Gene Lkb1 (Slime mold)

Lkb1

Species: Slime mold
Alias: Lkb1, DDB0229349, DdisK033
External Links: DictyBase Link ,
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: LKB

Sequence

Name Sequence Type Origin Length Description Download
Lkb1.AA Protein None 586 None Fasta, JSON
Lkb1.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of Lkb1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Lkb1.AA LKB 40-301 55 1.1e-225 676.76 In-house 1-265 (265) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-265/265
Sequence Identity: 55% (148 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFIIEEKGKLYIVYEYVGGGTSQNILENAPNGR
|..|.|||||.|||||..|||.|..|.||||.|...|..||.|...|.|||.|.|..|..|.|.|||.|..|||.|.|.|.||...||.|..|...|..|
YMMGDVLGEGSYGKVKECMDSYTLCRRAVKIMKKKKLRRIPNGWQNVKKEIQILKRMHHRHVIQLIDVFYNEEKQKMYMVMEYCVCGTMQEMLDMQPCKR

LPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQF-QTTFSPFKIDIWAMGVTLY
.|..|..|.|.||...|||.|||...|.||||.|.|.||.|.||..||||||.........|...|.|||||||||.... ..|||.||.|||.||||||
MPIWQAHFYFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRDDCCTTSQGSPAFQPPECANGNHDTFSGFKVDIWSMGVTLY

LMTIGKFPFSGANMFVLFENISKCKIEFPN--DLDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
.||.||.||.|.||..|||||.||..|.|.  |.||||.|||||.||.||..|||..||..||| 
NMTTGKYPFEGDNMYKLFENIGKCQWEMPCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIMHHPWF
Kinase Lkb1.AA CAMKL 40-301 30 6.1e-113 361.8 In-house 1-297 (297) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YILGEVLGEGAYGKVKDGMD-SFTQKRVAVKILKRARLKKIPGGEAS-----------VLKEINITKKLH---NKHIIKLIDHFIIEEK----GKLYIVY
|..|..||.|..|||| ... ..|...||.||... .....|  ..            . .||.| |.|.    ..|||| ...  .|.    .|.|.| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVGGGT--SQNILENAPN--GRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHAN--VLKLSDFGVAEDSS-Q-LEDFECLSRSYGSPAFQ
||..||    .. ... ..  ||.|.|. ...|||...| .|.||..| ||||||.|||... .  ..|..||| .     .   . . |. . |||...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPELTQF-QTTFSPFKIDIWAMGVTLYLMTIGKFPFS-------GANMFVLFENISKCKIEFPN---DLDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
.||. |  .. .  .|.|||..||.|| |  |..||        |.. . ..... .|  ..|.   ... |. .||...|||.  .|... ||.||||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase Lkb1.AA CAMK 45-301 22 2.3e-91 294.62 In-house 1-425 (425) Show / Hide 
Range on Protein: 45-301
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

VLGEGAYGKVKDGMDSFTQ------------KRVAVKILKRARLKK------------------------IPGGEASVLKEINITKK-------LHNKHI
.||.|..|||| ...  |.            ..||.||... .||.                         |  ...|..||.| ||       |. ..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLIDHFI------------IEEKG------KLYIVY---EYVGGG----TSQNILENAPN-------------GRLPPHQSQFIFRQLIEACEYIHSQK
|||....               .|.      ..|.|    ||. ||       . .   ..             ||.. .. ...|||...| .|.||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKPDNILFTHA-----------------NVLKLSDFGVA--EDS-------------------SQLEDFECLSRSYGSPAFQP-PELTQFQ----
| |||.||.|||...                  | .|..||| |   |.                   .. .. . .. . |.|.. . ||. . .    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------TTFSPFKIDIWAMGVTLYLMTIGKFPFSGA-------------NMFVLFENISKCKIEFPND------------------------LDKDLV
         .  ..|.|.|..|| || |  |..|| |              |.  |||.| |.| .|| .                        ....  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLIKGILQVDHIQRFSLGQIKNHPWC
.||...||||  .|... |..|||| 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Lkb1.AA S_TKc 40-301 28 2.9e-76 260.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFIIEEKGKLYIVYEYVGG--GTSQNILENAPN
| .....|.||.|||. . .  |...||.||.|            ....||.| || | ..|.||.|.|     ..||.| ||..|  |.   .... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

GR----LPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQFQTTFSPFKIDIWAM
..    .|. . .|...|...| ||.||..|.|||.||.|||...  ..|..|||.|            .   |.| . .||.      ....|.|.|. 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GVTLYLMTIGKFPFSGANMFVLFENISKCKIEFPNDLDKDLVNLIKGILQVDHIQRFSLGQIKN-------HPWC
|..|| |  |. ||.  .|...|..|           .... ..|...||.|  .| .  .. .       ||| 
GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Lkb1.AA CAMKK 40-301 24 2e-71 225.8 In-house 1-396 (396) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-396/396
Sequence Identity: 24% (99 aa)

YILGEVLGEGAYGKVKDGMDSFT-QKRVAVKILKR----ARLKK----------------------IPGGEASVLKEINITKKLHNKHIIKLIDHFII--
| |....|.|..||||   .. . || .|.||...     .|||                      .. ..  | .||.| ||.....|.||.   .|  
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYE--VIDD

EEKGKLYIV-YEYVGGGTSQNILENAP----NG-------------------RLPPHQ---------------------SQFIFRQLIEACEYIH-SQK-
..  |.|.|  ||. .|  ... .. .    |.                    .   |                      . .||. | . ||.| .|| 
PQNDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKA

------------------ILHRDIKPDNILFTHAN---VLKLSDFGVAEDSSQLEDF--EC-------LSRSYGSPAFQPPELTQF--QTT---------
                  | ||||||.|||... .   ..|..||||.   .. ...   |       |..  | |||..|||     |..         
CSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRF

---FSPFKIDIWAMGVTLYLMTIGKFPFSGANMFVLFE---NISKCKIEFPN-------------DLDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
   .. ...||||.||||| .. || || . | . |..    | .  |.||              ..  ||..|||. |. .  .| .. |||.||| 
RFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase Lkb1.AA AMPK 40-301 36 3.2e-67 198.63 In-house 1-254 (254) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-254/254
Sequence Identity: 36% (96 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFII-EEKGKLYIVYEYV-GGGTSQNILENAPN
||.|. .|||..|||| |    |.. ||.||| . ..|.      .. .|| | |..   |||.| .  .| | .  ...| ||| ||     |  .   
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQ-DMVERIQREIHILKLFRHPHIIQLYE--VIIETPTDIFMVMEYVSGGELFDYIVKH---

GRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQFQTTFSPFKIDIWAMGVTL
|||. ....  | | | . ||.|  .| ||| || |.|. | . .|. |||    |   .| | |. . |||    ||. . .   .| ..|||  || |
GRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGL---SNMMKDGEFLKTACGSPCYAAPEMISGKLYCGP-EVDIWSCGVIL

YLMTIGKFPFSGANMFVLFENISKCKIEFPNDLDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
| |  |. ||   |  .|. .| ... . | .| ..  .|||..|||| ..|..  .|.||||.
YAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase Lkb1.AA Pkinase 40-301 26 4.8e-65 227.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLK--EINITKKLHNKHIIKLIDHFIIEEKGKLYIVYEYVGGG----TSQNILE
| .|...|.|..|.|. ...  |.|.|||||.|.   .. .. . . ..  || | |.|. ..|..|.| |    |...|.| ||..||        ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

NAPNGRL--PPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHANVL----KLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQFQTTFSPFK
   .|..  .... .|...|.... ||.||..|.|||.||.|||. . ...    |..|||.|.  . .   . ..   |.| . .||. ....  .| |
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP-K

IDIWAMGVTLYLMTIGKFPFSGA------NMFVLFENISKCKIEFPNDLD---------------------KDLVNLIKGILQVDHIQRFSLGQIKNHPW
.|.|..|..|| |  |..||.|.      .. .....| .....|. . .                     ...  .||..|..|  .| .  ||..|||
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

C
 
F
Kinase Lkb1.AA Ciliate-E2 40-301 22 3.7e-64 219.12 In-house 1-365 (365) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVA----------------VKILKRARLKKIPGGEASVLKEINITKKLH----------------NKHIIKLIDH
|.. ...|.|..|.|. . .  .||..|                ||| . |   ... .  ....||.| ....                ...|||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FIIEEKGKLYIVYEYVGGGTSQNILENAPN---------GRLPPHQSQFIFRQLIE---------------ACEYIHSQK-ILHRDIKPDNILFTHANVL
|. . . ..|.| ||. ||. . ...| .          ...   . ..|..|...               | ||.||.. |.||||||.||||     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLSDFGVAEDSSQLED--------FECLSRS----------------------YGSPAFQPPELTQFQT-------TFSPFKIDIWAMGVTLYLMTIGKF
|..||| . . .. ..         ...  .                      .|.| ...||  . .        .   .|.|||..||.|| |  ||.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFSGANMFVLFENISKCKIEFP------------------NDLDKDLVNLIKG----ILQVDHIQRFS-LGQIKNHPWC
||        ...| .|||.||                  ......  .|||     .||.|  .|..   ||.|||| 
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Lkb1.AA Ciliate-E2-Unclassified 40-301 22 6.6e-58 198.7 In-house 1-352 (352) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRV-----AVKILKRARLKKIPGGEASVLKEINITKK----------------LHNKHIIKLIDHFIIEEKGKLYI
|......|.|..|||.   .. ..  .     . || .......       ..... . .|                |...|.... .... . | ..||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VYEYVGGGTSQNILENAPN---------------GRLPPHQSQ-----FIFRQLIEACEYIHSQK-ILHRDIKPDNILFTHAN---VLKLSDFGVAEDSS
|.||. ||. ...... ..                ...  |..     |.|.|.... ||.|... |.||||||.||||.  .    .|..||| .  . 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QLED-------------FECLSRSYGSPAFQ----PPELTQFQTTFSP--FKIDIWAMGVTLYLMTIGKFPFSGANMFV----------------LFENI
| ..             .. ..   |.| ..    .||. | |    .  .|.|||..|| || |  |..||.. |                   |..||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

SKCKIEFPN--------DLD---KDLVN-LIKGILQVDHIQRFSLGQIKNHPWC
 ...|.||.        ...   ||..| |.. .|...  .| .. ||.|||| 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Lkb1.AA ULK 40-301 27 8.5e-55 188.37 In-house 1-324 (324) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-324/324
Sequence Identity: 27% (89 aa)

YILGEVLGEGAYG-KVKDG--MDSFT-QKRVAVKILKRARLKKIPGG------EASVLKEINITKKLH------NKHIIKLIDHFIIEEK--GKLYIVYE
|.| ..||.|..| ||  |  ... | .. ||.|.  .  ..|..          .  .||.| |||.      . ||.||.| |  |..    .||..|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWF--ETSNHNNIYIIME

YVGGGTSQNILENAPN-------GRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHAN------------VLKLSDFGVAEDSSQ--LEDFE
|  ||. ......  .       .||.  . . .|.|..... ..|...| ||||||.||| .. .            |||..||| |       .|.. 
YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM

CLSRS-----YGSPAFQPPELTQ---FQTTFSPFKIDIWAMGVTLYLMTIGKFPFSGANMFVLFEN--------------ISKCKIEFP-----NDLDKD
| .        |.| .  |.. |    |  .. .| ||| .|. .| |  || ||..     ....              | . .|.||     . . ..
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE

LVNLIKGILQVDHIQRFSLGQIKNHPWC
. .||.. ||.|  .|.|  .| |||| 
CKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Lkb1.AA ULK 40-301 25 1.6e-53 184.11 In-house 1-329 (329) Show / Hide 
Range on Protein: 40-301
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YILGEVLGEGAYGKVKDGMDSFT----QKRVAVKILKRARLKKIPGG------EASVLKEINITKKLH--------NKHIIKLIDHFIIEEK--GKLYIV
|.| ..||.|..|||  | .  |    .. ||.|.. .  .....          .. .|| | |||.        ...|.||.| |  |..    .||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF--ETSNHNNIYII

YEYVGGGTSQNILENAPN--------GRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHAN------------VLKLSDFGVAED-SSQLED
.||  ||. ......  .        .||.  . . .|.|..... ..|...| ||||||.||| .  .            |||..||| |   .. ...
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

FECLSRSY------GSPAFQPPELTQ---FQTTFSPFKIDIWAMGVTLYLMTIGKFPFSGANMFVLF-----EN----------ISKCKIEFPND-----
 . .          |.| .  |.. |    |  .. .| ||| .|. .| |  || ||..   . ..     ..          | | ...||.|     
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

LDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
. ... .||.. ||.|  .|.|  .. |||| 
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Lkb1.AA MARK 40-188 38 5.6e-39 125.16 In-house 1-151 (262) Show / Hide 
Range on Protein: 40-188
Range on HMM: 1-151/262
Sequence Identity: 38% (59 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFIIE--EKGK-LYIVYEYVGGGTSQNILENAP
| .. ..|.|.|.||| . .  |...||.||... .| . |    .|  ||.| |||. ..||||  . .||  .... .|.. ||..||   . ....|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLND-PQWMKNVMREIEIMKKLDHPNIIKL--FHVIEQDTEQHQIYLIMEYASGGELYDYIKAHP

NGRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHAN--VLKLSDFG
||||.      ||||...| .| ||. | ||||||.|||  . .    |..|||
NGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase Lkb1.AA MARK 207-301 35 3.7e-25 79.34 In-house 167-262 (262) Show / Hide 
Range on Protein: 207-301
Range on HMM: 167-262/262
Sequence Identity: 35% (34 aa)

GSPAFQPPELTQFQTTFSPFKIDIWAMGVTLYLMTIGKFPFSGAN--MFVLFENISKCKIEFPNDLDKDLVNLIKGILQVDHIQRFSLGQIKNHPWC
|.|.. .||... .    | |.|||..|| || |. |.||| |..  .  |...| ..| ..|  . |.. |||. .|.|.  .| .. .| .||| 
GTPPYMAPEIFLKKPYDGP-KVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase Lkb1.AA TyrKc 40-305 21 3.3e-15 23.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-305
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKL--HNKHIIKLIDHFIIEEK------GKLYIVYEYVGGGTSQNI
  ||..|||||.|.|  |. .     |||| ||          ..  ..|..| .||  |...|..|.   .....      . |.|| ||. .|  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LENAPNGRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPDNILFTHANVLKLSDFGVAEDSSQL-------EDFEC----LSRSYGSPAFQPPELTQFQ
| .  .  |.. .   .  |  . .||.||... |||.   |.| .. .. | |||| . |           .         ...       .||   . 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NY

TTFSPFKIDIWAMGVTLY-LMTIGKFPFSG-----ANMFVLFENISKC-KIEFPND--------LDKDLVNLIKGILQVDHIQRFSLGQIKNHPWCIKYI
 .|. .| |.|. ||... ..| |. | .|      . . ..|.. .    . | .          ... ...|   . |  .| .  .|      ....
GKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase Lkb1.AA Pkinase_Tyr 40-126 29 9e-10 33.72 Pfam 1-92 (270) Show / Hide 
Range on Protein: 40-126
Range on HMM: 1-92/270
Sequence Identity: 29% (29 aa)

YILGEVLGEGAYGKVKDGMDS----FTQKRVAVKILKRARLKKIPGGE---ASVLKEINITKKL-HNKHIIKLIDHFIIEEKGK--LYIVYEYVGGG
 ..|..|||||.|.|. |        |.  ||||.||     .    .   .. ..|..| |.| |...|..|.   ......   .||| ||. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY-GVCTDQGEPNQIYIVMEYMPHG
Kinase Lkb1.AA Pkinase_Tyr 154-190 43 0.000345 14.81 Pfam 122-158 (270) Show / Hide 
Range on Protein: 154-190
Range on HMM: 122-158/270
Sequence Identity: 43% (16 aa)

EACEYIHSQKILHRDIKPDNILFTHANVLKLSDFGVA
...|| .|... |||.   |.| |. || | .||| |
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA