Gene DDB0229339 (Slime mold)
DDB0229339
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0229339.AA | Protein | None | 959 | None | Fasta, JSON |
| DDB0229339.kin_dom | Protein Kinase Domain | None | 258 | None | Fasta, JSON |
Protein domains of DDB0229339.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0229339.AA | Dicty6 | 488-754 | 94 | 1.7e-251 | 816.19 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 488-754 Range on HMM: 1-267/267 Sequence Identity: 94% (251 aa) IGSAGNASVFEGTYKGMPIACKEMPVSGTYEQRVDSIKEIAAVGQIEDLGGCTVVKTVGVLKYNEKLFLVMVKEKCNLLSFLSNKSEILKMQRGGIWTSI ||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||.||||||.|||||||||||||||||.||||||||||.|||||| IGSAGNASVFEGTYKGMPIACKEMPVSGTYEQRVDSIKEIAAVGQIKDLGCCTVVKTIGVLKYNQKLFLVMVKEKCNLLSFLCNKSEILKMQREGIWTSI FKISKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTLWYRCPRLGDCSGDEKTLNHYNEKSEIYSLGIILWELI |||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||.||||||||||||||||||||||||| FKISKDILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTMWYRCPRLGDCSEDEKTLNHYNEKSEIYSLGIILWELI CIAMTGTYVSPKIALFQNEVDFSIWIHKDYRFSFPIGTPQSLVKLITSMCLPCRDRRPTVHQILDEV ||||||||.||||.|||||||||||||||||||||||||||.|||||.|||||||||||| |.||.| CIAMTGTYISPKIPLFQNEVDFSIWIHKDYRFSFPIGTPQSFVKLITRMCLPCRDRRPTVRQVLDNV |
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| Kinase | DDB0229339.AA | TKL | 564-754 | 18 | 8.7e-21 | 71.58 | In-house | 124-364 (364) | Show / Hide |
Range on Protein: 564-754 Range on HMM: 124-364/364 Sequence Identity: 18% (47 aa) NLLSFLSNKSEILKMQRGGIWTSIFKISKEILKGLISLRE--------VGMYHRDFKTANFLVSNTGK--------------ILISDFGTSRDENEKRFN .||..| | .......| .|. | .. ||| |..| || . .. . |.|||.||. ... . SLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM TFAK------------------TIGTLWYRCPRLGDCSGDEKTLN---------HYNEKSEIYSLGIILWELIC--IAMTGTY--VSPKIALFQNEVDFS . . .||. . | . . ... . . |.||. .|| ||.|||... . | . .|| . | NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDYPYMPMIFQD-P-FE IWIHKDY----RFSFP------------IGTPQSLVKLITSMCLPCRDRRPTVHQILDEV ... ... | | .|.|. ||.. . . . ||. .||.. EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | DDB0229339.AA | TKL-Unique | 589-687 | 28 | 4e-16 | 53.51 | In-house | 114-222 (290) | Show / Hide |
Range on Protein: 589-687 Range on HMM: 114-222/290 Sequence Identity: 28% (33 aa) KISKEILKGLISLREVG--MYHRDFKTANFLVSNT-----GKILISDFGTSRDENEKRFNTFA--------KTIGTLWYRCPRLGDCSGDEKTLNHYNEK |. . | .|.. | . ..||| |. ||||.| .| |.|||.|. . .|. .|.. ...| . .. . ..|.|| KMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV--LRMNF---CQYSEK SEIYSLGIILWELI |..|| ||.|||.. SDVYSFGIVLWEIA |
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| Pkinase | DDB0229339.AA | Pkinase | 482-754 | 20 | 7.4e-16 | 57.15 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 482-754 Range on HMM: 1-293/293 Sequence Identity: 20% (64 aa) IDFHTQIGSAGNASVFEGTYKGMP--IACKEMPVSGTYEQRVDSIK---EIAAVGQIEDLGGCTVVKTVGVLKYNEKLFLVMVKEKCNL-LSFLSNKSEI . .. .||| . ..|.... || . |.|....... .. . ||. . . . .|.. .. .. .. .|| | |. |. . ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVM--EYCEGGLY-VMDLFDY LK-MQRGGI---WTSIFKISKEILKGLISLREVGMYHRDFKTANFLVSNTGKI----LISDFGTSR---DENEKRFNTFAKTIGTLWYRCPRLGDCSGDE .. ...|.. . . .. ..||.|| . . | ||| | .|.|..|.| | |.||| .. | ..||. ||.||. | . ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC---GTPWYMAPEV------- KTLN---HYNEKSEIYSLGIILWELIC------------IAMTGTYVSPKIALFQNEVDFSIWIHKDYRFSFPI--------GTPQSLVKLITSMCLPCR .. .| |. ..|.|.||.|..| .. .. .| ... |.. |. . |.| |.. ..... ..|.... .. --IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDP DRRPTVHQILDE--V .||| .||| . KKRPTAEQILQHPWF |
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| Kinase | DDB0229339.AA | ARK | 608-753 | 32 | 7.8e-16 | 54.21 | In-house | 126-280 (280) | Show / Hide |
Range on Protein: 608-753 Range on HMM: 126-280/280 Sequence Identity: 32% (50 aa) HRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTLWYRCPRLGD--CSGDEKTLN--HYNEKSEIYSLGIILWELICIAMTGTYVSPKIAL- |||.|. |.||. .. ..||| || . | |. || | | . . |. . | ||..|| .||.|||.||.. .|.| | HRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYSMGIIMWEMVYRCINGCYMRPYSEYK -FQNEVDFSIWIH---KDYRFSFPIGTPQSLVKLITSMCLPCRDRRPTVHQILDE .| || | | .. | . |...|..|..||. . | ||. .|. | HIKNAFDFQILIQTSKNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE |
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| Kinase | DDB0229339.AA | Ciliate-E2 | 589-688 | 21 | 9.5e-15 | 47.04 | In-house | 149-291 (365) | Show / Hide |
Range on Protein: 589-688 Range on HMM: 149-291/365 Sequence Identity: 21% (33 aa) KISKEILK---------------GLISLREVG-MYHRDFKTANFLVSNTGKILISDFGTSRDENEK------------------------------RFNT .|.|.||. .| .| . . ||| | | |. | |.|||.|.. ... .|. YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNM FAKTIGTLWYRCP----RLG---DCSGDEKTLNHYNEKSEIYSLGIILWELIC | ..||. | .| . . . .. ..|..|. |.|||.|| |... FNTICGTPGYMAPEILNGKKYDNQ-----QKQKGYDYKCDIWSLGVILYEMLF |
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| S_TKc | DDB0229339.AA | S_TKc | 482-762 | 17 | 1.2e-14 | 37.7 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 482-762 Range on HMM: 1-231/231 Sequence Identity: 17% (51 aa) IDFHTQIGSAGNASVFEGTYKG--MPIACKEMPVSGTYEQRVDSIKEIAAVGQIEDLGGCTVVKTVGVLKYNEKLFLVMVKEKC---NLLSFLSNKSEIL ... .||. . ..|. .. |. |.|... . ..||. . . .|| .| ..|..|| .|.... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG K---MQRGGIWTSIFKISKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTLWYRCPRLGDCSGDEKTLNHYNE- . . .. .. ..|...| . . | ||| | .| |... | |.||| .| .||.||. | . .|. LRFPFPE-HAR----FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------GYGKC KSEIYSLGIILWELIC---IAMTGTYVSPKIALFQNEVDFSIWIHKDYRFSFPIGTPQSLVKLITSMCLPCRDRRPTVHQILD-EVGIIETEFL |. ..|.|.||.|..| ..|.. . .... .| .. ..|||. ..| |. | ... KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | DDB0229339.AA | MSN | 590-681 | 36 | 5.4e-12 | 35.64 | In-house | 109-197 (265) | Show / Hide |
Range on Protein: 590-681 Range on HMM: 109-197/265 Sequence Identity: 36% (34 aa) ISKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSR--DENEKRFNTFAKTIGTLWYRCPRLGDCSGDEKTLNHYNEKSEIYSLGI |..|||.|| | . . ||| | | |. . .. . ||| | | | ||| ||| .. | .| ||. | .|...|.|| ICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTF---IGTPYWMAPEVIAC--DENPDATYDYRSDLWSVGI |
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| Kinase | DDB0229339.AA | STE | 587-688 | 25 | 1.1e-11 | 37.65 | In-house | 153-263 (359) | Show / Hide |
Range on Protein: 587-688 Range on HMM: 153-263/359 Sequence Identity: 25% (31 aa) IFKISKEILKG-LISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENE------------------KRFNTFAKTIGTLWYRCPRLGDCSGDEKTL | .| ..|||| | | . . ||| | || |. . ..|||.. .. .. |||. | . | .. | . IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQG-RD NHYNEKSEIYSLGIILWELIC ..|..|. |.|||. ..|... KGYDTKCDIWSLGCTIIEMAT |
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| Kinase | DDB0229339.AA | Ciliate-E1 | 585-677 | 27 | 1.1e-10 | 31.38 | In-house | 109-202 (202) | Show / Hide |
Range on Protein: 585-677 Range on HMM: 109-202/202 Sequence Identity: 27% (26 aa) TSIFKISKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEKRFNTFAKTIGTLWYRCPRLGDC--SGDEKTLNHYNEKSEIY . . .| . ...||| |. . .||| | .| |..| |. ...|||.|. ... .. .. | |..| | .. . .| ||.|| QQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | DDB0229339.AA | CDK | 608-655 | 34 | 1.8e-10 | 29.57 | In-house | 131-188 (284) | Show / Hide |
Range on Protein: 608-655 Range on HMM: 131-188/284 Sequence Identity: 34% (20 aa) HRDFKTANFLVSNTGK-----ILISDFGTSRDENEK-----RFNTFAKTIGTLWYRCP ||| |..| |..|.|. . | ||| .| . .|. . . ||||| | HRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP |
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| Kinase | DDB0229339.AA | LZK | 591-638 | 41 | 3.7e-09 | 26.96 | In-house | 93-140 (241) | Show / Hide |
Range on Protein: 591-638 Range on HMM: 93-140/241 Sequence Identity: 41% (20 aa) SKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEK ||.| .|. | ||| | | |.|.. . |.|||||. ||. SKQIAQGMHYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEM |
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| TyrKc | DDB0229339.AA | TyrKc | 482-754 | 19 | 5.3e-08 | -93.29 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 482-754
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)
IDFHTQIGSAGNASVFEGTYKGMPIACKEMPVSGTYEQRVDSIKEIAAVGQI--EDLGGCTVVKTVGVLKYN-------EKLFLVM--VKEKCNLLSFLS
| . ..|. |..||.| .. | | . . | | ..|. .. . .|. .|| | |..|| .. .|...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPN---IVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR
NKSEILKMQRGGIWTSIFKISKEILKGLISLREVGMYHRDFKTANFLVSNTGKILISDFGTSRDENEK-----RFNTFAKT---IGT--LWYR-----CP
.. . |.|. ... | .| | . . ||| . | ||.. . . ||||| ||| .. . . |. | | .| |
KHRPKLCMKD------LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI
RLGDCSGDEKTLNHYNEKSEIYSLGIILWELICIAMTGTYVSPKI---ALFQNEVDFSIWIHKDYRFSFPIG--------TPQSLVKLITSMCLPCRDRR
. ...|| ..| |. .||. .| . . . . .. . || | |. . ..... . . |
----------NYGKFTTKSDVWSFGVCMWEI----FTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR
PTVHQILDEV
|| .| ..
PTFSEIHECF
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| Kinase | DDB0229339.AA | LZK | 671-686 | 50 | 0.002957 | 6.74 | In-house | 165-180 (241) | Show / Hide |
Range on Protein: 671-686 Range on HMM: 165-180/241 Sequence Identity: 50% (8 aa) NEKSEIYSLGIILWEL .|| |.| |..|||. SEKVDIWSFGVVLWEM |
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