Gene DDB0229335 (Slime mold)
DDB0229335
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0229335.AA | Protein | None | 663 | None | Fasta, JSON |
| DDB0229335.kin_dom | Protein Kinase Domain | None | 264 | None | Fasta, JSON |
Protein domains of DDB0229335.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0229335.AA | Dicty7 | 318-585 | 66 | 6.7e-224 | 750.12 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 318-585 Range on HMM: 1-271/271 Sequence Identity: 66% (179 aa) LGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDCSLHDYIQNNNIDFDLFFEL .||||..||...|.|.|..|||||.|||||||..|.|..|.|..|||..|||||.|||.||||||||||.||.|||||.||.||.|||.|.|.|||||.| IGRGGFSTVHKAVYKNIQNQGNEIIIPVAIKIFKQYYDDKFVRIYKEVSIHQKIQGICIPKLFGCVKLNFGFSIIIERCDCDLHNYIQCNQINFDLFFIL ALKMVITIRNLHKCHLN---EIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELNDNILYNEKSDIYSLGVSFMMLLY ...||.|||..|.||.| .|.||||||||||.||..|..||..|||||||||.||||.|||.||||.|.||||..||.||||.|||||.|.|||||.| STQMVNTIRQVHNCHPNAEINIYHRDIKPHNWLIKKIDDNHVVFISDFGLSRENTETNECTLQQYRGTNVHIPPECYDNFLYNEQSDIYSVGISFMMLAY KVVYGKMENPFYEFKISKMEYFKTVVALENFLVPIVPTFLPDSFKEFLFSTMNRIYTCRPNSEECVERLIT |||||||..|..|..||.|.|||.....||||.||.|.||||.||.||||.|||.|.||||..||.| . KVVYGKMVHPYHEYQISDMPYFKNIIQNENFLIPIIPPFLPDRFKRFLFSMMNRMYECRPNIKECIEEIQK |
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| Kinase | DDB0229335.AA | ARK | 399-531 | 34 | 6.3e-22 | 76.57 | In-house | 86-228 (280) | Show / Hide |
Range on Protein: 399-531
Range on HMM: 86-228/280
Sequence Identity: 34% (50 aa)
SLHDYIQNNNIDF--DLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND----
||. . || .|| |.|| .. || |. ||. | |||.| | || . . ..|||||| | ..|. || | |||... ||. .
SLYHIMNNNKMDFGWDRFFKWMMQMVRGINCLHNWTP-QIVHRDLKSLNLLV---NENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDI
-------NILYNEKSDIYSLGVSFMMLLYKVVYGKMENPFYEF-KIS
..|..|||.||.|. . . | ...|. . |. |. .|.
DDDYVSNGKHYTTKSDVYSMGIIMWEMVYRCINGCYMRPYSEYKHIK
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| Kinase | DDB0229335.AA | TKL | 399-583 | 19 | 2.3e-20 | 70.07 | In-house | 124-364 (364) | Show / Hide |
Range on Protein: 399-583
Range on HMM: 124-364/364
Sequence Identity: 19% (48 aa)
SLHDYIQNNNIDFDLFFELALKMVITIRNLHKCHL-----NEIFHRDIKPHNWLVKK-TK----------DELVVVLSDFGLSRENSETNENTLQKY---
||..|.. ..... .|| . . || .. | |||.|..| ||.. . .. .. ..||||||..|...... ...
SLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMM
---------------RGTSVFIPPELNDNI----------------LYNEKSDIYSLGVSFMMLLYKVVYGKMENPFYEFKISKME------YFKTVVAL
.|| . .||. .. |.||.|.|| |. . .| . |.|... . |. . .|..
ESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDPFEEMFMMVCD
ENFLVPIV-----------PTFLPDSFKEFLFSTMNRIYTCRPNSEECVERL
.. || .. |.|.|. . .. . ||. .|...||
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | DDB0229335.AA | MSK | 419-512 | 30 | 1.2e-16 | 52.83 | In-house | 108-204 (277) | Show / Hide |
Range on Protein: 419-512 Range on HMM: 108-204/277 Sequence Identity: 30% (30 aa) LKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND----NIL-YNEKSDIYSLGV-SFMML .. |. .. .|. . | |||.|| | | .|. |.|.|||..|.. . .| .. ...| . .||. . . |.| |..|||| ...|| RELVMAVDHMHQKG---IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTML |
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| Pkinase | DDB0229335.AA | Pkinase | 312-515 | 19 | 2e-16 | 59.13 | Pfam | 1-208 (293) | Show / Hide |
Range on Protein: 312-515 Range on HMM: 1-208/293 Sequence Identity: 19% (44 aa) IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYK----ELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDC-----SLHD ... .|.|. |.|| .. | ||.|| ... ..... |..|....| . .|.... . .. | .. .|.| YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD YIQ---NNNI--DFDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDEL--VVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELND-NI ||. .... . . .. .. . .|.. | |||.|| | |.. .... | ..||||.. . . |... . ||. ...||. . YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQ LYNEKSDIYSLGVSFMMLLYK | |.|..|.|. . .| . YYGPKVDMWSCGCILYEMLCG |
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| Kinase | DDB0229335.AA | C8 | 428-509 | 29 | 1.8e-15 | 50.28 | In-house | 136-226 (226) | Show / Hide |
Range on Protein: 428-509 Range on HMM: 136-226/226 Sequence Identity: 29% (27 aa) LHKCHLNEIFHRDIKPHNWLVKKTKDEL-VVVLSDFGLSRENSETNENTLQKYR---GTSVFIPPELNDN-----ILYNEKSDIYSLGVSF . |. .| |||||||| ||. . .. . |.|||.. |. . ..| || .. || |. .||..|.|. VNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| S_TKc | DDB0229335.AA | S_TKc | 312-584 | 19 | 2.9e-15 | 46.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 312-584
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)
IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKINGICGPKLFGCVKLNVGFGIIIERFDC---SLHDYIQNNN
| ...|.|. |.|| .. |. ||||| ...|..|..| . ||... . .. | | .|.|||....
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
ID-----FDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTLQKYRGTSVFIPPELNDNILYNE-KSDI
|. . . | ... | || . | |||.|| | |. . .. ..||||.|. . || ...||. |. |.|.
RHGLRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDW
YSLGVSFMMLLY-KVVYGKMENPFYEFKISKMEYFKTVVALENFLVPIVPTFLPDSFKEFLFSTMNRIYTCRPNSEECVE--------RLI
.|.|. . .|. . . ... ||. . ....|.|. ... . || |. . .
WSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | DDB0229335.AA | Ciliate-E2 | 431-507 | 25 | 5.8e-15 | 47.78 | In-house | 176-284 (365) | Show / Hide |
Range on Protein: 431-507
Range on HMM: 176-284/365
Sequence Identity: 25% (30 aa)
CHLNE-IFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSETNENTL----QK--------------------------YRGTSVFIPPELNDNIL----
.| . |.|||||| | |. . ..|||||..... |.|.. .| . || . .|| .
LHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ
-----YNEKSDIYSLGV
|..|.||.||||
QKQKGYDYKCDIWSLGV
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| Kinase | DDB0229335.AA | CAMK | 431-507 | 19 | 8.3e-15 | 43.44 | In-house | 195-322 (425) | Show / Hide |
Range on Protein: 431-507
Range on HMM: 195-322/425
Sequence Identity: 19% (25 aa)
CHLNEIFHRDIKPHNWLVKKTKDE--------------LVVVLSDFGLSRENSETNENT----------------------LQKYRGTSVFIP-PELNDN
|| . | |||.|| | |. . .|. . ..|||.... . ..|. .. . || ... ||.
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG
IL--------------YNEKSDIYSLGV
|..|.|. |.||
KGHCNMQNATDEEKPYYGPKCDMWSCGV
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| Kinase | DDB0229335.AA | TKL-Unique | 399-507 | 28 | 9.5e-15 | 48.6 | In-house | 86-216 (290) | Show / Hide |
Range on Protein: 399-507 Range on HMM: 86-216/290 Sequence Identity: 28% (37 aa) SLHDYIQ-----------NNNIDFDLFFELALKMVITIRNLHKCHLNEIFHRDIKPHNWLVKKT--KDELVVVLSDFGLSRENSETNENTLQ-------- ||.|... |..... .. .|.... .|| | | |||.|. | || |. . ..|||||. || |..|. SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQ KYRGTSVFIPPELNDN--ILYNEKSDIYSLGV |. ..||. . .|.||||.|| |. TRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI |
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| Kinase | DDB0229335.AA | Ciliate-C8 | 432-509 | 25 | 1.6e-14 | 48.73 | In-house | 136-238 (238) | Show / Hide |
Range on Protein: 432-509 Range on HMM: 136-238/238 Sequence Identity: 25% (26 aa) HLNEIFHRDIKPHNWLVKKT-KDELVVVLSD------FGLSRENSETNE-------NTLQKY-----RGTSVFIPPELNDN------ILYNEKSDIYSLG | ..| |||||||| || .. . . |.| ||... . . .. . | |. ...||. .. .. |||.||.| HCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVG VSF . . LVL |
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| Kinase | DDB0229335.AA | STE | 432-506 | 28 | 9.2e-14 | 45.08 | In-house | 169-255 (359) | Show / Hide |
Range on Protein: 432-506 Range on HMM: 169-255/359 Sequence Identity: 28% (27 aa) HLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSE---------------TNENTLQKYRGTSVFIPPELNDN------ILYNEKSDIYSLG | . | |||||| | |. | |.|||.. .. |. . || . || .. |..|.||.||| HSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLG |
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| Kinase | DDB0229335.AA | TyrKc | 312-583 | 17 | 2.3e-08 | -87.35 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 312-583 Range on HMM: 1-280/280 Sequence Identity: 17% (57 aa) IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSKLVEVYKELAIHQKI--NGICGPKLFGCVKLN-------VGFGIIIE--RFDCSL |. .||.| |.|| |..| |.||.| . . ..|. | |. . . .|.|.. |. | .| ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDL HDYIQNNNIDFDLFFELALKMVITIRNLHKC-----------HLNEIFHRDIKPHNWLVKKTKDELVVVLSDFGLSRENSET------NENTLQKY--RG .||.... . .. . |.. | . . |||. | ||.. . .| |||||||. . . .| | KDYLRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG TSVF----IPPELNDNILYNEKSDIYSLGV------SFMMLLYKV----------VYGKMENPFYEFKISK---MEYFKTVVALENFLVPIVPTFLPDSF ... .|| . ...|||..| || .. . | |. . .. .. . | | .. .. . KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------F-----VCCPDEMY KEFLFSTMNRIYTCRPNSEECVERL . . .. .||. .|..|.. Q-IMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | DDB0229335.AA | STE | 312-372 | 19 | 2e-06 | 19.27 | In-house | 1-86 (359) | Show / Hide |
Range on Protein: 312-372 Range on HMM: 1-86/359 Sequence Identity: 19% (17 aa) IERRNELGRGGNGTVYSGVLKE---IDSQGNEI------SIPVAIK-IPTQFYK----------------SKLVEVYKELAIHQKIN |. ..|.|. |||| .. .. |. . .|. .||| .. . . ... .. ||. |..| | WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCN |
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| Pkinase_Tyr | DDB0229335.AA | Pkinase_Tyr | 312-367 | 27 | 7e-06 | 20.45 | Pfam | 1-56 (270) | Show / Hide |
Range on Protein: 312-367 Range on HMM: 1-56/270 Sequence Identity: 27% (16 aa) IERRNELGRGGNGTVYSGVLKEIDSQGNEISIPVAIKIPTQFYKSK---LVEVYKELAI |. .||.| |.|| |..| .. . ||||.|. . . .. . . .|..| ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI |
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| Kinase | DDB0229335.AA | CAMK | 317-374 | 22 | 6.6e-05 | 10.96 | In-house | 1-91 (425) | Show / Hide |
Range on Protein: 317-374 Range on HMM: 1-91/425 Sequence Identity: 22% (21 aa) ELGRGGNGTVYSGVLKEIDSQGNEIS------IPVAIKI----------PTQFYKS--------------------KLVEVYKELAIHQKINGI .||||. |.|. .. |. . .. . ||||| . |.| | .. .|..|..|..|..|| TLGRGSFGKVKLCIHKNTTGKERV-HHIYTNGQKVAIKIIDKKKLKDKQN-QDY-SNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGI |
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| Kinase | DDB0229335.AA | TKL | 318-349 | 28 | 0.005486 | 6.61 | In-house | 1-33 (364) | Show / Hide |
Range on Protein: 318-349 Range on HMM: 1-33/364 Sequence Identity: 28% (11 aa) LGRGGNGTVYSGVLKEIDSQGNEISIP------VAIKI .|.|| |.|| |... ..... | ||.|. IGSGGFGEVYKGKWRGWGGKC-----PSDTGKDVAVKK |
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| Kinase | DDB0229335.AA | Ciliate-E2 | 312-327 | 31 | 0.227238 | 0.44 | In-house | 1-16 (365) | Show / Hide |
Range on Protein: 312-327 Range on HMM: 1-16/365 Sequence Identity: 31% (5 aa) IERRNELGRGGNGTVY .. . .|.|. |.|| YKFIKKIGQGNFGSVY |
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| Kinase | DDB0229335.AA | Pkinase_Tyr | 453-507 | 27 | 1.613575 | 2.38 | Pfam | 146-202 (270) | Show / Hide |
Range on Protein: 453-507 Range on HMM: 146-202/270 Sequence Identity: 27% (16 aa) DELVVVLSDFGLSRENSETNEN-TLQKYRGTSVF-IPPE-LNDNILYNEKSDIYSLGV ...|| .||||.| .. . . .. .. .|| .|... ...|||..| || ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGV |
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