Gene DDB0231196 (Slime mold)
DDB0231196
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0231196.AA | Protein | None | 965 | None | Fasta, JSON |
| DDB0231196.kin_dom | Protein Kinase Domain | None | 267 | None | Fasta, JSON |
Protein domains of DDB0231196.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0231196.AA | Dicty6 | 465-731 | 94 | 2.7e-254 | 825.29 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 465-731 Range on HMM: 1-267/267 Sequence Identity: 94% (253 aa) IGSAGNASVFEGTYKGIPIACKEMPVSGTYEQSVDSIKEIAAVGQIKKLGCATVVETIGVLKYNQKLFLVMVKEKCNLLSFLCNKSEILKMQREGIWTSI ||||||||||||||||.|||||||||||||||.||||||||||||||.|||.|||.|||||||||||||||||||||||||||||||||||||||||||| IGSAGNASVFEGTYKGMPIACKEMPVSGTYEQRVDSIKEIAAVGQIKDLGCCTVVKTIGVLKYNQKLFLVMVKEKCNLLSFLCNKSEILKMQREGIWTSI FKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRLNTFAKTIGTMWYRCPRLGDCSEDEKTLTHYNEKSEIYSLGIILWELV |||||||||||.||||.|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.||||||||||||||||||. FKISKDILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTMWYRCPRLGDCSEDEKTLNHYNEKSEIYSLGIILWELI CVAMTGTYISPKIPLFQNEVDFLIWIHKDYRFSFPVGTPQSFVKLITRMCLPFRDRRPTVRQVLDNV |.||||||||||||||||||||.||||||||||||.||||||||||||||||.|||||||||||||| CIAMTGTYISPKIPLFQNEVDFSIWIHKDYRFSFPIGTPQSFVKLITRMCLPCRDRRPTVRQVLDNV |
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| Kinase | DDB0231196.AA | TKL | 465-731 | 16 | 5e-21 | 72.45 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 465-731
Range on HMM: 1-364/364
Sequence Identity: 16% (65 aa)
IGSAGNASVFEGTYKG----------IPIACKEMPVSG-----------------------TYEQSVDSIKEIAAVGQIKKLGCATVVETIGVLKYNQK-
||| | . |. |...| ..| | ... |.| .|. . ....| . .| .|. .....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LFLVMV-KEKCNLLSFLCNKSEILKMQREGIWTSIFKISKDILKGLVSLREAG--------MYHRDFKTANFLVSNTGK---------
|..|| .. .||..| | ......|| .|. | . . ||| |..| || . ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP
-----ILISDFGTSRDENEKRLNTFAK------------------TIGTMWYRCPRLGDCSEDEKTLT---------HYNEKSEIYSLGIILWELVC--V
. |.|||.||. ... .. . .|| . | . . ... . |.||. .|| ||.|||... .
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
AMTGTY--ISPKIPLFQNEVDFLIWIHKDY----RFSFP------------VGTPQSFVKLITRMCLPFRDRRPTVRQVLDNV
| . . ..|| . | ... ... | | .|.|. ||... . . . ||. ..|.
----PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | DDB0231196.AA | TKL-Unique | 566-664 | 29 | 2.1e-18 | 61.68 | In-house | 114-222 (290) | Show / Hide |
Range on Protein: 566-664 Range on HMM: 114-222/290 Sequence Identity: 29% (34 aa) KISKDILKGLVSLREAG--MYHRDFKTANFLVSNT-----GKILISDFGTSRDENEKRLNTFA--------KTIGTMWYRCPRLGDCSEDEKTLTHYNEK |. .|| .|. | . ..||| |. ||||.| .| |.|||.|. . .|. .|. ...| . .. ..|.|| KMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-----CQYSEK SEIYSLGIILWELV |..|| ||.|||.. SDVYSFGIVLWEIA |
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| Kinase | DDB0231196.AA | ARK | 585-730 | 30 | 2.1e-16 | 56.31 | In-house | 126-280 (280) | Show / Hide |
Range on Protein: 585-730 Range on HMM: 126-280/280 Sequence Identity: 30% (47 aa) HRDFKTANFLVSNTGKILISDFGTSRDENEKRLNTFAKTIGTMWYRCPRLGD---CSEDEKTL-THYNEKSEIYSLGIILWELVCVAMTGTYISP--KIP |||.|. |.||. .. ..||| || . . | |. ||. | | . . .| . ||..|| .||.|||.||.| .|.| | . HRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYSMGIIMWEMVYRCINGCYMRPYSEYK LFQNEVDFLIWIH---KDYRFSFPVGTPQSFVKLITRMCLPFRDRRPTVRQVLDN .| || | | .. | . | ..|.....||.. . | ||. ... HIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE |
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| S_TKc | DDB0231196.AA | S_TKc | 459-739 | 16 | 6.3e-15 | 42.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 459-739 Range on HMM: 1-231/231 Sequence Identity: 16% (49 aa) IDFHTQIGSAGNASVFEGTYKG--IPIACKEMPVSGTYEQSVDSIKEIAAVGQIKKLGCATVVETIGVLKYNQKLFLVMVKEKC---NLLSFLCNKSEIL ... .||. . ..|. .. |. |.|... . ..||. . .. .| ..| ..|..|| .|....... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG K---MQREGIWTSIFKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRLNTFAKTIGTMWYRCPRLGDCSEDEKTLTHYNE- . . .. .. . |...| . . | ||| | .| |... | |.||| .| .|| ||. | . .|. LRFPFPE-HAR----FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------GYGKC KSEIYSLGIILWELVC-------VAMTGTYISPKIPLFQNEVDFLIWIHKDYRFSFPVGTPQSFVKLITRMCLPFRDRRPTVRQVLD-NVKAIKKEFL |. ..|.|.||.|..| ..|. | .... .| ... ..|||. ..| ... . ... KCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Pkinase | DDB0231196.AA | Pkinase | 459-731 | 18 | 1.7e-13 | 48.78 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 459-731 Range on HMM: 1-293/293 Sequence Identity: 18% (60 aa) IDFHTQIGSAGNASVFEGTYKGIP--IACKEMPVSGTYEQSVDSIK---EIAAVGQIKKLGCATVVETIGVLKYNQKLFLVMVKEKCNL-LSFLCNKSEI . .. .||| . ..|.... || . |.|....... .. . ||. .. . .|..... ..... .|| | |. |. . ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVM--EYCEGGLY-VMDLFDY LK-MQREGI---WTSIFKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKI----LISDFGTSR---DENEKRLNTFAKTIGTMWYRCPRLGDCSEDE .. ... .. . . .. . ||.|| . . | ||| | .|.|..|.| | |.||| .. | ..||. || ||. | . . ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC---GTPWYMAPEV--IR--- KTLTHYNEKSEIYSLGIILWELVCVAMTGTYISPKIPLFQNE-------VDFLIWIHKDYRFSFPVGTP---------------------QSFVKLITRM . ..| |. ..|.|.||.|..| . |.|... ...| .. ...|. .. ... ..|... -GGQYYGPKVDMWSCGCILYEMLC----------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC CLPFRDRRPTVRQVLDN--V . . .||| .|.| . LCKDPKKRPTAEQILQHPWF |
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| Kinase | DDB0231196.AA | Ciliate-E2 | 566-665 | 25 | 3.3e-13 | 41.67 | In-house | 149-291 (365) | Show / Hide |
Range on Protein: 566-665 Range on HMM: 149-291/365 Sequence Identity: 25% (38 aa) KISKDILK---------------GLVSLREAG-MYHRDFKTANFLVSNTGKILISDFGTSR---DENEKRL---------------------------NT .|.| ||. .| .| . . ||| | | |. | |.|||.|. |.|..|. |. YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNM FAKTIGTMWYRCP-RLGDCSED-EKTLTHYNEKSEIYSLGIILWELVC | ..|| | .| |. ..| ... ..|..|. |.|||.|| |... FNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF |
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| Kinase | DDB0231196.AA | CDK-Unclassified | 571-632 | 23 | 2.1e-12 | 37.0 | In-house | 130-207 (324) | Show / Hide |
Range on Protein: 571-632 Range on HMM: 130-207/324 Sequence Identity: 23% (18 aa) ILKGLVSLREAGMYHRDFKTANFLVSNTG-----KILISDFGTSRDEN-----------EKRLNTFAKTIGTMWYRCP .|.|.. | .... ||| |..| ...|.. .. | ||| .... .. . . | ||| | MLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVSTRWYRAP |
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| Kinase | DDB0231196.AA | MSN | 567-658 | 35 | 8.9e-12 | 34.93 | In-house | 109-197 (265) | Show / Hide |
Range on Protein: 567-658 Range on HMM: 109-197/265 Sequence Identity: 35% (33 aa) ISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSR--DENEKRLNTFAKTIGTMWYRCPRLGDCSEDEKTLTHYNEKSEIYSLGI |...||.|| | . . ||| | | |. . .. . ||| | | | ||| ||| .. | .| ||. . | .|...|.|| ICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTF---IGTPYWMAPEVIAC--DENPDATYDYRSDLWSVGI |
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| Kinase | DDB0231196.AA | CDK | 571-632 | 30 | 3e-11 | 32.07 | In-house | 117-188 (284) | Show / Hide |
Range on Protein: 571-632 Range on HMM: 117-188/284 Sequence Identity: 30% (22 aa) ILKGLVSLREAGMYHRDFKTANFLVSNTGK-----ILISDFGTSRDENEK-----RLNTFAKTIGTMWYRCP .|.|| . . . ||| |..| |..|.|. . | ||| .| . ..|. . . |.||| | LLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP |
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| Kinase | DDB0231196.AA | STE | 564-665 | 24 | 3.2e-11 | 36.0 | In-house | 153-263 (359) | Show / Hide |
Range on Protein: 564-665 Range on HMM: 153-263/359 Sequence Identity: 24% (30 aa) IFKISKDILKG-LVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENE------------------KRLNTFAKTIGTMWYRCPRLGDCSEDEKTL | .| ..|||| | | . . ||| | || |. . ..|||.. .. .. |||. | . | .. . . IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQG-RD THYNEKSEIYSLGIILWELVC .|..|. |.|||. ..|... KGYDTKCDIWSLGCTIIEMAT |
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| Kinase | DDB0231196.AA | LZK | 551-615 | 35 | 3e-09 | 27.23 | In-house | 76-140 (241) | Show / Hide |
Range on Protein: 551-615 Range on HMM: 76-140/241 Sequence Identity: 35% (23 aa) EILKMQREGIWTSIFKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENEK |.|. .|. . ||.| .|. | ||| | | |.|.. . |.|||||. ||. EVLRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEM |
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| TyrKc | DDB0231196.AA | TyrKc | 459-731 | 17 | 2.3e-08 | -87.37 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 459-731 Range on HMM: 1-280/280 Sequence Identity: 17% (56 aa) IDFHTQIGSAGNASVFEGTYKGIPIACKEMPVSGTYEQSVDSIKEIAAVGQI-KKL--GCATVVETIGVLKYN-------QKLFLVM--VKEKCNLLSFL | . ..|. |..||.| |. | | . . .... .| .|| .| .|| . |..|| .. .|...| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYL CNKSEILKMQREGIWTSIFKISKDILKGLVSLREAGMYHRDFKTANFLVSNTGKILISDFGTSRDENEK-------RLNTFAKTIGTM------------ .. . |.|. ... .| .| | . . ||| . | ||.. . . ||||| ||| .. . ... |. RKHRPKLCMKD------LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC WYRCPRLGDCSEDEKTLTHYNEKSEIYSLGIILWELVCVAMTGTYISPKIPLF--QNEVDFLIWIHKDYRFSFPVG--------TPQSFVKLITRMCLPF . ...|| ..| |. .||. .| . . . . . . .. . || | |. . | ..| . I--------------NYGKFTTKSDVWSFGVCMWEI----FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHE -RDRRPTVRQVLDNV . ||| ... . DPEDRPTFSEIHECF |
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| Kinase | DDB0231196.AA | LZK | 648-663 | 50 | 0.002957 | 6.74 | In-house | 165-180 (241) | Show / Hide |
Range on Protein: 648-663 Range on HMM: 165-180/241 Sequence Identity: 50% (8 aa) NEKSEIYSLGIILWEL .|| |.| |..|||. SEKVDIWSFGVVLWEM |
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| Kinase | DDB0231196.AA | TKL-Unique | 461-486 | 38 | 0.123431 | 1.76 | In-house | 1-26 (290) | Show / Hide |
Range on Protein: 461-486 Range on HMM: 1-26/290 Sequence Identity: 38% (10 aa) FHTQIGSAGNASVFEGTYKGIPIACK | ||. | ..|. |...|.|.| | FWNKIGEGGYGQVYKGKWRGYPVAIK |
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