Gene YES (Human)

YES

Species: Human
Alias: HsT441, c-yes, C-YES, Yes, YES, P61-YES, YES1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 18p11.32,

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
YES.NA RNA Sugen Kinome 4685 None Fasta, JSON
YES.AA Protein Sugen Kinome 543 None Fasta, JSON
YES.kin_dom Protein Kinase Domain Sugen Kinome 250 None Fasta, JSON

Protein domain

Protein domains of YES.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3_1 YES.AA SH3_1 97-144 46 2.3e-24 85.0 Pfam 1-49 (49) Show / Hide 
Range on Protein: 97-144
Range on HMM: 1-49/49
Sequence Identity: 46% (23 aa)

VALYDYEARTTEDLSFKKGERFQIINNTEG-DWWEARSIATGKNGYIPS
||||||.|.. ..||||||. ...|. ... |||..|.. ||. |..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3 YES.AA SH3 94-151 41 2.5e-23 84.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 94-151
Range on HMM: 1-58/58
Sequence Identity: 41% (24 aa)

TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPAD
  ..|||||.|.. ..||||||. ..... ....||..|   ||. |..|||||.. |
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 YES.AA SH3_2 95-150 23 1.4e-13 50.45 Pfam 1-68 (68) Show / Hide 
Range on Protein: 95-150
Range on HMM: 1-68/68
Sequence Identity: 23% (16 aa)

IFVALYDYEA-RTTED-----LSFKKGERFQII---NNTEGDWWEA-RSIATGKN--GYIPSNYVAPA
 .... ||.. . ...     |.||||. . .|   .   ..||.. ..|..|.   |..||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 YES.AA SH2 158-240 62 2e-51 152.8 Pfam 1-81 (81) Show / Hide 
Range on Protein: 158-240
Range on HMM: 1-81/81
Sequence Identity: 62% (52 aa)

WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
||.||. |..|||||.||||..| |||||||.|.| |.|| ||...  ||.||||.|...||||||||.| .|..|| || ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 YES.AA SH2 156-246 45 4.3e-37 130.46 SMART 1-87 (87) Show / Hide 
Range on Protein: 156-246
Range on HMM: 1-87/87
Sequence Identity: 45% (42 aa)

EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITT--RAQFDTLQKLVKHYTEHADG
..||.|.. |..||.||.|||.. | ||||.||...|.|.||.|.      . ||||.||..|.|.|||..  | .|..|  || ||. ...|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase YES.AA SrcA 277-526 90 8.60000000001e-227 724.4 In-house 1-250 (250) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-250/250
Sequence Identity: 90% (226 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDM
.|||..||||||||||||||||||||||||||||||.|||||.||||||||||||||.|||||||||||||||.|.|||||||||...||||||||||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM
|||.|.||||.|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL
.||||||||||||.|||||.|||||||||. ||.|||.|||||||.||||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase YES.AA Src 277-526 76 1e-203 683.09 In-house 1-255 (255) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-255/255
Sequence Identity: 76% (194 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLK-EGDGKYLKLPQLV
..|. |||||.|||||||.|||.||||.|||||||| ||||||||||||||||.||| ||||.|.| |||||||.||.|||||.|| .|.|..|.||||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP
|||||.|.||||.|.||||||||.|.|.|||||.|||.|||||||||.  |.||.||.|||||||||||||..|||||||||||||||| ||.||.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMVNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL
|||| |.|||.|||||||||||..||..|.| .|  ||.|||..||||||.|.||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase YES.AA SFK-Src 277-530 62 1.7e-186 558.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-259/259
Sequence Identity: 62% (163 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD
 ||| |||.| ||.|| |.||.|| ||.||||||.|  | ||||||.||||||..|. ||||    |||||.|| |  |||||.|.|  |. |..|||||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPY
||||.| |||| |  |..|||| | |.|||.| |||..|||..| .. |.| |||..|||||||||||||... || ||||||||||| .|.|| ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMVNREVLEQVER--GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYF
||| | ||| ||.|  |||||||..||. ....|  ||.. ||.|||||  .  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase YES.AA SrcB 277-527 70 2.8e-166 558.7 In-house 1-251 (251) Show / Hide 
Range on Protein: 277-527
Range on HMM: 1-251/251
Sequence Identity: 70% (178 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDM
|.|. ||| | |||||||..|. .|||.||.|.||| |||||.|| .||.| ||.|| |||||. |||||.||.| ||.||||||  .|  |.||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM
.||||.|||||||||||||||||||||| | |.||||||||||.||||||||| |||||||||||||  .| ||||||||||||| .|.|| ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE
 | ||....|||||||.|. ||| | ..| .|||. |.|||||.|.|| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase YES.AA Src-Unclassified 277-526 53 1.5e-156 526.35 In-house 1-284 (284) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-284/284
Sequence Identity: 53% (151 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPG---TMMPEAFL--------QEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGD
..|  |||.| ||||| | | |   ||.||..||   || |||||        ||||||||.|| .|| |||| | |||.||.||.|..||||..|.||.
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKYLKLPQL------------VDMAAQIADGMAYIERMNYIHRDLRAANILVGENL-----VCKIADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|.|| .. .            ||.|||.| || | |   |.|||| | |.|.|.|      | |..|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCP--QGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL
|| |.|||||||.|||  |. |||..||||| ||||||.|||||||| |  ..||... | .|  || |||. ||||.    ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase YES.AA Pkinase_Tyr 277-526 50 1.5e-150 510.54 Pfam 1-270 (270) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-270/270
Sequence Identity: 50% (136 aa)

LRLEVKLGQGCFGEVWMGTWN-----GTTKVAIKTLKPGTMMP----EAFLQEAQIMKKL-RHDKLVPLYAVVS--EEP--IYIVTEFMSKGSLLDFLKE
...  |||.|.||||..|||.     ....||.|.||.|.| .    |.|..||.|||.| .|...| ||.|..  .||  ||||.|.| .|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
   |.. |....|..|..|||.||.| |..|.|||||.| |.||.||.|.||.||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILQTELVTKGRVP-YPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL
|.|  |..| |. | |||| | ||.|.. |.|||||||..||. ...|| .||..||..||||..|...|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase YES.AA Frk 277-530 64 3.2e-143 482.1 In-house 1-260 (260) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-260/260
Sequence Identity: 64% (168 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQL
..|  .|| | ||||| | || || ||.|||||||| |. ||.|||||||||| ||. ||||   ||||||.|| | .|||...|.  .. |. ....||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR
||||||.| ||||.| .||||||| | |.||||...|||||||||| |. |||  | .|.||.||||||||||| | .||||||||||||| ||..| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYF
.||||| |.|||..|..|||||.| .||. | |.|  ||..||..||||| .|  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase YES.AA Src-Echino1 277-526 61 6.8e-139 467.72 In-house 1-252 (252) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-252/252
Sequence Identity: 61% (156 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD
||.. |.|.| .|||| | ||| |.||.||||..|| | .|| || .|||.||. .| .||| |.. ||||||| ||.|.|.|.||.|..| .|...|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPG
| |.|| || |... |..|||| | |.|||.  |||||||||||......| ..||||.||||||||||||||||||||||||||| ||.|| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MVNREVLEQVERGYRMPCPQGCPESLHEL-MNLCWKKDPDERPTFEYIQSFL
| |||||.||.|||||| .. ||.||... |  || |||  |||||.. .|.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase YES.AA TyrKc 277-526 43 2.2e-133 450.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-280/280
Sequence Identity: 43% (123 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKL--RHDKLVPLYAVVSE--------EPIYIVTEFMSKGSLLDFLKEGDGK
..|. ||| |.||||. |||.  ..||.|.||...   |.|..||.||.||  .|. .| ||.|...        ||..||.|.|..|.|.|.|..  .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 |....|.... |||.||.|....|.||||| | |.|||||...||.||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILQTELVTKGRVPYPG-----MVNREVLEQVERGYRMPCPQG--------CPESLHELMNLCWKKDPDERPTFEYIQSFL
|||||..  |. | |  ||||     | |.||.|.|..|||||.|.         ||. ....|  ||. ||..||||. | ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase YES.AA SRM 277-527 51 1.4e-123 415.28 In-house 1-253 (253) Show / Hide 
Range on Protein: 277-527
Range on HMM: 1-253/253
Sequence Identity: 51% (131 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGT-MMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLV
  |  |||.| ||||| | | |  .||||  |    |  . . .| | |||||| ... |.||.|  .|.||.|| | ||.|. .|.. |.| |..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYP
|.| |.| ||.| |  ||||||| | |.|||.|..||..|||||||| |  |    . . |.|||||||| |. . .||||||||||  |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE
|| | | . |..||||||||  || . | ||  ||..||..||.|      | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase YES.AA TK 277-526 26 2.2e-121 408.92 In-house 1-486 (486) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LRLEVKLGQGCFG---EVWMGTWNGT--------------------------TKVAIKTLKPG-TMMPEA--------------FLQEAQIMKKLR----
..|. |||.| ||   ||..|.|.|                           |.||.|.||.| .| .|.              ||.||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVPLYAVVSEE-------------PIYIVTEFMSKGS----LLDFLK--EGDGKY-----------------------------------------
 |. .| ||.|....             |..||.|.|..|.    |.|.|.   ....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKLPQLVDMAAQIADGMAYIERM------NYIHRDLRAANILVGENLV-----------CKIADFG---
                               | ..||. |..|||.||.|....      |..|||| | |.|||||.|           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILQTELVTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|  |..| |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------REVLEQVERG--------------YRMPCPQGCP--------------ESLHELMNLCWKKDPDERPTFEYIQSFL
 |         .||.|...||              .|||.|..||              | ...||  ||..||..||||. ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase YES.AA Tec 277-528 44 1.1e-106 360.68 In-house 1-254 (254) Show / Hide 
Range on Protein: 277-528
Range on HMM: 1-254/254
Sequence Identity: 44% (113 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLP-QLV
| .   ||.| || | .| | .  .||||..| |.|  | |..||..|.|| | ||| || | |.. |||||||.|..|.||..|.|  ..  |    | 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYP
.|  ..  |||| || ..||||| | | |||.. | |..|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED
 | | || |.| .|.|.  |. |.... . |. ||.  |.|||||.   . ...
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase YES.AA S_TKc 277-530 25 2.7e-55 190.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSK--GSLLDFLKEGDG----KYLK
 ..  |.|.| ||.|. .....   .|||| .|      | ...| ||.|| .|. .| || |  .. .|.|.|...   |.|.|..|.  .    ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILQTELVTK
  .   ...||.....|. ... |||||  .|||. |  . ||.||||||..                . |||      ..  |.|.||.|..  |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQS-----FLEDYF
|. |.|     ......            .... .... |..|||..|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YES.AA Pkinase 277-526 26 1.1e-45 162.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQ-----EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKG----SLLDFLKEGDG
.... |.|.| ||.|. ... || | ||.|..|  .  ..   .     |.||||.|.|.  | || .. ..  ||.|.|.. .|    .| |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVC----KIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
. .     .. ... ||. |..|. .|. |||||  .|||. .| ..    ||.|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILQTELVTKGRVPYPGM------VNREVLEQVER-GYRMPCPQGCP-------------------ESLHELMNLCWKKDPDERPTFEYIQSF--L
|.|..  |... || |.||         ....... .  .. ..|. |.                   |.. .... |..||| .|||.| |     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF