Gene ZAP70 (Human)
ZAP70
Sequence
Protein domains of ZAP70.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH2 | ZAP70.AA | SH2 | 10-87 | 40 | 1.4e-34 | 103.32 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 10-87 Range on HMM: 1-81/81 Sequence Identity: 40% (33 aa) FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV---RFHHFPIERQLNGTYAIAGGKAHCGPAELCEFY ...|.|||.|||..|. |. || ||.|.. .. |.|.||...| |..|. | |. ||.| |.|.. .| .||.|.| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | ZAP70.AA | SH2 | 8-93 | 37 | 2.9e-27 | 97.82 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 8-93 Range on HMM: 1-87/87 Sequence Identity: 37% (33 aa) LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAG--GKAHCGPAELCEFYSRDPDG |...| |||.|||. || || || ||.|.. .. |.||||. .. ...|. |.|. .| | |.. .. .. || ..|.. |.| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | ZAP70.AA | SH2 | 163-239 | 38 | 5.7e-36 | 107.43 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 163-239 Range on HMM: 1-81/81 Sequence Identity: 38% (31 aa) WYHSSLTREEAERKLYSGAQTDGKFLLRPRK-EQGTYALSLIYGK---TVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYL ||| ...|.|||| |... ..|| ||.|.. ..| |.||. .. |.|| | ... |.|.| ...||..|..|||. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | ZAP70.AA | SH2 | 161-245 | 38 | 4.3e-29 | 103.88 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 161-245 Range on HMM: 1-87/87 Sequence Identity: 38% (34 aa) MPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQDKAGKYCIPE--GTKFDTLWQLVEYLKLKADG .|||| ..|||||..| .. . || ||.|.. | |.||. ... |.||.| ... |||.| | ..||..| .||.. . ..| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Kinase | ZAP70.AA | Syk | 338-587 | 66 | 2e-208 | 698.68 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 338-587 Range on HMM: 1-257/257 Sequence Identity: 66% (170 aa) LIADIELGCGNFGSVRQGVYRMR-----KKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKRE |..|.|.||||||||..|.|.|. |..|.||||.|| .....||..|.|||||.|.|||.|.|||.||.|.||..|.|||||..||.||.|...|. LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH EIPVSNVAELLH-QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMW ||...||.||.| ||.|||.|||||.|||||||||||||||||||||||||.|||||||..||.|...||||.||||||||...|||..|||||.||||| EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW EALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL |..|||||||..|||.|||.|||.|.||.||..||.|.|.||..||||||.|||.|. EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | ZAP70.AA | Pkinase_Tyr | 338-593 | 42 | 3.4e-130 | 441.55 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-270/270 Sequence Identity: 42% (116 aa) LIADIELGCGNFGSVRQGVYR--MRKKQIDVAIKVLKQGTEKAD--TEEMMREAQIMHQL-DNPYIVRLIGVCQ--AEA--LMLVMEMAGGGPLHKFLVG .. . .|| |.||.|..|... . ...|.||.|.||.|. . . |..||||.||.|| ..| ||||.||| | ...||| . .| |...| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK K---REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY-TARSAGKWPLKWYAPECINFRKFSSRSDVWS . .. .... . .|...|| |||.||..||||||||.|. . . .||.||||.... .|.|| ..|. ||.| ||.||||||..||.. ||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS YGVTMWEALSYGQKP-YKKMKGPEVMAFI-EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM .||.||| ..||..| |. |. ||...| |.| ||.||. ||.|.| || .|| |. |||| | . ... FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | ZAP70.AA | TyrKc | 338-593 | 39 | 2.8e-129 | 436.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-280/280 Sequence Identity: 39% (115 aa) LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL--DNPYIVRLIGVCQA--------EALMLVMEMAGGGPLHKFLV . . .||.|.|| |..|... |.||.|.|| .. |..||||.||..| ..| ||||.||| | ||.||| . .| |...| ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD------DSYYTARS--AGK--WPLKWYAPECINFRKFS .|...... . .|.. || ||..||..||||||||.|. ..| .||||||||.... | ..||.... || .|..|.||||||..||. KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT SRSDVWSYGVTMWEALSYGQKPYKK-----MKGPEVMAFIEQGKRMECPPE--------CPPELYALMSDCWIYKWEDRPDFLTVEQRM . |||||.||.||| ..|||.|| |. ||.....||.||..||. ||.|.| .|..|| .. |||| | .. ... TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | ZAP70.AA | TK | 338-593 | 22 | 1.3e-103 | 348.3 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 338-593
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)
LIADIELGCGNFG---SVRQGVYRMR-----------------------KKQIDVAIKVLKQGTEKADTEEMM-------------REAQIMHQLD----
.. .|| |.|| |..| .|.| .....||.|.|| |.. ...|... .||..| ...
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-NPYIVRLIGVCQAEA-------------LMLVMEMAGGGP----LHKFLVGKREE--------------------------------------------
| ||||.||| .. .|.|||.. .| |...| .|..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IPVSNVAELLHQVSMGMKYLEEK------NFVHRDLAARNVLLVNRHY-----------AKISDFG---
... .|.. || ||..| |||||||||||.|. ... .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LSKALGADDSYYTAR-----------------------SAGKWPLKWYAPECIN---------FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK
|..... || ||... | ||.|..|.||||.| ..||.. |||||.||.||| ..|||.|| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
G----------PEVMAFIEQG--------------KRMECPPECP--------------PELYALMSDCWIYKWEDRPDFLTVEQRM
||| ....| ||..|| || .|.| || .|| |. ||||.| .. ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | ZAP70.AA | Ack | 338-593 | 37 | 6.2e-91 | 306.96 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-266/266 Sequence Identity: 37% (100 aa) LIADIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKAD--TEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREE- . .|| | ||.|..|. . | | ||.|.|. . ... .. .||..|||.|| | .||| || . . |.|.|.| .| |. | ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK-HCRT -IP-VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR-HYAKISDFGLSKALGADDSYYTARSAG--KWPLKWYAPECINFRKFSSRSDVWSYGV .. .. . . |. ||| ||| |...||||||||.|| . .||.||||. ||| . ||. | |. | ||||...|.||. ||||..|| AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV TMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM |.|| |||..|.. . | ... |. | | . |. ||...|..| || . .||| | .. . TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | ZAP70.AA | FAK | 338-598 | 39 | 6.9e-90 | 301.37 | In-house | 1-285 (285) | Show / Hide |
Range on Protein: 338-598
Range on HMM: 1-285/285
Sequence Identity: 39% (113 aa)
LIADIELGCGNFGSVRQGVYRMRKK-------------------------QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALML
.| | || | |||| | .|.|||| |. ... .|. | || ||.|.| | ||.|||.|. . .
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI
VMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN
.||.. | | ..| .... . |..| | ||| |.||||| |||||| . . | ||||| . |.||| | || | || .|| ||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESIN
FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY
|| | . |||| .|| ||| |.|| ||. .| .| ||.| |. || ||| || ||. || | .|| | . ... |
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
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| Kinase | ZAP70.AA | UTK | 338-593 | 33 | 1.2e-89 | 304.17 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-296/296 Sequence Identity: 33% (99 aa) LIADIELGCGNFGSVRQGVYRMRK---KQIDVAIKVLKQGTEKADTEE----MMREAQ---IMHQLD-NPYIVRLIGVC-QAEALMLVMEMAGGGPLHKF .. .|| |.|| |. . .. . .. |||.||.. . . ...| |.||. .| |.. |...||.||| | | .|.|.|.. .| | .. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LVGKREEIP-----VSNV--AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH--------YAKISDFG---LSKALGA--------DDSYYTARSAG | |.. | ... . ... || ||....||||||||||. ||..| .||.||| .|..... .. ||.|.... LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNC-LVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD KWPLKWYAPECINFR-KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM .||..|.|||... . .|.. |||||.||..|| ...|..||. | ..| .... | ||.||..|| ..| || .|| | ..|||| ...|.| RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | ZAP70.AA | Fer | 338-594 | 33 | 5.2e-85 | 288.74 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 338-594 Range on HMM: 1-283/283 Sequence Identity: 33% (96 aa) LIADIELGCGNFGSVRQG---VYRMRKKQIDV---AIKVLKQGTEKADTE---EMMREAQIMHQ-LDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFL . . ||.|.|| |..| ......|...| |.|| | .|.|..| |.|.||.|| . .| |..|...||| . ...|.|||.. || | ..| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL VGKREE-IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN-RHYAK--ISDFGLSKALGADDSYYTAR-SAGKWPLKWYAPECINFRKFSSRSD . .. ... . ..|.. ||.||..|| .|||.||||.|. . .. | |||||.|... . . |. . | | | .| |||..... .|. .| KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD VWSYGVTMWEALSYGQKPYKK----MKGPEV----MAFIEQ-GKRMECPPECPPELYALMS-DCWIYKWEDRPDFLTVEQRMR |||.||..|| . |..|| || .| .. |.. |..| .|...|||.. .| .|| .. |||| . .. |... VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | ZAP70.AA | Eph | 338-593 | 41 | 1.3e-84 | 284.18 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-264/264 Sequence Identity: 41% (110 aa) LIADIELGCGNFGSVRQGVYRMR-KKQID----VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKRE . . .| | || |..| ... .|. |||| ||.| . . .|| || | | | |.|| || ... .| | | |.| .|| . . IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS---YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVT .. | ..| . ||||| . |.|||||||||.|. . |.|||||| | |.| || | || |..| ||| | .|||.| |||||||. QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV MWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM ||| .||| .|| | . .|. |||| | |..||. |. || ||| . ..|| | .. . MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
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| Kinase | ZAP70.AA | EGFR | 338-594 | 40 | 3.2e-83 | 276.15 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 338-594 Range on HMM: 1-258/258 Sequence Identity: 40% (104 aa) LIADIELGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPV | . || | || | |.. . .| ||||||.. |.. .|||..|| .| .|.|..|||.||| .. ..|| . | | .. ...| LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY . |. ||.||||. |||||||||||. || ||||.| | .|. |.| . || | || | ||| .|.. ..|||||||||.|| . . QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTF GQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR |||||. .. |. ..|.|.|.. || | .| .| ||. . || | .... GQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | ZAP70.AA | Src | 338-593 | 39 | 8.5e-81 | 274.23 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 338-593 Range on HMM: 1-255/255 Sequence Identity: 39% (102 aa) LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIP . .|| |.|| | .|.. .....||.|.||.|| ..| .||||| .|. . .|.| || | | | | | ..| |. ... IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLH VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS . . .. ||. ||.|||..|..|||||||||| . .|. |||| . . || |.||. | | || |||.||...|. |||||.|. ..| . LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA-LMSDCWIYKWEDRPDFLTVEQRM ||. ||. |. .||. .|.| || ||..||.||| .| || . |.|| | . . . YGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | ZAP70.AA | TK-Unique | 338-593 | 32 | 3.1e-74 | 252.95 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 338-593
Range on HMM: 1-294/294
Sequence Identity: 32% (95 aa)
LIADIELGCGNFGSVRQGVYRMRK----KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPYIVRLIGVCQAEA--LMLVMEMAGGGPLHKFLVGKR
| ....| |.|| | | .. .. ||. ||.| || . . | ....|.|.| .|. |.||...|.|. |..|| . .| | ..| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
-------------------------EEIPVSNVAELLHQVSMGMKYLEE--KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL
|.| .. . |. .||.||.. |..|||||.|||||| ... .||.|||... . .. | . .| |. |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI
KWYAPECIN--FRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC-PPELYALMSDCWIYKWEDRPDFLTVEQRM
.| ||| . . . ...|||||.||.||| ...|. || .|. ...| |..|.||. |..| ..|.| ||. || .. |.||.| .. .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
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| Kinase | ZAP70.AA | S_TKc | 338-597 | 23 | 7.4e-45 | 156.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 338-597
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)
LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGG--GPLHKFLVGKREE---
..| | ||.|.... . . ||||..| | ..|| ||... . |.||.|..|.| . | .|||...| | |..... .. .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTM
.| .. ...|. ...|. .....|||| |.|| . ||.||||.. | . . . ||| . ... ..|.|| |...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL
WEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ-----RMRACY
.| |. |. |. .... ... . .||. ... |. . |.|| . | ..
YEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | ZAP70.AA | Pkinase | 338-584 | 23 | 2.6e-32 | 115.32 | Pfam | 1-282 (293) | Show / Hide |
Range on Protein: 338-584 Range on HMM: 1-282/293 Sequence Identity: 23% (69 aa) LIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMR---EAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGG----PLHKFLV . .| |.||.| |. ..| ||.|..| .|| . .. | |.|||. |. |.||||..... . .||| ..|| |. .. YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS -GKREEI--PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA----KISDFGLSKAL-GADDSYYTARSAGKWPLKWYAPECIN-FRKFSS .. . . . . |. |..|. .....|||| |.|..|. . ||.||||.| . .| .| . | . ||| |. .. .. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGP RSDVWSYGVTMWEALSYGQKPYKKM----KGPEVMAFIEQGKRMECPPECP-----------------------PELYALMSDCWIYKWEDRP ..|.||.|....| |. |. |.. . . |. |.. .. . . ..| .|. ....|. .. ..|| KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
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