Gene DDB0219793e (Slime mold)
DDB0219793e
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0219793e.AA | Protein | None | 962 | None | Fasta, JSON |
| DDB0219793e.kin_dom | Protein Kinase Domain | None | 755 | None | Fasta, JSON |
Protein domains of DDB0219793e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0219793e.AA | PEK | 83-837 | 53 | 0.0 | 1635.42 | In-house | 1-758 (758) | Show / Hide |
Range on Protein: 83-837 Range on HMM: 1-758/758 Sequence Identity: 53% (410 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKN-------TTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTSLSTSNGKQI |..|...|.||.|.||..|||.|...||.|.|.|.| ......|||.|||.|||.|.|.|||||..|||||.|||||...|.|||.||.||||| FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI DSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQ ||...|.|||||..||||||....|..|.||.||||||.|||..||......|..|||..|..||.|.|.......|||||...........|.|.||.| DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ FPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRH ..||..||.||||..|||.|.|||..|.||.|.|||||..||.|.||.||||.|.|.|....|......|..|...|.|..||.|.|....|..|.|..| YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH RRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNN ...||....||.|..|..||....|||.|.||...|...||.........||..||.||||.|.||..|..|...|...||.||....|||||||||||| MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN KNNIVSPKINRITTLFIVMQLYSQTLSQWLENR-PPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDG ||....|..|.|............||..|..|| ..........|..|.|||.|..||||||.|||||||.|.|......|||||||||||||||||||| KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG GGLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSS |......|||||...||||..||.|||..|||.||.|.||.|||||||||||.|||||||||||||||||||||||||||||| |.|.|.| GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ----T-TIT-TISVSPS SSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGLYNEKTDIYSLGIIL ..|||.||||||||.||||||.|.||||||...||....||.....|.....|..||.|..|.|.|.|.|..||.||..|||||..||.|.||||||.|. KPSSISTPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIF FELYFP-ISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSDLF |||..| .||.||..|...|||||..||.|.||||...|.|..||..||||||.|..|...|.| FELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF |
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| Kinase | DDB0219793e.AA | PEK | 83-837 | 25 | 2.3e-249 | 834.68 | In-house | 1-655 (655) | Show / Hide |
Range on Protein: 83-837
Range on HMM: 1-655/655
Sequence Identity: 25% (212 aa)
FCEIEKVGKGGY-GSVFKVKNKLDGEYYALKKIPFKNTT---------------KTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTS
|.||...||||. |.|.||.|||||.|||.|.|...... |. .|||||||||||.|||.||||||.||.|..| ..........
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ
LSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSP----QKKKNVNNNNNNSKKKALDQSG--------------AG
|..|........ |...||.| .|...| .. |||...|.... |..|..|.|||... ...||...............| ..
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTE
DDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSR-FKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDS
..|...||..|||...|||.|. .. .|....|...|||..........|.. .....|||.||......|....................|..|...||
NENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDS
QGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPS
..........||.||...|... |.|.|..|.|.|..|.|............. .... ||... . |. . .
KNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ--------------------------YQCHYLYIQMEYCEKK
LRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNV
.......||. . | ...|.. . .|..||..... |.... .|...... .. .|| ............ ..||.||. || ||||.|.|||||||.|.
TLRDWIDNNG-C-P-VQFNYW-R-RNSCKNHYNNY-IMNQC-CFQSTWSM-NM-RQW-DENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNI
FLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHT--------------------IVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQL
|| ....||| ..| |||||| .|. . ....... ...| |....|.. ... ..| |.
FLDCDGQHHQ-------------------MQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMW-SNN-YHI-QP-
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSV
----------------------------------------------------------------------------------------------------
STGTSLSRSLEHCKHTSAVGTLTYSSPEQKKG------LYNEKTDIYSLGIILFELYFPISTRM-EKARVLTDLRN------GVLP-KSFLQKYPKVSEL
|| ....|||.||..|||..|.|||| .| ||.|.|.||||||.||...|..| | |....|||||. | .| |.| .|||| ...
---TS-MFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADF
ILLMMKTNPDERPSASDILKSDLF
|..|.. .|..||||..||....|
IQWMLSHDPQQRPSAQQILQHEFF
|
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| Kinase | DDB0219793e.AA | STE | 83-837 | 9 | 1.4e-43 | 151.06 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 83-837
Range on HMM: 1-359/359
Sequence Identity: 9% (80 aa)
FCEIEKVGKGGYGSVFKVKNKL---------------DGEYYALKKIPFKNTTK---------------TFLEKVLREVKTLASLN--HRNIVRYHSAWL
. |||.|||..|.|.| .|. ||..| |.....| .. . ....|.|.|.. .| | |||.|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
-ETEELLPPSSSMASTSLSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGD
| ..
KEGHN-----------------------------------------------------------------------------------------------
DNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQG
----------------------------------------------------------------------------------------------------
FDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLR
----------------------------------------------------------------------------------------------------
SSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRI-TTLFIVMQLYS-QTLSQWLE-NRPPDQ-----------VNEEENLNIFKQICIG-LRYIHS
. ..|.|.| . . .|.. .. . . . ..|.. | .||. | | |.||
-----------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS
KGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHT-----------IVSSTPSPTPTSTPSLTPVNSHISPIDQIINI
..|||||.||.|..| | | |||.. | | |
HHIIHRDIKPANILL-----------------------------VKLCDFGVCGQLTDSMANIQSNNII-------------------------------
NQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSST
----------------------------------------------------------------------------------------------------
TPSVSTGTSLSRSLEHC------KHTSAVGTLTYSSPEQKKGL-------YNEKTDIYSLGIIL---FELYFPIST-RMEKARVLTDLRNGVLP------
| | .. ||| . .|| .. |..| ||.|||. . . | .. .| .. ... .
---------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC
----KSFLQKY----------------------PKVSELILLMMKTNPDERPSASDILK--SDLF
.. . |. . | . . .|..||.||. || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
|
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| Kinase | DDB0219793e.AA | HRI | 83-158 | 53 | 4.5e-37 | 128.19 | In-house | 1-76 (613) | Show / Hide |
Range on Protein: 83-158 Range on HMM: 1-76/613 Sequence Identity: 53% (41 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPP | . | .|||||| |.||..|||...|| ||| | ||. . |..||||.|| |.| |||||| ||.| . . | FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQIQP |
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| Kinase | DDB0219793e.AA | CMGC | 83-778 | 8 | 5.1e-34 | 108.49 | In-house | 1-329 (513) | Show / Hide |
Range on Protein: 83-778
Range on HMM: 1-329/513
Sequence Identity: 8% (72 aa)
FCEIEKVGKGGYGSVFKVKNKLDG--------------EYYALKKIP---FKNTTK------TFLEKVLREVKTLASLN-----------------HRNI
. |.|.|.| || |.| ..|. . |..|.||| .... | | . |||.| | || | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
VRYHSAWLETE---------ELLPPSSSMASTSLSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNN
|. . . ..
VKLYDIFYHKNSDGNEYEDKHI------------------------------------------------------------------------------
NNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFS
----------------------------------------------------------------------------------------------------
LDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQ
----------------------------------------------------------------------------------------------------
QQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPD-------QVNEEE---------
| | . |..|. . ..| | ..| ..| .| .
---------------------------------------------I-S--Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP
---NLNIF------KQICIGLR--YIHSKG--IIHRDLKPGNVFLVRE----------EDHHQQSSFSNISSSFEENSDGGGLL----------VSLGDF
... .||. || |.||.. |||||||| |. . . . . ..||
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS------------------------EDWNPCQKNGRLKICDF
GLAVQHTI---------------VSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTV
||| . . |
GLARWYHPHSDHHFQQQPQSFKNVN---------------------------------------------------------------------------
SLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGL---------
. . .|. | |. | .|| |
---------------------------------------------------------------KDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYS
--YNEKTDIYSLGIILFELY
|... |. |.| |..|.|
MHYTTPIDMWSVGCIFAEMY
|
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| Kinase | DDB0219793e.AA | GCN2 | 742-837 | 37 | 1.6e-31 | 107.38 | In-house | 410-511 (511) | Show / Hide |
Range on Protein: 742-837 Range on HMM: 410-511/511 Sequence Identity: 37% (38 aa) HTSAVGTLTYSSPEQKKGLYNEKTDIYSL-GIILFELYFP-ISTRMEKARVLTDLRNGVLPKSFLQ----KYPKVSELILLMMKTNPDERPSASDILKSD ||..||| | .||| |. ||.| |.||| |||.||. .| .| ||.. .|..||. .|. | .... ..| . . .|..||||...|... HTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHE LF . FL |
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| Kinase | DDB0219793e.AA | HRI | 742-837 | 48 | 1.1e-29 | 101.61 | In-house | 517-613 (613) | Show / Hide |
Range on Protein: 742-837 Range on HMM: 517-613/613 Sequence Identity: 48% (47 aa) HTSAVGTLTYSSPEQKKG-LYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSDLF ||| ||| || |||| | | | | ||.|.|||||. | | ||.| ||| .| | .| | . | | .. . | |||| .|.|.|| HTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF |
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| Kinase | DDB0219793e.AA | GCN2 | 83-151 | 48 | 5.7e-26 | 87.66 | In-house | 1-72 (511) | Show / Hide |
Range on Protein: 83-151 Range on HMM: 1-72/511 Sequence Identity: 48% (35 aa) FCEIEKVGKGGYGSVFK-VKNKLDGEYYALKKIPF--KNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLE | ||. .|||| |.| | |.|..|| |||.||.| |. ... | .||||.|..|.|...|||. ||.| FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE |
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| Kinase | DDB0219793e.AA | PEK-Unclassified | 743-835 | 36 | 1.3e-23 | 78.99 | In-house | 731-835 (835) | Show / Hide |
Range on Protein: 743-835 Range on HMM: 731-835/835 Sequence Identity: 36% (38 aa) TSAVGTLTYSSPEQK------------KGLYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASD || .|| ||||.|| || .|||||.|||.|.. .. | ||. . . .. | ||| | |.|.. |.| . | || | TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK ILKSD | . IEQTL |
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| Kinase | DDB0219793e.AA | WEE | 83-156 | 36 | 2.1e-22 | 72.02 | In-house | 1-81 (297) | Show / Hide |
Range on Protein: 83-156 Range on HMM: 1-81/297 Sequence Identity: 36% (30 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKK--IPFKNTTKTFLEKVLREVKTLASLN-------HRNIVRYHSAWLETEELL | |..|.|.| .|.|.|.....|| || || ||. . . . ||||. ...| | .||||.||| |. .. FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYS--ERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMY |
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| Kinase | DDB0219793e.AA | PEK-Unclassified | 83-154 | 33 | 1.4e-21 | 71.63 | In-house | 1-77 (835) | Show / Hide |
Range on Protein: 83-154 Range on HMM: 1-77/835 Sequence Identity: 33% (26 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFK-----NTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEE | .. |.|.||...|... .|.| || |.| . || ..|| .| .|| ||.|| | | |. FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEI |
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| Kinase | DDB0219793e.AA | PKR | 83-149 | 46 | 5.6e-20 | 68.12 | In-house | 1-61 (272) | Show / Hide |
Range on Protein: 83-149 Range on HMM: 1-61/272 Sequence Identity: 46% (31 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAW | .||..| ||.| ||| | ..|| |..|.. . | || .||. || |.| |||.||| | FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN------EKAEHEVQALAKLDHVNIVHYHSCW |
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| Kinase | DDB0219793e.AA | NEK | 83-155 | 33 | 2.4e-19 | 65.09 | In-house | 1-81 (286) | Show / Hide |
Range on Protein: 83-155 Range on HMM: 1-81/286 Sequence Identity: 33% (27 aa) FCEIEKVGKGGYGSVFKVKNKLDGEY-----YALKKIPFKNTTKTFLEKVL-REVKTLASLNHRNIVRYHSAWLETE--EL . .|.|.|.| .|.|.||. | || |..||| ..| . .. . ||. |..|.| |||.|. ...| . | YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCL |
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| Kinase | DDB0219793e.AA | PKR | 490-552 | 50 | 4.6e-18 | 61.17 | In-house | 96-159 (272) | Show / Hide |
Range on Protein: 490-552 Range on HMM: 96-159/272 Sequence Identity: 50% (32 aa) LFIVMQLYSQ-TLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVRE ||| | . || ||..|| ..| |... || | |||||..|||||||.|.||| | LFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDE |
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| Kinase | DDB0219793e.AA | NEK | 519-587 | 27 | 9.1e-18 | 59.48 | In-house | 117-170 (286) | Show / Hide |
Range on Protein: 519-587 Range on HMM: 117-170/286 Sequence Identity: 27% (20 aa) LNIFKQICIGLRYIHSK-----GIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLA ...| |.|..|.|.|.. |.|||.|| |.|| .. .| .||||.. WDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY--------------------HNVKIGDFGIS |
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| Kinase | DDB0219793e.AA | Pkinase | 83-155 | 26 | 2.4e-17 | 62.44 | Pfam | 1-75 (293) | Show / Hide |
Range on Protein: 83-155 Range on HMM: 1-75/293 Sequence Identity: 26% (20 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLR--EVKTLASLNHRNIVRYHSAWLETEEL .. ..|.|.|..|.|.| ..| .|. .|.|.|. ... . ... .| |.. ...||| ||||.. .. . .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI |
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| Kinase | DDB0219793e.AA | S_TKc | 83-837 | 8 | 8e-17 | 63.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 83-837
Range on HMM: 1-231/231
Sequence Identity: 8% (67 aa)
FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTSLSTSNGKQIDSDIKNI
. ..|.|||..|.|.|...| .|...|.|.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------
IYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDF
----------------------------------------------------------------------------------------------------
KQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSS
----------------------------------------------------------------------------------------------------
EGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSP
.. |. . . | . . .
--------------------------------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVF
KINRITTLFIVMQLYSQ---TLSQWLENRPP----DQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGG
. |..|| . .. .| . ...|.. . .| . ...||| .| |.||.||||||||| |..| .
QD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------
GLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSS
. ..||||| |
--HIKICDFGLARQL-------------------------------------------------------------------------------------
SSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGLYNE-KTDIYSLGIIL
|. .||. | .|| |. | |..|.|.||
-------------------------------------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL
FELYF---PISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILK-------SDLF
.|.. | . . . . .. | . ..| ... .|..||.| ..|. |
YEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | DDB0219793e.AA | Pkinase | 515-605 | 32 | 1.3e-14 | 52.71 | Pfam | 107-175 (293) | Show / Hide |
Range on Protein: 515-605 Range on HMM: 107-175/293 Sequence Identity: 32% (30 aa) EEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHTIVSSTPSPTPTSTP |.| ....||. || |.||.||||||||| |.... ...| | ..||||| |. . ... |.. || EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA-------------------CVKICDFGLAKQFDY-NNS-MTTFCGTP |
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| Kinase | DDB0219793e.AA | PKR | 741-835 | 36 | 8e-13 | 42.12 | In-house | 178-272 (272) | Show / Hide |
Range on Protein: 741-835 Range on HMM: 178-272/272 Sequence Identity: 36% (35 aa) K-HTSAVGTLTYSSPEQ-KKGLYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSD | | ||| | |||| | ||| ||.|| || | .|| . .|||.|.. . | |. .. |..|| |.||. KSRTRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL |
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| Kinase | DDB0219793e.AA | HRI | 490-558 | 36 | 7.7e-12 | 37.23 | In-house | 394-475 (613) | Show / Hide |
Range on Protein: 490-558 Range on HMM: 394-475/613 Sequence Identity: 36% (30 aa) LFIVMQLYSQTLSQWLENR-------------PPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQ |.| ||| . .| |. | | . || . .|| || |. ||| ..|.|||.|| |.|| . | | LHIQMQLCELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQ |
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| Kinase | DDB0219793e.AA | GCN2 | 430-549 | 27 | 2.4e-11 | 35.56 | In-house | 212-341 (511) | Show / Hide |
Range on Protein: 430-549 Range on HMM: 212-341/511 Sequence Identity: 27% (40 aa) KQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNN----------------NNNNNKNNIVSPKIN------RITTLFIVMQLYS-QTLSQWLE .|.||. | .|.|... . . .. . || ...| ..|.|. | . . .|.|.| . ||.| .. EQEQQNNQSFQPKQEDHQ------------NQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYID NRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFL | . . . | .| || || ||||.|.||||||| |.|| NHGWCMDHD-ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFL |
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| Kinase | DDB0219793e.AA | PEK-Unclassified | 521-549 | 43 | 3.3e-10 | 30.8 | In-house | 618-647 (835) | Show / Hide |
Range on Protein: 521-549 Range on HMM: 618-647/835 Sequence Identity: 43% (13 aa) IFKQICIGLRYIHSKG-IIHRDLKPGNVFL | .|| .|..||. . ..|||.|| |.|. ITRQIIKALYHIHHQCKMVHRDIKPHNIFV |
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| Kinase | DDB0219793e.AA | WEE | 515-758 | 7 | 7.8e-10 | 29.25 | In-house | 110-162 (297) | Show / Hide |
Range on Protein: 515-758
Range on HMM: 110-162/297
Sequence Identity: 7% (18 aa)
EEENLNIFKQICIGLRYIHSK-GIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSH
|.. .|. .|| ||..|||. |..| |.||.|.|. .. .|
EWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIV-NN---------------------------------------------------
ISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPS
----------------------------------------------------------------------------------------------------
TPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKK
..| .
----------------------------------------DQQNN
|
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| Kinase | DDB0219793e.AA | WEE | 793-837 | 22 | 2.7e-08 | 24.03 | In-house | 244-297 (297) | Show / Hide |
Range on Protein: 793-837 Range on HMM: 244-297/297 Sequence Identity: 22% (12 aa) DLRNG-------VLP-KSFLQKYPK-VSELILLMMKTNPDERPSASDILKSDLF ..|.| .| |...... . .|| .||. .|. ||.....|.... QIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | DDB0219793e.AA | Pkinase | 743-837 | 19 | 6.6e-08 | 29.04 | Pfam | 169-293 (293) | Show / Hide |
Range on Protein: 743-837 Range on HMM: 169-293/293 Sequence Identity: 19% (24 aa) TSAVGTLTYSSPEQ--KKGLYNEKTDIYSLGIILFELYF--PISTRM----EKARVLTDLRNGVLPKSFLQKY-----------------------PKVS |. .||. | .|| . | | |..|.|.||.|... |. . .. . ... |. . . . TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK ELILLMMKTNPDERPSASDILKSDLF ..| . . .| .||.| .||... | DFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | DDB0219793e.AA | NEK | 808-837 | 30 | 3e-06 | 18.7 | In-house | 257-286 (286) | Show / Hide |
Range on Protein: 808-837 Range on HMM: 257-286/286 Sequence Identity: 30% (9 aa) PKVSELILLMMKTNPDERPSASDILKSDLF .. ..|| .| . .|..|||...||. . QDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | DDB0219793e.AA | NEK | 733-777 | 40 | 7e-06 | 17.19 | In-house | 169-217 (286) | Show / Hide |
Range on Protein: 733-777 Range on HMM: 169-217/286 Sequence Identity: 40% (20 aa) LSRSLEHC--KHTS-AVGTLTYSSPEQKKGL-YNEKTDIYSLGIILFEL .|. |.| . .. ||| | |||. .. ||.| || ||| .|.|. ISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM |
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| Kinase | DDB0219793e.AA | TyrKc | 83-636 | 6 | 1.2e-05 | -131.16 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 83-636
Range on HMM: 1-280/280
Sequence Identity: 6% (45 aa)
FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIP-----FKNTTKTFLEKVLREVKTLASL--NHRNIVRYHSAWLET-------EELLPPSSSMASTSLS
..| | | .| |.| . | |. |. . .| .|| . . .| .| |||| . . .. | |. |. .|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK
TSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSD
| .
DYLRKHRPK-------------------------------------------------------------------------------------------
DSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTE
----------------------------------------------------------------------------------------------------
SFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNN
----------------------------------------------------------------------------------------------------
NNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSF
.. .. |.. ||. | .|.|||..||||| |. . ..
--------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------
EENSDGGGLLVSLGDFGLAVQHTIV-------SSTPS----PTP-------------------------------------TSTPSLT-----PVNSHIS
| .||||. .. . . . .| |...
---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI
PIDQIININQQLQQ-------------------------------QQQQQQQ
. . | . .. ..
EYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
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| Kinase | DDB0219793e.AA | CMGC | 800-837 | 14 | 4.4e-05 | 11.65 | In-house | 437-513 (513) | Show / Hide |
Range on Protein: 800-837 Range on HMM: 437-513/513 Sequence Identity: 14% (11 aa) PKSFLQKYPKVSE---------------------------------------LILLMMKTNPDERPSASDILKSDLF ||.. ...|. .. |. |.. .||.|..|...|. . | PKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | DDB0219793e.AA | Pkinase_Tyr | 83-146 | 25 | 0.009648 | 9.91 | Pfam | 1-70 (270) | Show / Hide |
Range on Protein: 83-146 Range on HMM: 1-70/270 Sequence Identity: 25% (19 aa) FCEIEKVGKGGYGSVFKVKNKLDGEYY----------ALKKIPFKNTTKT-FLEKVLREVKTLASL-NHRNIVRYH ..| |.| .|.|.| |... | |... . . . ..|. .||.|.. .| .| ||||.. ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY |
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| Kinase | DDB0219793e.AA | GCN2 | 582-657 | 30 | 0.022835 | 3.6 | In-house | 350-400 (511) | Show / Hide |
Range on Protein: 582-657 Range on HMM: 350-400/511 Sequence Identity: 30% (23 aa) GDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ |||||| .| || ||.|||| . ... |. .|..|..|||.|..| GDFGLATNNKMESQ-------------------------INRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ |
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| Kinase | DDB0219793e.AA | Pkinase_Tyr | 214-542 | 3 | 0.127782 | 6.11 | Pfam | 99-137 (270) | Show / Hide |
Range on Protein: 214-542
Range on HMM: 99-137/270
Sequence Identity: 3% (13 aa)
RVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSND
| ..
RKHR------------------------------------------------------------------------------------------------
VSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPN
----------------------------------------------------------------------------------------------------
PSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQV
.....
----------------------------------------------------------------------------------------------EDKQPL
NEEENLNIFKQICIGLRYIHSKGIIHRDL
. .. |.. ||. |. | .||..|||||
TMKDLLQMCWQIAKGMEYLESKNCIHRDL
|
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| Kinase | DDB0219793e.AA | WEE | 764-777 | 64 | 0.289996 | 0.08 | In-house | 216-229 (297) | Show / Hide |
Range on Protein: 764-777 Range on HMM: 216-229/297 Sequence Identity: 64% (9 aa) KTDIYSLGIILFEL | ||.|||| ..|| KADIFSLGITIYEL |
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| Kinase | DDB0219793e.AA | Pkinase_Tyr | 757-778 | 27 | 2.377264 | 1.81 | Pfam | 187-208 (270) | Show / Hide |
Range on Protein: 757-778 Range on HMM: 187-208/270 Sequence Identity: 27% (6 aa) KKGLYNEKTDIYSLGIILFELY . | ...|.|..| |. ..|.. NYGKFTTKSDVWSFGVLMWEIF |
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