Gene DhkL (Slime mold)
DhkL
Sequence
Protein domains of DhkL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DhkL.AA | Dicty3 | 113-222 | 36 | 2.9e-07 | 19.83 | In-house | 197-258 (351) | Show / Hide |
Range on Protein: 113-222 Range on HMM: 197-258/351 Sequence Identity: 36% (40 aa) NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNSSNDIYMNSPSSTLSSPGNAGNNLPIGCTKPNVPKSPYSPSPPHLYKSNSTSYLKSSFFSGNGS |||.|||||||||||||||||||||||||||||||| ..| | .|. . NNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNN------------------------------------------------IYSNKQY SSSSSSTTTT .... | . | KQKCYSICGT |
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| Response_reg | DhkL.AA | Response_reg | 641-679 | 30 | 0.001034 | 15.86 | Pfam | 77-115 (115) | Show / Hide |
Range on Protein: 641-679 Range on HMM: 77-115/115 Sequence Identity: 30% (12 aa) VIVLTESTDPSEFCQYIDAGATDYIPQPISPILLDLRLT .|..| |.. ....||| |||. |..| | .. IIMCTAHGDEDDAVEALQAGANDYITKPFDPDELHAAIR |
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| PAS | DhkL.AA | PAS | 702-810 | 24 | 2.7e-09 | 33.64 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 702-810 Range on HMM: 1-120/120 Sequence Identity: 24% (30 aa) RKMVTCIEN-SPDCVEIWDPSGHIQYLNLAFSEMTGFARWELLGKEFSNLIDNT------EIIPNMWATLTDKKTWNGFIRTRHN-----NNTLIYFEAS . ... ||| .|| . .|| .| | |.| |. .|.|..| |..|| .. || .. | .| . .. ..| .|. ... ...| EHYRRIIENNLPDPIFVWDEDGWILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWCEVR ISPVLDQFQQILYYNCTKRDV .|..| ..|... |. .|. WCPYRDPGGEIHGFCCFMHDI |
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| PAS_4 | DhkL.AA | PAS_4 | 708-815 | 19 | 8.5e-07 | 27.84 | Pfam | 1-123 (123) | Show / Hide |
Range on Protein: 708-815 Range on HMM: 1-123/123 Sequence Identity: 19% (24 aa) IENSPDCVEIW-DPSGHIQYLNLA----FSE-MTGFARWELLGKEFS----NLI----DNTEIIPNMWATLTDKKTWNGFIRTRHNNNTLIYFEASI-SP ..||||. .. || |...|.| | . | . |... |..|. . .. . .. ... . | .... . . |.| ..| .. .| FDHSPDCIAVCKDPDGRYRYANPACSNWYREWWFGWPPEEWIGRTWWGEMWPPELEDPHQQRFHRQWRRVLEGEEPIFFHHHHHHPNGEERWWEWRYQHP VLDQFQQILYYNCTKRDVTQKRI ..| ... . .. ||.|. | LRDPDGEVIGVIWICRDITERRR |
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| PAS | DhkL.AA | PAS | 702-769 | 26 | 2.4e-05 | 25.01 | SMART | 1-68 (68) | Show / Hide |
Range on Protein: 702-769 Range on HMM: 1-68/68 Sequence Identity: 26% (18 aa) RKMVTCIENSPDCVEIWDPSGHIQYLNLAFSEMTGFARWELLGKEFSNLIDNTEI-IPNMWATLTDKKT ... . .||.|| . .||. | | | | |. .|.|. . ||.|. ...||. . .. . . . . ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ |
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| PAC | DhkL.AA | PAC | 771-813 | 25 | 0.000676 | 20.19 | SMART | 1-43 (43) | Show / Hide |
Range on Protein: 771-813 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) NGFIRTRHNNNTLIYFEASISPVLDQFQQILYYNCTKRDVTQK .. .| .. . ..|. ..|..|. |. |..|. |. ||.|.. TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER |
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| HisKA | DhkL.AA | HisKA | 831-895 | 33 | 9.3e-22 | 79.53 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 831-895 Range on HMM: 1-89/89 Sequence Identity: 33% (30 aa) SRLR-LSMMSHDIRTPMSNIIGMADLLLD----------TSLSQHQ-------------HHYLEIIKNSSNTLLTIINDILDISKIEAG .. . |..|||..|||.. |.|.|.||.| | |. | . |||.|..... .. .|||.||.|.|||| AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| HisKA | DhkL.AA | HisKA | 831-895 | 43 | 1.2e-21 | 78.46 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 831-895 Range on HMM: 1-69/69 Sequence Identity: 43% (30 aa) SRLR-LSMMSHDIRTPMSNIIGMADLLLD-TSLSQHQ--HHYLEIIKNSSNTLLTIINDILDISKIEAG .. . |..|||..|||.. |.|.|.||.| | |. | . |||.|..... .. .|||.||.|.|||| AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HATPase_c | DhkL.AA | HATPase_c | 942-1058 | 33 | 2.6e-34 | 121.63 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 942-1058 Range on HMM: 1-120/120 Sequence Identity: 33% (43 aa) GPSSRLNQILTNLLGNSLKFTDK-GEISICCLLNDETDSEYEIKVDVRDTGIGIKK------EALPLLFKAFTQAEG-TITRQYGG--SGLGLAICKELV | || |...||..|..|.| . |.|.. . | .. . |.|.|.|| . | .| .| .| .... |.||| .||||.||...| GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-----DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIV HLAFNGEISVESQYGHGSTFTCILKFK . ..|.|.|||. |.|.|||. |... EQ-HGGTIWVESEPGGGTTFTFTLPLE |
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| HATPase_c | DhkL.AA | HATPase_c | 942-1059 | 28 | 1.2e-30 | 109.11 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 942-1059 Range on HMM: 1-130/130 Sequence Identity: 28% (42 aa) GPSSRLNQILTNLLGNSLKFTDK--------------GEISICCLLNDETDSEYEIKVDVRDTGIGIKK------EALPLLFKAFTQAEG--------TI | || |.|.|||.|..|.|.. |.|.. . |.|.|.|| . | .| .| .| .... GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-----------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSR TRQYGG--SGLGLAICKELVHLAFNGEISVESQYGHGSTFTCILKFKK .|.||| .||||.|||..| . ..|.|.|| .||| |. .. SRKYGGGLTGLGLSICKRIVEQ-HGGTIWVE------TTFTFTLPLER |
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| Kinase | DhkL.AA | HisK | 944-1057 | 28 | 5.5e-30 | 104.77 | In-house | 3-164 (164) | Show / Hide |
Range on Protein: 944-1057 Range on HMM: 3-164/164 Sequence Identity: 28% (46 aa) SSRLNQILTNLLGNSLKFTDKG------EISICCLLNDETDS----------------------EYEIKVDVRDTGIGIKKEALPLLFKAFTQAEG---- .|. ||| ||..|.||||.|| |.| . ..... .. |...| |||.|...| . .||.| . . PNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQM ---TITRQYG-----GSGLGLAICKELV-HLA------FNGEISVESQYGHGSTFT-CILKF | | . | ||||.||. |. | |..|.|.|..|.||||. .|... IKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN |
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| REC | DhkL.AA | REC | 1311-1488 | 13 | 5.5e-05 | 14.25 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 1311-1488 Range on HMM: 1-150/150 Sequence Identity: 13% (29 aa) AKMLFIERN----DTSRGNLF------KQLLAWNIQ--------LELVEDGE-------SGFRKWKQSIESN--------SPYSIIIMDLNTP------- . | .. . . | | . | .... . . ||| ....... .. .|. .||||.. | MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG GVDGASLPMRIKKELELMQQHLQQQQEQEQQQQQEQQQSELQKQPDVENKNSSQNNDNNNNNNKSNSSGGNQCIYRSPIIMLMPIQFLNSQLEDNLKDAG |.|| | ||. ||||| . . .. .|| GMDGIELCRRIR-----------------------------------------------------------------PIIMLT--AHDDEEDRVRALEAG VCAILSKPIRMSQLADVF . . ..||... .| .. ADDYITKPFDPEELLARI |
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| Response_reg | DhkL.AA | Response_reg | 1326-1374 | 28 | 0.352173 | 6.79 | Pfam | 13-59 (115) | Show / Hide |
Range on Protein: 1326-1374 Range on HMM: 13-59/115 Sequence Identity: 28% (15 aa) LFKQLLA--WNI-QLELVEDGESGFRKWKQSIESNSPYSIIIMDLNTPGVDG ...|.| . . ....|||.. ..|.. . .||||.| ||.|| GLRQILEQKEGYEVVAEADDGEEALEWWQEHH-----PDLIIMDINMPGMDG |
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| REC | DhkL.AA | REC | 1569-1688 | 24 | 1.9e-36 | 128.3 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 1569-1688 Range on HMM: 1-150/150 Sequence Identity: 24% (40 aa) GKVLVVDDN----HINIQILS------KMLQTVGCE--------VDSVLSGA-------DALAKINQSSGDS----------YDAIFLDIQMP------- ..|.|||. ... ..|. ..|. |.| ||.. .|. .||..... ... .| |..||.|| MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG DMDGFQVSRKIREREKKFSLPRVAIIATTANVFKEDQLKCFDAGMDDFISKPIKRAEIKEII .|||... |.|| ||. ||. || ....||.||.|.||... |. . | GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | DhkL.AA | Response_reg | 1571-1689 | 30 | 1.4e-31 | 115.7 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 1571-1689 Range on HMM: 1-115/115 Sequence Identity: 30% (37 aa) VLVVDDNHINIQILSKMLQ-TVGC-EVDSVLSGADALAKINQSSGDSYDAIFLDIQMPDMDGFQVSRKI-RERE-KKFSLPRVAIIATTANVFKEDQLKC ||.|||.... ..| ..|. |. .|... .|..||... . .| |..||.||.|||... |.| |... . . ||. ||. ..| ... VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH---PDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDEDDAVEA FDAGMDDFISKPIKRAEIKEIIK ..||..|.|.||....|....|. LQAGANDYITKPFDPDELHAAIR |
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