VRK3

Species: Human
Alias: LOC51231, VRK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13,

Classification

Group: CK1
Family: VRK

Sequence

Name Sequence Type Origin Length Description Download
VRK3.NA RNA Sugen Kinome 2129 None Fasta, JSON
VRK3.AA Protein Sugen Kinome 474 None Fasta, JSON
VRK3.kin_dom Protein Kinase Domain Sugen Kinome 295 None Fasta, JSON

Protein domain

Protein domains of VRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VRK3.AA VRK 166-432 43 7.80000000001e-178 573.51 In-house 1-284 (284) Show / Hide
Range on Protein: 166-432
Range on HMM: 1-284/284
Sequence Identity: 43% (123 aa)

WKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYS------------TPLLAIPTCMGFGVHQDK
|.|.........|..|.|.|... .|....|....... ....|.||.|..|.||||||.|..||.| ..            .|.|.||.|.|||.|...
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP-PHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN

---YRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP-EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSP
   |||.|.|..||.||........|..|...|||.|||.||.||.|||||||||...|.||.... ....||.|..||.|.||||.|||..|.|..|..
GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC

HEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLP--NTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYL
|.|..||.|||.||||.|||||||..|||||..||||.|||..||.  ..|.....||||.|........|..|........||.
HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM

Kinase VRK3.AA CK1 209-449 19 4.9e-54 185.85 In-house 49-339 (339) Show / Hide
Range on Protein: 209-449
Range on HMM: 49-339/339
Sequence Identity: 19% (58 aa)

GRLFNEQNFFQRAAKPLQVNKWKK-------LYSTPLLAIPTCMGFGVHQ---DKYRFLVLPSLGRSLQSALDV--SPKHVLSERSVLQVACRLLDALEF
|... .. ..|. .|. . .|| |       . .......| .  .. |.   |.|...|.. ||..|.. ..    ... .| ...|..|...|.|||.
GQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEY

LHENEYVHGNVTAENIFVDP--------------EDQSQVTLAGYGFAF-RYCPSGKHV----------AYVEGSR----SPHEG-DLEFISMDLHKGCG
.|.. ..| .. ..|. ..               ..  || .  .|.|  .|.....|.           . .  .     .. |  ... |.. |.|. 
MHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKE

PSRRSDLQSLGYCMLKWLYGF--LPWTNCLPNTE-D---IMKQKQKFVDKPGPFVGPCGHWIRPS-----ETLQKYLKVVMALTYEEKPPYAML
..|| || |..|... || |   |||.|.  ... .   ..|.|..| |.. . . ..  .   .     . . |..|....|.|...|.|.|.
QGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI

Kinase VRK3.AA CK1-D 241-390 28 6.3e-11 34.63 In-house 57-205 (261) Show / Hide
Range on Protein: 241-390
Range on HMM: 57-205/261
Sequence Identity: 28% (43 aa)

IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG--
||.   .|   | |  .|.  || ||        ..  | . || .|  ..  .|..| ....|  .  .|  .    . . | .  .| | ||  .   
IPEIRWCGQEGD-YNVMVMDLLGPSLEDLFNYCHRK-FSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTH

KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW
.|..| |       |   . |.  |.|   ||| || |||| .. .  | |||
QHIPYRE--NKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW

Kinase VRK3.AA Ciliate-E6 252-315 30 1.1e-10 30.51 In-house 22-87 (154) Show / Hide
Range on Protein: 252-315
Range on HMM: 22-87/154
Sequence Identity: 30% (20 aa)

DKYRFLVLPSLGRSLQSALD-VSPKHVLSER-SVLQVACRLLDALEFLHENEYVHGNVTAENIFVD
..| | |.......||  .  .. |  .  .   ....| |. |.| || . ||..| | .|||.|
ENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLD

Kinase VRK3.AA CK1-A 241-449 25 1.9e-09 29.39 In-house 57-261 (261) Show / Hide
Range on Protein: 241-449
Range on HMM: 57-261/261
Sequence Identity: 25% (54 aa)

IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRY--CPSG
||.   .|  .| |  .|.  || ||     .  ..  . . || .|  ..  .|..||  ..|  .  .|  .  .    .. |  .| | .|    . 
IPHMRWYGCEKD-YNVMVMDLLGPSLEDLFNFCKRR-FTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTR

KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMA
.|. | |       |   . |.. | |   ||| |. |.||.|. .  | |||     .|      |        |    |     |.| .  |.. . .
QHIPYREDKN--LTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGF--PAE-FCMYMNYCRN

LTYEEKPPYAML
| .||.| |  |
LRFEEQPDYMYL

Kinase VRK3.AA Jak 279-319 34 8.7e-08 23.67 In-house 116-156 (299) Show / Hide
Range on Protein: 279-319
Range on HMM: 116-156/299
Sequence Identity: 34% (14 aa)

SERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ
.| ...|.|  .......|... |.||.| | || || |..
TEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGH

Kinase VRK3.AA TTBKL 241-322 21 3e-06 17.36 In-house 62-147 (288) Show / Hide
Range on Protein: 241-322
Range on HMM: 62-147/288
Sequence Identity: 21% (19 aa)

IPTCMGFGVHQDKYRFLVLPSLGRSLQSAL-DVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ----SQV
.|.|.. | ....|.|.|.  .|..||    .   |...|..... .. ..|.||  .|.. ..|  |   |. .. .|.    ...
FPKCHCSG-KRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRH

Kinase VRK3.AA CK1-Unclassified 362-397 50 9e-06 13.02 In-house 188-223 (244) Show / Hide
Range on Protein: 362-397
Range on HMM: 188-223/244
Sequence Identity: 50% (18 aa)

HKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT
|.|   ||| || ||||...  | | ||| |  .|.
HLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANN

S_TKc VRK3.AA S_TKc 152-473 9 1e-05 -92.63 SMART 1-231 (231) Show / Hide
Range on Protein: 152-473
Range on HMM: 1-231/231
Sequence Identity: 9% (34 aa)

LPTGTVL-----------TDKS-GRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLL
   . ..           ..|. ||.  .|                                        .. .| .  ..          .  .   |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------EHIRREIQILKK----------HHPNIVKLY

AIPTCMGFGVHQDKYRFLVLPSLGR---SLQSALDVSPKHV----LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFR
 .           .. ..|.  ..    .| . ..  ..|     ..|  .  ... ...|||..|..  .|  .  |||..|     .. ..  |.| .
DVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQ

YCPSGKHVAYVEGSRSPHEGDLEFISMD------LHKGCGPSR-RSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPS
.                   .    . .      |    | .. ..|  |.| ..   |.|  |.     . . ..|.                      
L-------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------

ETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQ---DLRVSPYDPIG-------LPMV
                       ... .. .||   . | .  .           | .
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase VRK3.AA Ciliate-C3 284-325 30 1.2e-05 16.6 In-house 99-140 (140) Show / Hide
Range on Protein: 284-325
Range on HMM: 99-140/140
Sequence Identity: 30% (13 aa)

LQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA
||..  .| |...|||   ||| .  .|| .  .|. ..   
LQISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF

Kinase VRK3.AA CK1-G 253-390 27 4.8e-05 12.94 In-house 69-208 (266) Show / Hide
Range on Protein: 253-390
Range on HMM: 69-208/266
Sequence Identity: 27% (39 aa)

KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD---PEDQSQVTLAGYGFAFRY--CPSGKHVAYVEGSR
||  .|.  || ||    |.   .  | ..|..||  ... .| .|. . . . |  .|  .     .||  . .  .| |  |  .  ..|..| |  .
KYNIMVMDLLGPSLEDLFDWCDRK-FSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--H

SPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW
    |   . |   | |   ||| |. .||   .  | | |||
KSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPW

Kinase VRK3.AA CK1-G 430-449 40 0.00253 7.02 In-house 247-266 (266) Show / Hide
Range on Protein: 430-449
Range on HMM: 247-266/266
Sequence Identity: 40% (8 aa)

KYLKVVMALTYEEKPPYAML
.||. |  | ..|.| |  |
TYLRYVRRLDFFECPDYDYL

Kinase VRK3.AA TTBKL 437-453 29 0.022367 3.92 In-house 272-288 (288) Show / Hide
Range on Protein: 437-453
Range on HMM: 272-288/288
Sequence Identity: 29% (5 aa)

ALTYEEKPPYAMLRNNL
.|.| . |.| |... .
SLRYYDRPDYEMIYECF

Kinase VRK3.AA CK1-D 426-449 29 0.055039 2.6 In-house 238-261 (261) Show / Hide
Range on Protein: 426-449
Range on HMM: 238-261/261
Sequence Identity: 29% (7 aa)

ETLQKYLKVVMALTYEEKPPYAML
.  |.|.  .  | ...|| |. |
SEFQQYMNYCRNLKFDDKPDYCYL

Kinase VRK3.AA TTBKL 358-410 30 0.305701 0.03 In-house 197-247 (288) Show / Hide
Range on Protein: 358-410
Range on HMM: 197-247/288
Sequence Identity: 30% (16 aa)

SMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDK
|.. | ..  .|  || |. | .   . | ||||| . ....|.. |..  |.
SPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTN-MEDKMEIEHMKKNMKDE