Gene DDB0229333 (Slime mold)
DDB0229333
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0229333.AA | Protein | None | 392 | None | Fasta, JSON |
| DDB0229333.kin_dom | Protein Kinase Domain | None | 281 | None | Fasta, JSON |
Protein domains of DDB0229333.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0229333.AA | Dicty1 | 46-348 | 52 | 5.70000000001e-226 | 756.98 | In-house | 1-327 (327) | Show / Hide |
Range on Protein: 46-348 Range on HMM: 1-327/327 Sequence Identity: 52% (171 aa) ITKKTIYACDINGTMFQTYNMDTNRLLIIKKISLLQFKNHLQGRMMLRNCHYQRFFNHHPFVSGFKVSKRK-------------------SLNIKTKNLI | || | || || .| ||.|..||||||...|||||.|.|||||||.||.|.|||.||.|...... |.|.....|| IDPNTIVDCGTNGIMFRAFNFDTQRRVIIKKISVFMFKNHLMGHMMLRNCHFQRHFQHHPHVSTFQSIFKRKCSDNYQPPLTSILNSIINSNNNNQQHLI ESPVDDGTDLYFEFDQSDFTLYQMIRSDKAASRKQCPYVLYQLLTTIKYINSAGVIHRSLDP-KTIAVNKEYKTKLFDFSFSISTDYPTDIFFK-DYEET .....|..|.|||..|..|||||||..||.....||.|.|||||.|||...|||||||.||| .||.|...|..||..|.|...||.|.|.||. ||... LIQQKDDDDFYFEYIQPQFTLYQMIHNDKMLDQYQCCYFLYQLLMTIKFMHSAGVIHRDLDPENTIFVDQNYCIKLTEFYFCFPTDCPPDFFFNKDYDTN PWPYRSPETIIMLKEFSFECDVWSIGVIFAELILGEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKS---RHGGIKKRIPNATEE |||||.||||.|.||..|.||||.|||||||.|||..|||....|..||.|..|||.|||||||...||||..|......|| .|.|||.|....... PWPYRAPETIWMNKEYTFACDVWNIGVIFAEMILGKRLFRTQNFQDHLISIYKLIGNPTYDECKYVVNGFAIFFYMEYNRKSTFQPHFGIKRRFKGCNQD EIEILEGMLCWNPKKRWPIERIIQHPY .||.|.|||||.|.|||||..|.|||| QIELLQGMLCWDPRKRWPINQILQHPY |
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| Kinase | DDB0229333.AA | CMGC | 58-349 | 17 | 6.2e-56 | 181.85 | In-house | 13-513 (513) | Show / Hide |
Range on Protein: 58-349
Range on HMM: 13-513/513
Sequence Identity: 17% (88 aa)
GTMFQTYN--------------MDTNRLLIIKKISLLQFKNHLQG---------RMMLRNCHYQRFFN----------------HHP-FVSGFKVSKRKS
|. .. .. ..||.. ||||.. . . . . .. || . . . .| ||. |. . . ..|
GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKN
LN---------IKTKNLIESPVDDGTDLYFEFDQSDFTLYQMIRSDK---------AASRKQ------------CPYVL------YQLLTTIK--YINSA
. |. . . .||. |. | .|||.|.. . | . . | . ||.|. .| |. |.
SDGNEYEDKHIIS--------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSH
G--VIHRSLDPKTIAVNKE--------------------YKTKLFDFSFSISTDYPTDIFF-------------------KDYEETPWPYRSPETIIMLK
. .||| | | | .|.. .. |. || .. ... . | .| . ||.|| .. |
WGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWK
EFS---------FECDVWSIGVIFAELILG--------EQLFRGESK-----------QSLLIEISELIGTPT---------------YDECKESTN---
. . ..|.||.| ||||...| . || |.| . | .| ...|||| .| . ..
HYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPW
------------------GFARNFILNIPLKSRHG--GIKKRIPN-----------------------------------ATEEEIEILEGMLCWNPKKR
||||.| . . . .. .|. .|. .... |. |..||...|.||
YNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKR
WPIERIIQHPYF
. .| . |||||
ITAEQALQHPYF
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| Kinase | DDB0229333.AA | p38 | 164-349 | 36 | 4.4e-33 | 110.23 | In-house | 110-289 (289) | Show / Hide |
Range on Protein: 164-349 Range on HMM: 110-289/289 Sequence Identity: 36% (67 aa) YVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFSISTDYPTDIFFKDYEETPWPYRSPETIIMLKEFSFECDVWSIGVIFAELILGEQLF . .||.| ||| |||.||| | | |||| . . || . ..| .| | | ||.|| . .. |.||.| | |||| |. || FLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDEMTGYVATRW-YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLF RGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPNATEEEIEILEGMLCWNPKKRWPIERIIQHPYF .|. . | .| ...|||. . . |||.| ..| | .. ..|. .|. || || | || | .||||| PGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRR-DFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | DDB0229333.AA | MAPK | 228-349 | 33 | 1.4e-32 | 109.82 | In-house | 197-328 (328) | Show / Hide |
Range on Protein: 228-349 Range on HMM: 197-328/328 Sequence Identity: 33% (44 aa) YRSPETIIML---KEFSFECDVWSIGVIFAELIL-GEQLFRGESKQSLLIEISELIGTPTYDECKEST-NGFARNFILNIP-LKSRHG-GIKKRIPN--- ||.|| |.. .. . |.||.| ||||.. . .||.|.. . . | |..|||. . .. . . |||.| . . |. . . .| .|| YRAPE-IMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF -ATEEEIEILEGMLCWNPKKRWPIERIIQHPYF |. . | || || ..|.||. .| .||||| NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | DDB0229333.AA | ERK7 | 164-349 | 31 | 1.3e-31 | 105.13 | In-house | 104-292 (292) | Show / Hide |
Range on Protein: 164-349 Range on HMM: 104-292/292 Sequence Identity: 31% (61 aa) YVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSF--SISTDY---PTDIFFKDYEETPWPYRSPETIIMLKEFSFECDVWSIGVIFAELIL |..|||| |||. |. |||| | | | .. | |. || ||. . . .| | | ||.|| . ... | |||| | .|.. YIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRW-YRAPEILLGSHRYTKGVDMWSIGCILGEMLR GEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPNATEEEIEILEGMLCWNPKKRWPIERIIQHPYF | .| | | . | |.|. ||. . . .| | . ... .... ... .|.. .. |..| .|. ||||| .| .|||| GKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | DDB0229333.AA | ERK1 | 147-349 | 32 | 1.5e-31 | 111.11 | In-house | 88-289 (289) | Show / Hide |
Range on Protein: 147-349 Range on HMM: 88-289/289 Sequence Identity: 32% (66 aa) LYQMIRSDKAASRKQCPYVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFSISTDYPTDI--FFKDYEETPWPYRSPETIIMLKEFSFEC ||..... . . | | |||.| .||| || |.|| | | . .|. |. || .| .| | .| | | || || .. | . LYKLLKTQHLSNDHIC-YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW-YRAPEIMLNSKGYTKSI DVWSIGVIFAELILGEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPNATEEEIEILEGMLCWNPKKRWPIERII |.||.| | ||.. .| | | | ..| | |. . | |||.. .| |.. .. |.| . ...|. || .||.|| ..| . DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKV-PWARLFPKADSKALDLLDKMLTFNPHKRITVEEAL QHPYF ||| AHPYL |
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| Kinase | DDB0229333.AA | nmo | 142-349 | 30 | 1.7e-30 | 90.52 | In-house | 86-292 (292) | Show / Hide |
Range on Protein: 142-349 Range on HMM: 86-292/292 Sequence Identity: 30% (64 aa) QSDFTLYQMIRSDKAASRKQCPYVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFSISTDYPTDIFFKDYEETPWPYRSPETIIMLKEFS ||| | ..| | .. | |||.| .||. ||...|| . | . || . |. || . . | . || || .. . .. QSD--LHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQY-YRAPEILMGARHYT FECDVWSIGVIFAELILGEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPN---ATEEEIEILEGMLCWNPKKRW |.||.| |||||. || .| | | .|.|||. .. | .| |.. .| |.| .. || | ...| || ..| || SAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEG-AKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRI PIERIIQHPYF .. ..||| SCKDALAHPYL |
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| Kinase | DDB0229333.AA | ERK5 | 129-349 | 29 | 1.7e-28 | 100.99 | In-house | 72-295 (295) | Show / Hide |
Range on Protein: 129-349 Range on HMM: 72-295/295 Sequence Identity: 29% (67 aa) PVDDGTDLYFEFDQSDFTLYQMIRSDKAASRKQCPYVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFS--IST--DYPTDIFFKDYEET | . | | || . | |.| |.. . | |||.| .||. || |||| | | . || |. || ..| .| .| | PYSEMKDVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVAT PWPYRSPETIIMLKEFSFECDVWSIGVIFAELILGEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILN-IPLKSRHGGIKKRIPNATEEEI | || || .. .... ||||.| || |.| |.| | | | . .|.| . .|.. .| . ..| | | . RW-YRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPK-DWEKVYPKADRQAL EILEGMLCWNPKKRWPIERIIQHPYF ..| || . | .| . . .|||. DLLARMLRFEPSERITVNKALQHPFL |
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| Kinase | DDB0229333.AA | ERK | 164-349 | 33 | 1.6e-24 | 87.83 | In-house | 112-307 (307) | Show / Hide |
Range on Protein: 164-349 Range on HMM: 112-307/307 Sequence Identity: 33% (67 aa) YVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFSISTD-YPTDI------FFKDYEETPWPYRSPETIIMLKEFSFECDVWSIGVIFAEL | .||.| .||| ||.|||| | |. | ||. | || .. | . .. |...| | | ||.|| . ... . . |.||.|.||||. YFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRW-YRAPEIMLSWQKYTKAMDIWSCGCIFAEM ILGEQLFRGESKQSLLIEISELIGTP-TYDECKESTNGFARNFILNIPL-----KSRHGGIKKRIPNAT--EEEIEILEGMLCWNPKKRWPIERIIQHPY . . ||.|.. . .| ..|||| . .. .. .. |...| | | |. ....||| . |. || || ..|.||. .| ..||| LGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKP----WENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPY F | F |
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| Kinase | DDB0229333.AA | Pkinase | 227-349 | 24 | 1.6e-19 | 70.1 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 227-349 Range on HMM: 176-293/293 Sequence Identity: 24% (31 aa) PYRSPETIIMLKEFSFECDVWSIGVIFAELILGEQLFRGE----SKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPNATEEE .|..|| | .. . ..|.||.|.|..|...|. .|.|. . . . | . |.|. .. .. .. .. . . . ... .|..|| WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEEC IEILEGMLCWNPKKRWPIERIIQHPYF .......||..||||. .| | |||.| KDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | DDB0229333.AA | MAPK-Unclassified | 227-349 | 23 | 3.1e-18 | 62.14 | In-house | 413-575 (575) | Show / Hide |
Range on Protein: 227-349 Range on HMM: 413-575/575 Sequence Identity: 23% (39 aa) PYRSPETIIMLKEFSFECDVWSIGVIFAELILG-----------EQLFRGES--------------------KQSLLIEISELIGTPTYDECKESTNGFA .|| || . ..|... | |||| ||||... .|| |.. .|. . | . |.| | . |. | WYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSA RNFILNIPLKSRHGGIKKRIPNATE----------EEIEILEGMLCWNPKKRWPIERIIQHPYF | .| | . . .. .. |.| .. || ||.|| .. . .|||| RKYIQSFKCKTPV-HFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | DDB0229333.AA | S_TKc | 58-349 | 18 | 2.4e-14 | 33.55 | SMART | 13-231 (231) | Show / Hide |
Range on Protein: 58-349
Range on HMM: 13-231/231
Sequence Identity: 18% (56 aa)
GTMFQTYNMDTNRLLIIKKISLLQFKNHLQGRMMLRNCHYQRFFNHHPFVSGFKVSKRKSLNIKTKNLIESPVDDGTDLYFEFDQSDF---TLYQMIRSD
|. .. .. .|.|. ||.|. ....| . |||.. .| . ... ..||. .. | .|...|..
GKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNI------------VKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKR
KA------ASRKQCPYVLYQLLTTIKYINSAGVIHRSLDPKTIAVNKEYKTKLFDFSFSISTDYPTDIFFKDYEETPWPYRSPETIIMLKEFSF-ECDVW
. . .. ...||.. ..|. | |.||| | | | ... |. || .. . . ||| |..|| . ... .||.|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPW-YMAPEVL----GYGKCKCDWW
SIGVIFAELILGEQLFRGESKQSLLIEISELIGTPTYDECKESTNGFARNFILNIPLKSRHGGIKKRIPNATEEEIEILEGMLCWNPKKRWPIERIIQ--
|.|.|..|.. |. .|. . .. ..|| ..| .......|...|.||. . . |
SCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE
-----HPYF
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WDIKCHPWF
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| Kinase | DDB0229333.AA | MAPK-Unclassified | 143-188 | 40 | 5.1e-07 | 20.86 | In-house | 91-137 (575) | Show / Hide |
Range on Protein: 143-188 Range on HMM: 91-137/575 Sequence Identity: 40% (19 aa) SDFTLYQMIRSDK-AASRKQCPYVLYQLLTTIKYINSAGVIHRSLDP | | |.| |.|. . .. | .||.|. .||. ||..||| | | SLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKP |
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| Kinase | DDB0229333.AA | MAPK | 144-196 | 41 | 9e-06 | 15.75 | In-house | 99-153 (328) | Show / Hide |
Range on Protein: 144-196 Range on HMM: 99-153/328 Sequence Identity: 41% (23 aa) DFTLYQMIRSDKAASRKQCPYVLYQLLTT--IKYINSAGVIHRSLDPKTIAVNKE . |.| |.|.. | . . | .||.| .||| ||.|||| | | |.||.. ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN |
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| Kinase | DDB0229333.AA | Pkinase | 145-184 | 29 | 2.440618 | 2.28 | Pfam | 89-132 (293) | Show / Hide |
Range on Protein: 145-184 Range on HMM: 89-132/293 Sequence Identity: 29% (13 aa) FTLYQMIR--SDKAA--SRKQCPYVLYQLLTTIKYINSAGVIHR . |. .|. .... | ..| ..||.| ..|. | |.||| MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR |
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