Gene Cdk8 (Slime mold)

Cdk8

Species: Slime mold
Alias: Cdk8, Ddcdk8, DDB0191261, DdisK048
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
Cdk8.AA Protein None 380 None Fasta, JSON
Cdk8.kin_dom Protein Kinase Domain None 303 None Fasta, JSON

Protein domain

Protein domains of Cdk8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk8.AA CDK8 48-348 53 8.4e-247 782.9 In-house 1-329 (329) Show / Hide 
Range on Protein: 48-348
Range on HMM: 1-329/329
Sequence Identity: 53% (175 aa)

YEIGSGTYGMVYKADDKKR---PNNKVAVKKFRSTK------EGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHR
..||.||||.||||..||.   ||...|.|.||..|      ||.|.|..|.|||.|..||...|...|..|.||.|||.....|||||.||..|||.||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

ENGSHFSDAT------IKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKE--CGTVKIGDFGLARIFQSPLKPLNENG-VVVTIWYRSPELLLGSK
.|..|..|.|      .||..||.|.||||||||||.||||||.||.|||.|.|  ||.|||.|.|.||||..|||||.... ||||.|||.||||||..
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTRAVDIWAIGCIFAELITTKPLFPGKEK--DPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSS----MEAFPN-SLAKCVG---IDENS
|||.|.||||||||||||||..|.|..||.  |.|.......||...|..|.|.|...||||||..||..||..    |...|| ||.....   |...|
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

QAYDLLSKMILYDPSKRITASEALDHPYF
.||.||.||...||.||||...|..||||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase Cdk8.AA CDK 44-348 42 1.8e-152 491.24 In-house 1-284 (284) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-284/284
Sequence Identity: 42% (143 aa)

YTFSYEIGSGTYGMVYKADDKK--R--PNNKVAVKKFRSTK-----EGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPK---------DKLLYLIFDY
|    .|| |||| |||| ||.  |  ... || ||.|  .     |.||.. || ||| ||||| ..|||||.|||.  .         .. ||..|.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEFDLFGIIKYHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKE-CGTVKIGDFGLARIFQSPLK---PLNENG-VVVTIWYR
.. || ....             ||...|| |.|.||.||||..||||||.|||..  |.. ||..||.||||||.|..|..   |...   .||| |||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

SPELLLGSKHYT--RAVDIWAIGCIFAELIT---TKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGI
.||||||||||.   ..|.|..||||||..|    ||||||.            || .||.|..| || |.||....||..                   
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------

DENSQAYDLLSKMILYDPSKRITASEALDHPYF
       |||.||  |||.|||.|..||.||||
-------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Cdk8.AA CMGC 44-348 26 2.9e-131 433.97 In-house 1-513 (513) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-513/513
Sequence Identity: 26% (138 aa)

YTFSYEIGSGTYGMVYKADDK-------------KRPNNKVAVKKFRSTK---------EGEGLSLTAYREIGLLKELS----------------NEN-I
|.    ||.||||.|||. ||             .. |..||.||... .         |..|.. .|.||| .||.|.                ..| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLLDVCLNPK---------------DKLLYLIFDYAEFDLFGIIKYHRE-----NGSHFSDAT------------IKSLI------WQVLNGIH--YLH
|||.|..  ..               .. |||.|.| . ||...|| ..      .. ..|.              ||...      .|.|.|..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--VIHRDLKPSNILVMGEGKE----------------CGTVKIGDFGLARIFQSPLKPLNE-------------------NGVVVTIWYRSPELLLG
|.|  .|||||||.|||.  ...                  |..||.||||||.. .. .. ..                      ||| |||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SKHYT---------RAVDIWAIGCIFAELITT--------KPLFPGKEK----DPKIPSLFQDDQVEKIIRVLGKPT---------------LDMWPDIK
.||||          ..|.|..||||||..|         ||||||.      | |       || .||..|||.||                . ||...
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

H---------------------------------LPEWKRLSSMEAFPN------------SLAKCVGID----------------ENSQAYDLLSKMIL
                                  .|.|.. .  . ||.            .. .. . .                ...|| |||.||  
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

YDPSKRITASEALDHPYF
|||.|||||..||.||||
YDPDKRITAEQALQHPYF
Kinase Cdk8.AA CDC2 44-348 42 1.6e-115 356.65 In-house 1-301 (301) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-301/301
Sequence Identity: 42% (135 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEG--LSLTAYREIGLLKELS-NENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHREN
|.    || |||| |||. |..     ||.||.| . | ||     || ||| .||||   .||||| ||  .   . ||..|.| ..||    .     
YQKIEKIGEGTYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPK

GSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAI
..|.. ...||...| |.|.|..|.. ..||||||.|||.  .|.    .||.|||||| |. |....  .  ||| |||.||.|||.|.|. .||.|.|
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI

GCIFAEL---ITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLP-------EWKRLSSMEAFPN-SLAKCVGIDENSQAYDLLSKMI
||||||.   .| ||||.|   |  |  ||      || |.|| |. . ||... ||       .||.    . .||    |   .  . .. |||..|.
GCIFAEMFMDVTKKPLFHG---DSEIDQLF------KIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQML

LYDPSKRITASEALDHPYF
 |||.|||.| |||.||||
QYDPQKRISAKEALQHPYF
Kinase Cdk8.AA CDK7 44-348 35 3.7e-107 286.45 In-house 1-288 (288) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-288/288
Sequence Identity: 35% (109 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFR---STKEGE-GLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRE
|.    || |... |||| |..    .||.|| .   .. | . |.  || ||| .|.|.. .|.. |.|.        ..|.||. . ||  .||    
YEKIKHIGEGQFATVYKACDHQTG-QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIK---D

NGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWA
.   .  | ||.   ..| |. |.| ||. |||||| | |.     | | .||.|||||| . || . .  .  |||.|||.|||| | .||. .||.|.
KSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM----NENGQLKIADFGLARFYGSPNRIYTHQ--VVTRWYRAPELLFGARHYGTGVDMWS

IGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRITA
.|||||||.   | .||   |  |      || ..| . || ||   ||..  ...   . .  ..     . . .     . ||...| . .|.||.|.
VGCIFAELMLRVPYLPG---DSDI------DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTC

SEALDHPYF
...| .|||
TQCLKMPYF
Kinase Cdk8.AA PITSLRE 44-348 40 3e-105 355.94 In-house 1-295 (295) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-295/295
Sequence Identity: 40% (125 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRST--KEGEGLSLTAYREIG-LLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHREN
.   . |. |||| ||.| ||.  .  || |..     || ||  .|. |||  .|..|  .|||... . .       |....| | || ...  ... 
FQCLNRIHEGTYGVVYRAKDKRT-DEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR

GSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAI
   |.   ||.|. | |.|....|.||..||||| ||.|        |  ||.|||||| ..||.||.    .||| |||.||||||.| |. .||.| .
NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS----HKGILKICDFGLAREYGSPIKPYTP--CVVTLWYRAPELLLGCKKYSTPVDMWSV

GCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFP-NSLAKCVG--IDENSQAYDLLSKMILYDPSKRI
||||||.|| ||||.||            ||...|   .| ||   ||... || ||.. ...  | | | | ..     . ...||| .|  |.| .||
GCIFAEFITMKPLFQGKS---------EIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRI

TASEALDHPYF
|||.||.||.|
TASDALKHPWF
Kinase Cdk8.AA CDK5 44-348 40 4.6e-96 304.04 In-house 1-287 (287) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-287/287
Sequence Identity: 40% (124 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENGSH
|     || ||||.|||| .|.     || |. |   | ||   || ||| |||||  .||| | ||     .| | |.| .   ||    ||  . .  
YEKMEKIGEGTYGTVYKARNKET-HEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS--EKKLTLVFEFCDQDL---KKYMDSCNGE

FSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCI
 . ..|||...| | |. . |.. | |||||| | |.  .    |. | .|||||| |  | .       ||| ||| |  |.|||||.  .|.| .|||
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKN----GELKLADFGLARAFGIPVRCYSHE--VVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

FAELI-TTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWK-RLSSMEAFPNSL--AKCVGIDENSQAYDLLSKMILYDPSKRITA
|||.. . .||||| .         ..||  .| ...| |. | || | .||..|      . .|     .. |    ...  |||.||. ..| .||.|
FAEMANAGRPLFPGND---------VEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISA

SEALDHPYF
 .|| ||||
KAALHHPYF
Kinase Cdk8.AA S_TKc 44-348 28 8.6e-95 322.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEF---DLFGIIKYHREN
|..  .||.|..| |||. .||  . .||.|. .          ...||| .||.   .|||||.||. .   . ||....|..    ||| .|| .. .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

GSH--FSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTR-AVDI
| .  |.  .......|..... |.||...|||||||.|||.        ..||.||||||..         . ...| ||..||.|    .|.. ..|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDW

WAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRI
|..|||..|... .|.||               |........|                                      ..| |...|.  .||.||.
WSCGCILYEMLCGYPPFP---------------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRP

TASEALD-------HPYF
|| |||        ||.|
TA-EALQDEWDIKCHPWF
Kinase Cdk8.AA MAPK 44-348 36 4.7e-91 308.8 In-house 1-328 (328) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-328/328
Sequence Identity: 36% (130 aa)

YTFSYEIGSGTYGMVYKADDKK-----RPNNKVAVKKFR-------STKEGEGLSLTAYREIGLLKEL-SNENIVKLLDVCLNP-----KD----KLLYL
|.    ||.| ||.| .|.||.     . ..|||.||.        ..|        .|||| ||...   |||.||||.         ..    . .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-------RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYI

IFDYAEFDLFGIIKYHRENGSHFSDATIKSLIWQVLNG--IHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQS-PLKPLNENGV-----
.... | ||  |||  .    . ||  |.....|.|.|  . |.||  |||||||||||||     | ...||.||||||.. .   .. ...       
VMELMETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV----NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQK

------VVTIWYRSPELLLG--SKHYTRAVDIWAIGCIFAELIT-TKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMW---P-D------IKHL-
      |.| |||.||..|.  ..||| |||.|..||||||..|  |||||||            || ..|. |||.|. ...   . .      |. | 
MHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKD---------YIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLG

--PEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRITASEALDHPYF
  |  .. .  . |||..      . |.|| |||.||   ||.||||. ||| ||||
NLPKYPKKPWEKMFPNANF-----NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Cdk8.AA CRK7 44-348 33 3.7e-87 295.88 In-house 1-343 (343) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-343/343
Sequence Identity: 33% (120 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKE---GEGLSLTAYREIGLLKELSNENIVKLLDVCLNP-------KDK-LLYLIFDYAEFDLFG
|    .||.|||| |||| . |. .  || ||.|.  |    ||   || ||| .|..|  .|||.| .. .         |.|   |..|.|.  || |
YEMIMQIGEGTYGQVYKAKN-KHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

IIKYHRENG--SHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPL-KPLNENGVVVTIWYRSPELLLGSK
      |..   |||   .|..  | | |. |.| . ..|||.| ||||.   |.    ||| |||||| . |   ..   |  |.| ||| |||||| .
LL----ESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGE----VKIADFGLARLYNSEEKRRPYTN-RVITLWYRPPELLLGEE

HY--------------------------------------TRAVDIWAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIK
.|                                      . ..|.|  |||..|| | ||.|.|.       ..   .| ||| .. | |. . ||.. 
RYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNN------EM---AQLEKIYKICGSPNPNNWPEVM

HLPEWKRLSSMEAFPNSLAKCVGIDEN-----SQAYDLLSKMILYDPSKRITASEALDHPYF
 || |. .     .   | . .   ..     ... ||| ||  .||.||.||.|.|.|..|
KLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Cdk8.AA Pkinase 44-348 31 2.3e-78 271.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-293/293
Sequence Identity: 31% (100 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYR--EIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEF-----DLFGIIK-
|..   ||||..| |||. .|. .  .||||...  .| ..   |. |  || ..|.|. .|||.|.|.. .  .. .|....|.|      ||| .|. 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-YHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRA
 .|.   . ||. ..|. ..|.| |. |.||...|||||||.|||.  .|  . .|||.|||||. |.   .    .....|.||..||...|...|...
WRHGCF-Y-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPS
||.|..|||..|... .|.|||.  ...      .|| ..| |..|.|.   ||     .  . ..  .      .. . .  .. . |...... .||.
VDMWSCGCILYEMLCGRPPFPGHC-WHD----N-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPK

KRITASEALDHPYF
||.|| ..| ||.|
KRPTAEQILQHPWF
Kinase Cdk8.AA CDK10 44-348 38 1.2e-73 250.98 In-house 1-285 (285) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-285/285
Sequence Identity: 38% (116 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENGSH
.     .| ||||.||.| | .  .  ||.|| |  || .|| . . ||| ||...  ||||.| .|    .   ..|. .| | ||  ..       . 
FEKLNRVGEGTYGIVYRARDMRS-DEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLD---NMPQP

FSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCI
|... .| .. |.| |..|||.|..|||||| ||.|.  .|  |  .|. |||||| .  | ||.     .||.||| ||||||..  | |.|.||.|||
FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKG--C--IKVADFGLARMYGVPVKPMTPK--MVTLWYRAPELLLGCRTQTTAIDMWAVGCI

FAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRITASEAL
 .||.  |||.||      |       |.. || .|| |   .||   .||  .. .  .   | | .   .  .|    ||  ...|.| || || |.|
LGELLVHKPLMPGNS---EI------HQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS-GRRLLNFLFMYNPKKRATAEECL

DHPYF
.  ||
ESSYF
Kinase Cdk8.AA Pkinase_Tyr 44-199 33 7.3e-16 54.35 Pfam 1-159 (270) Show / Hide 
Range on Protein: 44-199
Range on HMM: 1-159/270
Sequence Identity: 33% (56 aa)

YTFSYEIGSGTYGMVYKADDK---KRPNNKVAVKKFRSTKEGEGLSLTA------YREIGLLKEL-SNENIVKLLDVCLNPKDK-LLYLIFDYAEF-DLF
 ||  ..|.| .|.|||.  |   . .. .||||. .     || .  .       ||. ..|.| ...|||.|. ||.  ..   .|... |..  || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

GIIKYHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLAR
   . |||.. ...  .. .  ||. .|  ||.|.  |||||   |.||     | ..|||.||||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICDFGLAR
Kinase Cdk8.AA TyrKc 44-348 24 1.3e-14 13.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-348
Range on HMM: 1-280/280
Sequence Identity: 24% (80 aa)

YTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKEL--SNENIVKLLDVCLNP-----KDKLLYLIFDYAEF-DLFGIIK
 |.  ..|.| .| |||.  |     .||||. .. .         .||. ....|  ...|||.|. ||. .      .. |.... |..  ||   ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSP--------LKPLNE--NGV-VVTIWYRSPEL
.||..   .. ..  |  ||. .|  ||||. .|||||   |.||  ..    ||||.||||.|   .          .   |  .|  .. |   .|| 
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLGSKHYTRAVDIWAIGCIFAELITT-KPLFPGKEKDPKIPSLFQDDQVEKIIRVL---GKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQ
.   . .| . |.|. |    |. |  ..  || ..         ...| . ..      .|  |  | .              |       |.  .   
I-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------F-------VCCPDEM-

AYDLLSKMILYDPSKRITASEALDHPYF
 |.. ..   .||..| | ||   | .|
-YQIMKQCWHEDPEDRPTFSEI--HECF