity: 59% (166 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKS-FTDKKDIAEFKKEFQIVSALRAPGVVYFHGAGIKD-----KLCIVMEYCSRGSLYHILKDDTTQFTW
|.|....|.|.|.|||||...|.||||||||| .||...|.||||||||.|..|.|.||||.||.|..     |||.|||||||||||||.......|.|
LEYTCKIGSGSSCKVYKGKYRGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDFGW

DNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSRFDTGSNLETLGKLRGTYAYVAPEVYF-----------GKKYTTKSDVYS
|.||....|.......|||||||..|||||||||||.||||.|.||||||||.|.||.|||||.|||.||.|||||.           ||.|||||||||
DRFFKWMMQMVRGINCLHNWTPQIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYS

MGIILWEMTYRCIKGTHLLPYAEYPHLK--FDYQILISSAKKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFYEE
||||.|||.||||.|....||.||.|.|  ||.||||...|...|||.|.|.||.|||||......|...||.. |..||
MGIIMWEMVYRCINGCYMRPYSEYKHIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE
Kinase DDB0229848.AA TKL 607-862 27 7.5e-84 284.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 607-862
Range on HMM: 1-364/364
Sequence Identity: 27% (104 aa)

LGTGASGKVYKGTFNG----------QEVAIKVLKS----FTDKKD---------------------IAEFKKEFQ-IVSALRAPGVVYFHGAGIKDK--
.| |..|.||||...|          ..||.|..||    ...|..                     . .|..|   . | || | .| | |. .  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCIVMEYCSRGSLYHILKDDTTQFTWDNFFNLGTQAINSLDSLHNWT------PQVLHRDLKSLNLLVTENWT--------------V
            ||||||||..|||.|.|        |. ....  ..   .. ||...      |...|||||| |.|| ||||              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KICDFGLSRFDTGS------------------NLETLGKLRGTYAYVAPEVYFGK----------------KYTTKSDVYSMGIILWEMTYRCIKGTHLL
|||||||||| ..|                  | .|... .||... ||||  |.                .|..|.||||.||.|||.  ||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

PYAEYPHLKFDYQ-----ILISSAKKDVRPTTP------------ENAPESLKNLIARTLVKDSTLRPTTLEFYEEL
||..||.   . |     ...  ..|  ||. |            ...|.|.|.|. .    | . ||. .|  ..|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DDB0229848.AA TKL-Unique 606-862 30 2.8e-66 226.53 In-house 4-290 (290) Show / Hide 
Range on Protein: 606-862
Range on HMM: 4-290/290
Sequence Identity: 30% (89 aa)

LLGTGASGKVYKGTFNGQEVAIKVLK--SFTDKKDIAEFKKEFQIVSALR-APGVVYFHGAGI----KDK-LCIVMEYCSRGSLYHILK---------DD
..|.|..|.||||...| .||||...  .   .. . ||..|  . . |. .| .| . |. .    . . .|||||||..||||  |           .
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

TTQFTWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTEN-----WTVKICDFGLSRFDTGSNLETLGKL--------RGTYAYVAPEVYFG--K
 . ... .. ..  ..   .. ||.  | ..||||||.|.||..|     | .||||||||.| . .| .|.. .         |.. ..||||  .  .
NCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFC

KYTTKSDVYSMGIILWEMTYRCIKGTHLLPYAEYPHLKFDYQILISSAKKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFYEEL
.|..|||||| ||.|||.  |.|  |   || ..   ....... .  ..  ||. |.. |.....|| .    |.. ||.  | ...|
QYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DDB0229848.AA Dicty4 601-843 34 7.2e-62 205.17 In-house 1-254 (277) Show / Hide 
Range on Protein: 601-843
Range on HMM: 1-254/277
Sequence Identity: 34% (91 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVL---KSFTDKKDIAEFKKEFQIVSALRAPGVVYFHGAGI-----KDKLCIVMEYCSRGSLYHILKD-----
..  ...|.|. |.|||||  |.|||.|.|   .   | . . ||.||  | . .| | .. | || .     . |.|||.||...|.|| .| |     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-DTTQFTWDNFFN---LGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSR-FDTGSNLET-LGKLRGTYAYVAPEVYFGKKYTTKSDV
 . ..  |  .     ..  |   .  ||. .| ..|||||| |||| .||.||.||||||. . ..... . .    || ...||||  .. |. |.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSMGIILWEMTYRCIKGTHLLPYA-EYPHLKFDYQILISSAKKDVRPTTPENAPESLKNLIAR
|| ||.|||.       |   ||. ..  .    |. .. . |  ||  | . | |.| ||..
YSFGIVLWEIL------TRQEPYQKHHMPY---MQFVRAVCNKKLRPPIPDWCPPSWKHLIQW
Kinase DDB0229848.AA MLK 601-862 30 8.2e-53 181.52 In-house 1-291 (291) Show / Hide 
Range on Protein: 601-862
Range on HMM: 1-291/291
Sequence Identity: 30% (92 aa)

LTYNVLLGTGASGKVYKGTFNGQE-----VAIKVLKS--FTDKKD----IAEFKKEFQIVSALRAPG----VVYFHGAGIKD-K-LCIVMEYCSRGSLYH
..    .| |..|||.||.. ...     ||.|  ..  | || |    . .|..|. ... |. |     ...| |. ... . .|||||||. ||||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ILKDDTT-------------QFTWDNFFNLGTQAINSLDSLHNWTP-QVLHRDLKSLNLLVTE------NWTVKICDFGLSRFDTGSNLETLGKLRGTYA
.|.. ..               . | ..|  .|  . .. ||.  | .. |||||| |.|..|      . |.||||||.||. . .  ..  . .||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YVAPEVY---FGKKYTTKSDVYSMGIILWEMTYRCIKGTHLLPYA-EYPHLKFDYQILISSAKKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFY
. ||||     . ||. |.||.| |..||||       |  .||. .|  .    .|..  | .  ||. | ..||..|.|. .    |.  ||.  .  
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML------TREVPYKQHYDPM----AIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIV

EEL
..|
QHL
Kinase DDB0229848.AA DRK 601-868 33 1e-49 166.59 In-house 1-258 (258) Show / Hide 
Range on Protein: 601-868
Range on HMM: 1-258/258
Sequence Identity: 33% (90 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKSF-TD-KKDIAEFKKEFQIVSALRAPGVVYFHGA-GIKDKLCIVMEYCSRGSLYHILKDDTTQFTWDNF
    .  | |  | |. ||  | .||.| |.    .  . . ||..|  . . || | .. | |.  .    ||.||| .||||| || |.  .  |   
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

FNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLS-RFDTGSNLETLGKLRGTYAYVAPEVYFGKKYTTKSDVYSMGIILWEMTYRCI
  ..  .   .  ||. .| ..|||||| |||| |.| ||. ||||| ||       .     ||   .||||     || | |||| .|.|||.  | .
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

KGTHLLPYAEYPHLKFDYQILISSAKKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFYEELLKIRDE
      ||.  | .    |. .|  .   || .|.. |     |. . .  | . ||.     .| |.. . 
------PYFGMPTF----QVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPS----MQECLERLEA
Kinase DDB0229848.AA Dicty5 601-791 35 2.1e-47 161.22 In-house 1-196 (260) Show / Hide 
Range on Protein: 601-791
Range on HMM: 1-196/260
Sequence Identity: 35% (71 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKSFT-DKKDIAEFKKEFQIVSALR--APGVVYFHGAGIKDKLC--IVMEYCSRGSLYHILKDDTT----Q
         ||||.||.| ..|  |||||. .      |. ||..|  |.|.     | .. . ||. ...    .| |||..|||   |.|        
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP

FTWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSR-FDTGSNLET-LGKLRGTYAYVAPEVYFGKKYTTKSDVYSMGIILW
  .     .   . .|.  ||     . ||||||.| |.||||..|| ||| ||  |   .  . .    || .. |.|.. |. |. | |||| ||.||
IAYFQQLHMAIDIAQSMRHLHSM--NIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHV----GTQCWMACELFNGQPYHQKCDVYSFGIVLW

EM
||
EM
Kinase DDB0229848.AA S_TKc 601-863 26 4.3e-43 150.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 601-863
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

LTYNVLLGTGASGKVYKGTFNG--QEVAIKVLKSFTDKKDIAEFKKEFQIVSALRAPGVVYFHGAGIKDKLCIVMEYCSR--GSLYHILKDDTTQ-----
 .   ..| || |||||.. ..  ..||||..|          ...| || .  . | .| ....   |.|..|||||.   |.|....|.  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSRFDTGSNLETLGKLRGTYAYVAPEVYFGKKYTT-KSDVYSMGIILWE
|.      .  | .. |. .|.   ...|||||  |.|..|  ..|||||||.|.           . ||  |.||||    .|.. |.|..| |.||.|
FPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MTYRCIKGTHLLPYAEYPHLKFDYQILISSAKKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFYE--------ELL
| ...       |.    ...  ....                ....|..| . |.|| . |||  |  .        . .
MLCGY------PPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229848.AA Pkinase 601-862 26 1.4e-42 151.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 601-862
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

LTYNVLLGTGASGKVYKGTFNGQE--VAIKVLKSFTDKK--DIAEFK-KEFQIVSALRAPGVVYFHGAGI-KDKLCIVMEYCSRG----SLYHILK-DDT
..    .| |..|.|||..  | .  ||.|..|  ..|.  |.. ..  | ||   |. | .| ....   ||....|||||  |    .|..... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TQF--TWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTV----KICDFGLSR-FDTGSNLETLGKLRGTYAYVAPEVYF-GKKYTTKSDV
. |  ...   .  .| .  |. .|.    ..|||||. |.|. .| ..    |||||||.. ||   | . .  . ||. |.||||   |..|..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSMGIILWEMTYRCIKGTHLLPYAE-----YPHLKFDYQILISSAKKDVRPTTPE---------------NAPESLKNLIARTLVKDSTLRPTTLEFYEE
.|.|.||.||  .      .. . .     . ...  ..|.    . |   . ..               |..|..| .| . | || . |||  .  . 
WSCGCILYEMLCGR-----PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase DDB0229848.AA TKL-ciliate2 601-794 35 9.2e-37 119.87 In-house 1-214 (273) Show / Hide 
Range on Protein: 601-794
Range on HMM: 1-214/273
Sequence Identity: 35% (76 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKSFTDKK-DIAEFKKEFQIVSALRAPGVVYFHGAGIKD-KLCIVMEYCSRGSLYHILKDDTTQFTWDNFF
|. .  .  |  | .||  .    ||.|  |   |..  | .|  | . . ||| | .| | ||  |    ||.|||| ||||. .|...  . ||.   
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

NLGTQAINSLDSLHNWTPQVLHRDLK--------------------SLNLLVTENWTVKICDFGLSRFDTGSNLETLGKLRGTYAYVAPEVYFGKKYTTK
 .   .      ||   | ..|||||                    |||.|| .|   |. |||  |     |  |  |. ||| ..||||     || |
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTN-KI-GTYQWMAPEVIKAFYYTEK

SDVYSMGIILWEMTYR
 ||.| .|||||.  |
ADVFSYSIILWEIASR
Kinase DDB0229848.AA STE 602-863 19 1.6e-36 126.53 In-house 1-359 (359) Show / Hide 
Range on Protein: 602-863
Range on HMM: 1-359/359
Sequence Identity: 19% (73 aa)

TYN-VLLGTGASGKVYKGT--------FNGQE---------VAIKVLKSFTDK----------------KDIAEFKKEFQIVSALR--APGVVYFHGAGI
  .   .| ||.|.|||.          .|..         .|||...  ...                ... ...|| .| . ..   | .| ..|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD--------KLCIVMEYCSRGSLYHILK-DDTTQFT------------WDNFFNLGTQAINS-LDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGL
|.        .|.|.|||.. |||  |.|    ....             .       | .   |. ||.    . |||.|. | |.     ||.||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

SRFDTG---------------SNLETLGKLRGTYAYVAPEVYFG------KKYTTKSDVYSMGIILWEMTYRCIKGTHLLPYAEYPHLKFDYQILISSAK
.   |                .. .    . ||  . ||||  .      |.|.||.|..| |. ..||       |   |........  ..|......
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM------ATGKPPWHDMHPMRAMFMIPFNYHM

KD----------VRPTTPENAP-------------------ESLKNLIARTLVKDSTLRPTTLEFYE---ELL
 .            |. |..                     ...|. |.. |.||   |||. .  .   . .
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase DDB0229848.AA Pkinase_Tyr 601-791 32 4.7e-35 119.35 Pfam 1-207 (270) Show / Hide 
Range on Protein: 601-791
Range on HMM: 1-207/270
Sequence Identity: 32% (68 aa)

LTYNVLLGTGASGKVYKGTFN------GQEVAIKVLKSFTDKKD--IAEFKKEFQIVSAL-RAPGVVYFHGAGI--KDK--LCIVMEYCSRGSLYHILKD
.| .  || || |.||||| .      ...||.|.||  .....  ...| .| .| . | . | .| ..|. .  ..   ..|||||.  |.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D---TTQFTWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSRF-DTGSNL-ETLGKLRGTYAYVAPEVYFGKKYTTKSDVY
      ..|     .  .|  . .. |..      ||||   | ||||| .||||||||.|     ..   . |. .      |||. . .|.||||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SMGIILWEM
| |. .||.
SFGVLMWEI
Kinase DDB0229848.AA TyrKc 601-862 28 1.3e-29 105.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 601-862
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKSFTDKKDIAEFKKEFQIVSAL--RAPGVVYFHGAGIK--------DKLCIVMEYCSRGSLYHILKDDTT
.| .  || || |.||||| . ..||.|.||. .    ...| .| .| . |  . | .| ..|. ..        . |.|||||.. |.| . |..   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QFTWDNFFNLGTQAINSLDSLHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSRFDTGS-----NLETLGK-----LR--GTYAYVAPEVYFGKKYTTK
..... . .  .|. .  . ||    .. ||||   | ||.|| ||||.||||||. .       . ..  |      .    .   |||. . .|.|||
KLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVYSMGIILWEMTYRCIKGTHLLPYAE---YPHLKFDYQILISSAKKDVRPTTPEN--------APESLKNLIARTLVKDSTLRPTTLEFYEEL
|||.| |. .||.  .. .     || .       . . | .|   |.  |.  |.|        .|. . ... .    |   |||  | .|..
SDVWSFGVCMWEIFTYGQQ-----PYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229848.AA Shk 711-791 46 1.5e-26 92.2 In-house 117-199 (269) Show / Hide 
Range on Protein: 711-791
Range on HMM: 117-199/269
Sequence Identity: 46% (39 aa)

LHNWTPQVLHRDLKSLNLLVTENWTVKICDFGLSR-FDTGSNLET-LGKLRGTYAYVAPEVYFGKKYTTKSDVYSMGIILWEM
||   .  .|||||. |||| .||.||.||||.|    ....|   .    ||  . ||||  .. |  |.|||| ||||||.
LHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEI
Kinase DDB0229848.AA Shk 601-691 35 9.2e-15 49.55 In-house 1-94 (269) Show / Hide 
Range on Protein: 601-691
Range on HMM: 1-94/269
Sequence Identity: 35% (33 aa)

LTYNVLLGTGASGKVYKGTFNGQEVAIKVLKSF-TDKKDIAEFKKEFQIVSALRAPGVVYFHGA--GIKDKLCIVMEYCSRGSLYHILKDDTTQ
 .   .||.|. ||||||.  |.|||.||..    | .   .|.|| .| | .. | .. | ||   .  |. || | . .|.|   |.|. ..
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVK
Kinase DDB0229848.AA TKL-ciliate2 822-863 33 0.000118 10.81 In-house 232-273 (273) Show / Hide 
Range on Protein: 822-863
Range on HMM: 232-273/273
Sequence Identity: 33% (14 aa)

KKDVRPTTPENAPESLKNLIARTLVKDSTLRPTTLEFYEELL
.. .||| | | |  . .|. |    .  |||.  |   || 
CNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase DDB0229848.AA Shk 826-843 50 0.185427 1.45 In-house 226-243 (269) Show / Hide 
Range on Protein: 826-843
Range on HMM: 226-243/269
Sequence Identity: 50% (9 aa)

RPTTPENAPESLKNLIAR
||  |   | ||| ||..
RPPIPDDCPKSLKHLIQK