Gene DDB0220138 (Slime mold)
DDB0220138
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0220138.AA | Protein | None | 1248 | None | Fasta, JSON |
| DDB0220138.kin_dom | Protein Kinase Domain | None | 291 | None | Fasta, JSON |
Protein domains of DDB0220138.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRR_TYP | DDB0220138.AA | LRR_TYP | 501-524 | 41 | 0.000338 | 21.19 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 501-524 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) LYNLKKLILDNNQITTIPIECVEP | ||..| |.|||.|..| . .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | DDB0220138.AA | LRR_1 | 458-479 | 40 | 0.000644 | 18.06 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 458-479 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) HLTILDLSH-N--NLH-EICRE-LGNL .|..||||. | || .| . . || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 503-525 | 37 | 0.002471 | 15.99 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 503-525 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) NLKKLILDN-N--QIT-TIPIECVEPL ||..| |.. | ..| .|| .| | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 456-478 | 33 | 0.010288 | 16.14 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 456-478 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) LKHLTILDLSHNNLHEICREL-GN | .|. ||||.|.| .. ... .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | DDB0220138.AA | LRR_1 | 481-501 | 33 | 0.013724 | 13.35 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 481-501 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) FLRELYLSN-N--SL-KKFPT--TGNL |..|.||. | .| ...| || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 525-548 | 29 | 0.022725 | 13.32 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 525-548 Range on HMM: 1-24/24 Sequence Identity: 29% (7 aa) LIQLQTLDLSFNKIGTITSSTTTT | .|..||||.|.. .. . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 479-498 | 35 | 0.024144 | 13.57 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 479-498 Range on HMM: 1-20/20 Sequence Identity: 35% (7 aa) LSFLRELYLSNNSLKKFPTT ..|..|. |||.|...| PPHLKWLNVSNNQLTELPEL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 435-456 | 33 | 0.047751 | 11.43 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 435-456 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) NLEQLIMFN-N--NLS-DVPSS-IEFL ||. | . . | ||. ..|.| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 479-500 | 45 | 0.0531 | 10.3 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 479-500 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LSFLRELYLSNNSLKKFPTT--GN |. ||||.|||| |. | .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 409-432 | 29 | 0.10394 | 7.91 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 409-432
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)
VQGYKIIDLSFNNIKSIPLDAFTN
. |||.|.....| .|| .
LPNLRELDLSNNQLTHLPPGAFQG
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| LRR_1 | DDB0220138.AA | LRR_1 | 413-433 | 36 | 0.113259 | 10.1 | Pfam | 8-31 (26) | Show / Hide |
Range on Protein: 413-433 Range on HMM: 8-31/26 Sequence Identity: 36% (9 aa) KIIDLSF-N--NI-KSIPLDAFTNI ...||| | |. ..|| ..| | QHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 527-544 | 45 | 0.14402 | 9.73 | Pfam | 1-22 (26) | Show / Hide |
Range on Protein: 527-544 Range on HMM: 1-22/26 Sequence Identity: 45% (10 aa) QLQTLDLSF-N--KI-GTITSS .||.|||| | .. |.| .| NLQHLDLSGCNCCNLTGHIPPS |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 433-455 | 29 | 0.409554 | 3.03 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 433-455 Range on HMM: 1-24/24 Sequence Identity: 29% (7 aa) ISNLEQLIMFNNNLSDVPSSI-EF .||. | ||.|. .|. . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 456-475 | 35 | 0.412569 | 4.16 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 456-475 Range on HMM: 1-20/20 Sequence Identity: 35% (7 aa) LKHLTILDLSHNNLHEICRE ||..|. |.|.| | . PPHLKWLNVSNNQLTELPEL |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 501-520 | 40 | 0.959786 | 1.36 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 501-520 Range on HMM: 1-20/20 Sequence Identity: 40% (8 aa) LYNLKKLILDNNQITTIPIE .||.| .|||.|. | PPHLKWLNVSNNQLTELPEL |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 433-452 | 30 | 1.066593 | 1.01 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 433-452 Range on HMM: 1-20/20 Sequence Identity: 30% (6 aa) ISNLEQLIMFNNNLSDVPSS ..|. | ||.|.. | PPHLKWLNVSNNQLTELPEL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 572-593 | 40 | 7.2e-05 | 21.44 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 572-593 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) NLKQLNLSH-N--ELQ-EIPSS-LRHL ||. |.||. | |. .||.| . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 570-592 | 33 | 0.000681 | 20.18 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 570-592 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) MKNLKQLNLSHNELQEIPSSL-RH . ||. |.||.| |...|. . .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 686-709 | 37 | 0.002182 | 18.5 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 686-709 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) LTKLVDLQLYNNQISSLPISFLKC |..| | | |||...|| . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 663-684 | 45 | 0.00324 | 17.93 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 663-684 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LSNLKKLNLNNNNLKELPSNI--G |.||..|.|.||.|..||... | LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | DDB0220138.AA | LRR_1 | 665-686 | 33 | 0.003794 | 15.33 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 665-686 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) NLKKLNLNN-N--NL-KELPSN-IGFL ||..|.|.. | || ...|.. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 593-616 | 29 | 0.006129 | 17.01 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 593-616 Range on HMM: 1-24/24 Sequence Identity: 29% (7 aa) LSKLHSLSIDYNQISVLPDKVVAS |..| .|. ..||.. ||. . .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 663-682 | 50 | 0.026995 | 13.2 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 663-682 Range on HMM: 1-20/20 Sequence Identity: 50% (10 aa) LSNLKKLNLNNNNLKELPSN ..||.|| .||.|.||| . PPHLKWLNVSNNQLTELPEL |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 640-659 | 40 | 0.03478 | 12.36 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 640-659 Range on HMM: 1-20/20 Sequence Identity: 40% (8 aa) LSSLIELNASNNVIELLPDS ..| .||.||| .. ||. PPHLKWLNVSNNQLTELPEL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 688-709 | 25 | 0.038791 | 11.75 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 688-709 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) KLVDLQLYN-N--QIS-SLPIS-FLKC .| | | . | ... ..| | | .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 593-612 | 30 | 0.060404 | 10.53 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 593-612 Range on HMM: 1-20/20 Sequence Identity: 30% (6 aa) LSKLHSLSIDYNQISVLPDK ..| .| ...||.. ||. PPHLKWLNVSNNQLTELPEL |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 570-589 | 45 | 0.099362 | 8.88 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 570-589 Range on HMM: 1-20/20 Sequence Identity: 45% (9 aa) MKNLKQLNLSHNELQEIPSS .|| || |.|.| | | PPHLKWLNVSNNQLTELPEL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 617-639 | 37 | 0.109026 | 7.74 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 617-639 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) LSRLAKLTISNNKIKQLP-FAINN |. | .| |||....|| | .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | DDB0220138.AA | LRR_1 | 595-617 | 18 | 0.138516 | 9.79 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 595-617 Range on HMM: 1-26/26 Sequence Identity: 18% (5 aa) KLHSLSIDY-N--QIS-VLPDKVVASL .| .|.... | ... .|. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 619-640 | 25 | 0.139419 | 9.78 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 619-640 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) RLAKLTISN-N--KI-KQLPFA-INNL .| .| .|. | .. ...| . || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | DDB0220138.AA | LRR_1 | 642-663 | 25 | 0.166137 | 9.51 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 642-663 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) SLIELNASN-N--VIE-LLPDS-ICYL .| .|. |. | .. .|.| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | DDB0220138.AA | LRR_TYP | 640-661 | 37 | 0.264954 | 4.58 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 640-661 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) LSSLIELNASNNVIELLPDSI--C |..| ||. ||| .. ||. . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_BAC | DDB0220138.AA | LRR_BAC | 617-636 | 35 | 0.523557 | 3.37 | SMART | 1-20 (20) | Show / Hide |
Range on Protein: 617-636 Range on HMM: 1-20/20 Sequence Identity: 35% (7 aa) LSRLAKLTISNNKIKQLPFA ..| .| .|||... || PPHLKWLNVSNNQLTELPEL |
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| Kinase | DDB0220138.AA | TKL-Unique | 948-1235 | 34 | 2e-140 | 472.78 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 948-1235
Range on HMM: 1-290/290
Sequence Identity: 34% (111 aa)
FFNLIGQGGFSKVYHGVWRSKDVAIKQIEL---QNNKSLDDFRREVGILSKLKPHENLLAYYGACK----HANYCYIITEYLPRGSLHDLLHR-------
|.|.||.||...||.|.||...|||||... ..|.....|..|| ...||..|.|.. |.|.|. ......|..||.|.|||.|.||.
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
-EQLMKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNA-----LKIKIADFGLASFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSI
.. .||...|.|..||..|.|.|.|...||||.|.|||..|.||.|. ..|||.||||. |..|......|....|.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------------------
SNNNNNGTTSVDQSRLAYAFYAAPEILNS--KHFSEKSDVFSFGTILWELVTNKI------PFDGMDPYEVKELLKS---GKRLEIPENCNEVLKNIIQD
.|.|.......|||.|.. ...||||||.|||..|||..|.|| |..|||.....|.... ..|..||..|.. ....||.
-----------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQ
CWNQQSEDRPTFLSIYHRL
||......||.| .|.|||
CWHHDPSQRPSFDEIIHRL
|
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| Kinase | DDB0220138.AA | TKL | 952-1235 | 21 | 8.4e-87 | 294.69 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 952-1235
Range on HMM: 1-364/364
Sequence Identity: 21% (86 aa)
IGQGGFSKVYHGVWRS----------KDVAIKQIELQNNKSLDD-------------------------FRREVGILSKLKP-HENLLAYYGACKHANY-
||.|||..||.|.|| ||||.|.. .|... .. |..|. |..... |.|.. ..|.|. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------CYIITEYLPRGSLHDLLHREQLMKLDFKQKVSFAICVALGCYHLSTYE------PPIYHTDLKTKNLLVTNALK--------------
..|..|| |.|||...|| . |....|. .|.|...| . . ||| | |||.||.|| . ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC
IKIADFGLASFA------------------------KKSLTT---------IINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTSVDQSRLAYAFYA
.||.||||. | ... ......|... .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI-----------------------------------
APEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEV----------KELLKSGKRLEIP------------ENCNEVLKNIIQDCWNQQSEDRPT
.. ..... .|||.||.||| .|||..| ..|......... . . |.|..|| ..| . .|...||||.. |.||.
DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS
FLSIYHRL
|. | .||
FQEILKRL
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| Kinase | DDB0220138.AA | TK | 946-1235 | 16 | 9.2e-55 | 181.64 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 946-1235
Range on HMM: 1-486/486
Sequence Identity: 16% (86 aa)
IQFFNLIGQGGFS---KVYHGVWRSK---------------------------DVAIKQIELQNNKSLDDFRR--------------EVGILSKLK----
|.. . .|.| | .|| | ||.. .||.|.. . .. | ..|. |. ......
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
PHENLLAYYGACKHA------------NYCYIITEYLPRGS----LHDLLH-------------------------------------------------
|.|.. ||.| . ..|..|| | |. |.| |.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-----REQLMKLDFKQKVS-------------------FAICVALGCYHLSTYEP----PIYHTDLKTKNLLVTNALK-----------IKIADFGLA--
..... |..|. .. .. .| |. .|. . | || . | ||.. .. .|||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
--SFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTSVDQSRLAYAFY-----------------------------------------
|| . |
GSG-------------------------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW
AAPEILNSKH---------FSEKSDVFSFGTILWELVT-N-KIPFDGMDP---------YEVKELLKSG--------------KRLEIPENCN-------
||| ||... |..||||.||| .||..| . . ||. || |.|..| |.. |..|
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM
-------EVLKNIIQDCWNQQSEDRPTFLSIYHRL
|.. ..|.||. . |||||| ....|
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
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| Kinase | DDB0220138.AA | TyrKc | 946-1235 | 27 | 1.9e-51 | 178.12 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 946-1235 Range on HMM: 1-280/280 Sequence Identity: 27% (88 aa) IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQNNKSLDDFRREVGILSKL-KPHENLLAYYGACKHA-------NYCYIITEYLPRGSLHDLLHREQLM |.. .| | | .||.|.|. .||.| . . ||.|| |..|| . |.|... ||.| . .|..|| | |.|.| |.. . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK KLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKKS-LTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTT | |...||.. .| |. .|. .. | || . | ||.. . .||.||||. . . . . . -LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------------------------ESKDYY SVD---QSR--LAYAFYAAPEILNSKHFSEKSDVFSFGTILWELVTN-KIPFDG-----MDPYEVKELLKSGKRLEIPEN--------CNEVLKNIIQDC .. ... | . ||| .| . |..||||.||| .||. |. . | | |...|| |..|.|.|...|.| | . . .|...| RKKEHKGGKTMLPI-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC WNQQSEDRPTFLSIYHRL |. . |||||| |.... WHEDPEDRPTFSEIHECF |
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| Kinase | DDB0220138.AA | S_TKc | 946-1242 | 20 | 2e-48 | 168.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 946-1242 Range on HMM: 1-231/231 Sequence Identity: 20% (63 aa) IQFFNLIGQGGFSKVYHGVWRS--KDVAIKQIELQNNKSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPR--GSLHDLLHREQLMK--- .. ..||.|.|.||| ..... . ||||.| ...|||. ||.| |.|. .|... . .. |...||.. |.|.|.... . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKKSLTTIINNNNNTNNTATSSTTTSSANGANSISNNNNNGTTS .. . ... .... .. . | | ||| |.|... |||.||||| . PFPE-HARFYMYQICCALEYC--HSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------- VDQSRLAYAFYAAPEILNSKHFSE-KSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYH--R . .| |||.| ... |.|. |.| ||.|... . ||. ..... .... . .|..|. |.. |.||| . . . --TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW LENLMKSI . ... . DIKCHPWF |
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| Kinase | DDB0220138.AA | Dicty4 | 946-1096 | 38 | 1.4e-41 | 136.54 | In-house | 1-166 (277) | Show / Hide |
Range on Protein: 946-1096 Range on HMM: 1-166/277 Sequence Identity: 38% (64 aa) IQFFNLIGQGGFSKVYHGVWRSKDVAIKQI--ELQN--NKSLDDFRREVGILSKLKPHENLLAYYGACK----HANYCYIITEYLPRGSLHDLLHR---- |.. ..||.|.|..|| | || |.||.| || . | .||.|| |..|. | |.. .||| | . | |||.|.|.|. ||| INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR-HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE -EQLMKLDFKQKVS---FAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLASFAKK | |||. . |. .|.| .| . | | | |||. |||| ...|..||||. || QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK |
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| Kinase | DDB0220138.AA | DRK | 946-1095 | 36 | 1.3e-35 | 118.14 | In-house | 1-152 (258) | Show / Hide |
Range on Protein: 946-1095 Range on HMM: 1-152/258 Sequence Identity: 36% (56 aa) IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQN-N--KSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLHREQLMKLDFK | | || |.. |. | || ||.| . | | . | .|.||. ....| | | . |.| |..||.||||| || | . ..| IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLR-HPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI-EMDWP QKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLAS-FAK . .. .| | | .| | | |||. |||| ..|.|||||. | | LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKK |
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| Kinase | DDB0220138.AA | Pkinase_Tyr | 946-1091 | 31 | 5.1e-34 | 115.84 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 946-1091 Range on HMM: 1-158/270 Sequence Identity: 31% (51 aa) IQFFNLIGQGGFSKVYHGVWR------SKDVAIKQIELQNNKS---LDDFRREVGILSKLKPHENLLAYYGACK-HANY--CYIITEYLPRGSLHDLLHR |.| .|.| | .||.|.|. .||.| . . .. ..|| ||. |...| |.|.. .||.| . ||..|| | |.|.| |.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK E--QLMKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLA . .|. |....... .| |. .|. . | || ..| |||. ...||.||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLA |
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| Kinase | DDB0220138.AA | Pkinase_Tyr | 1150-1235 | 41 | 5.1e-34 | 115.83 | Pfam | 182-270 (270) | Show / Hide |
Range on Protein: 1150-1235 Range on HMM: 182-270/270 Sequence Identity: 41% (37 aa) APEILNSKHFSEKSDVFSFGTILWELVT-NKIP-FDGMDPYEVKELL-KSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRL ||| .| . |..|||| ||| .||..| ..| . ||...||.|.. ..| |...|||| . . .....||... |||||| |...| APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | DDB0220138.AA | MLK | 946-1104 | 29 | 6.1e-32 | 108.13 | In-house | 1-193 (291) | Show / Hide |
Range on Protein: 946-1104 Range on HMM: 1-193/291 Sequence Identity: 29% (58 aa) IQFFNLIGQGGFSKVYHGVWRSKD-----VAIKQIE--LQNNKSL-----DDFRREVGILSKLKPHEN----LLAYYGACKHANY-CYIITEYLPRGSLH ||| || |.| ||. |.|| || ||.|... || .||..|. .|..|. |.| . ||.|. .. .|..||.. |||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILS-HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY DLLHREQL------------MKLDFKQKVSFAICVALGCYHLSTYEP-PIYHTDLKTKNLLVTN------ALKIKIADFGLASFAKKSLTTIINN ..|| .. |. .....| .| | | .| || | ||| .|.|... .. ||.|||.. . ... |. .| NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN |
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| Kinase | DDB0220138.AA | LRRK | 1148-1237 | 32 | 9.2e-31 | 106.05 | In-house | 245-351 (351) | Show / Hide |
Range on Protein: 1148-1237 Range on HMM: 245-351/351 Sequence Identity: 32% (35 aa) YAAPEILN---SKHFSEKSDVFSFGTILWELVTNK-IPFDGMD-------PYEVKELLKSGKRLEIPEN-CNE-----VLKNIIQDCWNQQSEDRPTFLS . ||||.. . ..||.|..||| |||||.| . .|||..| ...... ..| | ||.. |.. ... ||.||... ..||.| . WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQ IYHRLEN | ||. IVKRLSQ |
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| Kinase | DDB0220138.AA | Pkinase | 946-1114 | 25 | 1.7e-29 | 105.35 | Pfam | 1-175 (293) | Show / Hide |
Range on Protein: 946-1114 Range on HMM: 1-175/293 Sequence Identity: 25% (48 aa) IQFFNLIGQGGFSKVYHGVWRSKD--VAIKQIELQNNKSLDD--FRR--EVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRG----SLHDLLHREQ ... ||.|.|..||...... ||.|.|.....|| | || |. |. .| |.| . .|... ...|...||.. | .|.|...... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR LMKL--DFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKI----KIADFGLASFAKKSLTTIINNNNNTNNTATS .. . .. ... .. | ... .. | | ||| |.|. | | ||.||||| ... . || .| . |. HGCFYFSEWECKFYMYQILRGLEYC--HSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTP |
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| Kinase | DDB0220138.AA | TK-Unique | 1150-1235 | 37 | 9.5e-28 | 92.83 | In-house | 204-294 (294) | Show / Hide |
Range on Protein: 1150-1235 Range on HMM: 204-294/294 Sequence Identity: 37% (34 aa) APEILN--SKHF-SEKSDVFSFGTILWELVTN-KIPFDGMDPYEVKELLKSGKRLEIPENC-NEVLKNIIQDCWNQQSEDRPTFLSIYHRL |||.| ... ..|||| ||| ..||..|. . |. ||.. .. |... |.|.. ||.| .. . |... ||. |.||.| .| ||| APESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | DDB0220138.AA | Src | 946-1091 | 35 | 3.7e-27 | 89.27 | In-house | 1-144 (255) | Show / Hide |
Range on Protein: 946-1091 Range on HMM: 1-144/255 Sequence Identity: 35% (52 aa) IQFFNLIGQGGFSKVYHGVWRS-KDVAIKQIELQNNKSLDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLH-REQLMKLDFKQ |.. .||| | |. |.|. .||.| . . | ..| .| |. ||. ||.|.. | | ||.||| .||| | |. ... .| ..| IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ KVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFGLA ...| || | |. . | || .| || . . |.|||||| LIDMAAQVAEGMAYLESMN--YIHRDLAARNVLVGENNVCKVADFGLA |
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| Kinase | DDB0220138.AA | Dicty4 | 1148-1237 | 33 | 6.7e-27 | 86.89 | In-house | 183-277 (277) | Show / Hide |
Range on Protein: 1148-1237 Range on HMM: 183-277/277 Sequence Identity: 33% (32 aa) YAAPEILNSKHFSEKSDVFSFGTILWELVTNKIPFD--GMDPYEVKELLKS-GKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHR--LEN . |||.. .. . ||.||.||| .|||..| ..|. .|.. .. .. . . |..|| .| .| ||.||. . ||.| | | || WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | DDB0220138.AA | MLK | 1150-1235 | 36 | 6.3e-26 | 86.99 | In-house | 201-291 (291) | Show / Hide |
Range on Protein: 1150-1235 Range on HMM: 201-291/291 Sequence Identity: 36% (33 aa) APEIL---NSKHFSEKSDVFSFGTILWELVTNKIPFD-GMDPYEV-KELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRL |||.. . .|||.||.|.| .|||..| ..|.. ..|| .. . |.|. || .|.| .|. ...|||| ...||.| .| | APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | DDB0220138.AA | Dicty5 | 946-1089 | 34 | 6.4e-26 | 86.2 | In-house | 1-149 (260) | Show / Hide |
Range on Protein: 946-1089 Range on HMM: 1-149/260 Sequence Identity: 34% (52 aa) IQFFNLIGQGGFSKVYHGVWRSKDVAIKQIELQN--NKSLDDFRREVGILSKLK-PHENLLAYYGACKH-ANYCYIITEYLPRGSLHDLLHREQL---MK . | | | .|| |. . .||||| | ...| ||| |.| . | |. .||| . .| ...||| .||| ..| VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQP LDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTKNLLVTNALKIKIADFG . . |....|| .| . || | | ||| | |.| .|||| ||| IAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFG |
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| Kinase | DDB0220138.AA | LRRK | 946-1094 | 22 | 4e-25 | 85.82 | In-house | 66-295 (351) | Show / Hide |
Range on Protein: 946-1094 Range on HMM: 66-295/351 Sequence Identity: 22% (54 aa) IQFFNLIGQGGFS-KVYHGVWRS----------------------------KDVAIKQIELQ-----------NN-----------------------KS . . ..||.||| .|| . ||. ..||||.... || .. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA LDDFRREVGILSKLKPHENLLAYYGACKHANYCYIITEYLPRGSLHDLLH---REQL------MKLDFKQKVSFAICVALGCYHLSTYEPPIYHTDLKTK . ||.|| |.|.|. | |.. .| | . . ...||.| |.|...|| . .. .. .|.|. |. .| | .| ||| |.|||. FREFRHEVWIMSHLN-HPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKI--ALQIAKGMEYLHSHNPPIIHRDLKSP NLLV---T---------NALKIKIADFGLAS--FA | |. . .. ..||||||. . .. NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC |
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| Kinase | DDB0220138.AA | Src | 1150-1235 | 40 | 1.4e-24 | 80.36 | In-house | 168-255 (255) | Show / Hide |
Range on Protein: 1150-1235 Range on HMM: 168-255/255 Sequence Identity: 40% (36 aa) APEILNSKHFSEKSDVFSFGTILWELVT-NKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKN-IIQDCWNQQSEDRPTFLSIYHRL ||| .| .|. |||| ||| |.|.|| ..| ||. || . .. | |. |.|| . | . |.. ||... |.|||| ... | APEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | DDB0220138.AA | Dicty5 | 1148-1239 | 33 | 9.8e-23 | 75.08 | In-house | 169-260 (260) | Show / Hide |
Range on Protein: 1148-1239 Range on HMM: 169-260/260 Sequence Identity: 33% (31 aa) YAAPEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKSGKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRLENLM . |.|. |.. . .| ||.||| .|||. | | |.| . . . .| | .|| | |.| || | ||.| | .| .. WMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | DDB0220138.AA | DRK | 1150-1237 | 35 | 1.5e-21 | 69.83 | In-house | 170-258 (258) | Show / Hide |
Range on Protein: 1150-1237 Range on HMM: 170-258/258 Sequence Identity: 35% (32 aa) APEILNSKHFSEKSDVFSFGTILWELVTNKIPFDGMDPYEVKELLKS-GKRLEIPENCNEVLKNIIQDCWNQQSEDRPTFLSIYHRLEN |||.| . . || ||.||. .|||.|| ..|. || . | | |. .|..| ..|||| ||.. . ||| APEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | DDB0220138.AA | TK-Unique | 946-1091 | 24 | 1.5e-20 | 67.63 | In-house | 1-180 (294) | Show / Hide |
Range on Protein: 946-1091
Range on HMM: 1-180/294
Sequence Identity: 24% (45 aa)
IQFFNLIGQGGFSKVYHGVWRS--------KDVAIKQIELQNNKS-LDDFRREVGILSKLKPHENLLAYYGACKHA-NYCYIITEYLPRGSLHDLLH---
. ....||.| |. |..| .. | ||.|. . ... .|| .| ....|..|.|.. .|.| . .|| ||.|.|.| ..|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
---------------------REQLMKLDFKQKVSFAICVALGCYHLST--YEPPIYHTDLKTKNLLVTNALKIKIADFGLA
. .. .. |. ..||. .| | .|. .. | | || ..| |.|. ...||.|||.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRDLCARNVLLTEDKVCKICDFGMA
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| Kinase | DDB0220138.AA | Pkinase | 1147-1235 | 18 | 4e-17 | 61.62 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 1147-1235 Range on HMM: 176-293/293 Sequence Identity: 18% (22 aa) FYAAPEILN-SKHFSEKSDVFSFGTILWELVTNKIPFDGM----DPYEVKELLKSGKRLEIPENCN-----------------------EVLKNIIQDCW .|.|||... ... . |.|..|.| ||.|... . ||.| . .. ..... .. ...... | .| .| .|. WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL NQQSEDRPTFLSIYHR--L .. ..|||. | . . CKDPKKRPTAEQILQHPWF |
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