Pdk1A

Species: Slime mold
Alias: Pdk1A, pdkA, DdisK015, DDB0216243
External Links: DictyBase Link ,
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
Pdk1A.AA Protein None 686 None Fasta, JSON
Pdk1A.kin_dom Protein Kinase Domain None 381 None Fasta, JSON

Protein domain

Protein domains of Pdk1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Pdk1A.AA PDK1 69-449 43 1.9e-220 682.79 In-house 1-307 (307) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-307/307
Sequence Identity: 43% (175 aa)

FIIGKVLGEGSYGAVVLGTEKET----QQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSN-----HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIK
||.||..|||||..|.|..||||    ...|||||.||..||.|.|.|||..||||.|..|     ||.||||.|||..|||||.|||.|..|||||..|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

K--VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTG---KILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNL
|  .||||...|..|.||||..||||||.||.||||||||||...| |..||||||.   ||||..||.||.|.|||.|                     
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQ---------------------

SVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEY
         |.|....                                                                 ..|..| ||..||||||||
---------QHNKGMD-----------------------------------------------------------------KPEEDKQTRCKSFVGTAEY

VSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGK-----TEFLTFQKVSNRELVYPIN--MNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHP
|||||...||.....|.||||||||||..|..||||.     .|..||||........|.|  ..|..||||.||||..|.|||.|....||....||||
VSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQIKAHP

FF
||
FF

Kinase Pdk1A.AA AGC 69-449 24 8.10000000001e-148 385.12 In-house 1-395 (395) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-395/395
Sequence Identity: 24% (119 aa)

FIIGKVLGEGSYGAVVLGTEK------ETQQQYAIKILEKKQ---IIKENKIKYVQIE------------KEIFCKSN----------HPNIVK-LFFTF
| . ||.|.||.| | |  .|       |...||.|.|.||    |.|.|.......|            ..|. | |          ||.||| |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RSEQC--LYYVLELCS--------QGD-LLHQIK----KVGSFDYRSCQYYVAE-------IISGLEHLHS-LGIVHRD-LKPENILMSSDLHVKITDFG
 ...   || |.|...         |.  |....    | |.||   ...| ||       |...||.||| .||.||| |||||||. .| |.|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TGKILPPPQSSQQQQQQ------------------QQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNN
  |...  .. .|| .|                  . .                       .  .... |.|. .|                        
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDT-N-----------------------K-CNPNNWQRNN-MS------------------------

NNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNN------SFVG--TAEYVSPELISNKETSTDSDLWA--LGCIIYQMASG
                                         . | .. || .      .|.|  |.||..|| .     .   | |.  |||..|.| .|
-----------------------------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG

RVPFRGKT----------EFLTFQKVSNR------ELVYP----------INMNPVIKDLVEKLLVIKPTDRLGS-SSTPG--GFDNLKAHPFF
. ||.|..          .. .|||. |.      .. .|           .. |  |||..|||.  |..|||.  .. |  |.. .|.||.|
YPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase Pdk1A.AA S_TKc 69-449 22 8.7e-91 308.83 SMART 1-231 (231) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-231/231
Sequence Identity: 22% (89 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQ--GDLLHQIKKVGS---
. |....|.|..| | ....|.|....||||.           . .. | .|  | .|||||||. .|.. ..|| |.|.|..  |||.. ||| |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL
   |.   ...|...|...||..||.||.||||||||||...  |.||.|||  ..|                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELI
                                                                                     ..|.|| .|..||..
-------------------------------------------------------------------------------------TTFCGTPWYMAPEVL

SNKETST-DSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF
     ..  .| |..|||.| |..|. ||.  .....|.|.            |  ||...|.|.  |..|..      .    |.||.|
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Pdk1A.AA Ciliate-E2 69-449 18 7.6e-84 284.87 In-house 1-365 (365) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-365/365
Sequence Identity: 18% (92 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQ-----------------------YAIKILEKKQIIKENKIKYVQ----------IEKEIFCKSNHPNIVKLFFT
... |..|.|..| | ... ...|.|                       ||.||..|.||.  ......           .||.|  . |||||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--SEQCLYYVLELCSQGDLLH-------------------QIKKVGSFDYRSCQ-------YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDLHV
|   .....|.|.|.|..|||..                    .|... . .  .|       .|.|.||..||.||| . |.|||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGTGKILPPPQSSQQQQQQQQQ----------------QQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTT
||.|||. |.. ...  ...  ||..                |                                                         
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQ---------------------------------------------------------

TTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELISNKE---------TSTDSDLWALGCIIYQM
                                                | .    |...||..|..|| ...|.          .. .|.|.||.|.|.|
------------------------------------------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

ASGRVPFRGKTEFLTFQKVSNRELVYP------------------INMNPVIKDLVEK----LLVIKPTDRLGSSSTPGGFDNLKAHPFF
 .|. ||        .|.  . .. .|                   .  .  |||  |    .|. .|  |..      |.. .. ||.|
LFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF

Kinase Pdk1A.AA RSK 72-449 23 1.2e-79 270.89 In-house 1-278 (278) Show / Hide
Range on Protein: 72-449
Range on HMM: 1-278/278
Sequence Identity: 23% (94 aa)

GKVLGEGSYGAVVLGTEK---ETQQQYAIKILEKKQIIKENK-IKYVQIEKEIFCKSN-HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGS---
 ||||.|.||.| |  ..    |.|.|| |.|.|. |.. .| ....  | .|   .. ||.||.|. .|. |. || ..|.|. |.|.  ..| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSS---DLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDL
|. . ...| |||.. .||||..||.||||||||||  .   . |.|.||||  |..                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

TQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPK-LTRNNSFVGTAEYVSPEL
                                                                               ..   . ..|..|.||. ||.
------------------------------------------------------------------------------RCDHNQWTMTFCYTIEYMAPEM

IS----NKETSTDSDLWALGCIIYQMASGRVPFRG---KTEFLTFQKVSNRE--LVYP--INMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPF
.     ..  .   |.| ||...| | .|..||.|   ..   ..... . .  |  |   .. .  |||. |.|   | .|||.   |.. . .|.||.
LKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG--PQDAEEIKQHPW

F
|
F

Kinase Pdk1A.AA AktR 69-449 26 1.5e-76 260.62 In-house 1-268 (268) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-268/268
Sequence Identity: 26% (104 aa)

FIIGKVLGEGSYGAVVLGTEK-ETQQQYAIKILEKKQIIKENKIKYVQIEKEIFC-KSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDY
| . |.||.| .| |.| ..| ..|.|||.|.. || ||..|...... |. |   ..||| ||||...| .. .|....| |  |.|.. .|| . |. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

RSCQYYVAEIISGLEHLHSL-GIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQ
   . | |.|. .||.||.   |. |||||||||. .| ||||||||  |                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

NRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIP--KLTRNNSFVGTAEYVSPELISN-
                                                                        ..   .  ...||.|| ||..|| | . 
-----------------------------------------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKK

KETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE-LVYPINMNP--VIKDLVE-KLLVIKPTDRLGSSSTPGGFDNLKAHPFF
|     .|.||.|. || | .|  ||  |     |||  . . .  |.....    |||.. |||   |. |||...   |.. .| ||.|
KGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN--GWEEIKSHPWF

Kinase Pdk1A.AA Ciliate-E2-Unclassified 69-449 20 5.8e-75 255.36 In-house 1-352 (352) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-352/352
Sequence Identity: 20% (94 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYV----QIEKEIFCK------------------SNHPNIVKLFFTFRSEQCLYYVL
..|.|..|.|..| | .  .|...|.||.|.. |.||.| ..|...    ...||...|                  ..||.|||.|..|...|..| |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELCSQGDLLHQIKKVGS-----------------FDYRSCQ-----YYVAEIISGLEHLHSLG-IVHRDLKPENILMSSDL---HVKITDFGTGKILPPP
|.| .|||.  ||| ..                 |. . ..     .| |.|..|||.||. . |.|||.||||||....    ..||.|||  | .  .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

QSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTN
. ..  .|                                                                                            
NNCD-TNQ--------------------------------------------------------------------------------------------

TNINTNINANINNIKTTEIPKLTRNNSFVGTAEYV----SPELISNKETSTD----SDLWALGCIIYQMASGRVPFRGKTEFL----------------T
                . |.|  . ..|.|| .|     .||.. ... ..     .| |.||.|.|.|  |. || ....                   
-------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

FQKVSNRELVYP--------INMNPVIKDLVE----KLLVIKPTDRLGSSSTPGGFDNLKAHPFF
.|.  .... .|         . .|  ||...    |.|. .|  |.       .|. .. ||.|
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-------TFEQILNHPWF

Kinase Pdk1A.AA CAMK 74-431 17 7.1e-74 237.24 In-house 1-414 (425) Show / Hide
Range on Protein: 74-431
Range on HMM: 1-414/425
Sequence Identity: 17% (92 aa)

VLGEGSYGAVVLGTEKETQ------------QQYAIKILEKKQIIK-------------------------ENKIKYVQIEKEIFCKSN-------HPNI
.||.||.| | |...|.|.            |..||||..||.. .                         ... | |. | ||  | .       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFFTFRS-------------------EQCLYYVL---ELCSQG----DLLHQIKKVGS---------------FDYRSCQYYVAEIISGLEHLHSLGI
.||. .. .                   ....| |.   |.|| |    ||.  |.. |.               |. | ...|.  |.|.....||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILMSSD-----------------LHVKITDFGTGKILPPPQSSQ----QQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNR
|||||||||||....                   .||.|||  ....| ...     ... . .  .|                                
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQW-------------------------------

TSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNS--------FVGTAEYVS-PE
                                                                             . .        |.|| ||.. ||
-----------------------------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPE

LISNKE--------------TSTDSDLWALGCIIYQMASGRVPFRGK-------------TEFLTFQKVSNRELVYPINMNPV-----------------
... |                .  .| |..|.| | | .|. ||.|.             ..  .|.|. . .  .|  . .                  
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF

-------IKDLVEKLLVIKPTDRL
        |||. |.|.  |..|.
HHFVSQECKDLIRKMLQVDPEKRM

Kinase Pdk1A.AA MAST 69-449 26 5e-72 231.4 In-house 1-334 (334) Show / Hide
Range on Protein: 69-449
Range on HMM: 1-334/334
Sequence Identity: 26% (109 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRS
| . |... | ||.| |   |.| . .|.|.. | . |. | .. ||.|. |.  .  | .||.| .| ... |. |.|  . ||. . .. .|.|| . 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

CQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKI-----------------LPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNV
 . |.||.. .|| ||| |||||||||.|.| .|. |.|.||||  |.                 .                                  
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI----------------------------------

NNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTA--AGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFV
                                         ||   . |.|.... ..    | |.|||.|  |....   .   .    .   .|.. .
----------------------------------------FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQ-IQQQQEQPQCQQQNMRPHNIHQNKQCC

GTAEYVSPELISNKE-TSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRE---LVYP--------INMNPVIKDLVEKLLVIKPTDRLGSSSTP
|| .| .||.| ..   .  .| |..| |.|.   | .|| ..|  ..||.. ||.     .|        . | |. .||.||||   | .|||...  
GTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANN--

GGFDNLKAHPFF
 | |  | ||||
-GADEVKQHPFF

Kinase Pdk1A.AA Ciliate-E2b 69-217 37 5.1e-54 162.59 In-house 1-152 (272) Show / Hide
Range on Protein: 69-217
Range on HMM: 1-152/272
Sequence Identity: 37% (57 aa)

FIIGKVLGEGSYGAVVLGTE-KETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVG--SFD
.|. | || | .| | |. . |.|.|.||.|  .| |||..|  |. ..||..  | |||.|.|.. .|...|..| ..|.|. ..|.  |  .|   . 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

YRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKIL
    | |.|.|. .|| ||...|..||.|||||.  .. ..|. |.|| |..
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHM

Kinase Pdk1A.AA PKC 69-212 38 2e-46 148.39 In-house 1-145 (262) Show / Hide
Range on Protein: 69-212
Range on HMM: 1-145/262
Sequence Identity: 38% (56 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCK-SNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYR
|   |||| ||.| |.|.  |.|.. ||||.| |  ||.   .  ...|| ..   ..||  ..|. .| ..  |..|.| .  ||| ..| ... |. .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

SCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG
    | ||||..|  ||. ||. |||| .|.|. .. |.||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFG

Kinase Pdk1A.AA Pkinase 69-212 37 1.8e-45 161.85 Pfam 1-157 (293) Show / Hide
Range on Protein: 69-212
Range on HMM: 1-157/293
Sequence Identity: 37% (59 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQ-IEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQG----DLLHQIK--KV
. ||...|.||.| | ....| |....|.||..|. . .. ..  .   | .|  . ||||||.|. .|.... .| |.|.|  |    || . |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSF--DYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHV----KITDFG
|.|  ... |. |. .|..|||..|| ||.||||||||||.... |.    ||.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG

Kinase Pdk1A.AA Pkinase 343-449 21 1.5e-24 87.85 Pfam 167-293 (293) Show / Hide
Range on Protein: 343-449
Range on HMM: 167-293/293
Sequence Identity: 21% (29 aa)

TRNNSFVGTAEYVSPELIS-NKETSTDSDLWALGCIIYQMASGRVPFRGK------TEFLTFQKVSNRELVYPI---------------------NMNPV
. ...|.|| .|..||.|  ... .. .| |..|||.|.|..|| ||.|.      ..   ....  ..| ...                     |... 
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

IKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFF
 ||.....|  .|..|..       .. .. ||.|
CKDFIKWCLCKDPKKRPT-------AEQILQHPWF

Kinase Pdk1A.AA PKC 346-449 29 4e-24 74.96 In-house 158-262 (262) Show / Hide
Range on Protein: 346-449
Range on HMM: 158-262/262
Sequence Identity: 29% (31 aa)

NSFVGTAEYVSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTP-GGFDNLK
..| || .|..|| .. .| .   | ||.|   |.|  |. || |..|   || . ... .||. .   .... ....  .|..|||.  .. .|... .
STFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIR

AHPFF
.||||
EHPFF

Kinase Pdk1A.AA Ciliate-E2b 342-449 26 4.9e-22 63.9 In-house 159-272 (272) Show / Hide
Range on Protein: 342-449
Range on HMM: 159-272/272
Sequence Identity: 26% (31 aa)

LTRNNSFVGTAEYVSPELIS-----NKETSTDSDLWALGCIIYQMASGRVPFRGKTE--FLTFQKVSNR--ELVYPINMNPVIK--DLVEKLLVIKPTDR
.||. . .|| .|  ||.|.     .|  .. .|.|..| . | . .|.||.  . .      |.. .   |. .|  .  ...  .|....|   | .|
MTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVR

LGSSSTPGGFDNLKAHPFF
||     | .. ||.||.|
LG-----GSYSWLKSHPWF

Kinase Pdk1A.AA Pkinase_Tyr 69-212 31 2.7e-17 59.18 Pfam 1-156 (270) Show / Hide
Range on Protein: 69-212
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FIIGKVLGEGSYGAVVLGTEK----ETQQQYAIKILEKKQIIKEN--KIKYVQIEKEIFCKS-NHPNIVKLFFTFR-SEQC--LYYVLELCSQGDLLHQI
 ..||.||||..| |..|| |    .|... |.|.| | .  .|.  . .  . | .| ..  .|||||.|       ..   .| |.|..  ||||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK----VGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG
.|     ....      . ..| .|.|.|.| ...||||   |.| .....|||.|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG

Kinase Pdk1A.AA TyrKc 69-260 20 3.3e-11 -41.44 SMART 1-280 (280) Show / Hide
Range on Protein: 69-260
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS--NHPNIVKLFFTFRSE-------QCLYYVLELCSQGDLLHQIK
   ||.|||| .| |..|| |   .| |.| | .        ..    | .| ||   .|||||.|.   ...       . |. |.|... |||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KVGS-FDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFG------------------------TGK-------------------
| .  .  .   ..   | .| |.||| ...||||   |.| .....|||.|||                         ||                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-------------------ILPPPQ------SSQQ--QQQQQQQQQQLPTN--------SSGNLSSLLNNVNNL---------SVSTDL
                     |.|       | |.  .. .|      | |         .  . ..     .           .  ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

PDK1_PH Pdk1A.AA PDK1_PH 584-681 40 4.1e-41 142.91 In-house 1-112 (112) Show / Hide
Range on Protein: 584-681
Range on HMM: 1-112/112
Sequence Identity: 40% (45 aa)

SKW---LN-NGENVIYQGLVWKRKGFSI----KKRQLILTDTPRLIYIDPKKMELKGEIPWS-DSIKPKLK-----SNNNFVIKTPKRKYLLEDVAHNPQ
..|   |  .||.....| | ||||..     |.|||||||.|||.|.||..|..||||||| .......|     .   | |.||.|.| .||. ....
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

KWVDSIKSVILS
||.. |  |.  
KWCEAIEKVCKR

PH Pdk1A.AA PH 593-682 27 2.2e-05 25.11 SMART 1-82 (82) Show / Hide
Range on Protein: 593-682
Range on HMM: 1-82/82
Sequence Identity: 27% (25 aa)

VIYQGLVWKRKGFSIKKRQLILTDTPRLIYIDPKKMELKGEIPWSDSIKPKLKSNNNFVIKTPKRKYLLEDV-AHNPQKWVDSIKSVILSS
||..| . |... . ||| ..|..  .|.| ..|  ..||.|| ||  . .      | |.. .| |..    .   |.|...|...| ..
VIKEGWLYKKSK-RWKKRWFVLFN-DCLYYYKDK--KPKGSIPLSDC-TVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN