Gene DhkA (Slime mold)
DhkA
Sequence
Protein domains of DhkA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CHASE | DhkA.AA | CHASE | 835-1039 | 23 | 9.9e-28 | 100.31 | Pfam | 1-203 (203) | Show / Hide |
Range on Protein: 835-1039 Range on HMM: 1-203/203 Sequence Identity: 23% (52 aa) VFPSTSEDQFVPFSKL---WSDNAEGLEGIMWAPRVSNLDRYTWEIEHS---VKIREI--V-TNPNNSSDMRDVPAAAASDYYPILFSEPQS-SNDHFKG .|.| |.| ... . .. |. || |||||. .| | . ...| ...... ||... .|.||.. .|.. | . | ASDSVSRDEFERYVNSLDQLLRRYPGIQGIGWAPRVPHEQRAAFEQQMRAEGFPDFNIQNWEPDADGQW-----PAPHRDPYFPITYIYPFDWGNERALG YNIYSDMWRRPSLNKTRDTGEKVSVASPYINKLANVPKNSRSNVLLYIYQAVYTYGKVLSTVED--RR---HEVIGFASCRFFISRMVSASLQRLTEEDS ...||. ||... . ||||. |... .. | . .. .| .| .||. | ...|||. || .. .|... | . ......| .. | FDMYSEPVRREAMERARDTGQP--VLTGPVT-LVQEG---QRGFL--MYMPVYRGGMPPTTVEQPPRRPGNQALWGWVYAVFRMDDLMEGLL-NQ---DG LDLYVFDLDSTPIGELIYYR ......|..... |||.| IAIRIYDGTDGADGELFYGS |
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| PAS_3 | DhkA.AA | PAS_3 | 1293-1361 | 25 | 1e-08 | 31.74 | Pfam | 27-94 (94) | Show / Hide |
Range on Protein: 1293-1361 Range on HMM: 27-94/94 Sequence Identity: 25% (18 aa) FLAELIHPDDKQKFISEIKKTI-TRETSIMEIECRMRKKYGGYLYIIMRGKVVS-NETSFKDNSLRMAGTL .....||||| ......... . ...... |.| |.|.| |.. .. ||.|. .| . . .|| |.. DWYHHIHPDDRERVRQAHQEHWKLKKGQPYECEYRIRHKDGEWRWVRDRGRVIRWDENG---QPVRMIGVH |
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| PAC | DhkA.AA | PAC | 1322-1367 | 17 | 1.2e-05 | 26.01 | SMART | 1-43 (43) | Show / Hide |
Range on Protein: 1322-1367 Range on HMM: 1-43/43 Sequence Identity: 17% (8 aa) EIECRMRKKYGGYLYIIMRGKVVSNETSFKDNSLRMAGTLRDMTSR ..|.|...| |.. .. ...... . ... ... .. ||.| | TWEYRFYRKDGSWIWVQVSWTPIRD---WQGQPQYWICVHRDITER |
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| HisKA | DhkA.AA | HisKA | 1386-1451 | 33 | 1.4e-27 | 98.88 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 1386-1451 Range on HMM: 1-89/89 Sequence Identity: 33% (30 aa) AKSAFVATVSHEVRTPLSGVIGVSDLLLE----------TNLSEEQ-------------RDYVQTIQKSSQALLTIINDILDYSKLESR ||. |.|..||| ||||....| ..||.. |.|..|| |.|..|||.... .. .|||.||.|..|. AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| HisKA | DhkA.AA | HisKA | 1386-1451 | 44 | 4.1e-27 | 97.45 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 1386-1451 Range on HMM: 1-69/69 Sequence Identity: 44% (31 aa) AKSAFVATVSHEVRTPLSGVIGVSDLLLE-TNLSEEQ--RDYVQTIQKSSQALLTIINDILDYSKLESR ||. |.|..||| ||||....| ..||.. |.|..|| |.|..|||...| .. .|||.||.|..|. AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HATPase_c | DhkA.AA | HATPase_c | 1497-1619 | 41 | 1.7e-39 | 139.72 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 1497-1619 Range on HMM: 1-120/120 Sequence Identity: 41% (55 aa) GDAMRMRQVLLNLLSNAIKFTSR-GHVLTDISVDDSIPPTNTEEEIIHLCITIEDTGIGIPQ------SLFDSIFEPFSQADN-STTRKYGG--TGLGLS ||. |..||..||..||||.| ||. .. || |..||.||.|.||| . . ||||| ..|. |. ||||| |||||. GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-----------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLY ITKRLIEEVMGGTIQVSSIVGQGSKFKCIIPFL | .|..|. .||||.|.| .|.|..| . .|. ICRRIVEQ-HGGTIWVESEPGGGTTFTFTLPLE |
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| HATPase_c | DhkA.AA | HATPase_c | 1497-1620 | 34 | 7.3e-36 | 126.39 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 1497-1620
Range on HMM: 1-130/130
Sequence Identity: 34% (53 aa)
GDAMRMRQVLLNLLSNAIKFTSR--------------GHVLTDISVDDSIPPTNTEEEIIHLCITIEDTGIGIPQ------SLFDSIFEPFSQADN----
||..|.||||.|||.||||.| |.. .. .||.||.|.|||. . . ||||| ..|.
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-----------------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSR
----STTRKYGG--TGLGLSITKRLIEEVMGGTIQVSSIVGQGSKFKCIIPFLL
|..||||| ||||||| ||..|. .||||.|. ..| .| .
MCPDSRSRKYGGGLTGLGLSICKRIVEQ-HGGTIWVE------TTFTFTLPLER
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| Kinase | DhkA.AA | HisK | 1497-1613 | 25 | 9.1e-27 | 93.17 | In-house | 1-158 (164) | Show / Hide |
Range on Protein: 1497-1613
Range on HMM: 1-158/164
Sequence Identity: 25% (40 aa)
GDAMRMRQVLLNLLSNAIKFT------SRGHVLTDISVDDSIPP--------TNTEEE--------IIHLCITIEDTGIGIPQSLFDSIFEPFSQ-----
| .| .|.|.||.|||.||| ..|.. .. .. .. .. .|. ...|...|||.|.|... ||..|..
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH
-----ADNSTTR--KYGGTGLGLSITKRLIEEVMG-------GTIQVSSIVGQGSKFK
.| . | ||||.| ..|.. . . ||| | ||.||.|.
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFS
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| REC | DhkA.AA | REC | 2025-2142 | 19 | 1.4e-31 | 112.13 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 2025-2142 Range on HMM: 1-150/150 Sequence Identity: 19% (32 aa) KKALIVEDN----ELNRKVLA------QLFKKIDWT--------ISFAENGR-------EALKEITGER------------CFDIVFMDCQMP------- .. |||.|. ...|..|. .|..| ... . | .|. |||. . .| .|...||..|| MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG VLDGFQTTKIIRSKERENNWKRMNIVALSAGSSSSFVQDCLDSGMDSFMGKPITLATLKDAL .||..... || |..|.| .. . .. .|..|.| .. ||... | ... GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | DhkA.AA | Response_reg | 2027-2143 | 25 | 6.7e-26 | 95.33 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 2027-2143 Range on HMM: 1-115/115 Sequence Identity: 25% (31 aa) ALIVEDNELNRKVLAQLFK-KIDW-TISFAENGREALKEITGERCFDIVFMDCQMPVLDGFQTTKII-RSKERENNWKRMNIVALSAGSSSSFVQDCLDS |||.|..|.|..|.|... | . . |..|.|||. . .. .|...||..|| .||..... | | .. . . . |....| .. . .. .|. VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH-PDLIIMDINMPGMDGLELCRRIRRQHP-HPQ---TPIIMCTAHGDEDDAVEALQA GMDSFMGKPITLATLKDALA |.. . ||. .. |..|.. GANDYITKPFDPDELHAAIR |
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