Gene SAMK-D (Slime mold)
SAMK-D
Sequence
Protein domains of SAMK-D.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Sam7 | SAMK-D.AA | sam7 | 24-85 | 22 | 0.000211 | 13.61 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 24-85 Range on HMM: 1-70/70 Sequence Identity: 22% (16 aa) WDNETVCKWLLNNIKTIQKVSIEIFQANEI-----IGKDLEFLTDKILLKMGV---GIRDILNFKFEYQI |. |.|| || . . .. |....| |..| .|.. |..||. | |. . ... . WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR |
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SAM_2 | SAMK-D.AA | SAM_2 | 21-71 | 26 | 0.000886 | 15.82 | Pfam | 1-54 (71) | Show / Hide |
Range on Protein: 21-71 Range on HMM: 1-54/71 Sequence Identity: 26% (15 aa) YKKWDNETVCKWLLNNIKTIQKVSIEIFQANEIIG-KDL-EFLTDKIL--L-KMGV .. |..|.|| || .|. . ..| ...|.| ..| . .| | .||. VHYWTFEDVCEWLR-SIGM-CCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGI |
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Kinase | SAMK-D.AA | SAMK | 134-392 | 55 | 2.8e-201 | 654.11 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 134-392 Range on HMM: 1-295/295 Sequence Identity: 55% (164 aa) YQYIETISKNKFCEIEKYKKSQTKVNEYIIIKKIIKNSTLNEEKLINEIDTIYLLDHPNLIKIIGYCKDKNYFYIGMKYYETFKFKQSNIS----KFGKN ||||||||..|||..||||||..|.||.||||.|.|||.||||..||||...|..||||.|||||||||.||.||.||||.....|..|.| ..... YQYIETISRGKFCIVEKYKKSKKKTNEFIIIKRINKNSNLNEEMIINEINMLYSIDHPNIIKIIGYCKDENYYYIAMKYYPKGSIKKNNKSIKSKNQSPY FEQVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENNEPILIDFGLSYKSIDLLTN--------------------------------QKTQFI .|..||||||||||||||||||.|||||..||..||||||||.||||||||||||.||..|| .|||.. SEMNIRKISFKILSAIDYLHSLNPPIIHRDINCDNILLDNENDEPILIDFGLSYKEIDDNTNNDDDNYDNHNHNHNHNHNHNHDNDNDNDTNVKFKTQCC SPCFITPEYFYKKTKNKISKEADIFSFGSTISNMIKGGTDFKEDEEGFEELKRTFAGVLTSRDKVSFDYRSLFTEINKDEPCFRPSSKELLKSFW |||...|||...|.|...|||.||.|||.||..||.||||||||.|.....|..........|......|.||.||||.|.||||.||.|||.|| SPCWASPEYIHNKEKQHFSKECDIYSFGCTIFEMIVGGTDFKEDWEPWYKKKNHQIHLPKIPDYMTLECRILFNEINKYEQCFRPDSKQLLKFFW |
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Kinase | SAMK-D.AA | Ciliate-E2-Unclassified | 134-334 | 21 | 2e-22 | 74.65 | In-house | 1-266 (352) | Show / Hide |
Range on Protein: 134-334 Range on HMM: 1-266/352 Sequence Identity: 21% (58 aa) YQYIETISKNKFCEIEKYKKSQTK-------VNEYIIIKKIIKNST---LNEEKLINEID-------------TIYLLDHPNLIKIIGYCKDKNYFYIGM | |..| . |... | .....| . ..|.|. .... .||.| .|.. . ..||...| . . .||...|| | YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM KYYETFKFKQ-SNISKF--------------GKNF-EQVIR-----KISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENN--EPILIDFGLSYKSID | | . .| ...|. .| | || .. .. ||....|||. ||| .| |||.||... .. .||||.|.|... EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ L---------------LTNQKTQFISPCFI----TPEYFYKKTKNKIS-KEADIFSFGSTISNMIKG ...|. .|... ||.. .. .. . ...||.|.| . |. | NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG |
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Kinase | SAMK-D.AA | Ciliate-E2 | 134-334 | 20 | 1.8e-21 | 70.49 | In-house | 1-292 (365) | Show / Hide |
Range on Protein: 134-334 Range on HMM: 1-292/365 Sequence Identity: 20% (60 aa) YQYIETISKNKFCEIEKYKKSQTKVNE-----------------YIIIKKIIKNSTLNEEKLINEIDTIY-----------------LLDHPNLIKIIGY | |. | . | . | |. ... .. . | .. .|. |. . |. .. |. .|.|||.||.. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC CK--DKNYFYIGMKYYETFKFKQ---SNISKFGKNFE-------QVIRKISFKILS---------------AIDYLHSLEPPIIHGNINAKNILLDNENN . |.|..|. | |.. .. .| |.....| . |..|. .||. |. |||| . ||| .| |||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----- EPILIDFGLSYKSID------------LLTNQK----TQFI----------------SPCFITPEYFYKKT------KNKISKEADIFSFGSTISNMIKG . .|||||| | | .... | ... .| . || . .| .. ....||.|.| .. |. | -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG |
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Kinase | SAMK-D.AA | TKL | 140-325 | 18 | 1.1e-20 | 71.21 | In-house | 1-276 (364) | Show / Hide |
Range on Protein: 140-325 Range on HMM: 1-276/364 Sequence Identity: 18% (53 aa) ISKNKFCEIEKYKKSQTKV------NEYIIIKKIIKNS----TLNE-----------------------EKLINEIDTIYLLDHPNLIKIIGYCKDKNY- | . |.|. | | .. . .. . .||. ... |.|. .....|| . |.|||.....|||.. .. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------FYIGMKYYE--T-FKFKQSNISKFGKNFEQVIRKISFKILSAIDYLHSLE------PPIIHGNINAKNILLDNENNE----------- ..| | |.. . . . . ... ... | ....|||| . ||||| ... ||||.|. .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD --PILIDFGLSY------KSIDLLTN-------------QKTQFISPCFITPEYFYKKTK-------------NKISKEADIFSFG . . ||||| .. | |. || .|.. || . .... . |. .|..||| WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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Kinase | SAMK-D.AA | STE | 134-334 | 21 | 1.3e-16 | 55.3 | In-house | 1-264 (359) | Show / Hide |
Range on Protein: 134-334 Range on HMM: 1-264/359 Sequence Identity: 21% (59 aa) YQYIETISKNKFCEIEKYKKS------QTKVN-------EYIIIKKIIKNSTL-----------------NEEKLINEIDTIYLLD--HPNLIKIIGYCK .. || | | | . | .. .|. . |.. ||.. ... .......||.. .. ||| .| .|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF DK-------NYFYIGMKYYE--TFKFKQSNISKFGKNF-----------EQVIRKISFKILSA-IDYLHSLEPPIIHGNINAKNILLDNENNEPILIDFG .. .. .| | | . .. . . ||.. |..|..| . || . .||||. ||| | . |||| |.||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG LSYKSIDLL-------------TNQ-KT-QFI-SPCFITPEYFYK-KTK--NKISKEADIFSFGSTISNMIKG .. . .| . |.| |. |. .| . || . ... .. . .|| |.| || |. | VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG |
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Kinase | SAMK-D.AA | CAMK | 166-325 | 18 | 1.7e-15 | 45.74 | In-house | 37-321 (425) | Show / Hide |
Range on Protein: 166-325 Range on HMM: 37-321/425 Sequence Identity: 18% (52 aa) KIIKNSTLN-----------------------------EEKLINEIDTIYL-------LDHPNLIKIIGYCKD-------------------KNYFYIGM |||. . | .... .||. . |||||.||.. . | ....|. | KIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVM ------KYYETFKFKQSNISKFGKN--------------F-EQVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNEN----------------NE | | . | . |.. | |. |.. |.||..|.||. |.| . |||||. | | EIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNN PILIDFGLS--YKSIDLLT---------------------NQKTQFISPCFIT-PEYFYKKT-----------KNKISKEADIFSFG .||||.. ... . .. ||.. .|... || . .|. | .....|. | | IKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG |
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Kinase | SAMK-D.AA | S_TKc | 134-393 | 21 | 1.2e-14 | 37.91 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 134-393 Range on HMM: 1-231/231 Sequence Identity: 21% (60 aa) YQYIETISKNKFCEIEKYKKSQTKVNEYIIIKKIIKNSTLNEEKLINEIDTIYLLDHPNLIKIIGYCKDKNYFYIGMKYYET-----FKFKQSNISK--- |. ...| | | . | .. ... ||.| |....||. .|||..|..... | ...|. | | .. |.. ... .. YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FGKNFEQVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENNEPILIDFGLSYKSIDLLTNQKTQFISPCFITPEYFYKKTKNKISK-EADIF | | ..|.. |..|..|.||. ||| . |||||. . ..||||. . .|. .| .. || . . .| ..|. FPFP---E-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWW SFGSTISNMIKGGTDFKEDEEGFEELKRTFAGVLTSRDKVSFDYRSLFTEINKDEPCFRPSSKELLK-------SFWF |.| .. |. | . | .....| .. | . ... . . .| ||. |.|. || SCGCILYEMLCGYPPFP-------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | SAMK-D.AA | Ciliate-E1 | 140-322 | 20 | 4.8e-11 | 32.64 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 140-322 Range on HMM: 1-202/202 Sequence Identity: 20% (42 aa) ISKNKFCEIEKY--KKSQTKVNEYIIIKKIIKNSTLNEEKLINEIDTIYLLD-HPNLIKIIGYCK-DKNYFY-IGMKYYETFKFKQSN----------IS |... | . | ....... . .||. ... . .....|.|.. | . . ..|.|| | | |.||.. | . ... ... . .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ KFGKNFE-QVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENNEPILIDFGLSY--KSIDLLTNQKTQFISPCFITPEYF----YKKTKNKISK . ..| | . .| | .. .. .||.. |||..|. .||| .|. .. .. |||.| |. .. . |...... ...|. . . ..||.. QNQNQFTFQQKMQIIFQLIDGLIELHQYN--IIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY EADIF . ||. KSDIY |
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Kinase | SAMK-D.AA | Pkinase | 166-400 | 20 | 7.8e-11 | 39.39 | Pfam | 30-264 (293) | Show / Hide |
Range on Protein: 166-400 Range on HMM: 30-264/293 Sequence Identity: 20% (52 aa) KIIKNSTLNEEKLIN-----EIDTIYLLDHPNLIKIIGYCKDKNYFYIGMKYYETF----KFKQSNIS-KFGKNF---EQVIRKISFKILSAIDYLHSLE |||| .. ...|... || |.||| ....... ||.. |. | | | . . || . ...| |...... ||....|.|| KIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM- PPIIHGNINAKNILLDNENNEP----ILIDFGLSYKS-IDLLTNQKTQFISPCFITPEYFYKKTKNKISKEADIFSFGSTISNMIKGGTDFKED--EEGF ||| . |||.| .|... ..||||. . . . .| .| .. || . . .......|..|.| .. |. | . |... ... -GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN- EELKRTFAGVLT---SRDKVSFDYRSLFTEINKDEPCFRPSSKELLKSFWFVEPPQPS . . .. .. ..| . .|.|. .. . . . .|.. . ... HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTF-HNWSE |
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Kinase | SAMK-D.AA | CAMK-Unique | 134-282 | 18 | 1.2e-10 | 31.17 | In-house | 1-220 (363) | Show / Hide |
Range on Protein: 134-282 Range on HMM: 1-220/363 Sequence Identity: 18% (40 aa) YQYIETISKNKFCEIEKYKKSQTKVNEYIIIKKI-----IKNST-------------LNEEKLINEIDTIYLLDHPNLIKIIGY----CKDKN------- | .. | .. |... . . . |.. . ..| .|. . . || .|.. ..||||.||. .. |.. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------YFYIGMKYYETFKFKQSNISK-------------------FGKNFE--QVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNE----- |.|| | | . .. .. |. | .. |....|||. |.||. |.|... . ||.. .. IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQD--IVHRDLKLENIMVCYSFKDNN ----------NNEPILIDFGLS |. |.||||. HHRDFPYDWSNWHIKLCDFGLC |
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Kinase | SAMK-D.AA | TKL-Unique | 246-325 | 29 | 3.9e-09 | 28.55 | In-house | 124-215 (290) | Show / Hide |
Range on Protein: 246-325 Range on HMM: 124-215/290 Sequence Identity: 29% (27 aa) DYLHSLEPPIIHGNINAKNILLDNENNEPI----LIDFGLSYKSIDLLTNQKT--------QFI-SPCFITPEYFYKKTKNKISKEADIFSFG .|||..||||||... .|.|.||..|. ..||||| . ... .. .. |. . || . ...|. .|..||| YYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFG |
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Kinase | SAMK-D.AA | CAMKL | 241-282 | 46 | 2.3e-08 | 22.62 | In-house | 136-176 (297) | Show / Hide |
Range on Protein: 241-282 Range on HMM: 136-176/297 Sequence Identity: 46% (20 aa) ILSAIDYLHSLEPPIIHGNINAKNILLDNENN-EPILIDFGLS |.||..|.||. |.| | . |||||. .| .||||.| IVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFS |
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Kinase | SAMK-D.AA | TyrKc | 134-391 | 16 | 3.1e-07 | -105.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 134-391 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) YQYIETISKNKFCEIEKYKKSQTKVNEYIIIKKIIKNSTLNEEKLINEIDTIYLL--DHPNLIKIIGYCKDK-------NYFYIGMKYYETFKFKQSNIS . .... |.|. | . . . .|.. ... .| ...|. | .|||.....|.| .. .| | | . |. . ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK KFGKNFEQVIRKISFKILSAIDYLHSLEPPIIHGNINAKNILLDNENNEPILI---DFGLSYKSIDLLTN------QKTQFIS---PCF--IT-----PE . .| . .... | . .|||| ..|| . | |.|..... . |||| | |. ... . . . || HRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGL---SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE YFYKKTKNKISKEADIFSFGSTI-----------SNMIKGGTDFKEDEEGFEELKRTFAGVLTSRDK---------VSFDYRSLFTEINKDEPCFRPSSK . ..| . . |..||| .. ..||. .....| .| .|. . . . . |. . .. . .| ||. . CI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQ--GYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS ELLKSF |. . | EIHECF |
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Kinase | SAMK-D.AA | TKL-Unique | 136-214 | 22 | 6e-06 | 17.17 | In-house | 1-83 (290) | Show / Hide |
Range on Protein: 136-214 Range on HMM: 1-83/290 Sequence Identity: 22% (19 aa) YIETISKNKFCEIEKYKKSQTKVNEYIIIKKIIKNSTLNE--EKLINEIDTIYLLD-HPNLIKIIGYCK----DKNYFYIGMKYYE ...| ...... |.| ...| |..... ... || ....||. .. |. |||. ...|||. . ....| | |.. FWNKIGEGGYGQVYKGKWRGYPVA--IKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCP |
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Kinase | SAMK-D.AA | CAMKL | 166-210 | 20 | 0.016422 | 3.66 | In-house | 31-100 (297) | Show / Hide |
Range on Protein: 166-210 Range on HMM: 31-100/297 Sequence Identity: 20% (14 aa) KIIK--NSTLNEEKLIN--------------EIDTIYLLD---HPNLIKIIGYCKDKNY------FYIGM |||. .... .. | || .|. ||| ||. .... .|. | KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM |
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Kinase | SAMK-D.AA | CAMK-Unique | 377-393 | 47 | 0.031653 | 2.92 | In-house | 347-363 (363) | Show / Hide |
Range on Protein: 377-393 Range on HMM: 347-363/363 Sequence Identity: 47% (8 aa) EPCFRPSSKELLKSFWF .| .| |.||||.. |. DPDHRWSAKELLEHQWI |
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Kinase | SAMK-D.AA | STE | 377-393 | 31 | 0.074117 | 2.49 | In-house | 341-359 (359) | Show / Hide |
Range on Protein: 377-393 Range on HMM: 341-359/359 Sequence Identity: 31% (6 aa) EPCFRPSSKELLK--SFWF .| ||....||| .. DPNKRPTASQLLKSEHPFI |