Gene 7TMK2 (Slime mold)

7TMK2

Species: Slime mold
Alias: 7TMK2, DdisK105, DDB0220006
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
7TMK2.AA Protein None 704 None Fasta, JSON
7TMK2.kin_dom Protein Kinase Domain None 227 None Fasta, JSON

Protein domain

Protein domains of 7TMK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7TMK2.AA Other-Unique 320-543 10 8e-21 67.74 In-house 1-249 (249) Show / Hide 
Range on Protein: 320-543
Range on HMM: 1-249/249
Sequence Identity: 10% (27 aa)

HELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMKDCTNEDIESLENEIRVYEKLKSPY-------------IVSYQGSSKVVGSSGQIFEIRLFMEYIPH
. ..| | .| .......||.... . .  ..  .|...| .. | .|..|. ... .             .......  . ... ..... ...... |
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIH-CIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEH

TLD--KYLLARSVCGDSNGGGSSRNLKNYFLHMQEYQS------------SPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISI
...  ..... . . ..|      |..|...... .              .....|.....||| | ...... . ......|..|.| .... ..|...
WMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHF

GLDNLHAN--------KIAHRDLKSNNIFVTLSESEVKICKIGDFDISRSFNNPKVLNV
|  ..| |        ..  ....... ..   ......|.  .. . .  .... .  
GCYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Pkinase 7TMK2.AA Pkinase 317-524 19 3.8e-16 58.17 Pfam 1-154 (293) Show / Hide 
Range on Protein: 317-524
Range on HMM: 1-154/293
Sequence Identity: 19% (44 aa)

IAIHELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMKDCTNEDIE--SLEN--EIRVYEKLKSPYIVSYQGSSKVVGSSGQIFEIRLFMEYIPH-----T
. |.. .| |..|  | ||. |. .    ..|||..| ..... .  .. .  ||..  .|..|.|| . ..      .. |    . ||| ..      
YHIGRKIGSGSFGC-VYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMD

LDKYLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLHANKIAHRDL
|  |. .                                                       ...   | | . ..  |.|||  ||. .|...| ||||
LFDYIST-------------------------------------------------------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDL

KSNNIFVTLSESEV----KIC
|. ||..  .. ..    |||
KPENILID-NNGHIDACVKIC
Kinase 7TMK2.AA TKL 323-537 17 1e-15 53.08 In-house 1-206 (364) Show / Hide 
Range on Protein: 323-537
Range on HMM: 1-206/364
Sequence Identity: 17% (48 aa)

LGMGGSGAMVHKCTVKK------GPLRGGTFAVKVMKD--CTNEDI-------------------------ESLENEIRVYEKLKSPYIVSYQGSSKVVG
.| ||.|  |.| . .       . ..| . |||..|   . ....                         . .|.||..  .|. | ||.. |...  .
IGSGGFG-EVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

SSGQIFE-------IRLFMEYIPH-TLDKYLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYS
. .   .       . . |||.|. .|  ||.                                                                   .
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------------------------------------------------WH

QVVWYLYQISIGLDNLHANK--------IAHRDLKSNNIFVTLSES----------EVKICKIGDFDISRSFNN
| .   ..|. |.. ||...        |.||||||.||.|               .   |||.|| .||....
QRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ
Kinase 7TMK2.AA NEK8 477-532 41 1.2e-14 38.11 In-house 115-167 (278) Show / Hide 
Range on Protein: 477-532
Range on HMM: 115-167/278
Sequence Identity: 41% (23 aa)

YFRYSQVVWYLYQISIGLDNLHANKIAHRDLKSNNIFVTLSESEVKICKIGDFDIS
||   ...||. |.....  .| . | |||||  ||| | . .   . ||||| ||
YFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRM---VVKIGDFGIS
Kinase 7TMK2.AA NEK 481-537 35 1.3e-13 44.67 In-house 114-175 (286) Show / Hide 
Range on Protein: 481-537
Range on HMM: 114-175/286
Sequence Identity: 35% (22 aa)

SQVVWYLYQISIGLDNLHAN-----KIAHRDLKSNNIFVTLSESEVKICKIGDFDISRSFNN
.|......|....|. .| .     || |||.|..||| | . .. .. ||||| ||. .|.
EQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNH
Kinase 7TMK2.AA STE-Unique 478-532 42 2.9e-13 42.95 In-house 400-457 (616) Show / Hide 
Range on Protein: 478-532
Range on HMM: 400-457/616
Sequence Identity: 42% (26 aa)

FRYSQVVWYLYQISIGLDNLHANK--IAHRDLKSNNIFVTLSE----SEVKICKIGDFDIS
|. ..| ||.|||  ||. ||  .  | |||||..||| . .     . ||||   ||...
FPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC---DFGHA
Kinase 7TMK2.AA NEK4 481-537 49 1.4e-11 37.98 In-house 102-154 (257) Show / Hide 
Range on Protein: 481-537
Range on HMM: 102-154/257
Sequence Identity: 49% (28 aa)

SQVVWYLYQISIGLDNLHANKIAHRDLKSNNIFVTLSESEVKICKIGDFDISRSFNN
.|||    || ..|  .|  .| |||||  ||| |       | ||||| |||  ||
YQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLT----KKNIIKIGDFGISRVLNN
Kinase 7TMK2.AA CDK 399-539 18 1.9e-11 32.75 In-house 95-167 (284) Show / Hide 
Range on Protein: 399-539
Range on HMM: 95-167/284
Sequence Identity: 18% (27 aa)

LFMEYIPHTLDKYLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLH
. .||..| | ||.                                                                      . .|..|.  ||. .|
MVFEYMDHDLKKYMD---------------------------------------------------------------------IKCYMWQLLRGLHYCH

ANKIAHRDLKSNNIFVTLSESEVKI--CKIGDFDISRSFNNPK
 |.| ||||| .|| ..   ...     ||.||  .| |..|.
SNWIMHRDLKPQNILINNNGEVK-CGRLKIADFGLARAFGIPH
Kinase 7TMK2.AA STE 318-422 20 6.5e-11 34.9 In-house 1-138 (359) Show / Hide 
Range on Protein: 318-422
Range on HMM: 1-138/359
Sequence Identity: 20% (29 aa)

AIH-ELLGMGGSGAMVHKCTVKKGPLRGGT------------FAVKVMK--DCTN---------------EDIESLENEIRVYEKLK--SPYIVSYQGSS
  . | .| |..|  . .. .|....   |            .|.|.|.  .|.|               |.......||..  |..  .|.|| | |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KVVGS-SGQIFEIRLFMEYIPH-TLDKYLLARSVCGDSN
 . |  ...  |. ..|||..  .||. .  .  ||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPL
Kinase 7TMK2.AA S_TKc 317-681 16 2.3e-10 -24.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 317-681
Range on HMM: 1-231/231
Sequence Identity: 16% (63 aa)

IAIHELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMKDCTNEDIESLENEIRVYEKLKSPYIVSYQGSSKVVGSSGQIFEIRLFMEYIPH---TLDKYLL
  |....| |. |  |.||. ||    |  .|.|..|       |....||.. .| . |.|| . ..           .. ..|||...   .| .|. 
YEILRKIGKGAFG-KVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIK

ARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLHANKIAHRDLKSNNIF
 |   |                                                      ....|   ..  |.|||  .|. .| ..| |||||  ||.
KRGRHG------------------------------------------------------LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL

VTLSESEVKICKIGDFDISRSFNNPKVLNVLSNPTALQQQKLNNFFQSATTTTTTEQTTE--PIEVAATTTPQTIHSAFQHDILSFGFIVLDFLTLSN-Y
..         ||.|| ..| .                              ||   | .  . ||         .. .  |. |.| |.  .|.    .
LDE------HIKICDFGLARQL------------------------------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPF

SCFDSKFDTSNYYDDDKFNNKSNTKIKKPDLPDYIKKDEKLWEPVIQLYKSCTSDDPNKRPSSLGVK--------FHLA
.      .    ..  .                         ...... . |   ||.|||.   .             
P------QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7TMK2.AA STE 481-537 31 3.3e-10 32.35 In-house 151-199 (359) Show / Hide 
Range on Protein: 481-537
Range on HMM: 151-199/359
Sequence Identity: 31% (18 aa)

SQVVWYLYQISIG-LDNLHANKIAHRDLKSNNIFVTLSESEVKICKIGDFDISRSFNN
||. ....||  | |. || ..| |||.|. ||..         .|. || .. ....
SQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTD
Pkinase_Tyr 7TMK2.AA Pkinase_Tyr 317-529 21 1.4e-09 33.12 Pfam 1-155 (270) Show / Hide 
Range on Protein: 317-529
Range on HMM: 1-155/270
Sequence Identity: 21% (46 aa)

IAIHELLGMGGSGAMVHKCTVK-KGPLRGGTFAVKVMKDCTNED---IESLENEIRVYEKL-KSPYIVSYQGSSKVVGSSGQIFEIRLFMEYIPH-TLDK
| . . || |  | .|.|.| | ..   . . |||..|. . ..   .|.. .|...  .| . | ||.. |     | ..   .| . ||| ||  |..
ITFGKKLGEGAFG-EVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

YLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLHANKIAHRDLKSN
|| ...                                                          .  .  .. . . .||. |.. |..... ||||   
YLRKHR--------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NIFVTLSESEVKICKIGDF
|. ||    | ...||.||
NCLVT----ENNVVKICDF
Kinase 7TMK2.AA LRRK 488-548 31 1.7e-09 29.76 In-house 171-244 (351) Show / Hide 
Range on Protein: 488-548
Range on HMM: 171-244/351
Sequence Identity: 31% (23 aa)

YQISIGLDNLHANK--IAHRDLKSNNIFV-TLSES-------EVKICKIGDFDISR--SFNNPK-VLNVLSNPT
.||. |.. || ..  | |||||| ||.. ....        .  ..||.|| |||  .   .. .  .. ||.
LQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPG
Kinase 7TMK2.AA TKL-Unique 452-534 35 3.6e-08 25.1 In-house 93-166 (290) Show / Hide 
Range on Protein: 452-534
Range on HMM: 93-166/290
Sequence Identity: 35% (31 aa)

QNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLHANK--IAHRDLKSNNIFVTLS--ESEVKICKIGDFDISRS
|||||||||.. .             . ..|.|    .|. |...|| ..  |.|||||| |. |.    . |..| || || .|..
QNNNNNNNNNNNCK------------LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNI-KICDFGLSKF
Kinase 7TMK2.AA TyrKc 317-680 13 6.9e-08 -95.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 317-680
Range on HMM: 1-280/280
Sequence Identity: 13% (55 aa)

IAIHELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMKDCTNEDIESLENEIRVYEKL--KSPYIVSYQGSSKVVG----SSGQIFEIRLFMEYIPHTLDK
|   . || |  |  |.|.| |       . |||..|...   .| . .|.|.  ||  . | ||   |     |    ...... .  .|..    |..
ITLGKKLGEGAFG-EVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD--LKD

YLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNSPLIQPQQQQQYVYPYYFRYSQVVWYLYQISIGLDNLHANKIAHRDLKSN
|| ..                                                              .  .. . . .||. | . || ... ||||   
YLRKHRPK-----------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAAR

NIFVTLSESEVKICKIGDFDISRSFNNP-------KVLNVLS--NPT-----------ALQQQKLNNFFQSAT------------TTTTTEQTTEPIEVA
|. |.       ..||.||  ||   .        ..  . .  .             ..      . | ...             |   .   ..|.  
NCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-

ATTTPQTIHSAFQHD-ILSFGFIVLDFLTLSNYSCFDSKFDTSNYYDDDKFNNKSNTKIKKPDLPDYIKKDEKLWEPVIQLYKSCTSDDPNKRPSSLGVK
   ..| ..   ..   .     ..    .|                                   .    ... . ..   |.|   ||..||.   ..
-MMSNQEVIEYVKQGYRMPQPPNDY--P-MS-----------------------------------FVCCPDEMYQ-IM---KQCWHEDPEDRPTFSEIH

FHL
  .
ECF
Kinase 7TMK2.AA TKL 635-680 23 5e-06 17.65 In-house 313-364 (364) Show / Hide 
Range on Protein: 635-680
Range on HMM: 313-364/364
Sequence Identity: 23% (12 aa)

KIKKPDLPDYIKK------DEKLWEPVIQLYKSCTSDDPNKRPSSLGVKFHL
| ..| .|.  .        .  ......| . | . ||.|||| . .. .|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 7TMK2.AA TKL-Unique 319-412 28 0.000141 12.27 In-house 1-91 (290) Show / Hide 
Range on Protein: 319-412
Range on HMM: 1-91/290
Sequence Identity: 28% (29 aa)

IHELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMK---DCTNEDIESLENEIRVYEKLK-SPYIVSYQGSSKVVGSSG----QIFEIRLFMEYIPH-TLD
. ...| ||.      ..|.||  ||   |.|. .   |  || .. .|||... .||. .| || |      .| .     .. .  ..|||.|. .|.
FWNKIGEGGY------GQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHY------MGYCMDHQVYPPNMCIVMEYCPGGSLY

KYL
..|
DVL
Kinase 7TMK2.AA LRRK 317-461 9 0.000864 9.27 In-house 1-79 (351) Show / Hide 
Range on Protein: 317-461
Range on HMM: 1-79/351
Sequence Identity: 9% (16 aa)

IAIHELLGMGGSGAMVHKCTVKK-----------------------GPLRGGTFAVKVMKDC----TNEDIESLENEIRVYEKLKSPYIVSYQGSSKVVG
. | |..| ||.|. |.. ....                       . ... . |.|... .    .|.  .                            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CN----------------------------

SSGQIFEIRLFMEYIPHTLDKYLLARSVCGDSNGGGSSRNLKNYFLHMQEYQSSPQSSISYYQNNNNNNNNS
                                                                |.|||||.
----------------------------------------------------------------NSNNNNNL
Kinase 7TMK2.AA NEK 352-384 32 0.001915 8.45 In-house 39-72 (286) Show / Hide 
Range on Protein: 352-384
Range on HMM: 39-72/286
Sequence Identity: 32% (11 aa)

MKDCTNEDIESLE-NEIRVYEKLKSPYIVSYQGS
|. .. .. . .  ||.|. ..||.|.||.|  |
MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDS
Kinase 7TMK2.AA STE-Unique 319-384 25 0.00267 6.91 In-house 1-69 (616) Show / Hide 
Range on Protein: 319-384
Range on HMM: 1-69/616
Sequence Identity: 25% (18 aa)

IHELLGMGGSGAMVHKCTVKKGPLRGGTFAVKVMKDCTNED------IESLENEIRVYEKLKSPYIVSYQGS
...  . .||.  ||.|. ||    . . |.|| .  .  |      .. . .||    .|....|| | |.
NCQQMIGRGSFGNVHNCQNKK---DCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGH
Kinase 7TMK2.AA LRRK 651-682 28 0.003001 7.33 In-house 320-351 (351) Show / Hide 
Range on Protein: 651-682
Range on HMM: 320-351/351
Sequence Identity: 28% (9 aa)

LWEPVIQLYKSCTSDDPNKRPSSLGVKFHLAN
.|  . .| ..| . ||.|||..  .   |  
PWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ