Gene Pdk1A (Slime mold)
Pdk1A
Sequence
Protein domains of Pdk1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | Pdk1A.AA | PDK1 | 69-449 | 43 | 1.9e-220 | 682.79 | In-house | 1-307 (307) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-307/307 Sequence Identity: 43% (175 aa) FIIGKVLGEGSYGAVVLGTEKET----QQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSN-----HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIK ||.||..|||||..|.|..|||| ...|||||.||..||.|.|.|||..||||.|..| ||.||||.|||..|||||.|||.|..|||||..| FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK K--VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTG---KILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNL | .||||...|..|.||||..||||||.||.||||||||||...| |..||||||. ||||..||.||.|.|||.| KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQ--------------------- SVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEY |.|.... ..|..| ||..|||||||| ---------QHNKGMD-----------------------------------------------------------------KPEEDKQTRCKSFVGTAEY VSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGK-----TEFLTFQKVSNRELVYPIN--MNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHP |||||...||.....|.||||||||||..|..||||. .|..||||........|.| ..|..||||.||||..|.|||.|....||....|||| VSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQIKAHP FF || FF |
|||||||||
Kinase | Pdk1A.AA | AGC | 69-449 | 24 | 8.10000000001e-148 | 385.12 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-395/395 Sequence Identity: 24% (119 aa) FIIGKVLGEGSYGAVVLGTEK------ETQQQYAIKILEKKQ---IIKENKIKYVQIE------------KEIFCKSN----------HPNIVK-LFFTF | . ||.|.||.| | | .| |...||.|.|.|| |.|.|.......| ..|. | | ||.||| |...| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF RSEQC--LYYVLELCS--------QGD-LLHQIK----KVGSFDYRSCQYYVAE-------IISGLEHLHS-LGIVHRD-LKPENILMSSDLHVKITDFG ... || |.|... |. |.... | |.|| ...| || |...||.||| .||.||| |||||||. .| |.|.|||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG TGKILPPPQSSQQQQQQ------------------QQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNN |... .. .|| .| . . . .... |.|. .| LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDT-N-----------------------K-CNPNNWQRNN-MS------------------------ NNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNN------SFVG--TAEYVSPELISNKETSTDSDLWA--LGCIIYQMASG . | .. || . .|.| |.||..|| . . | |. |||..|.| .| -----------------------------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG RVPFRGKT----------EFLTFQKVSNR------ELVYP----------INMNPVIKDLVEKLLVIKPTDRLGS-SSTPG--GFDNLKAHPFF . ||.|.. .. .|||. |. .. .| .. | |||..|||. |..|||. .. | |.. .|.||.| YPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
|||||||||
Kinase | Pdk1A.AA | S_TKc | 69-449 | 22 | 8.7e-91 | 308.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-231/231 Sequence Identity: 22% (89 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQ--GDLLHQIKKVGS--- . |....|.|..| | ....|.|....||||. . .. | .| | .|||||||. .|.. ..|| |.|.|.. |||.. ||| |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL |. ...|...|...||..||.||.||||||||||... |.||.||| ..| RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------- TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELI ..|.|| .|..||.. -------------------------------------------------------------------------------------TTFCGTPWYMAPEVL SNKETST-DSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF .. .| |..|||.| |..|. ||. .....|.|. | ||...|.|. |..|.. . |.||.| ---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
Kinase | Pdk1A.AA | Ciliate-E2 | 69-449 | 18 | 7.6e-84 | 284.87 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-365/365 Sequence Identity: 18% (92 aa) FIIGKVLGEGSYGAVVLGTEKETQQQ-----------------------YAIKILEKKQIIKENKIKYVQ----------IEKEIFCKSNHPNIVKLFFT ... |..|.|..| | ... ...|.| ||.||..|.||. ...... .||.| . |||||.|.. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FR--SEQCLYYVLELCSQGDLLH-------------------QIKKVGSFDYRSCQ-------YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDLHV | .....|.|.|.|..|||.. .|... . . .| .|.|.||..||.||| . |.|||.||||||. . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KITDFGTGKILPPPQSSQQQQQQQQQ----------------QQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTT ||.|||. |.. ... ... ||.. | KIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQ--------------------------------------------------------- TTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELISNKE---------TSTDSDLWALGCIIYQM | . |...||..|..|| ...|. .. .|.|.||.|.|.| ------------------------------------------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM ASGRVPFRGKTEFLTFQKVSNRELVYP------------------INMNPVIKDLVEK----LLVIKPTDRLGSSSTPGGFDNLKAHPFF .|. || .|. . .. .| . . ||| | .|. .| |.. |.. .. ||.| LFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF |
|||||||||
Kinase | Pdk1A.AA | RSK | 72-449 | 23 | 1.2e-79 | 270.89 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 72-449 Range on HMM: 1-278/278 Sequence Identity: 23% (94 aa) GKVLGEGSYGAVVLGTEK---ETQQQYAIKILEKKQIIKENK-IKYVQIEKEIFCKSN-HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGS--- ||||.|.||.| | .. |.|.|| |.|.|. |.. .| .... | .| .. ||.||.|. .|. |. || ..|.|. |.|. ..| .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSS---DLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL |. . ...| |||.. .||||..||.|||||||||| . . |.|.|||| |.. FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF------------------------------------------- TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPK-LTRNNSFVGTAEYVSPEL .. . ..|..|.||. ||. ------------------------------------------------------------------------------RCDHNQWTMTFCYTIEYMAPEM IS----NKETSTDSDLWALGCIIYQMASGRVPFRG---KTEFLTFQKVSNRE--LVYP--INMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPF . .. . |.| ||...| | .|..||.| .. ..... . . | | .. . |||. |.| | .|||. |.. . .|.||. LKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG--PQDAEEIKQHPW F | F |
|||||||||
Kinase | Pdk1A.AA | AktR | 69-449 | 26 | 1.5e-76 | 260.62 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-268/268 Sequence Identity: 26% (104 aa) FIIGKVLGEGSYGAVVLGTEK-ETQQQYAIKILEKKQIIKENKIKYVQIEKEIFC-KSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDY | . |.||.| .| |.| ..| ..|.|||.|.. || ||..|...... |. | ..||| ||||...| .. .|....| | |.|.. .|| . |. FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE RSCQYYVAEIISGLEHLHSL-GIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQ . | |.|. .||.||. |. |||||||||. .| |||||||| | EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-------------------------------------------------- NRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIP--KLTRNNSFVGTAEYVSPELISN- .. . ...||.|| ||..|| | . -----------------------------------------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKK KETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE-LVYPINMNP--VIKDLVE-KLLVIKPTDRLGSSSTPGGFDNLKAHPFF | .|.||.|. || | .| || | ||| . . . |..... |||.. ||| |. |||... |.. .| ||.| KGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN--GWEEIKSHPWF |
|||||||||
Kinase | Pdk1A.AA | Ciliate-E2-Unclassified | 69-449 | 20 | 5.8e-75 | 255.36 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-352/352 Sequence Identity: 20% (94 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYV----QIEKEIFCK------------------SNHPNIVKLFFTFRSEQCLYYVL ..|.|..|.|..| | . .|...|.||.|.. |.||.| ..|... ...||...| ..||.|||.|..|...|..| |. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM ELCSQGDLLHQIKKVGS-----------------FDYRSCQ-----YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDL---HVKITDFGTGKILPPP |.| .|||. ||| .. |. . .. .| |.|..|||.||. . |.|||.||||||.... ..||.||| | . . EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN QSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTN . .. .| NNCD-TNQ-------------------------------------------------------------------------------------------- TNINTNINANINNIKTTEIPKLTRNNSFVGTAEYV----SPELISNKETSTD----SDLWALGCIIYQMASGRVPFRGKTEFL----------------T . |.| . ..|.|| .| .||.. ... .. .| |.||.|.|.| |. || .... -------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL FQKVSNRELVYP--------INMNPVIKDLVE----KLLVIKPTDRLGSSSTPGGFDNLKAHPFF .|. .... .| . .| ||... |.|. .| |. .|. .. ||.| YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-------TFEQILNHPWF |
|||||||||
Kinase | Pdk1A.AA | CAMK | 74-431 | 17 | 7.1e-74 | 237.24 | In-house | 1-414 (425) | Show / Hide |
Range on Protein: 74-431 Range on HMM: 1-414/425 Sequence Identity: 17% (92 aa) VLGEGSYGAVVLGTEKETQ------------QQYAIKILEKKQIIK-------------------------ENKIKYVQIEKEIFCKSN-------HPNI .||.||.| | |...|.|. |..||||..||.. . ... | |. | || | . |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLFFTFRS-------------------EQCLYYVL---ELCSQG----DLLHQIKKVGS---------------FDYRSCQYYVAEIISGLEHLHSLGI .||. .. . ....| |. |.|| | ||. |.. |. |. | ...|. |.|.....||..| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VHRDLKPENILMSSD-----------------LHVKITDFGTGKILPPPQSSQ----QQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNR |||||||||||.... .||.||| ....| ... ... . . .| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQW------------------------------- TSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNS--------FVGTAEYVS-PE . . |.|| ||.. || -----------------------------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPE LISNKE--------------TSTDSDLWALGCIIYQMASGRVPFRGK-------------TEFLTFQKVSNRELVYPINMNPV----------------- ... | . .| |..|.| | | .|. ||.|. .. .|.|. . . .| . . VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF -------IKDLVEKLLVIKPTDRL |||. |.|. |..|. HHFVSQECKDLIRKMLQVDPEKRM |
|||||||||
Kinase | Pdk1A.AA | MAST | 69-449 | 26 | 5e-72 | 231.4 | In-house | 1-334 (334) | Show / Hide |
Range on Protein: 69-449 Range on HMM: 1-334/334 Sequence Identity: 26% (109 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRS | . |... | ||.| | |.| . .|.|.. | . |. | .. ||.|. |. . | .||.| .| ... |. |.| . ||. . .. .|.|| . FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM CQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKI-----------------LPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNV . |.||.. .|| ||| |||||||||.|.| .|. |.|.|||| |. . AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI---------------------------------- NNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTA--AGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFV || . |.|.... .. | |.|||.| |.... . . . .|.. . ----------------------------------------FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQ-IQQQQEQPQCQQQNMRPHNIHQNKQCC GTAEYVSPELISNKE-TSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE---LVYP--------INMNPVIKDLVEKLLVIKPTDRLGSSSTP || .| .||.| .. . .| |..| |.|. | .|| ..| ..||.. ||. .| . | |. .||.|||| | .|||... GTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANN-- GGFDNLKAHPFF | | | |||| -GADEVKQHPFF |
|||||||||
Kinase | Pdk1A.AA | Ciliate-E2b | 69-217 | 37 | 5.1e-54 | 162.59 | In-house | 1-152 (272) | Show / Hide |
Range on Protein: 69-217 Range on HMM: 1-152/272 Sequence Identity: 37% (57 aa) FIIGKVLGEGSYGAVVLGTE-KETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVG--SFD .|. | || | .| | |. . |.|.|.||.| .| |||..| |. ..||.. | |||.|.|.. .|...|..| ..|.|. ..|. | .| . MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS YRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKIL | |.|.|. .|| ||...|..||.|||||. .. ..|. |.|| |.. TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHM |
|||||||||
Kinase | Pdk1A.AA | PKC | 69-212 | 38 | 2e-46 | 148.39 | In-house | 1-145 (262) | Show / Hide |
Range on Protein: 69-212 Range on HMM: 1-145/262 Sequence Identity: 38% (56 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCK-SNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYR | |||| ||.| |.|. |.|.. ||||.| | ||. . ...|| .. ..|| ..|. .| .. |..|.| . ||| ..| ... |. . FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE SCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG | ||||..| ||. ||. |||| .|.|. .. |.||.||| HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFG |
|||||||||
Kinase | Pdk1A.AA | Pkinase | 69-212 | 37 | 1.8e-45 | 161.85 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 69-212 Range on HMM: 1-157/293 Sequence Identity: 37% (59 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQ-IEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQG----DLLHQIK--KV . ||...|.||.| | ....| |....|.||..|. . .. .. . | .| . ||||||.|. .|.... .| |.|.| | || . |. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GSF--DYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHV----KITDFG |.| ... |. |. .|..|||..|| ||.||||||||||.... |. ||.||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
|||||||||
Kinase | Pdk1A.AA | Pkinase | 343-449 | 21 | 1.5e-24 | 87.85 | Pfam | 167-293 (293) | Show / Hide |
Range on Protein: 343-449 Range on HMM: 167-293/293 Sequence Identity: 21% (29 aa) TRNNSFVGTAEYVSPELIS-NKETSTDSDLWALGCIIYQMASGRVPFRGK------TEFLTFQKVSNRELVYPI---------------------NMNPV . ...|.|| .|..||.| ... .. .| |..|||.|.|..|| ||.|. .. .... ..| ... |... S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE IKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF ||.....| .|..|.. .. .. ||.| CKDFIKWCLCKDPKKRPT-------AEQILQHPWF |
|||||||||
Kinase | Pdk1A.AA | PKC | 346-449 | 29 | 4e-24 | 74.96 | In-house | 158-262 (262) | Show / Hide |
Range on Protein: 346-449 Range on HMM: 158-262/262 Sequence Identity: 29% (31 aa) NSFVGTAEYVSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTP-GGFDNLK ..| || .|..|| .. .| . | ||.| |.| |. || |..| || . ... .||. . .... .... .|..|||. .. .|... . STFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIR AHPFF .|||| EHPFF |
|||||||||
Kinase | Pdk1A.AA | Ciliate-E2b | 342-449 | 26 | 4.9e-22 | 63.9 | In-house | 159-272 (272) | Show / Hide |
Range on Protein: 342-449 Range on HMM: 159-272/272 Sequence Identity: 26% (31 aa) LTRNNSFVGTAEYVSPELIS-----NKETSTDSDLWALGCIIYQMASGRVPFRGKTE--FLTFQKVSNR--ELVYPINMNPVIK--DLVEKLLVIKPTDR .||. . .|| .| ||.|. .| .. .|.|..| . | . .|.||. . . |.. . |. .| . ... .|....| | .| MTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVR LGSSSTPGGFDNLKAHPFF || | .. ||.||.| LG-----GSYSWLKSHPWF |
|||||||||
Kinase | Pdk1A.AA | Pkinase_Tyr | 69-212 | 31 | 2.7e-17 | 59.18 | Pfam | 1-156 (270) | Show / Hide |
Range on Protein: 69-212 Range on HMM: 1-156/270 Sequence Identity: 31% (50 aa) FIIGKVLGEGSYGAVVLGTEK----ETQQQYAIKILEKKQIIKEN--KIKYVQIEKEIFCKS-NHPNIVKLFFTFR-SEQC--LYYVLELCSQGDLLHQI ..||.||||..| |..|| | .|... |.|.| | . .|. . . . | .| .. .|||||.| .. .| |.|.. ||||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL KK----VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG .| .... . ..| .|.|.|.| ...|||| |.| .....|||.||| RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG |
|||||||||
Kinase | Pdk1A.AA | TyrKc | 69-260 | 20 | 3.3e-11 | -41.44 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 69-260 Range on HMM: 1-280/280 Sequence Identity: 20% (59 aa) FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS--NHPNIVKLFFTFRSE-------QCLYYVLELCSQGDLLHQIK ||.|||| .| |..|| | .| |.| | . .. | .| || .|||||.|. ... . |. |.|... |||.. .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR KVGS-FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG------------------------TGK------------------- | . . . .. | .| |.||| ...|||| |.| .....|||.||| || KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT -------------------ILPPPQ------SSQQ--QQQQQQQQQQLPTN--------SSGNLSSLLNNVNNL---------SVSTDL |.| | |. .. .| | | . . .. . . .. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
PDK1_PH | Pdk1A.AA | PDK1_PH | 584-681 | 40 | 4.1e-41 | 142.91 | In-house | 1-112 (112) | Show / Hide |
Range on Protein: 584-681 Range on HMM: 1-112/112 Sequence Identity: 40% (45 aa) SKW---LN-NGENVIYQGLVWKRKGFSI----KKRQLILTDTPRLIYIDPKKMELKGEIPWS-DSIKPKLK-----SNNNFVIKTPKRKYLLEDVAHNPQ ..| | .||.....| | ||||.. |.|||||||.|||.|.||..|..||||||| .......| . | |.||.|.| .||. .... TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN KWVDSIKSVILS ||.. | |. KWCEAIEKVCKR |
|||||||||
PH | Pdk1A.AA | PH | 593-682 | 27 | 2.2e-05 | 25.11 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 593-682 Range on HMM: 1-82/82 Sequence Identity: 27% (25 aa) VIYQGLVWKRKGFSIKKRQLILTDTPRLIYIDPKKMELKGEIPWSDSIKPKLKSNNNFVIKTPKRKYLLEDV-AHNPQKWVDSIKSVILSS ||..| . |... . ||| ..|.. .|.| ..| ..||.|| || . . | |.. .| |.. . |.|...|...| .. VIKEGWLYKKSK-RWKKRWFVLFN-DCLYYYKDK--KPKGSIPLSDC-TVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN |