Gene pk4 (Slime mold)
pk4
Sequence
Protein domains of pk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Med15 | pk4.AA | Med15 | 1-204 | 10 | 0.00237 | 10.83 | Pfam | 435-466 (945) | Show / Hide |
Range on Protein: 1-204 Range on HMM: 435-466/945 Sequence Identity: 10% (22 aa) QQQQQQQQQQQQQQQQQHQKTSPSTSFVDYNNINNSNGNNINGTTSTCNSTSSSKSNSKEIYNENNNNNNNNNNNSFTNVHNNNNNNNNNRKRRNSHISY |||||||.|.|.||||| | QQQQQQQHQAQHQQQQQQQ--------------------------------------------------------------------------------- DTPDSNNIDNNIESNDTESGFRKNSKKSTDNNNNNNNNNNNNNNNNNNNNNNNNNNNSCNINGNINNGNSNNINNNNCSNIDSTLADVSKHQYTNQHQQQ | ||||| -------------------------------------------------------------------------------------------QQQQQHQQQ QNIQ .. | MMQQ |
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Med15 | pk4.AA | Med15 | 246-509 | 11 | 0.049525 | 6.2 | Pfam | 426-470 (945) | Show / Hide |
Range on Protein: 246-509 Range on HMM: 426-470/945 Sequence Identity: 11% (30 aa) QQQHQQQNSQQQQNNQHQQQLQQQQYQQKHYNNNNNNNNNNQPQTSNQNIQHSQGLNYNQNQNQNQNQEAPIVVNSLILRSIGMMTSKISKDFEELTTFM ..| |||. |||| |||.|.|||| || CDQQQQQQQQQQQQQQHQAQHQQQQQQQ------------------------------------------------------------------------ KSSCPMLLRFSGVENSYHILEKLNNIITQSLEGLPKTPQCSQPPFNQLIPLSNTTTLTPNNYNNNNNNSNNNNNSNNNNNNNSNNNNSNNNNSNNSNNNN ---------------------------------------------------------------------------------------------------- NNSNNNNSNNNNSNNNNSNNNNNNSNNNNSNNNNSSNNNNNYSGFNDQQQQQQQQQQQQQQQQQ |||||.|||. || ||. -----------------------------------------------QQQQQHQQQMMQQMQQG |
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Kinase | pk4.AA | PKA | 679-934 | 52 | 7.29999999999e-178 | 597.19 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-263/263 Sequence Identity: 52% (139 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIV-KLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY |.....||.|||..|.||.| .|.. ..||.|....|.||.|. ||.|||..|.....|||| |.|.||.||||||...|..||||.|.|.|..|..| . FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP VTQIYAA-EIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKSMCGTPEYIAPEILSGH-GHGKSADWWSLGILIYEMLVGVPPFV ....||| .|||||||||.|.||||||||||.|||..||||.|||||||.....|...||||||.||||.... ||||| |||.|||||||||.|.||| HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY SEG-SQNDIFRLIREARIQVPPEVDQVA---RDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF .. ....|.. |....|. |...|. | .|||.||...|..||.|....|..|||||..| DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF |
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Kinase | pk4.AA | AGC | 679-934 | 30 | 6.4e-175 | 456.82 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-395/395 Sequence Identity: 30% (120 aa) FKLFDLLGSGSFAKVRLCQHI------PSERLFCMKILNQNK-IIRLR--QEVHVCNE------------KQVLMLTD----------NPFIVK-LYSTF |.. ..| ||| ||.|... ..... ||.|. . |.... .. |. .| ...|.. . .||||| |...| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF KDDRY--LYFLQEFIP---------GG-ELFDYIR---ANGSLSLYVTQIYAAE-------IVLALEYLHN-QDIIYRD-LKPENLLIDQYGHIKLTDFG .|... |||. |..| || ||| ... .|... ....|||| |||||||||. ..||.|| |||||.|.|. ||||||||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG FAKRIT-----------------------------------------------------ENTKSMCG--TPEYIAPEILSGHGHGKSADWWS--LGILIY ..|.. . |...|| ||||.||||| .||..|||| ||.|.| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMLVGVPPFVSEG---------SQNDIFRLIR------EARIQVP----------PEVDQVARDLIEKLVVTDVEKRLGSLEG-----GIEDIKNHPFF |||.| ||| .. .....| .|. . ... | ..... |.|||.|| . | |||||.... |.|.|||||.| EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | pk4.AA | Akt | 679-934 | 41 | 1.7e-114 | 367.45 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-264/264 Sequence Identity: 41% (110 aa) FKLFDLLGSGSFAKVRLCQHIPSERLF-CMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY | . ..||.|||.|| |.. ..... ||.| ..|| .| |. |. .| ...||||.|. | . .||| ....||||| ... . | FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED VTQIYAAEIVLALEYLHNQDIIYRD-LKPENLLIDQYGHIKLTDFGFAK-R-ITE--NTKSMCGTPEYIAPEILSGHGHGKSADWWS-LGILIYEMLVGV . |.|||.||.|.||...||||| |||||.|.|. |||.||||| .| |.. ||..||||||.|||||.|.||.|..|||. ||...|||. | RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR PPFVSEGSQNDIFRLIREARIQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF ||| .. . | .| .. .. | . ... ..|||..| | .||||. ......||.||.| PPFYNQD-HHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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Kinase | pk4.AA | AktR | 679-934 | 42 | 2.3e-113 | 382.92 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-268/268 Sequence Identity: 42% (113 aa) FKLFDLLGSGSFAKVRLCQHI-PSERLFCMKILNQNKIIRLRQEVHVCNEKQVLM-LTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSL |.. .||.| |.|| |.|. . ... ||.. |||...|. |. .|.... . ..||||||. .|.....|.|..|..||||||.... .. .| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE YVTQIYAAEIVLALEYLHNQ-DIIYRDLKPENLLIDQYGHIKLTDFGFAK----R-ITENTKSMCGTPEYIAPEILSG-HGHGKSADWWSLGILIYEMLV ....|.|.|.|||||||.. .||||||||||.|.|. ||.|.|||| .| . .| ..| ||||||.|||.. ||.||.|||..||.||||.. EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT GVPPFVSEGSQNDIFRLIREAR-IQVPPE--VDQVARDLIE-KLVVTDVEKRLGSLEGGIEDIKNHPFF | ||| .. .||..| .|.. . ...|. . . ..|||. || . .||||. |.|.||.||.| GCPPFYHK-NQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | pk4.AA | SGK | 679-934 | 38 | 1.5e-109 | 339.52 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-283/283 Sequence Identity: 38% (110 aa) FKLFDLLGSGSFAKVRLCQHIPS------------------ERLFCMKILNQNKII-------RLRQEVHVCNEK-QVLMLTDNPFIVKLYSTFKDDRYL |.. ..| ||| || . .| . .. ||.|... || . ...|. |. .| . ||||.| | . .| FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL YFLQEFIPGGELFDYIRANGSLSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAK---RITENTKSMCGTPEYIAPEILSGH || ... |||.| ... .... . .||||||.|||||| ||||||||||||.| | ||..||||| .| .. |.. |||||| |||.| .. YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ GHGKSADWWSLGILIYEMLVGVPPFVSEGSQNDIFRLIREARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF .|... |||.||.. |||..| ||| | . . |. .| || . |.|||. | |..||||. ....| ||||||| PHDRTVDWWCLGCVLYEMMYGLPPFYSR-NKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME-IKNHPFF |
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Kinase | pk4.AA | S_TKc | 679-934 | 37 | 2e-103 | 350.82 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-231/231 Sequence Identity: 37% (100 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPG--GELFDYIRANGS--- ... ...|.|.|.||..|.|. . |.. .||.. |...| |.|. . |.||||| .| | .||. |...| |.|||||. .|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKSMCGTPEYIAPEILSGHGHGK-SADWWSLGILIYEMLV .. ... |...|..||||.|.. ||.|||||||.|.|. |||..|||.|... ...||||.|.|||.| |.|| ..||||.|...||||. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC GVPPFVSEGSQNDIFRLIREARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGI--EDIKNHPFF | ||| .. .|..|. .. |.|.|.|. . | |||.. | .|||.||.| GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | pk4.AA | RSK | 681-934 | 39 | 3.9e-101 | 342.31 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 681-934 Range on HMM: 1-278/278 Sequence Identity: 39% (110 aa) LFDL--LGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQ-EVHVCNEKQVLMLTD-NPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGS--- | .| .| |.. .| |.| ..... ||.|...||.. |. | ..|... ||||.|. .|... .|| |...|||||. .. .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQ---YGHIKLTDFGFAKR-ITE---NTKSMCGTPEYIAPEILS----GHGHGKSADWWSLGI .| ..|.||||||.|.|| |.||.||||||| | |. ||||||||||.| . |.. |.| ||.|||.| . ||.|..||||||. FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV LIYEMLVGVPPFVSEGSQ---NDIFRLIREAR--IQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF |.||||.| ||| . . . ..|.. |.... | ... | |.||| |. | .||||. ...|.||.||.| LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | pk4.AA | Ciliate-E2 | 679-934 | 26 | 5.2e-95 | 321.96 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-365/365 Sequence Identity: 26% (103 aa) FKLFDLLGSGSFAKVRLCQHIPSER-----------------------LFCMKILNQNKIIRLRQEVHVC----------NEKQVLMLTDNPFIVKLYST .|. ..|.|.|..|..|... . .. |||...|.|. . || |.. |||..| . ..|.|.|.| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--DDRYLYFLQEFIPGGELFDYIR-------------------ANGSLSLYVTQ-------IYAAEIVLALEYLHNQD-IIYRDLKPENLLIDQYGHI |. || ..|. |.. ||.|||||. . .. ...| |.|.|.|||||||.. ||.||.||||.|. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KLTDFGFAKRITEN----------------------------------TKSMCGTPEYIAPEILS---------GHGHGKSADWWSLGILIYEMLVGVPP |..|||..|..... ... ||||.| |||||. ..|.....|.||||...|||| | || KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FVSEGSQNDIFRLIREARIQVPPE------------------VDQVARDLIEK----LVVTDVEKRLGSLEGGIEDIKNHPFF | .. | . |. |.. ..| . ||| | . . | |||.. |.|.|.|||.| F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF |
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Kinase | pk4.AA | RSK-Unclassified | 679-934 | 36 | 1.1e-94 | 297.82 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-283/283 Sequence Identity: 36% (104 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIR--ANGSLSL | |.| |.| || | . ..... ||.|. .|.|| . | |. .. .|. ||||.|| | ||| |. .||..| .. FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE YVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRI------------------------TENTKSMCGTPEYIAPEILSGHGHG ..||.|...|||||| .|.|||||||.| . .| ||..||||. . |.| ||| ||.|||.. . ||. DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT KSADWWSLGILIYEMLVGVPPFVSEGSQNDIFRLIREARIQVP--PEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF | ||| |||..||||.|.||. . .| .| | . ...| .. . .|||| || ||||. | .||| |||| KAVDWWTLGIVMYEMLFGCPPYYGN-NKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF |
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Kinase | pk4.AA | PKG | 679-934 | 41 | 3.4e-84 | 286.01 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-260/260 Sequence Identity: 41% (108 aa) FKLFDLLGSGSFAKVRLCQHIPSE-RLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGGELFDYIRANGSLSLY .| . || | | | | | . | | .|... |. ||. |. .||...| ....|||.|| ||.|..|.|.| | |||| .| |. . LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK VTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITENTKS--MCGTPEYIAPEILSGHGHGKSADWWSLGILIYEMLVGVPPFV |. |.| .| |..|||.. |||||||||||. |. | .|| ||||||.| .. | ||||||.|||| || |.|.|.||||..| |.| ||| TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS SEGSQNDIFRLIRE--ARIQVPPEVDQVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPFF . . .. .| .. | .. | ..| || |||.. .||.||| | | GS-DPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF |
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Kinase | pk4.AA | Pkinase | 679-934 | 29 | 3.9e-83 | 287.3 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 679-934 Range on HMM: 1-293/293 Sequence Identity: 29% (90 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVC-NEKQVLMLTDNPFIVKLYSTFKDDRYLYFLQEFIPGG----ELFDYIR--AN ... .|||||..|..|.|. .......||.. .. .. |. .| |.. . |.||.|| .| |....|. .|. .|| .|||||. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GSL--SLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHI----KLTDFGFA----KRITENTKSMCGTPEYIAPEILS-GHGHGKSADWWSL |.. | . . |. .|. .|||.|.. ||.|||||||.|||. ||| |..|||.| . ... ||||.|.|||.. | ..|...|.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GILIYEMLVGVPPFVSE----GSQNDIFRLIREARIQVPPEVD-----------------------QVARDLIEKLVVTDVEKRLGSLEGGIEDIKNHPF |...|||| | ||| .. . ...... | . ... . . . ..|.|... | .||.. .|.|..||. GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW F | F |
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Kinase | pk4.AA | MAST | 679-825 | 38 | 3.3e-53 | 160.57 | In-house | 203-352 (337) | Show / Hide |
Range on Protein: 679-825 Range on HMM: 203-352/337 Sequence Identity: 38% (57 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLTDNPFIVKLYSTFKD--DRYLYFLQEFIPGGELFDYIRANG-SLS |. ... | . .| | .|. . .| ||..| . .|. | .| |. .| ..|||.||....| ..||.. |. || . .|. | .. FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP LYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAK ...| ||.||.|||||...|. |||||.|.||| |||||||||..| EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSK |
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Kinase | pk4.AA | MAST | 832-934 | 44 | 1.5e-47 | 142.93 | In-house | 226-337 (337) | Show / Hide |
Range on Protein: 832-934 Range on HMM: 226-337/337 Sequence Identity: 44% (51 aa) KSMCGTPEYIAPEILSGHG-HGKSADWWSLGILIYEMLVGVPPFVSEGSQND-IFRLIRE--ARIQVPPE--------VDQVARDLIEKLVVTDVEKRLG |. ||||.|||||.. | | .||..||||.|| .|| |||.|||. . ... || | .| |.| . .|.|||.|| . |||| KQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGD-TPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG SLEGGIEDIKNHPFF . | ..||.|||| AN--GADEIKQHPFF |
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Kinase | pk4.AA | TyrKc | 679-928 | 20 | 1.7e-12 | -20.62 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 679-928 Range on HMM: 1-280/280 Sequence Identity: 20% (59 aa) FKLFDLLGSGSFAKVRLCQHIPSERLFCMKILNQNKIIRLRQEVHVCNEKQVLMLT--DNPFIVKLYSTFKDD-------RYLYFLQEFIPGGELFDYIR .| . ||.| | .|.... . . | |. .. . ..| .... ..| ||.|| .. |. . |. |.| | ||.| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR ANGS-LSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRITEN--------TKSM----CGTP----EYIAPEILSGHGHG ... |.. .. | |||| . .| ||| | |.. ...| .||| .. |.. .... .| ||| . . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT KSADWWSLGILIYEML-VGVPPFVSE----GSQNDIFRLIREA-RIQVPPE--------VDQVARDLIEKLVVTDVEKRLGSLEGGIEDI | || |....|.. | .| . | ........ | ||. . ..... | |.| | .|.. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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Kinase | pk4.AA | Pkinase_Tyr | 679-838 | 22 | 0.000444 | 14.44 | Pfam | 1-175 (270) | Show / Hide |
Range on Protein: 679-838 Range on HMM: 1-175/270 Sequence Identity: 22% (40 aa) FKLFDLLGSGSFAKVRLCQHI----PSERLFCMKILNQNKIIRL--RQEVHVCNEKQVLMLT-DNPFIVKLYSTFK-DDRY--LYFLQEFIPGGELFDYI .. ||.|.| .|... . |.|... . |.. .| .... ..| ||.|| ... .| |. |.| | || ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRED--FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL RA----NGSLSLYVTQIYAAEIVLALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFAKRI--TENT-KSMCGTP |. ...|.. ....| ..|||... .| ||| | |.. ...| .||| |. | ... .. |.. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK |