Gene DDB0216331 (Slime mold)
DDB0216331
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0216331.AA | Protein | None | 942 | None | Fasta, JSON |
| DDB0216331.kin_dom | Protein Kinase Domain | None | 614 | None | Fasta, JSON |
Protein domains of DDB0216331.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0216331.AA | Dicty8 | 4-617 | 92 | 0.0 | 1849.18 | In-house | 1-618 (618) | Show / Hide |
Range on Protein: 4-617 Range on HMM: 1-618/618 Sequence Identity: 92% (573 aa) YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKI |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.|.||.||||||.||||||.||..|.||||||||.|||||||| STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKIPQKQFYEWIYQICYGVQSIHRNHMIHRDLKSENIFISESQKIKI GDFGLAKKYENS----MSGVAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEGKFDRKAFKQEFDDSDEPIADLILDMLN |||||||.||.. .|.|.|||.|.|||||.||||.||.|||||||||||||||||||...|.|||..|...|||..|||||||..|.||||||||.| GDFGLAKQYEHHTGSIHSEVVGTYCYSSPEILNNKNYDRPTDIFSLGCIFYEMYTLNLLPHNRRYFGQDMINDRFDRMQFKQEFDDKYEKIADLILDMIN LDQNLRPTIDLILQNKLF ..||.|||||.|.||||| KNQNFRPTIDSIIQNKLF |
|||||||||
| Kinase | DDB0216331.AA | Ciliate-E2 | 4-617 | 11 | 4.2e-48 | 163.21 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 4-617
Range on HMM: 1-365/365
Sequence Identity: 11% (82 aa)
YEVVKLIGVGGEA-----KALLVKRI------------------NSDKLYVMKQRMFFLLEEAN--EGLCEAMS-----------LAKIQSPYIVRFEEV
|...|.|| |. . | .|.. . |.| ||. . .|. . . .. . | ....|.|... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FLDNNSNMFSLCIVMEYCEGGDLMD-------NLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNN
| .. . .. .|||||.||||.| . .. |.
FQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-------------------------------------------------------------
NNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSN
----------------------------------------------------------------------------------------------------
DSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTS
----------------------------------------------------------------------------------------------------
KTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLP
.. .. ...
------------------------------------------------------------------------------------K-D-KYFTEKEIKYIM
RKLFY-------TWIYQICLGVQSIHKNH-LVHLDLKSENIFLSESQKIKIGDFGLAKKYENS--------MSG--------------------------
..... .| .|.|.....|... .| |.| |||.. ||| ||||.||| .. ...
KQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNT
VAGTYYYLSPEILLNKN---------YSRPADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEG-KFD-RKAFKQ-----------EFDDSDEPIADLILD
..||..|..|||| .|. |. .||.|||.|.||| . .. |. |. |.| .....| .... .. |||
ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK
----MLNLDQNLRPT-IDLILQNKLF
||. |.. |.| .. ||... |
FGKRMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | DDB0216331.AA | Ciliate-E2-Unclassified | 4-617 | 11 | 4.5e-47 | 161.32 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 4-617
Range on HMM: 1-352/352
Sequence Identity: 11% (83 aa)
YEVVKLIGVGGEAKALLVKRINSDKLY-----VMKQRMFFLLEEAN--------EGLCEAM-------------SLAKIQSPYIVRFEEVFLDNNSNMFS
|...| || || .| ...... . .| .|.... . | . ... . .| ...|.||.....| | .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ----N
LCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYE
..|||||||||||.. . || . .
IYIVMEYCEGGDLWQYIKKRKKQK----------------------------------------------------------------------------
NFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDY
----------------------------------------------------------------------------------------------------
SSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMT
----------------------------------------------------------------------------------------------------
WWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFY-----TWIYQIC
. . || .|. . ... . ....||.
------------------------------------------------------------Q-----K-GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQIL
LGVQSIHKNH-LVHLDLKSENIFLSESQ---KIKIGDFGLAKKYENS------------------MSGVAGTYYYL----SPEILLNKNYSRP----ADI
.| ...|... .| |.| |||...... .||| |||..|||... |. ..||..|. .||.| ..||. . .||
QGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDI
FSLGCIFYEMYTLNLLPLTKRSFGQ---------------ELIEGKFDRKAFKQEFD------DSDEPIADLIL----DMLNLDQNLRPTIDLILQNKLF
.|||.|.||| . . .| .. | .|.. ..... ....|. .... .|.| ||. ..| |.|.. ||. .|
WSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | DDB0216331.AA | CAMK | 59-552 | 9 | 7.3e-43 | 135.49 | In-house | 98-327 (425) | Show / Hide |
Range on Protein: 59-552
Range on HMM: 98-327/425
Sequence Identity: 9% (55 aa)
PYIVRFEEVFLD-----------NNSN--MFS----LCIVM---EYCEGGDLMDNLFKRISDS--------FLKNSGLNNNQNNNNNNNNNLNSIVNNNI
| |... ||. | . |. . . ...|| |||.||.| | || .| .
PNIIKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ----------------------------
LNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLN
----------------------------------------------------------------------------------------------------
SQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRS
----------------------------------------------------------------------------------------------------
TTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQ
----------------------------------------------------------------------------------------------------
SPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYT-------WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQ-----------------KIKIGDF
. . . .. .. ||| .|. .|... ||.||| ||| |... .||| ||
--------------------------FDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
GLAKKYEN--------------------------SMSGVAGTYYYLS-PEILLNKN--------------YSRPADIFSLGCIFYEM
|.|.|.. |. . || .| . ||.|. | |....|. |.|.| | |
GFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM
|
|||||||||
| Kinase | DDB0216331.AA | CMGC | 4-554 | 9 | 9.7e-40 | 127.64 | In-house | 1-330 (513) | Show / Hide |
Range on Protein: 4-554
Range on HMM: 1-330/513
Sequence Identity: 9% (64 aa)
YEVVKLIGVGGEAKALLVKR--------------INSDKLYVMKQRM--FFLLEEAN----------EGLCEAMSLAKIQ-----------------SPY
||..| || | .. . ....... .| . | |.| | | . | ... ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN
IVRFEEVFLDNNSN-------------MFSLCIVMEYCEG--GDLMDNLFK-------------------RISDSFLKNSGLNNNQNNNNNNNNNLNSIV
||. ..| ..||. . .|..|.||.. ....| . |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRR----------------------------
NNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNEST
----------------------------------------------------------------------------------------------------
NNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGC
----------------------------------------------------------------------------------------------------
QIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQ
----------------------------------------------------------------------------------------------------
QLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWI------YQICLGVQ--SIHKNH--LVHLDLKSENIFLSESQK----------------
| . . |||. |. .|.. .| ||| ||| ... .
---------------------------------PPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ
----IKIGDFGLAKKYENS------------------------MSGVAGTYYYLSPEILLN----------KNYSRPADIFSLGCIFYEMYT
.||.|||||..|.. .. | .| .|||||. ..|. | |. |.||||.||||
KNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYT
|
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| Kinase | DDB0216331.AA | Pkinase | 467-617 | 28 | 2.6e-39 | 140.06 | Pfam | 113-293 (293) | Show / Hide |
Range on Protein: 467-617 Range on HMM: 113-293/293 Sequence Identity: 28% (52 aa) WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKI----KIGDFGLAK---KYENSMSGVAGTYYYLSPEILL-NKNYSRPADIFSLGCIFYEMYTLNLL ..|||. |.. .|.. .| |||.|||.... | ||.|||||| |||....||..|..||... .. |....|..|.|||.|||.. . YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRP PLTKRS------FGQELIEGKFDRKAFKQEFDDSD-------------------EPIADLILDMLNLDQNLRPTIDLILQNKLF | . ...|. . ... ... ... |. |.| ..|..| . |||.. ||| . | PFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | DDB0216331.AA | ULK | 53-617 | 10 | 3.2e-35 | 120.45 | In-house | 64-329 (329) | Show / Hide |
Range on Protein: 53-617
Range on HMM: 64-329/329
Sequence Identity: 10% (68 aa)
LAKI----QSPY----IVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRIS---DSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQST
. |. .... ||.. ..| . |. . |.||||.||||.. . |. | .
MKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYIIMEYCNGGDLEQYIKKNKKLPEDT-E--------------------------------------
TNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSI
----------------------------------------------------------------------------------------------------
SSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTS
----------------------------------------------------------------------------------------------------
PQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESS
----------------------------------------------------------------------------------------------------
LNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQK------------IKIGDFGLAKKYENS------MSGVA---
. .|. . ..||. | . .||. .| |.| .|| ... | .||.|||.||. .|. |
-------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEK
---GTYYYLSPEILL----NKNYS-RPADIFSLGCIFYEMYTLNLLPLTKRSFGQE-LIEGKFDRK---------AFKQEFDDS------DEPIADLILD
|| .| .|.|| .|.|. .||.||||||||| . . . . | .| | .. .. .|... . . |||
RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRR
MLNLDQNLRPTIDLILQNKLF
|| |.. | ... ......|
MLQYDEKDRISWEELFNHPWF
|
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| Kinase | DDB0216331.AA | ULK | 56-617 | 11 | 5.4e-35 | 121.63 | In-house | 70-324 (324) | Show / Hide |
Range on Protein: 56-617
Range on HMM: 70-324/324
Sequence Identity: 11% (70 aa)
IQSPY--IVRFEEVFLDNNS-NMFSLCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSS
...|. ||.. ..| . |. | ..|.||||.|||| . . |. .. .
LKHPNHHIVKLYDWFETSNHNN---IYIIMEYCNGGDLEQYIKKNKKLPE-T-E----------------------------------------------
IASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNND
----------------------------------------------------------------------------------------------------
LINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQ
----------------------------------------------------------------------------------------------------
PPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNN
----------------------------------------------------------------------------------------------------
CSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQK------------IKIGDFGLAKKYEN-SMSGVA-----------GTYYYLSP
. .|. . ..||| | . .||. .| |.| .|| ... | .||.|||.||. .| .|. || .| .|
--EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAP
EILL----NKNYS-RPADIFSLGCIFYEMYTLNLLPLTKRSFG-Q----ELIEG----KFDRKAFKQEFDDSD------EPIADLILDMLNLDQNLRPTI
.|| .|.|. .||.||||||||| . . . . .||. .. | . .|.. . . . ||| || |.. | ..
QILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISW
DLILQNKLF
. |.....|
EEIFNHPWF
|
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| Kinase | DDB0216331.AA | NEK | 467-556 | 39 | 2.5e-29 | 100.67 | In-house | 119-223 (286) | Show / Hide |
Range on Protein: 467-556 Range on HMM: 119-223/286 Sequence Identity: 39% (41 aa) WIYQICLGVQSIHKN-----HLVHLDLKSENIFLSESQK----IKIGDFGLAKKYENS--MSG--VAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMY | .|.||... .|.. . .| |.|. ||||. . . .||||||..| ... | . || ||.|||.. || |. .|| ||||. ||| WFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMC TL--N || . TLKPK |
|||||||||
| Kinase | DDB0216331.AA | NEK1 | 467-555 | 40 | 1.8e-27 | 92.46 | In-house | 109-217 (276) | Show / Hide |
Range on Protein: 467-555 Range on HMM: 109-217/276 Sequence Identity: 40% (44 aa) WIYQICLGVQSIHKNHLVHLDLKSENIFLS--ESQ---------------KIKIGDFGLAKKYENSM---SGVAGTYYYLSPEILLNKNYSRPADIFSLG | ||||... ||. | |.|| ||||. .. ..|.|||| |. ..| . ..|| ||||||| || | || ||| WFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLG CIFYEMYTL |. || || CVLYELCTL |
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| Kinase | DDB0216331.AA | NEK4 | 467-555 | 45 | 8e-25 | 86.17 | In-house | 107-198 (257) | Show / Hide |
Range on Protein: 467-555 Range on HMM: 107-198/257 Sequence Identity: 45% (42 aa) WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKIGDFGLAKKYENSM---SGVAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTL | || .. | .|. | .| ||| |||| |||||||... .|. . . || ||.|||. |. | || |||| ||| || WFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL |
|||||||||
| Kinase | DDB0216331.AA | S_TKc | 4-617 | 9 | 3.8e-19 | 70.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-617
Range on HMM: 1-231/231
Sequence Identity: 9% (60 aa)
YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL
||....|| |. .| ... ....... .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------
KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD
----------------------------------------------------------------------------------------------------
NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT
----------------------------------------------------------------------------------------------------
VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN
----------------------------------------------------------------------------------------------------
STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNN--------NN--NNCSTLLK----------LPRKLFYTWIYQICLGVQSIHKNHL
. . |.... . | . ... . .. .. . ...| .| ..||||.... .|...
---------EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI
VHLDLKSENIFLSESQKIKIGDFGLAKKYENSMSGVAGTYYYLSPEILLNKNYSR-PADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEGKFDRKAFKQE
.| ||| |||.|.| |||.|||||... . . || .|..||.| |.. ..|. |.|||.|||.. | |....
IHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------
FDDSDEPIADLILDMLNLDQNLRPTIDLILQ-------NKLF
... |.| .|. | . |||. .|| |
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | DDB0216331.AA | NEK | 4-92 | 34 | 7.1e-18 | 59.85 | In-house | 1-96 (286) | Show / Hide |
Range on Protein: 4-92 Range on HMM: 1-96/286 Sequence Identity: 34% (34 aa) YEVVKLIGVGGEAKALLVKRINSDKL-----YVMKQRMFFLL--EEANEGL-CEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCE-GGDLMD ||..| || | |. .|.|.. | ||.|. . . .| . . |. |.....|.||.. . |.....| .||||||||| ||||.. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNN--CLCIVMEYCEGGGDLYQ |
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| Kinase | DDB0216331.AA | Pkinase | 4-92 | 24 | 7.8e-15 | 53.54 | Pfam | 1-93 (293) | Show / Hide |
Range on Protein: 4-92 Range on HMM: 1-93/293 Sequence Identity: 24% (24 aa) YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLC-------EAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGG----DLMD |.... || |. .. . ..... |....|. . ....... . |. ......|.|||. ..| | .... .|||||||| ||.| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI---IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY---MVMEYCEGGLYVMDLFD |
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| Kinase | DDB0216331.AA | NEK1 | 4-91 | 41 | 6.6e-14 | 44.77 | In-house | 1-88 (276) | Show / Hide |
Range on Protein: 4-91 Range on HMM: 1-88/276 Sequence Identity: 41% (37 aa) YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLL--EEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLM |.. | || | ||.|||. . ..||.| . .| | . |. ||| | ||.. | | | . . | ||||||.||||| YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGI--LYIVMEYCDGGDLM |
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| Kinase | DDB0216331.AA | NEK4 | 4-94 | 35 | 6.5e-13 | 42.87 | In-house | 1-91 (257) | Show / Hide |
Range on Protein: 4-94 Range on HMM: 1-91/257 Sequence Identity: 35% (33 aa) YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFL---LEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNL |. .| .| | ||. | |||| .|| . .| . . || | . . | || . | . | . |.||| .|||||| | YCHMKVVGKGSYGEVWLVRHRRDKKQYVMK-KMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQF--LYIVMGFCEGGDLYRKL |
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| Kinase | DDB0216331.AA | Pkinase_Tyr | 49-510 | 7 | 2e-12 | 42.74 | Pfam | 53-159 (270) | Show / Hide |
Range on Protein: 49-510
Range on HMM: 53-159/270
Sequence Identity: 7% (36 aa)
EAMSLAKI-QSPYIVRFEEVFL-DNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNS
|| . .. . | |||. | . . .| ...|||||...||| | | |.
EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR------------------------------------------------
SGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESS
----------------------------------------------------------------------------------------------------
SFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIP
----------------------------------------------------------------------------------------------------
LNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNING
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NNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKIGDFGLAK
. .|. | . .||. | . . ....| || |. ..|. ..||.|||||.
-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
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| Kinase | DDB0216331.AA | TyrKc | 4-616 | 10 | 5.8e-12 | -29.26 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-616
Range on HMM: 1-280/280
Sequence Identity: 10% (68 aa)
YEVVKLIGVG-------GEAKALLV--KRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKI--QSPYIVRFEEVFLDNNSNMF----SLCIVMEYCEGG
. | .| | |..| . | | ...|. . . || . |. . | |||. | .. | | |.|||||...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHG
DLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSET
|| | | |. .
DLKDYLRKHRPK----------------------------------------------------------------------------------------
LKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISS
----------------------------------------------------------------------------------------------------
PGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKD
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KKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDL
|. | . . .||. | . .|.....| ||
----------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDL
KSENIFLSESQKIKIGDFGLAKKYENS----------MS----GVA--GTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTLNLLPLTK-----RSFGQ
|. ..| . .||.||||... .. .. | . ..|| . . .. |..| | .|..|. | | |
AARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS-NQ
ELIEGKFDRKAFKQEFDD-------SDEPIADLILDMLNLDQNLRPTIDLILQNKL
|.|| ... .| .| . . ..... . | . ||| | ..
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
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| Kinase | DDB0216331.AA | CAMK | 586-617 | 33 | 2.4e-05 | 12.42 | In-house | 387-425 (425) | Show / Hide |
Range on Protein: 586-617 Range on HMM: 387-425/425 Sequence Identity: 33% (13 aa) SDE-------PIADLILDMLNLDQNLRPTIDLILQNKLF ||| ||| ||. | . |.||. .|. . . SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | DDB0216331.AA | NEK | 592-617 | 34 | 0.001441 | 8.89 | In-house | 261-286 (286) | Show / Hide |
Range on Protein: 592-617 Range on HMM: 261-286/286 Sequence Identity: 34% (9 aa) DLILDMLNLDQNLRPTIDLILQNKLF .|| ||. | .||... ||.. . NLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | DDB0216331.AA | CMGC | 592-617 | 38 | 0.01604 | 3.06 | In-house | 488-513 (513) | Show / Hide |
Range on Protein: 592-617 Range on HMM: 488-513/513 Sequence Identity: 38% (10 aa) DLILDMLNLDQNLRPTIDLILQNKLF ||. || .| . |.|.. .|| | DLLKKMLQYDPDKRITAEQALQHPYF |
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| Acetyltransf_1 | DDB0216331.AA | Acetyltransf_1 | 868-917 | 29 | 2e-07 | 23.95 | Pfam | 25-78 (78) | Show / Hide |
Range on Protein: 868-917 Range on HMM: 25-78/78 Sequence Identity: 29% (16 aa) IGVSKEYRDLGVGQYLLKPVIEWAEH--QRKTVKAVVFSQKQ--INFFSKLGLS | |...|| |.| |.. .||||.. . ... ..|... . |.|. |.| IYVHPDYRGQGIGTRLMQHAIEWAREERGCHRIYLWVREHNHPAIRFYEKCGFK |
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