Gene Dyrk2 (Slime mold)

Dyrk2

Species: Slime mold
Alias: DdisK064, DDB0230102, Dyrk2
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
Dyrk2.AA Protein None 915 None Fasta, JSON
Dyrk2.kin_dom Protein Kinase Domain None 298 None Fasta, JSON

Protein domain

Protein domains of Dyrk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dyrk2.AA DYRK2 605-902 52 1.7e-207 681.33 In-house 1-318 (318) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-318/318
Sequence Identity: 52% (168 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHFQGYN
.||....|.|||.||||.||.||...||.|..||.|||||||..||.||......|...|...||...|||||||...||||||||||...| |||||..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENE-QIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVP
|.|||||...||..||||.|.||||.||||||||||....||||.|||||||||.. .|.|||||||||.||||||.||...||.||.|||..|..||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGSDEPEQLACIMEVLGAPPKSVIDNS-----TRKDIFFED-------------DGTPKPVKNSTTGELYTIGTKSFKDSIR-SGDEDFDNFILDCLK
||||..|..|.||.|||||.|||...|..     .|...||..             . ..........|. ...|.||.|.... ..||.|..||..|..
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WEPSQRITAEQGLKHDWI
|.||.|.|..|.|||.||
WDPSERMTPSQALKHPWI
Kinase Dyrk2.AA DYRK 605-902 55 1.8e-188 632.39 In-house 1-320 (320) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-320/320
Sequence Identity: 55% (179 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHFQGY-
.||....|.|||.||||..| ||.||||.||.||.||||.||..||||||||...||. .. .||. .|||.|||| ..|||||||||.||| |||||. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

NLNLVRRFGAQILTSLRFLSKR-NIIHADLKPENILLKSP-TKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTG
.|||||.|. ||||.|.||.|  ||||.|||||||.||.|  ||.||.|||||||||...|.|||||||||.||||||..|...||.|||||||.|.|||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

VPLFPGSDEPEQLACIMEVLGAPPKSVIDNS--TRKDIFFED------------DG------TPKPVKNSTTGELYTIGTKSFKDSIRSGDEDFDNFILD
 |||||..| .||||||||||.||| .||..  .||. ||..            .       |||...... |. .. |...... ..  |..| .||. 
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLKWEPSQRITAEQGLKHDWI
||.|.|..|||..| |.|.|.
CLQWDPHKRITPSQALQHPWF
Kinase Dyrk2.AA CMGC 605-902 20 1.3e-114 378.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-513/513
Sequence Identity: 20% (106 aa)

FEIVSILGQGSFCQVVKGYD--------------YKTGEMVALKILRNQKRFHNQAL-------------TEIKILEYLK-TNDPNS-----------TA
.||.. .|.|.. .|.|..|               .|.|.||.|...|.. ...||.              |||||..|. ..||               
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

SIVHLNNYFYFRN-----------------HLILTFELLSMNLYDFLKVNH--------------------------FQGYNLNLVRRFGAQILTSLR--
 ||.| ..||..|                 || | ||.. ..||...| |.                           . . . ..| .  |||..|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLSKRN--IIHADLKPENILLKSPTKS------------------GIKLIDFGSSCFENEQ------------------------IFTYIQSRFYRSPEV
.. ...  ||| ||||||||. . ...                   .|..|||.......                         . .|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGTK----------YDKSIDIWSLGCILVEIFTG--------VPLFPGSDE-----------PEQLACIMEVLGAPPKSVIDNST-------RKDIFFE
.|| |          |...||.||.|||. |..||         |||||..|            .||..|..||| |. ..|....       .......
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

DDG-------------------TPKPVKNSTTG--ELYTIGTKSFKDSIRS-----------------------------------GDEDFDNFILDCLK
  .                    .. ..|       . ..  |..|. .                                      |... ...  .|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WEPSQRITAEQGLKHDWI
..|..|||||| |.|...
YDPDKRITAEQALQHPYF
Kinase Dyrk2.AA DYRK1 605-840 56 3.8e-107 362.25 In-house 1-238 (321) Show / Hide 
Range on Protein: 605-840
Range on HMM: 1-238/321
Sequence Identity: 56% (135 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHFQGYN
.|| | .|.||| |||| || .. |.||.||..|.| | |||. ||..|| .  .|...   |||| . | ||||| | ||||| |||| |.  ||.|  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLVRRFGAQILTSLRFLSKR--NIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGV
|||.|.|  |..|.| |.|    .||| |||||||||  | .| ||.|||||||  .. |. ||||||||||||.||..|| .||.|||||||||. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFE
||| ||.| .|.  |.|||| ||| .|| . .   .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase Dyrk2.AA YAK 605-839 45 4e-92 312.36 In-house 1-239 (347) Show / Hide 
Range on Protein: 605-839
Range on HMM: 1-239/347
Sequence Identity: 45% (109 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYL-KTNDPNSTA---SIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHF
. .  .|||| | ||||     | |..| |.. |   .  || .||.||. | .  |||       |. .  .| ..||. | ||.||.|||..|| | |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFT
 |   .|.| .  ||| ..  |   .||| |||||||.|. | |  ||.||||||| |   . ||||.|.|||||.|... |  ||| ||||||..| | 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GVPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFF
|.|.|||  | .|.  | ..|| ||  .||    |  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase Dyrk2.AA S_TKc 605-902 26 1.6e-81 278.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-231/231
Sequence Identity: 26% (84 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSM---NLYDFLKVNHFQ
.||. ..|.|.| .| |... |||. ||.||..      .... ||.||.    . ||    ||.|  .|.  .|| . .|...    .|.|..| .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---HHPN----IVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----YNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDK-SIDIWSLGCILV
|    ..   .|.. .||.  | .. ...||| ||||||||| .     ||..|||....      |.. ...|..|||.   .|.| ..|.||.|||| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIFTGVPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFEDDGTPKPVKNSTTGELYTIGTKSFKDSIRSGDEDFDNFILDCLKWEPSQRITAEQG
| ..| |.||      |.. .....|                                                 .... .||  ||...|..|.|| . 
EMLCGYPPFP------QMQMMFKKIG-------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LK-------HDWI
|.       | |.
LQDEWDIKCHPWF
Kinase Dyrk2.AA HIPK 605-842 41 4.3e-72 226.22 In-house 1-240 (329) Show / Hide 
Range on Protein: 605-842
Range on HMM: 1-240/329
Sequence Identity: 41% (99 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHFQGYN
.|.. .||.| | ||||.    |.||||.|||.|.  .  |   |..||. |.. ...  . .|    .|  .||  | ||.|  |||||.| |.|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSG--IKLIDFGSSCFENEQIF-TYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTG
|. .|    |.|| |  | .  .||||||||||.|  ||.    .| |||||     . .  ||.|||.|| ||.||| .. ...|.|||||.. | | |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

VPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFEDD
 ||.||.|| .|   | .  . | .. .   ..|  ||. |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD
Kinase Dyrk2.AA PRP4 605-840 39 2.5e-65 223.36 In-house 1-240 (320) Show / Hide 
Range on Protein: 605-840
Range on HMM: 1-240/320
Sequence Identity: 39% (94 aa)

FEIVSILGQGSFCQVVKGYDYKTGE-MVALKILRNQKRFHNQALTEIKILEYLKTN--DPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVN-HF
.....  ||| |  |... |   |  ||| ||.||    |   | |. ||  |  .  |.|    .| . . |..|.|. | || .|||| . ||     
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGS-SCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIF
 |  |. || .  |..  |. | | ||.|||.|| |||  .  |. .|..|||| |  . . |  | .|||||.||.|.| .|| .||.|| || | |..
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGVPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFE
||  .|||.   . |  .|.. |. |.  | ..  || .|.
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase Dyrk2.AA DyrkP 605-805 42 6.1e-62 202.53 In-house 1-205 (323) Show / Hide 
Range on Protein: 605-805
Range on HMM: 1-205/323
Sequence Identity: 42% (88 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNH---FQ
. |.  ||   | . ..  | .|. |. .||. | | .  |.. |||.| |.  |       ...   ||| . || .  |||  |||.| | |     |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

GY-NLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFT
 |  .  . .   ||| .| ..    .|| ||||||||.||  |  .|.||||||||  . .  |.||| || ||||.| |||  ||.||||||| |..|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GVPLF
|  ||
GNVLF
Kinase Dyrk2.AA CDK 605-902 24 1.1e-61 196.05 In-house 1-284 (284) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-284/284
Sequence Identity: 24% (84 aa)

FEIVSILGQGSFCQVVKGYDYKTG-----EMVALKILRNQK--------RFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFR-----------NHL
.|..  .|.|.. .| |. | .||     ..|||| .| ..         |   |. ||..|  |    ||    || |   ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HPN----IVKLHDVCHTKNMDRNNKDKHENKL

ILTFELLSMNLYDFLKVNHFQGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSG------IKLIDFGSSCFENE--------QIFT-Y
 . || . . |. ...           .. .  |.|  | .. ...|.| |||| |||.   .. |      .|. ||| ..  .         . .|  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI---NNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE

IQSRFYRSPEVIL-GTKYD--KSIDIWSLGCILVEIFT---GVPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFEDDGTPKPVKNSTTGELYTI
.  . ||.||. |  ..|.   .||.||.|||..|.||   . |||||. | .|| .| ...| |  ..  . |    .                     
VVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------

GTKSFKDSIRSGDEDFDNFILDCLKWEPSQRITAEQGLKHDWI
                 ...  .|  .|..||.||| |.|.. 
-----------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Dyrk2.AA Pkinase 605-902 28 7.7e-61 213.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 605-902
Range on HMM: 1-293/293
Sequence Identity: 28% (91 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALT-----EIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSM-----NLYDF
..|....|.||| .| |... .||..||.||.. ... ...  |     ||.|.  |.   ||    || |  .|. ..|. . .|.. .      |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPN----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LK---VNHFQGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGI----KLIDFGSSCF---ENEQIFTYIQSRFYRSPEVIL-GTKYD
..    . |     . ....  |||  | .. ...||| ||||||||..   .  |    |..|||....    |.   |.  ...|..||||. |..|.
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

KSIDIWSLGCILVEIFTGVPLFPGS----DEPEQLACIMEVLGAPPKSVIDNSTRKDIFFEDDGTPKPVKNSTTGELYTIGTKSFKDSIRSGDEDFDNFI
...|.||.|||| | ..| |.|||.    .  .|...| ...|.|... .... ..  || .   . .              . ..      .|..  ||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWTF-HNWSEECKDFI

LDCLKWEPSQRITAEQGLKHDWI
 .||.. |..|.|||| |.|.|.
KWCLCKDPKKRPTAEQILQHPWF
Kinase Dyrk2.AA CLK 605-744 33 1.9e-54 161.27 In-house 159-312 (350) Show / Hide 
Range on Protein: 605-744
Range on HMM: 159-312/350
Sequence Identity: 33% (51 aa)

FEIVSILGQGSFCQVVKGYDYKTG-EMVALKILRNQKRFHNQALTEIK-ILEYLKTN-DPNSTAS--IVHLNNYFYF-RNHLILTFELLSMNLYDFLKVN
.|||. ||.| |  ||.  | | |   ||||| || ...  .| .||. |.. .... |||..    ....| .| .  .|  . |||.  ..|||.| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

H------FQGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSP--TK
.      ...| .. .|....|......|| .  ..| |||||||.. ..  |.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTH
Kinase Dyrk2.AA CLK 747-902 32 6.1e-32 92.49 In-house 186-350 (350) Show / Hide 
Range on Protein: 747-902
Range on HMM: 186-350/350
Sequence Identity: 32% (54 aa)

IKLIDFGSSC---FENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPEQLACIMEVLG-APPKSVIDNSTR----KDIF
|..|||||     |..|   | ...| || ||||||  .    |.|| ||||.|  ||. ||.. |. | || . ...|   |.. |  .||    |. .
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMI-QRTRRFKVKQKY

FEDDGTPKPVKNSTTGELYTIGTKSFKDSIRSGDEDFDNF---ILDCLKWEPSQRITAEQGLKHDWI
| ....   . .. .|       | .| . .. |.. . .   |  .|  .||.|||. . |.| . 
FYHNRLDWDW-HNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase Dyrk2.AA TyrKc 605-901 19 6.2e-11 -45.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 605-901
Range on HMM: 1-280/280
Sequence Identity: 19% (64 aa)

FEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYL-KTNDPNSTASIVHLNNYFYFR-------NHLILTFELLSM-NLYDFL
 .   .|| | |..|.||  .   ..|| | |.. .  .   . |..|.  | . . ||    || |  .             | . .|. .  .| |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-HHPN----IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KVNHFQGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQ-IF-----TYI-----QSR-----FYRSPEVILG
. .. .  ..     |  ||    ..|...|.|| ||   |.|....    .|  ||| | .  .         .|      ...        .||.|  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

TKYDKSIDIWSLGCILVEIFT-GVPLFPGS----DEPEQLACIMEVLGAPPKSVI----DNSTRKDIFFEDDGTPKPVKNSTTGELYTIGTKSFKDSIRS
 |.    |.|| |  . |||| | .  ||      .....    .  . .|.                                         |    . 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------F---VCC

GDEDFDNFILDCLKWEPSQRITAEQGLKHDW
 || ..  ...| . .|..| | .. .....
PDEMYQ-IMKQCWHEDPEDRPTFSE-IHECF
Kinase Dyrk2.AA Pkinase_Tyr 605-638 31 0.000406 14.57 Pfam 1-38 (270) Show / Hide 
Range on Protein: 605-638
Range on HMM: 1-38/270
Sequence Identity: 31% (12 aa)

FEIVSILGQGSFCQVVKGYDY----KTGEMVALKILRN
 ..   ||.|.| .|.||. .    .|.  || |.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase Dyrk2.AA PRP4 882-902 47 0.001194 9.33 In-house 300-320 (320) Show / Hide 
Range on Protein: 882-902
Range on HMM: 300-320/320
Sequence Identity: 47% (10 aa)

CLKWEPSQRITAEQGLKHDWI
||   |. ||| .. |||  |
CLMLDPKKRITCNEALKHPFI
Kinase Dyrk2.AA DYRK1 875-902 35 0.003255 6.57 In-house 294-321 (321) Show / Hide 
Range on Protein: 875-902
Range on HMM: 294-321/321
Sequence Identity: 35% (10 aa)

FDNFILDCLKWEPSQRITAEQGLKHDWI
|   |.  |...| ||||  . |.| ..
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase Dyrk2.AA DyrkP 868-902 34 0.008751 4.23 In-house 289-323 (323) Show / Hide 
Range on Protein: 868-902
Range on HMM: 289-323/323
Sequence Identity: 34% (12 aa)

IRSGDEDFDNFILDCLKWEPSQRITAEQGLKHDWI
.|  |  |  |. .||. .   | ||   |.| |.
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase Dyrk2.AA HIPK 883-902 30 0.042933 1.83 In-house 310-329 (329) Show / Hide 
Range on Protein: 883-902
Range on HMM: 310-329/329
Sequence Identity: 30% (6 aa)

LKWEPSQRITAEQGLKHDWI
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CTWDAHKRITPCEALNHPFV