Gene Erk1 (Slime mold)

Erk1

Species: Slime mold
Alias: Erk1, DDB0201635, DdisK069, erkA
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
Erk1.AA Protein None 529 None Fasta, JSON
Erk1.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of Erk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk1.AA ERK 149-437 65 1e-234 786.05 In-house 1-307 (307) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-307/307
Sequence Identity: 65% (201 aa)

YSIVKCIGHGAYGVVCSAKDNL-----TGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFK-HENLISIKDILKPNSKEQFEDVYIVSELMDTDLHQIIT
|.|.|.||||||||||||.|..     ||.|||||||..|||.....|||||||.|||||| |||.|...||..|||.||..|.|.|.|||.|||||||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SPQPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQG-------FMTEYVATRWYRAPEVILSWNKYTKAIDI
|.|.|||||||||.||.|.|||.||||||.||||||||.|.|..| |||||.||||..||..|        |||||||||||||||..|||.|||||.||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIFAELLGRKPLFQGKDYIHQITLIIETIGSP-SEEDICNIANEQARQFIRNMGN--QPKVNFANMFPKAN--PDAIDLLERMLYFDPSKRLTVEE
||.||||||.|||||||.||||.|||..|...||.| ||||...|..|.|...|.|..|  .|.... |.||.||  |.||||||.||.|||.||.||||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYF
.|.||||
CLEHPYF
Kinase Erk1.AA MAPK 149-437 59 1.6e-212 712.29 In-house 1-328 (328) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-328/328
Sequence Identity: 59% (196 aa)

YSIVKCIGHGAYGVVCSAKDNL------TGEKVAIKKISKAFDNLKDTKRTLREIHLLRHF-KHENLISIKDILKP------NSKEQFEDVYIVSELMDT
| |.|.||.|||||||||.|..      .|.||||||||..|.|. ..|||.|||.||||| .||| |...||..|      ||.|.|.|.|||.|||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIITSPQPLSDDHCQYFVYQMLRG--LKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDAT---HQG----------FMTEYVATRWYRAP
|||||| |.|||||||.|||.||.|||  ||.||||||.||||||||.|.||.|.||||| ||||..| .   |..          .|||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILS--WNKYTKAIDIWSVGCIFAELLG-RKPLFQGKDYIHQITLIIETIGSPSEEDICNIA-NEQARQFIRNM---GNQPKVNFANMFPK----ANPD
|..|.  |..||||.|.|||||||||.|. |||||.|||||.|..||.|..|.||||.|..|  .| ||..|...    ..||.....|||.    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLERMLYFDPSKRLTVEEALAHPYF
||||||.|| |||.||.||||||.||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk1.AA p38 149-437 51 2.2e-153 515.86 In-house 1-289 (289) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-289/289
Sequence Identity: 51% (152 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEK---VAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKP--NSKEQFEDVYIVSELMDTDLHQIITS
|  .. .| |||| ||.| |  ||.|   |||||... |    . ||| ||. ||.| .||| |.. |.  |  .| ..|.|||.|...|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

PQPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFA
 | ||||| |. |||.||||| ||||.. ||||||||. .|||| |.| | ||||  |.     ||.|||||||||||..|.| .||...|||||||| |
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE----MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMA

ELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAHPYF
||. ...|| |.|.|.|.. |.. .|.|.|| .  |..|.|| .|...   |. .|...|..||| ||||||.||  || ||.|.|||..||||
ELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk1.AA CMGC 149-437 28 3.5e-150 497.31 In-house 1-513 (513) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-513/513
Sequence Identity: 28% (147 aa)

YSIVKCIGHGAYGVVCSAKDNLTG--------------EKVAIKKISKAFDNLKDTK----------RTLREIHLLRHFK-----------------HEN
| |.| ||.|.||||....|..|.              |.||||||...| .  . |          |.|||| .|.|..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LISIKDILKPN---SKEQ---------FEDVYIVSELMDTDLHQIITSPQ---------PLSDDH------------CQYFV------YQMLRGLK--HI
.....||....   ..|.         |...|.| |.||.||.|.| . |         |||. |            ..||.      ||.|||||  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLINEDCLL--------------------KICDLGLARVEDATH--------------------QGFMTEYVATRWYRAPEVIL
||..  ..||||||.|.|||..| |                    |||| |||| ..  .                    . ..|.||.||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SW---------NKYTKAIDIWSVGCIFAELLGR--------KPLFQ-----------GKDYIHQITLIIETIGSP----------------SEEDICNIA
.|         ..||..||.|||||||||.. .        ||||.           ||..|.|. .|....|.|                .||..  | 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NEQARQFIRN---MGNQPKVNFANMFPK-----------------------------------ANPDAIDLLERMLYFDP
                    .| ||..|..    ...|. .. |.||.                                   ..|.|||||..|| .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRLTVEEALAHPYF
.||.|.|.||.||||
DKRITAEQALQHPYF
Kinase Erk1.AA ERK5 149-437 52 1.6e-142 479.82 In-house 1-295 (295) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-295/295
Sequence Identity: 52% (154 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNS-KEQFEDVYIVSELMDTDLHQIITSPQPL
| |.  || |||||||||.  ..|..||||||  ||| .   |||.||. .||||.|.|.| |.|||.|      . |||.| .||. |||||| | ||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLAR----VEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFA
. .|  ||.||.||||| .|||.|.||||||||||.|| | ||| | |.||       . || |||||||||||||||...| . ||.|||.||||||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRN-MGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAHPYF
|...|. .| || ||||. ||.. .| |.   |  .. .. . ..   . |.  ...  ..||| . |.||| ||| |.||.|.|| .|| ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk1.AA ERK1 149-437 57 5.1e-142 478.11 In-house 1-289 (289) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-289/289
Sequence Identity: 57% (168 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPLS
|  .. ||.||||.|||| |......|||||||  |.     .||||||..|  |||||.| |.||.. .. ||. ||||| .||.||| ... . |.||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

DDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDAT--HQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELL
 ||  ||.||.||||| |||||||||||||||||.|  | ||||| ||||. |    | ||.|||||||||||||..|    |||.||||||||| ||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

GRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAHPYF
  .|.| || |. |. .|.  .||||..|.  | ||.||.... .  .||| .| .|||| . |.|||..|| | | ||.|||||||||| 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk1.AA nmo 150-437 48 6.7e-130 401.91 In-house 2-292 (292) Show / Hide 
Range on Protein: 150-437
Range on HMM: 2-292/292
Sequence Identity: 48% (141 aa)

SIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPLSD
   . ||.||.||| |  |   | .||.||. . | ||  .||  ||. .|  |||.| .| .|||.|  |. |...|.| |||  |||.|| |||.|| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGRK
|| . |.||.||||| .||||.||||.|| |||.| .|.||||| |||||..  ..  ||. | | .|||||...   .|| |.|||||||||||||||.
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPK---ANPDAIDLLERMLYFDPSKRLTVEEALAHPYF
 ||| .  |.|. .|.. .| || ||.    .      .|    .|...          |. .|..|| ||| |||.||. ...|||||| 
ILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase Erk1.AA ERK7 149-437 46 4.5e-124 418.51 In-house 1-292 (292) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-292/292
Sequence Identity: 46% (138 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFK-HENLISIKDILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPL
| | | .| ||||.|  | |  |.. ||.|||  || |  |  || ||| .|. |. |.|.|.. ....    .   |.|.| | |.|||| .|   . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNIL

SDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLAR----VED-ATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIF
 | | || .||.|| .|..||.||.||||||||.|.. .|..|.|| ||||     |. . ... .|||||||||||||. |.  .|||..| ||.||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAHPYF
.|.|  ||.|.|   ..|| .|.|||. |..|||  |  . | . . .|. |..  . .|.|.. .|||||| |.| | | ||||.|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk1.AA ERK3 149-437 41 1e-104 337.95 In-house 1-300 (300) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-300/300
Sequence Identity: 41% (127 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQFED-----------VYIVSELMDTDL
.   .  | |  |.| || |.    |||||||.      |  |  ||||  .|   |.| . . ..| |   .  .|           |.|| |.|.|||
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIV--LTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDL

HQIITSPQPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLIN-EDCLLKICDLGLARVEDA--THQGFMTEYVATRWYRAPEVILSWNKYTKAID
  ..   |.||..| . | ||.||||| ||||||||||||| |..|| ||  ||| | |.||. |    | |...| . |.||| |. .|. | ||||||
ACVMEQ-QRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAID

IWSVGCIFAELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAH
.|. |||.||.|  |.|| |     |  || ..|    |||   .      ..|.|    |.     . .  . .|.|.||.|| |||. ||| |.|| |
MWAAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQH

PYF
||.
PYM
Kinase Erk1.AA S_TKc 149-437 29 1e-101 345.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQFEDVYIVSELMDT---DLHQIITSPQ
| |.. ||.||.|.|. .... ||..||||.|.         ....||| .|.. .|.|.. ..|.         ...|.| |..|.   ||...| . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------LSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTK-AIDIWSV
.      ..  |.....||....|...|| ...||||||.|.|..|   .|||| ||||.         | .. |.||.||||.    .|.| ..|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIFAELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALA-----
|||..|.| ..|.|.      |. .... ||                                      |.|.|.....| .||.||.|. |||.     
GCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYF
  ||.|
KCHPWF
Kinase Erk1.AA Pkinase 149-437 29 9.4e-98 335.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLR--EIHLLRHFKHENLISIKDILKPNSKEQFEDVYIVSELMDT-----DLHQII
| |...|| |..|.|. ...  ||..||.|.|.|  .. .  .. .|  ||.......|.| . ..|.          ..|.| |...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

T--SPQPL--SDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLL----KICDLGLARV-EDATHQGFMTEYVATRWYRAPEVILSWNKYTKA
.  .  ..  |...|. ..||.||||...|| ...||||||.|.||.... .    |||| |||.. .   ... || .. |.||.|||||.. ..|...
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSVGCIFAELLGRKPLFQGK----DYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTV
.|.||.|||..|.| ..|.|.|.    . . |. .| .. | | ..|. .  ..  .  .|         .    ........|.....| .||.||.| 
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

EEALAHPYF
|..| ||.|
EQILQHPWF
Kinase Erk1.AA MAPK-Unclassified 149-301 52 3.3e-84 286.05 In-house 1-161 (575) Show / Hide 
Range on Protein: 149-301
Range on HMM: 1-161/575
Sequence Identity: 52% (84 aa)

YSIVKCIGHGAYGVVCSAKDNLT-GEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQ--FEDVYIVSELMDT---DLHQIIT
|   | || ||||.|| |.|. . . .|||||. ..| |  |.||.||||..||.  |.|.| |.||. . . .   | |.||| ..| |   |||||| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SPQ-PLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLAR-VED
|.| .... | ||| || ||||| .|||...||||||||||||.||...||| |..| .||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase Erk1.AA MAPK-Unclassified 302-437 36 3.4e-61 209.63 In-house 399-575 (575) Show / Hide 
Range on Protein: 302-437
Range on HMM: 399-575/575
Sequence Identity: 36% (64 aa)

ATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGR-----------KPLFQGKD--------------------YIHQITLIIETIGS
..| . ||.||.|||||||| .||   |....||||.||||||.. .           .||| |.|                    .. || .|..  |.
CHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGM

PSEEDICNIANEQARQFIRNMGNQPKVNFA-NMFPKAN---------PDAIDLLERMLYFDPSKRLTVEEALAHPYF
| |||.  | . .||..|.  .  . | |   ||.||          ...||..  || |.|.|| | ..|| ||||
PPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk1.AA TyrKc 149-437 20 3.9e-15 22.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 149-437
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHF--KHENLISIKDILKPNSKEQF---EDVYIVSELMDT-DLHQIIT
 .  | .|.||.|.|. .. .   ..||.|.. .        .  .||. .....  .|.|.. .  .    .   |   | ..|| |.|.  ||.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SPQP-LSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDAT--------HQGF----MTEY-VATRWYRAPEVILSWNK
...| |. ..  .| .|  .|  ..|| |. ||||   | |..|.   ||.| ||.|  .                   . . .  ||. |||.|   .|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YTKAIDIWSVGCIFAEL--LGRKPLFQ------GKDYIHQITLIIETIGSPSE--EDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERML
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FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------------FVCCPDEMYQIMKQCW

YFDPSKRLTVEEALAHPYF
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HEDPEDRPTFSEI--HECF
Kinase Erk1.AA Pkinase_Tyr 149-323 26 2.4e-14 49.22 Pfam 1-186 (270) Show / Hide 
Range on Protein: 149-323
Range on HMM: 1-186/270
Sequence Identity: 26% (52 aa)

YSIVKCIGHGAYGVVCSAKDN----LTGEKVAIKKISKAFDNLKD--TKRTLREIHLLRHF-KHENLISIKDILKPNSKEQFED--VYIVSELMDT-DLH
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLL

QIITS----PQPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVE---DAT-HQGFMTEYVATRWYRAPEVI
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DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM-APECI