Gene DDB0230050_C2d (Slime mold)

DDB0230050_C2d

Species: Slime mold
Alias: DdisK288, DDB0230050_C2d, DDB0217416
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK-DD1

Sequence

Name Sequence Type Origin Length Description Download
DDB0230050_C2d.AA Protein None 680 None Fasta, JSON
DDB0230050_C2d.kin_dom Protein Kinase Domain None 378 None Fasta, JSON

Protein domain

Protein domains of DDB0230050_C2d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0230050_C2d.AA CDK-DD1 4-381 75 0.0 1078.35 In-house 1-379 (379) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-379/379
Sequence Identity: 75% (288 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEP-VEVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMSNPQCTLSLGQI
|.|.||||||.||||||.||||||..||||...|..|||||| ||.|||.||....|||.|.||||..|||..|...|..|.||||.|||.||..||..|
YQIISKCGQGIYGSVFKAIHKITHCMVALKNFKDWNQEDGEPKVECKYLMQLRHCKNIVHLIDHFYNFKNSKYVMVFEYFEHDLWKFMSNHQCYMSLPCI

KNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEIDMWSVGCILMEMINNSYLF
|.|..|||||...||..||||||||||||||...|.||.||||..|.|.|||||..|..||||.|||||||.|||.||||||||||||||||||.|.|.|
KCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGSCQYGPEIDMWSVGCILMEMITNFYMF

AGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQQQNENNYSKQHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKYNNISTSCLQSPSSS
||..|..||.||.||.||||||.|||||.|.|||..|.|||||||||||||||....|.|||||||||||||||||||||||||||||||||||||||||
AGSNEQQQLELICKLCGCPTEKNWPGVSQLQGYNQYFHKQQQQQQNENNYSKQYPSRNRNNNNNNNNNNNNNNNNNNNNNNNNNKYNNISTSCLQSPSSS

PPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALEHPWF
|||||||||||.||.||||||||||||||||||||||||||||||||||||.|||...||||.||||||..|||.||||
PPIGGYASSLSTDFKSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSFLDLIERMLTLCPKKRINTKEALQHPWF
Kinase DDB0230050_C2d.AA CDK 4-381 28 3.4e-146 470.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-284/284
Sequence Identity: 28% (119 aa)

YIILSKCGQGTYGSVFKGIHKITH-----SLVALKRVTDIAQ----E-DGEP----VEVKYLNQLKNLSNIVNLRDHFYIDKNS---------VLVLIME
| .| | |.|||| |.|...|.|.      .||||..    .    | .| |     |...| .|    |||.|.| .. .. .          |....|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FIEGDLWKIMSNPQCTLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGV-----LKLTDFGLSTSYSKR-----SEKFLSSNVVSLYYRPP
... ||.|.|.          ||....|||.|.  || |.|||||.||.|.||. ||.     ||..||||.  .. .       . ....|| | ||.|
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLLGSCIYG--PEIDMWSVGCILMEMIN---NSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQQQNENNYSKQHNNNNNNNNN
|||||| .|.  ..|||||||||. ||..   . .|| |  |. ||..||...|.|||..||||..||.|                              
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------------

NNNNNNNNNNNNNNNNNNNNNKYNNISTSCLQSPSSSPPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLD
                                                                                          || .|||..|
------------------------------------------------------------------------------------------DLLNKMLCYD

PKKRINSLEALEHPWF
|||||.. .||.||.|
PKKRISAEQALQHPYF
Kinase DDB0230050_C2d.AA CMGC 4-381 23 8.99999999999e-123 405.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-513/513
Sequence Identity: 23% (133 aa)

YIILSKCGQGTYGSVFKGIHKITH--------------SLVALKRVT-DIAQEDGEP-------------VEVKYLNQLK----------------NLSN
| |..|.|.|||| |.|...| |                .||.|..  .   |...               |.|.| .|.                .  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVNLRDHFYIDKNS---------------VLVLIMEFIEGDLWKIMSNPQC--------TLSLGQ------------IKNFT------KQLLEGVK--QC
||.|.|.|| ...                 | |..|... ||.... | |          ||  .            ||.|.      .|.|.|.|   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HVNG--IMHRDIKPANLLITTN--------------------GVLKLTDFGLSTSYSKRSEK--------------------FLSSNVVSLYYRPPELLL
| ..  |.|||.||.|.||. |                    |.||. ||||...|...|..                    .....||...||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSCIY---------GPEIDMWSVGCILMEMINN--------SYLFAGADE-----------TAQLDLIFKLFGCPT---------------EKSWPGVSS
|.  |         ...|||||||||. ||...         .|| | .|             ||..|||..| ||               |. ||....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPGYND-------------LFNKQQQQQQNENNYSKQHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKYNNISTSCLQSPSSSPPIGGYASSLSSDFNS
||.||              .  ......|. |.. ... .. .|   ...|... | |...... |. .|   .                      .|.|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVF-NW-IY---E---------------------EKFKS

NEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALEHPWF
. .      | |         . .  |... . |  .|| .|||..||.|||   .||.||.|
H-K------F-N---------H-Q--FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase DDB0230050_C2d.AA CDC2 4-381 29 5.3e-97 298.65 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-301/301
Sequence Identity: 29% (116 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRV-TDIAQED-GEPV----EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMS---NPQ
|  . | | |||| |.|.... |. .||||.. ..  .|. | |     |  .|  ||.  ||| |.| ...   . | .. |... || | |     ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

CTLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSS-NVVSLYYRPPELLLGSCIYGPEIDMWSVGCILM
  ...  .|....|.|.||  || ..|||||.|| |.|| ..|..|. ||||.   .  . . .   .|| | ||.||.|||.  |  ..||||.|||. 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EM---INNSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQ---QQNENNYSKQHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNK
||   ... .||.|  |  ||  ||. .| |.|..||||..|| |.  | . ..|   .. .||..|                                 
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKK---------------------------------

YNNISTSCLQSPSSSPPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALEHPWF
                                                        |   . | |  .|| ..|| .|| |||.. |||.||.|
--------------------------------------------------------KNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase DDB0230050_C2d.AA S_TKc 4-381 20 5.8e-84 286.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-231/231
Sequence Identity: 20% (81 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPVEVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEG---DLWKIMSNPQC-----
| || | |.|..|.|.|..|| |. .||.|..      .    |.. | .  .  |||.| |.|.    . | ..||...|   || ... . ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

TLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGP-EIDMWSVGCILME
 ..  ... ...|...... || .||.|||.||.|.|...  ..|..||||.. .        .. .....|..||.|     ||. ..|.||.|||| |
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MINNSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQQQNENNYSKQHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKYNNISTS
|.    .|       |....||. |                                                                           
MLCGYPPFP------QMQMMFKKIG---------------------------------------------------------------------------

CLQSPSSSPPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALE-------HPWF
                                                         |...|. .|.|. ||.||.   |||.       ||||
--------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0230050_C2d.AA Pkinase 4-381 22 1.9e-76 265.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-293/293
Sequence Identity: 22% (92 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPV------EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEG-----DLWKIMS-
| |..| |.|..|.|.|..|| |  .||.|..    .......      |..... | |  ||| |.| |.   .. . ..||. ||     ||. ..| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

NPQCTL--SLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVL----KLTDFGLSTSY-SKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEID
  ....  |  ..|.. .|.|.|.. || .||.|||.||.|.||  ||..    |..||||.  .   ...  ... .....|..||...|.  |||..|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

MWSVGCILMEMINNSYLFAGA----DETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQQQNENNYSKQHNNNNNNNNNNNNNNNNNNNNNNNN
|||.|||| ||..   .| |.    .   |. .|..  |.|.. .||  .| . .. ..  .                                      
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------------

NNNNNNKYNNISTSCLQSPSSSPPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALEHPW
                                                               ..    . .. .|. ...|..|||||..  ..|.|||
------------------------------------------------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase DDB0230050_C2d.AA CDK7 4-238 33 1.3e-74 197.99 In-house 1-239 (288) Show / Hide 
Range on Protein: 4-238
Range on HMM: 1-239/288
Sequence Identity: 33% (81 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVT----DIAQEDGEPV----EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMSNPQC
| .... | |... |.|.  . |   || |..         .||       |.|.|  ..   |...|.| |    |  . |...|.. ||  .    . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQH-DNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIKDKSI

TLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEIDMWSVGCILMEM
 |    ||......| |.  ||.| | |||.|| |||.  ||.||..||||  .|     . ....||  .|| |||| |  .||. .||||||||. | 
ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYG-SPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

INNSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDL
.     . |  .  ||  ||.  |.|||. ||...... |. .
MLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKF
Kinase DDB0230050_C2d.AA CDK5 4-236 43 2.3e-74 234.28 In-house 1-234 (287) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-234/287
Sequence Identity: 43% (104 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPV----EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMSNPQCTLSL
|  . | | |||| |.|.  | || .||||||       | |     |.  |  ||   ||| | |    .|   |.|. ||.  || | | . .  ...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKK--LTLVFEFCDQDLKKYMDSCNGEMDM

GQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEIDMWSVGCILMEMI-NN
  || |  ||| |.  || . ..||| || |||| .|| ||| ||||   .      . |. || | ||||  |.||  |   |||||.|||. ||. . 
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCY-SHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

SYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYN
  || |.|.. || .|||. | |.| .||... || |.
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYK
Kinase DDB0230050_C2d.AA PCTAIRE 4-235 41 4.7e-63 215.78 In-house 1-237 (291) Show / Hide 
Range on Protein: 4-235
Range on HMM: 1-237/291
Sequence Identity: 41% (101 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPV----EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMSNPQCTLSL
|| | | | |||  |.|.  | | .||||| .     | | |     ||  |  ||   ||| | | .. ..   | |. |... || . | .    .. 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIR-LEHEEGAPCTAIREVSLLKDLKH-ANIVTLHDIIHTHHQ--LTLVFEYMDMDLKQYMDDCGNIMNM

GQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEIDMWSVGCILMEMINNS
  .| |  ||| |   ||   |.||| || ||||   |.||| ||||    |  .  . |  ||.|.||||. |.|| .|  .|||| ||||. ||    
HNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY-SHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGR

YLFAGAD------ETAQLDLIFKLFGCPTEKSWPGVSSLPGY
 || |           ||..||.. | |.||.||||.|....
PLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEF
Kinase DDB0230050_C2d.AA PFTAIRE 4-236 42 6.2e-63 215.4 In-house 1-233 (287) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-233/287
Sequence Identity: 42% (102 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPV----EVKYLNQLKNLSNIVNLRDHFYIDKNSVLVLIMEFIEGDLWKIMSNPQCTLSL
|  | | | |.|  |.||| .|.  .|||| .  . || | |     |.  | .||  .||| |  |  |    .| .. |... || . |.     .  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIR-LQQEEGTPFTAIREASLLKNLKH-ANIVCL--HDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHP

GQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELLLGSCIYGPEIDMWSVGCILMEMINNS
  .. |  ||| |   ||   ..|||.|| ||||.  | ||| ||||    |  |  . |. || | ||||  ||||  |  ..||| ||||..||.   
NNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTY-SHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQ

YLFAGA-DETAQLDLIFKLFGCPTEKSWPGVSSLPGYN
 .| |  | | ||..|||. | |||  ||||..||.|.
PAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYK
Kinase DDB0230050_C2d.AA CRK7 4-243 34 6.7e-62 211.97 In-house 1-294 (343) Show / Hide 
Range on Protein: 4-243
Range on HMM: 1-294/343
Sequence Identity: 34% (102 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQ---EDGEPV----EVKYLNQLKNLSNIVNLRDHFYIDK------NSVL---VLIMEFIEGDLW
| ..   | |||| | |   | |  .||||.|        ..| |.    |.| | || |  |||||..   .||      ..      .. | .  || 
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL-NHQNIVNLKE-IVTDKQDASEFKKHKGSFYMVFEYMDHDLM

KIMSNPQCT-LSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRS-EKFLSSNVVSLYYRPPELLLGSCIY------
  . ..     |..|.| | ||||||.  || ....||||| .|.|.  .| .|..||||   | . . .. .   |. | |||||||||   |      
GLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHIL

--------------------------------GPEIDMWSVGCILMEMINNSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQ
                                ||||||||.|||| |  .   .| |  | |||..|.|. | |.  .|| |  ||..|..  |.|
KELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQ
Kinase DDB0230050_C2d.AA PITSLRE 77-238 45 1.3e-56 194.34 In-house 80-243 (295) Show / Hide 
Range on Protein: 77-238
Range on HMM: 80-243/295
Sequence Identity: 45% (75 aa)

LIMEFIEGDLWKIMSNPQ---CTLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKRSEKFLSSNVVSLYYRPPELL
..||..| ||  .| | .      ..|.|| .. ||| ||.  | | ||||| | .|||.. .|.||. ||||   |     | ....|| | || ||||
MVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP-IKPYTPCVVTLWYRAPELL

LGSCIYGPEIDMWSVGCILMEMINNSYLFAGADETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDL
||. .| . .||||||||. |.|    || |  |. |.. |||..| ||||.|||...||. . .
LGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMM
Kinase DDB0230050_C2d.AA CRK7 355-381 62 7.8e-12 36.88 In-house 317-343 (343) Show / Hide 
Range on Protein: 355-381
Range on HMM: 317-343/343
Sequence Identity: 62% (17 aa)

LDLASKMLTLDPKKRINSLEALEHPWF
|||. |||.||||||.   |.|.|.||
LDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase DDB0230050_C2d.AA CDK7 355-381 40 3.9e-11 25.47 In-house 262-288 (288) Show / Hide 
Range on Protein: 355-381
Range on HMM: 262-288/288
Sequence Identity: 40% (11 aa)

LDLASKMLTLDPKKRINSLEALEHPWF
||| ..|.|..| ||.   ..|..| |
LDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase DDB0230050_C2d.AA CDK5 355-381 48 3.8e-10 27.77 In-house 261-287 (287) Show / Hide 
Range on Protein: 355-381
Range on HMM: 261-287/287
Sequence Identity: 48% (13 aa)

LDLASKMLTLDPKKRINSLEALEHPWF
.|| .||| ..|..||   .||.||.|
MDLLQKMLQCNPNQRISAKAALHHPYF
Kinase DDB0230050_C2d.AA PITSLRE 355-381 55 5.2e-10 32.83 In-house 269-295 (295) Show / Hide 
Range on Protein: 355-381
Range on HMM: 269-295/295
Sequence Identity: 55% (15 aa)

LDLASKMLTLDPKKRINSLEALEHPWF
.||  .|||..||.||.  .|| ||||
FDLLNQMLTYNPKNRITASDALKHPWF
Kinase DDB0230050_C2d.AA PFTAIRE 339-381 39 5.5e-10 31.33 In-house 245-287 (287) Show / Hide 
Range on Protein: 339-381
Range on HMM: 245-287/287
Sequence Identity: 39% (17 aa)

KKLIDKFPHLVLLPSVLDLASKMLTLDPKKRINSLEALEHPWF
|||   .| . . |   ||..||| . |..|.   ||..||.|
KKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase DDB0230050_C2d.AA TyrKc 4-381 13 6.8e-10 -62.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-381
Range on HMM: 1-280/280
Sequence Identity: 13% (55 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRVTDIAQEDGEPVEVKYLNQLKNLSNI-------VNLRDHFYIDKN------SVLVLIMEFIE-GDLWKI
   . | | | .| |.||. |     || | . . |       .   .. .. ....       |.|     ...         | ..||. . ||| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

MSNPQCTLSLGQIKNFTKQLLEGVKQCHVNGIMHRDIKPANLLITTNGVLKLTDFGLSTSYSKR-------SEKFL----SSN-VVSLYYRPPELLLGSC
  ... .|.. .  .|  |  .|    | ... |||.   | |.. |.. | .|||||             . .      ... .. .   .|| .   .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

IYGPEIDMWSVGCILMEMINNSYLFAGA--------DETAQLDLIFKLFGCPTEKSWPGVSSLPGYNDLFNKQQQQQQNENNYSKQHNNNNNNNNNNNNN
.. .. | || |  . |.  .               .|  ..    .   .| .   | .|                                       
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---------------------------------------

NNNNNNNNNNNNNNNNNKYNNISTSCLQSPSSSPPIGGYASSLSSDFNSNEYNGYNQTFSNEDCLAISQKKLIDKFPHLVLLPSVLDLASKMLTLDPKKR
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---------------------------------------------------------------------------F--VCCPDEMYQIMKQCWHEDPEDR

INSLEALEHPWF
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PTFSEI--HECF
Kinase DDB0230050_C2d.AA PITSLRE 4-35 40 4e-06 18.69 In-house 1-32 (295) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-32/295
Sequence Identity: 40% (13 aa)

YIILSKCGQGTYGSVFKGIHKITHSLVALKRV
. .| . . |||| |...  | |   |||||.
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRL
Kinase DDB0230050_C2d.AA PCTAIRE 341-381 33 9e-06 16.33 In-house 250-291 (291) Show / Hide 
Range on Protein: 341-381
Range on HMM: 250-291/291
Sequence Identity: 33% (14 aa)

LIDKFPHLV-LLPSVLDLASKMLTLDPKKRINSLEALEHPWF
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LINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF