Gene SMG1 (Slime mold)
SMG1
Sequence
Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Herpes_gp2 | SMG1.AA | Herpes_gp2 | 111-554 | 6 | 5.1e-05 | 16.39 | Pfam | 204-288 (889) | Show / Hide |
Range on Protein: 111-554
Range on HMM: 204-288/889
Sequence Identity: 6% (30 aa)
TTTTATATAITPTPITTSQSTSSSMLNLPLKVGKESIETLFRNRFHPKNNIRETVLSSLQSILIPDLSDTINNTKENIEYFYNMIIDENNYILKLLLLNI
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TTTAATTTAATTTAATTTAATTTAA---------------------------------------------------------------------------
INDTKRNLVVYNYNQQHQLPIQNTSSPNTPSSTTTTTTTSTKPSKRGDKERERGRRNKDKINEKQLQQQQLQQLQLQQQLDHEGSSLYLPFSSLLSFIKP
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DKQQQPQQSQQSQLNEIDQMVRPKSLPKDDNDSDNFNIRVLEYNLKLLIKIYFKVSMYQDSIKTHIFDLYIQINQAISEQQRQLQEKEKESKTSKPIPQP
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IISLVIPTVLVSIGDIIKYKYATPSPPNLTPTTTTKMEEEERIINTILINEFKKTDVSIIESNLYLFECILSISVSNEPTIVVPNTTTATTATTATTSNT
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-------------------------------------------------------------------------------------TTAATTTAATTTAAT
STAAAATTTTPT-LSTSSSSLSPPASTQSSLSLSSSSSAVIAPTT
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TTAATTTAATTTESSEAATTTAATTADTTADTTADTTADTTADTT
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| HEAT | SMG1.AA | HEAT | 605-635 | 22 | 2.705776 | 4.88 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 605-635 Range on HMM: 1-31/31 Sequence Identity: 22% (7 aa) LLNITLFKLSDPSEQVKLSYLTLLSKMVSYF .|.. | |.||...|... . |....... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | SMG1.AA | HEAT | 1508-1538 | 25 | 0.008711 | 13.51 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1508-1538 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) IIPQLFARLSHPDTFVQKYVVEILNRIGRDN |.| |. |..|| |.. ... | .. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| Kinase | SMG1.AA | PIKK | 1804-2144 | 30 | 5.9e-102 | 345.03 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1804-2144 Range on HMM: 1-290/290 Sequence Identity: 30% (104 aa) TIQLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYK |. . . . ...|.||||. ..|.|| | ||.||.|||..|.|.|||. .. .| .|. . . | | |||||.|| .|||.||...|.|. ||| RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK NWYKNDQ-VYKQQQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEW .|.. . . | | ..|. ... .| . .. . .. | QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS-----------------------------------------------------YYKHQMQQQCMMYQHW PKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFE-KGAELKIPERVPFR | . .|..|.|| || ......| ..... . . ....| ||.|.|.. || .||||||..||..| ||||||||.. ||| .. |. || |||| PLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFR MTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLLETF .|. .. |.| .|| | || . ...|...|.....|....|.| LTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | SMG1.AA | PI3_PI4_kinase | 1833-2154 | 18 | 3.9e-61 | 214.2 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1833-2154 Range on HMM: 1-300/300 Sequence Identity: 18% (70 aa) LYYYLLKGREDLH--LDERIMQLL-----------------------NVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYK | ...|| .||. |.|.||.. .... ....|. . . . |..||.. .|.|.||. .... | ..... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV NDQVYKQQQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEIL .. .... . ..... . ... KCKHKHFNKEHKMWMKMWPDWWHLM-----------------------------------------------------------------------RMQK IQVLNELMQETPKWILQRELWFSSSSS-SELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILL--DLKTGEIVHIDYNICFE--KGAELKIPERVPFRM .| .. . ||| .| ...| .. . |.. . . ||.| |.|..|..|.||||.|||.. | .||...|||...||. |. .. ||||||| VEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRW TQ------IFEYAL------GLTGVQGTFRETSIQIMHLLRKNKDILLNLL-------ETFIYDPLFDWKH |. . .|. . .| |.||.. ... .||.......||| |....|.|..|. THWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | SMG1.AA | SMG1 | 1969-2096 | 52 | 5.6e-52 | 170.42 | In-house | 115-242 (242) | Show / Hide |
Range on Protein: 1969-2096 Range on HMM: 115-242/242 Sequence Identity: 52% (67 aa) NKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNI | |. || ...|.|| | | || | .|| .. || ||| || .| .||| | | . |||| || | ||..||.||||||||||. NPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNV LLDLKTGEIVHIDYNICFEKGAELKIPE |.|. |||.|||||.|||||| |..|| LIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | SMG1.AA | PI3Kc | 1835-2201 | 20 | 8.4e-45 | 156.07 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1835-2201
Range on HMM: 1-336/336
Sequence Identity: 20% (80 aa)
YYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQVYKQQQQQQQQLQ--QQQQQQQQQ
..|...||. |.|.||...... ....|| |. | |..||... .|.|.|| ...| .| |. .|.. ... .| .. . | .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM
QQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYAKITPLLEKAGLNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSS
. ||. . .. |. . . .. . . . ...|... | |. . .
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLY---DWFWEHFPDPN--------------------------------------------
SSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIP------ERVPFRMTQIFEYALG----LTGVQGTFRET
. . . ||.| .....|. |.||||.|||.|| |||...|||.. .|..| ..|.. |||||| |. . |. | .|. | ||..
--EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTC
SIQIMHLLRKNKDILLNLLETFIYDPL-FDWKHS-NKQTNNNNNNNNN-NNMNQAAGEQ------ESIEKK-QSSNNSSNPIISTPTKL
... ..||... ..||.|...|||. ..|. . .. . .. . . . ..|| . ||. .| .. . .. . ...
CCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | SMG1.AA | FRAP | 2023-2154 | 43 | 2.5e-41 | 143.64 | In-house | 119-251 (251) | Show / Hide |
Range on Protein: 2023-2154 Range on HMM: 119-251/251 Sequence Identity: 43% (58 aa) LQRELWFSSSSSSELFLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAEL-KIPERVPFRMTQIFEYALGLTGVQGTFRE |.. || | .| | . | |||| ||..||..||||||. ||.|. || |||||. ||| |.||..|||.| . |. .|..|..| LKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRN TSIQIMHLLRKNKDILLNLLETFIYDPLFDWKH |. .| .| .|. .. || |.||||| |. TCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | SMG1.AA | ATR | 2042-2144 | 41 | 2.7e-40 | 134.77 | In-house | 165-267 (267) | Show / Hide |
Range on Protein: 2042-2144 Range on HMM: 165-267/267 Sequence Identity: 41% (43 aa) QSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLL . | || | ....||.||||||| ||||.| .||.||.|||. | .| ....|| ||||.|. ....| . .| || . || ..|...| .. .. ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVW ETF ..| DCF |
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| Kinase | SMG1.AA | SMG1 | 1812-1937 | 50 | 1.1e-38 | 125.68 | In-house | 1-116 (242) | Show / Hide |
Range on Protein: 1812-1937
Range on HMM: 1-116/242
Sequence Identity: 50% (63 aa)
IYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQV
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ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRW------
YKQQQQQQQQLQQQQQQQQQQQQQQP
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----QQREAALQAQKAQDSYQTPQNP
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| Kinase | SMG1.AA | ATM | 2038-2152 | 46 | 2.9e-37 | 116.35 | In-house | 134-248 (304) | Show / Hide |
Range on Protein: 2038-2152 Range on HMM: 134-248/304 Sequence Identity: 46% (53 aa) FLKTQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDIL | | | || | |..||..|||||| |||. . |.|||| . ||.| | || ||||.| .|.||| | || . | .| .. | FEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETL LNLLETFIYDPLFDW | . | .||||||| LTIVEVLLYDPLFDW |
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| Kinase | SMG1.AA | DNAPK | 2032-2154 | 32 | 3.5e-25 | 88.46 | In-house | 177-301 (301) | Show / Hide |
Range on Protein: 2032-2154 Range on HMM: 177-301/301 Sequence Identity: 32% (41 aa) SSSSELFLKTQS-YSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFE-KGAELKIPERVPFRMTQIFEYALGLTGVQGTFRETSIQIMHL |.. | .| .. . |. |. . .. | |||||.| . .|.|. ||. | . | .|| |||.| | . .. | .. | | STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA LRKNKDILLNLLETFIYDPLFDWKH .|| . ||.| . || ||.|||| FRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | SMG1.AA | FRAP | 1834-1893 | 48 | 3.1e-20 | 71.13 | In-house | 2-61 (251) | Show / Hide |
Range on Protein: 1834-1893 Range on HMM: 2-61/251 Sequence Identity: 48% (29 aa) YYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVE |..||||.||. |||.||| . .|| |. . | | . ||.|||| .||| ||. YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVH |
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| Kinase | SMG1.AA | ATR | 1803-1934 | 26 | 1.3e-18 | 59.7 | In-house | 1-132 (267) | Show / Hide |
Range on Protein: 1803-1934 Range on HMM: 1-132/267 Sequence Identity: 26% (35 aa) VTIQLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIY | . . .| . ||||... |||| .| . | ..|| | | |. ........ | . .. . | |.|||| . ...| ||. . | .| AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL KNWYKNDQVYKQQQQQQQQLQQQQQQQQQQQQ . .| ..| | .| .| ... ... ..|. DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQK |
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| Kinase | SMG1.AA | DNAPK | 1820-1898 | 35 | 1.6e-10 | 34.35 | In-house | 19-97 (301) | Show / Hide |
Range on Protein: 1820-1898 Range on HMM: 19-97/301 Sequence Identity: 35% (28 aa) KPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPL .||.. . | | .. || ||| .| || || | . | . | | |..||. ||| ||. | | RPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL |
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| Kinase | SMG1.AA | ATM | 1836-1897 | 35 | 3.2e-09 | 25.18 | In-house | 2-63 (304) | Show / Hide |
Range on Protein: 1836-1897 Range on HMM: 2-63/304 Sequence Identity: 35% (22 aa) YLLKGREDLHLDERIMQLLNVVDQLLMNDKKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVP | |||.|| | . | . || . | | |.|||| || . | | .| QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIP |
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| FATC | SMG1.AA | FATC | 2312-2344 | 42 | 3.3e-13 | 45.35 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2312-2344 Range on HMM: 1-33/33 Sequence Identity: 42% (14 aa) KKLSIPDQIDLIIRESMNVENLSSTYEGWSPWV ..||...|.| |.| ...|||. | ||.||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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