Gene Nek4 (Slime mold)
Nek4
Sequence
Protein domains of Nek4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Nek4.AA | NEK4 | 4-257 | 71 | 1.8e-215 | 722.11 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-257/257 Sequence Identity: 71% (185 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLK--EREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKNEFIS |...|..|.||.|.|.|||...|||.|||||.||| .|...|...||...||||||||||||.||..|||.|||.|.|..||.|||...|...||.|.. YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE EYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLN-SSEFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEMITLKH |||...||.|||..|.|||.|...||||||||||||||||||||||||||||| ....|||||||||||||||||.|.||.||||||||||.|||||||| EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH AFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI |||||.|.|||.||.||||.|..|||||||||||||.|||||||||||||||||||| AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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Kinase | Nek4.AA | NEK | 4-257 | 50 | 4.3e-158 | 531.52 | In-house | 1-286 (286) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-286/286 Sequence Identity: 50% (144 aa) YDIIKQIGNGSHGDVYLVRSTIDKKK-----YVMKKIFLKER--EKTKDTL-HEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCE-SGDLFTT--- |.|||.||.||.| ||.||...|.|. ||.||| ... ....... .||..|.||||||||.|..||. |.|..|||.| ||| |||. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS LQKKK--NEFISEYQILDWFIQIALGLLYMHKK-----KVIHRDLKTQNIFLTKKNI----IKIGDFGISRVLNSS-EFAKT-MIGTPYYMSPECFGSRA ..|.| .....| ||.|||||..|.| |||.. |..|||.|.|||||||.|. .||||||||.|||.. ..|.| ..||||||||| . .. IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP YDFKSDIWSLGCCLYEMITL--KHAFDAK--EMPSLIFQILQG-QPLPISPN--YSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI |..|||||||||.|||| || ||.|.|. ||||...| .| |. ||... ||||||||. |.| | |..|||. .|..||.| YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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Kinase | Nek4.AA | NEK1 | 4-257 | 44 | 3.7e-123 | 415.46 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-276/276 Sequence Identity: 44% (122 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKK--KNEF |..||||| || | ..||... | . ||.| | . . .. . . . ||..|. .||||||.|.|||. . . | |.| ||. |||. ... |. YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLT--KKN---------------IIKIGDFGISRVLNSS-EFAKTMIGTPYYMSPECFGSRAYDF .|| ||..||.|| |.| ..|..|..|||.|.|||||| |. ..|.|||||.|.||.. |.|.| |||||| ||| . |. FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN KSDIWSLGCCLYEMITLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI ||||||||| ||| .||||.|.|. .. |. |.|| ||.| ||..||.|| |.. . | |||. .| . | | KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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Kinase | Nek4.AA | NEK8 | 4-257 | 37 | 1.7e-104 | 299.24 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-278/278 Sequence Identity: 37% (105 aa) YDIIKQIGNGSHGDVYLVRSTIDK--KKYVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKN-E | | .| |. | . | | . | .. . | | . . . . . |..||| | ||||..|...| .|.|. | | | |.. | | .|. .| YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHF-MEDNT-LMIEMEYADGGTLYQMIQHQQNKL FISEY----------------QILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKK-NIIKIGDFGISRVLNSSEFAKT---MIGTPYYMSPECFGSRA | | .||. |.|. ... .||.. . ||||||||||.|. ...|||||||| ..|. . | .||||||||| .. FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKP YDFKSDIWSLGCCLYEMITLKHAFDAKEMPSLIFQILQG-QPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI |..|||.|.||| |||| .|| ||.| | |. | |. ||| || .. || ..| . | .||| | || . YNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC |
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Kinase | Nek4.AA | S_TKc | 4-257 | 30 | 1.1e-94 | 321.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-231/231 Sequence Identity: 30% (82 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCES--GDLFTTLQKKKNEF-- |.|...|| |. | ||..| . ..... .|.| .... |...|.. .||||| ....|| ..|...| ||. ||||. ..|.. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSSEFAKTMIGTPYYMSPECFGSRAYDF-KSDIWSLGCCLYEMI ..| .. .. ||...| |.|....|||||| .||.|.. |||.|||..|.| .|..|||.||.|| . |.. |.|.||.||.||||. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQ-------MPYI . . |. . ..|... |... ... ..|.| |.|||.. ...| .|.. CGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | Nek4.AA | NEK-Unclassified | 4-257 | 40 | 1.5e-83 | 276.47 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-258/258 Sequence Identity: 40% (106 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKK--KNEFIS || | .| | | ||||| | |. | . . | | | . .||||.|| || | .|| || . | ||. |.| .||. ||| . YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQNKIIILSQLRHPHIVTYHDSF-FENAK-LFYTQDYCDGGNLDRRIQKHRKKNEPFD EYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSS-EFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEMITLKH | | |.||. . | | .|.||||||.||||||. .. .|||||||... . |.| .||. .|||| |. .||.||||| .||| | EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP AFDAKEMPSLIFQILQGQP------LPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI .||.. | .. . | |. |.| || |||... .|.. . .||| .| ..|| FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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Kinase | Nek4.AA | Pkinase | 4-257 | 28 | 5.3e-80 | 276.88 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-293/293 Sequence Identity: 28% (86 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLH----EVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESG----DLFTTLQ-K | |...|| || | ||. . . |....|.| ...... || | |. .. |.|||||.....|. .. ....| ||| | |||. .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW KKNEF-ISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNII----KIGDFGISRV--LNSSEFAKTMIGTPYYMSPECFG-SRAYDFKSDIW ... | || .. ... ||. || |.|....|||||| .||.. ... | ||.|||.... . ... ..| |||.||.|| .. |. |.|.| RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SLGCCLYEMITLKHAFDAK------EMPSLIFQILQGQPLPISPNYS--------------------QDLQNLVYQLLEKQPTKRPSIFDIFQMPYI |.|| ||||.. . |. . .. .|..|..... .|. . .... ... .|.| |.|||.. .|.| |.. SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | Nek4.AA | Ciliate-E2 | 4-257 | 23 | 1.8e-75 | 257.08 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-365/365 Sequence Identity: 23% (89 aa) YDIIKQIGNGSHGDVYLVRSTIDKK----------------------KYVMKKIF----LKEREKTKDTLHEVN----------VLSQLKHPNIVEYFES |..||.||.|..|.||... ..| |.. .||. ... .. .. . |.| .|.||.||||....|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FQIENNQFLCIIMAYCESGDLFTTLQKKKNEF---------ISEYQILDWFIQIAL---------------GLLYMHKKK-VIHRDLKTQNIFLTKKNII || .... . ..| ||. |||| ....| . ..|..|.. . ||. .| |.|.|. .||||.| .||.. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIGDFGISRVLNSS--------------------------------EFAKTMIGTPYYMSPECFGSRA---------YDFKSDIWSLGCCLYEMITLKHA || |||.|. .. . . ..| .|||.||.|| ... ||.|.||||||..||||.. |. KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FDAKEMPSLIFQILQGQPLPISPN------------------YSQDLQNLVYQ----LLEKQPTKRPS-IFDIFQMPYI | .|. . ... .... ||. ..| . .|.|.| ||.. . .|.. |.. F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | Nek4.AA | ULK | 4-257 | 27 | 2.5e-73 | 249.9 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-329/329 Sequence Identity: 27% (90 aa) YDIIKQIGNGSHGDVYLVRSTIDK----KKYVMKKIFLK-EREKTKD---------TLHEVNVLSQLK--------HPNIVEYFESFQIENNQFLCIIMA | .....| || | || | ..| .|.. |.| .. ...| .. |. .. .|| |||||.... |. |. . ||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YCESGDLFTTLQKKKN--------EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKN------------IIKIGDFGISRVLNSS----E ||. |||.. ..|.|. ..|| ... |.||. |. ..||...||||.| ||| ..... ..||.||| ....... . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ FAKTMI------GTPYYMSPECFGSR-----AYDFKSDIWSLGCCLYEMITLKHAFDAKEMPSLI---FQILQG-----------QPLPIS-----PNYS ..|. |||.||.|. . .. ||.|.||||||| .|||.. | | | ... | | ||| . |. | MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS QDLQNLVYQLLEKQPTKRPSIFDIFQMPYI .....| ...|......| |. ..|..| . PECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | Nek4.AA | ULK | 4-257 | 26 | 1.2e-72 | 247.7 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-324/324 Sequence Identity: 26% (86 aa) YDIIKQIGNGSHG-DVYLVRSTID---KKKYVMKKIF---LKEREKT-------KDTLHEVNVLSQLK---HPN--IVEYFESFQIENNQFLCIIMAYCE | .....| || | || | .. .... |.| ... .. . |.... .|| ||| ||.... |. |. ...||| ||. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN SGDLFTTLQKKKN-------EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKN------------IIKIGDFGISRVLNSSEFAKTMI-- |||.. ..|.|. ..|| ... |.||. |. ..||...||||.| ||| ..... ..||.||| ...... .....|. GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT --------GTPYYMSPECFGSR-----AYDFKSDIWSLGCCLYEMITLKHAFDAK--EMP----SLIFQ------ILQGQPLPIS-----PNYSQDLQNL |||.||.|. . .. ||.|.||||||| .|||.. | | . . .|| . . . ||... |. |.....| CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL VYQLLEKQPTKRPSIFDIFQMPYI ...|......| |. .||..| . IRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | Nek4.AA | CAMK | 9-257 | 19 | 1.7e-72 | 232.7 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 9-257 Range on HMM: 1-425/425 Sequence Identity: 19% (81 aa) QIGNGSHGDVYLVRSTIDK------------KKYVMKKIFLK----------------------------EREKTKDTLHEVNVLSQ-------LKHPNI ..| || | |.|.. . .. .|. .| | | . .. | ..|...... |.|||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VEYFESFQIEN-----------------NQFLCIIM---AYCESG----DLFTTLQKKKN-------------EFISEYQILDWFIQIALGLLYMHKKKV . .| .. .. .......| ||. | ||| ...... ..| . .| ||. .. |.|.... IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI IHRDLKTQNIFLTKK-----------------NIIKIGDFGISRVLNSSE------------------------FAKTMIGTPYYMS-PECFGS------ .||||| || |... | ||| ||| .......| ||. |||.||. || . . VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM --------RAYDFKSDIWSLGCCLYEMITLKHAFDAK-------------EMPSLIFQILQGQPL-P------------------ISPN----YSQDLQN . |..|.|.||.|. || | . . |... ... | .|..|. | || . ||. .. QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD LVYQLLEKQPTKRPSIFDIFQMPYI |. ..|.. |.||..| .. . | . LIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | Nek4.AA | NEK11 | 4-257 | 42 | 1.4e-69 | 237.44 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-259/259 Sequence Identity: 42% (112 aa) YDIIKQIGNGSHGDVYLVRSTIDKKK---YVMKKIFLKE--REKTKDTLHEVNVLSQLKHPNIVEYFESFQIENNQFLCIIMAYCESGDLFTTLQKKKN- | . ...| || | |||| |. |.| | | | | .||.|.|| || . || .| ..| ||| ||| || .| |. YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASF-MEQDNF-CIITEYCEGRDLDYRIQEYKQA -EFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVL-NSSEFAKTMIGTPYYMSPECFGSRAYDFKSDIWSLGCCLYEM .| ||..||||. || ||| ....||||| .|||| | |..||||||.||.| | . | |. ||| ||||| || ||||||| | |||| GKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEM ITLKHAFDAKEMPSLIFQILQGQPLPISPNYSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI . ||| . |.. .| |. . | ..| .. ..| |.| ||| || ..||. CCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM |
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Kinase | Nek4.AA | Pkinase_Tyr | 76-198 | 31 | 3.9e-27 | 92.51 | Pfam | 82-210 (270) | Show / Hide |
Range on Protein: 76-198 Range on HMM: 82-210/270 Sequence Identity: 31% (43 aa) LCIIMAYCESGDLFTTLQKK--KNEFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSSEFAKTMIGTPYY----- ..|.| |.. ||| . |.|. .. .. ..|.. .||| |. | . |. ||||| . |. .|..|..||.||| .| . . || IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---------YNDDYYYRKRG --------MSPECFGSRAYDFKSDIWSLGCCLYEMITL |.|||. . . |||.|| | ...|..|. GGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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Kinase | Nek4.AA | TyrKc | 4-257 | 24 | 1.8e-26 | 95.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-257 Range on HMM: 1-280/280 Sequence Identity: 24% (71 aa) YDIIKQIGNGSHGDVYLVRSTIDKKKYVMKKIFLKEREKTKDTLHEVNVLSQL--KHPNIVEYFESFQIE-----NNQFLCIIMAYCESGDLFTTLQKKK .|..|.| | ||. . . | | .. .| ..| .....| .||||| . . . |.|.| |.. ||| |.|.. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR NEFISEYQILDWFIQIALGLLYMHKKKVIHRDLKTQNIFLTKKNIIKIGDFGISRVLNSS------EFAKTM---IGTP-----YYMSPECFGSRAYDFK .. .. . |.. .||| | | |.|..||||| . |. .......||.||| || . . . ... |. |.|||. . . .| PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK SDIWSLGCCLYEMITL-KHAFDA-----KEMPSLIFQILQGQPLPISPN--------YSQDLQNLVYQLLEKQPTKRPSIFDIFQMPYI ||.|| | |..|. |. . .. .| .. || .|. || .... .. | . .| .||. .| .. SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | Nek4.AA | Pkinase_Tyr | 47-62 | 47 | 0.230861 | 5.24 | Pfam | 51-67 (270) | Show / Hide |
Range on Protein: 47-62 Range on HMM: 51-67/270 Sequence Identity: 47% (8 aa) LHEVNVLSQL-KHPNIV ..|.....|| .||||| MREAKIMKQLGHHPNIV |