Gene Nek2 (Slime mold)

Nek2

Species: Slime mold
Alias: DdisK102, Nek2, DDB0216282, Ddnek2
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
Nek2.AA Protein None 418 None Fasta, JSON
Nek2.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of Nek2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Nek2.AA NEK2 4-264 53 2.3e-208 698.5 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-319/319
Sequence Identity: 53% (171 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCRNERTY
||.|...|.||||...|..||.||..||||||||..|||||.|.||.|.|||..|||.|||||||.|||...|.|||.||.|.||||||.|||||.||.|
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

MDEEVIWRTLLQILSALQEIHN----------------RKDG--VILHRDIKPGNLFLDENKN-------------------------------------
|.||.|||...|...||||.||                |.||  .||||||||.|.|||...|                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGLAKILN-ESLYAHTFVGTPYYMSPEQIHGLKYNERSDVWSVGCLIYEMATLSPPFEATNQAQLTSKIQVGRYNPIPSQYSEHLSKVISLMI
  .||||||||..|| ....|||||||||||||||.||.||||.||.||||||||||..|.|||.|||||||..||..|....||.|||.||...|..||
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NVDPKSRPNVNELLGYSFI
|||...||...|.|....|
NVDHYHRPSIEEILQHPQI
Kinase Nek2.AA NEK 4-264 48 2.8e-154 518.83 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-286/286
Sequence Identity: 48% (140 aa)

YEILGALGKGSFGVVSKIKRKEDGRV-----LVWKEICYENMQEKEKQLLV-NEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCS-GGDLSQL---
|||.  .|.||||.| |..||.||..     .|||.| ..||.||||| .. |||.||..|||.|||.|||..|.. ...|.|.||.|  ||||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKKCRNERTYMDEEVIWRTLLQILSALQEIHNRKDG---VILHRDIKPGNLFLDENKN----IKLGDFGLAKILN-ESLYAHT-FVGTPYYMSPEQIHGL
|||......|..||.||. . |...||...|.|| |    |||||||| |.||. | |    .|.||||..|.|| .. .|.| .||||||||||.... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

KYNERSDVWSVGCLIYEMATLSP--PFEAT--NQAQLTSKIQVG-RYNPIPSQ--YSEHLSKVISLMINVDPKSRPNVNELLGYSFI
.||..||.||.||..|||.||.|  ||||.  |. .|  ||. |  |.||||.  ||. |...||.|...||..||..|..|  .||
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Nek2.AA NEK8 4-264 36 5.8e-93 265.73 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-278/278
Sequence Identity: 36% (102 aa)

YEILGALGKGSFGVVSKIKRKEDG--RVLVWKEICYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCRN--
||    .|.|.||..    ||||.     .||.|  . | ||| |.  ||...| .| | ||. |||  ..  .  | | || . || | |.| . .|  
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNT--LMIEMEYADGGTLYQMIQHQQNKL

---ER----------TYMDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDEN-KNIKLGDFGLAKILNESLYAHT---FVGTPYYMSPEQIH
   ||           |  |  |   . |..||.  .|      |||||.|. | |..     .|.||||..||.|    . |    ||||||||||   
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHN---ILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCE

GLKYNERSDVWSVGCLIYEMATLSPPFEATNQAQLTSKIQVG-RYNPIPSQYSEHLSKVISLMINVDPKSRPNVNELLGYSFI
| .||. ||.|..|| .|||..|   |||.|.  |  ||  .  |.||...||  .  ...    .||  || . ... .  .
GKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase Nek2.AA NEK1 4-264 44 9.1e-90 304.54 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-276/276
Sequence Identity: 44% (123 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCRNERTY
|... ..|.|||| . . |.||||...| |||  ..|||||..  .|||.||.|.|| |||.|..  .   .  |||.|| | |||| | |.. .     
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

MDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLD--ENK---------------NIKLGDFGLAKILNESL-YAHTFVGTPYYMSPEQIHGLK
  |  |     ||  ||. || ||   |||||||. |.||   .|                 .|||||| |..||... || | .||||| ||| .  . 
FSEDQIMHWFCQICLALNHIHDRK---ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKP

YNERSDVWSVGCLIYEMATLSPPFEATNQAQLTSKIQVGRYNPIPSQYSEHLSKVISLMINVDPKSRPNVNELLGYSFI
||  ||.|| ||  ||  ||. |||| |  .|  ||  |.| |||. ||. |.  .| | ...|..|| || .|   ||
YNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase Nek2.AA S_TKc 4-264 34 7.5e-89 302.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSG--GDLSQLIKKCRNER
||||  .|||.||.| | . |..||.   |.|          . . .|..||.| .| |||..|| . |   ..||..||.|.|  ||| ..|||.. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TY--MDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFGLAKILNESLYAHTFVGTPYYMSPEQIHGLKYNE-RSDVWSVGCL
..  ..| .... . ||..||. .|...   |.|||.|| |..|||  .||..|||||..|      .||.|||.||.|| .   .|.  ..|.||.||.
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IYEMATLSPPFEATNQAQLTSKIQVGRYNPIPSQYSEHLSKVISLMINVDPKSRPNVNELLG-------YSFI
.|||..  |||.   | |.. |. .          |. .   |. . ..||. || . |.|          ..
LYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Nek2.AA STE 4-264 25 8.5e-78 264.77 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

YEILGALGKGSFG-VVSKIKRK-----EDGRV---------LVWKEICYENMQ---------------EKEKQLLVNEVNILQKLK--HQNIVRYYDRII
.|... .|||.|| |. ....|     . |.|            |.. .|| .               ..|.| . .|..|..|..  |.|||.||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK---PSS--RLYIIMEHCSGGDLSQLIK---KCRNERT-------YMDEEVIWRTLLQILSA-LQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFG
..    ..   |.|.||...|| |...||   .| .. .       ...|..| . . ||| . |. .|. .   | ||||||.| .|     .|| |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKILNESLY-----------------AHTFVGTPYYMSPEQIHG------LKYNERSDVWSVGCLIYEMATLSPPF---EAT---NQAQLTSKIQV---
....|..|.                    |||||| .|.|| | .       .|....|.||.||.| ||||  ||.     .    ...  ...|    
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GRYNPIPS-------------------QYSEHLSKVISLMINVDPKSRPNVNELLG--YSFI
      |   |.|.                   ..|...   |..  . ||. ||....||    .||
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Nek2.AA Pkinase 4-264 30 5.4e-74 256.94 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVN--EVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGG----DLSQLIKKC
|.|.. .|.||||.| | ..| .|.. . |.|....  ....| ...  |. |...|.| ||||.||   |  ....|..||.| ||    ||. .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

RNERTYM--DEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNI----KLGDFGLAKI--LNESLYAHTFVGTPYYMSPEQIH-GLKYNE
  ... .  .|... . ..|||..|. .|..    |.|||.|| |...|.| .|    |..||||||   .  .  ..||.|||.||.|| |  | .|  
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

RSDVWSVGCLIYEMATLSPPFEAT----NQAQLTSKIQVGRYNPIPSQYS-----------------------EHLSKVISLMINVDPKSRPNVNELLGY
..|.||.||..|||..  |||       | .    .|.  .. |......                       | . ..|. ....|||.||.  ..|  
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

SFI
 ..
PWF
Kinase Nek2.AA NEK6 4-255 37 4.6e-67 219.71 In-house 1-252 (252) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-252/252
Sequence Identity: 37% (97 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEI-CYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCRNERT
..|   .||| |  | . .   |...   | .  .| | .| .|  . |...|..| |.|...||.  |.     | |..|    ||.|..||  . .. 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIEN--NELNIVLELADAGDMSRMIKHFKKQKR

YMDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFGLAKIL-NESLYAHTFVGTPYYMSPEQIHGLKYNERSDVWSVGCLIYE
 . |  ||.   |. |||. .| ..   ..|||||| | |.  |  .|||| || .    .   ||  |||||||||| ||   || .||.||.|||.||
LIPERTIWKYFVQLCSALEHMHSKR---VMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYE

MATLSPPF--EATNQAQLTSKIQVGRYNPIPSQ-YSEHLSKVISLMINVDPKSRPNV
|| |  ||  .  |   |  ||.   | |.|.. |||.|.. ....|. ||. ||..
MAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase Nek2.AA NEK4 4-264 35 3.6e-66 226.14 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-257/257
Sequence Identity: 35% (94 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCRNERTY
|...   ||||.| |  .. . |..  | | .   |   .|..    |...| .||| ||| | .         |||.|  | |||| .  |. .|.   
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQ--F

MDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFGLAKILN-ESLYAHTFVGTPYYMSPEQIHGLKYNERSDVWSVGCLIYEM
..|. .     ||  ||| .| ..   ||||| |  |.||     ||.||||....||  . .| | .|||||||||      |. .||.|| || .|||
LEEYQVVEWFVQIAMALQYMHEKH---ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEM

ATLSPPFEATNQAQLTSKIQVGRYNPIPSQYSEHLSKVISLMINVDPKSRPNVNELLGYSFI
.||   |.| .   |  .|  |.  |.| .||. |   .  |..  |. || . ...   .|
ITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase Nek2.AA STE20 4-264 30 2.6e-64 219.97 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-288/288
Sequence Identity: 30% (88 aa)

YEILGALGKGSFGVVSKIKRKEDGRV----LVWKEICYENMQE--KEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPS--SRLYIIMEHCSGGDLSQLIK
||.|  .|.||.|.| |   |. |..       | . .|. ..  .|......|..|....||.|||.||.  . . .  . |.|.||.|.|| |....|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

KCRNERT-----YMDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFGLAKILNE-----SL-YAHTFVGTPYYMSPEQIHG-
.| .         |.|| |   . ..| .|. .|...   | ||||| .|  |.|. ..|| |||..  |..           |||||||.|.|| | . 
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH---IIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

----LKYNERSDVWSVGCLIYEMATLSPPFEATNQAQLTSKIQVGRYNPI------PSQYSEHLSKVISLMINVDPKSRPNVNELLGYSFI
     .|....|.||.|  . |||.  ||.   .  .   .|  ..  |       |...| ..   .... ..||. || . .||  .||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Nek2.AA Ciliate-E2 4-264 22 2.9e-64 219.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

YEILGALGKGSFGVVSKIKRKEDGRVL------------------VWKEICYENMQEKEKQLLVNEVNILQ----------------KLKHQNIVRYYDR
|...  .|.|.||.| | |......                      |..  ..|...... . .| .|..                .|.| ||...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IIDKPSSRLYIIMEHCSGGDLSQLIKKCRNERT-------YMDEEVIWRTLLQILS---------------ALQEIHNRKDGVILHRDIKPGNLFLDENK
 ..|  . .|..|| |.|||| ..||...  |.       |..|. | .   |||.               ||...|...   |.|||||| |...    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

NIKLGDFGLAKILNES--------------------------------LYAHTFVGTPYYMSPEQIHGLK---------YNERSDVWSVGCLIYEMATLS
 ||. ||||.|.....                                  ..|..|||.||.|| . | |         |.. .|.||.|...||| .  
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFEATNQAQLTSKIQVGRYNP------------IPSQYSEHLSKVISL----MINVDPKSRPN-VNELLGYSFI
|||    | ..  ||.   ...            .. . |.     |.     |...||. |..  ...|   ..
PPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Nek2.AA Ciliate-E2-Unclassified 4-264 22 1.2e-60 207.84 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLV----NEVNILQKLK-----------------HQNIVRYYDRIIDKPSSRLYIIM
|.|.  .|.|.||.| | ..|... . . |...  ... . ... .    || ......|                 |........  ...    .||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EHCSGGDLSQLIKKC-------------RNERTYMDEEVIW-----RTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENK---NIKLGDFGLAKILN
| | ||||.| |||.             ...|   .|. .      . . |||..|. .|  .   |.|||||| |...|.|.   .||. |||..| ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

E----------------SLYAHTFVGTPYYM----SPEQIHGLKYNER----SDVWSVGCLIYEMATLSPPFEATNQAQ----------------LTSKI
.                .  ..||.|||.||    .|| . | .|...    .|.||.|...||| .  .||...|. |                | ..|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QVGRYNPIP-------SQYSEHLSKVIS----LMINVDPKSRPNVNELLGYSFI
. . ..  .        . |..    |.     |....|..|.. ...|   ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Nek2.AA TyrKc 4-264 22 3.7e-20 74.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-264
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYENMQEKEKQLLVNEVNILQKL--KHQNIVRYYDRIIDK-----PSSRLYIIMEHCSGGDLSQLIKK
 . .  || | ||.| | . |    | | | .  .      .. . .| .|. ||  .|.|||| |  ....      .  |.|.||....||| . ..|
ITLGKKLGEGAFGEVYKGTWK--IQVAV-KMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CRNERTYMDEEVIWRTLLQILSALQEIHNRKDGVILHRDIKPGNLFLDENKNIKLGDFGLAKILNES--------LYAHTF-VGTP-----YYMSPEQIH
.|..      .      .|| .  . .| .    . |||.   |  ..||. .| .||||.. . .          | ..   |.        |.|| | 
HRPK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GLKYNERSDVWSVGCLIYEMATL-SPPFEA-----TNQAQLTSKIQVGRYNPIPSQ--------YSEHLSKVISLMINVDPKSRPNVNELLGYSFI
  |... ||||| | ...|. |.  .| .       . ...  ... |.. |.|           .. . ....   . ||..||. .|.  ....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Nek2.AA Pkinase_Tyr 4-98 29 1.3e-10 36.61 Pfam 1-102 (270) Show / Hide 
Range on Protein: 4-98
Range on HMM: 1-102/270
Sequence Identity: 29% (31 aa)

YEILGALGKGSFGVVSKIKRK-----EDGRVLVWKEICYENMQEKE--KQLLVNEVNILQKL-KHQNIVRYYDRII--DKPSSRLYIIMEHCSGGDLSQL
 ...  ||.|.||.| | . |     ..  | | | .  |.  ...  .. . .|..|. .| .|.||||.|  ..  ..|. ..||.||.. .|||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAV-KML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDY

IKKCR
 .| |
LRKHR
Kinase Nek2.AA Pkinase_Tyr 140-264 27 1e-09 33.5 Pfam 141-270 (270) Show / Hide 
Range on Protein: 140-264
Range on HMM: 141-270/270
Sequence Identity: 27% (37 aa)

NLFLDENKNIKLGDFGLAKIL-NESLYAHTFVG---TPY-YMSPEQIHGLKYNERSDVWSVGCLIYEMATLS-PP-FEATNQAQLTSKI-QVGRYNPIPS
|  ..||. .| .|||||. . |.. | ..  |    |   |.|| |.  |... ||||| | |..|. |.   | ..    ...  .| . |.  |.| 
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE

QYSEHLSKVISLMINVDPKSRPNVNELLGYSFI
  .. . ... .  . ||. ||   |.  ....
NCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL