Gene VRK2 (Human)
VRK2
Sequence
Protein domains of VRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | VRK2.AA | VRK | 29-292 | 59 | 1.9e-202 | 653.39 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 29-292 Range on HMM: 1-284/284 Sequence Identity: 59% (169 aa) WVLGKKIGSGGFGLIYLAFP-TNKPE-KDARHVVKVE-YQENGPLFSELKFYQRVAKKDCIKKWIERKQ------------LDYLGIPLFYGSGLTEFKG |.|||.||.||||.||||.| |.||. |||..|||.| ..||||||.|..||||.||...|.||..... |..|||| ..|.|...|.| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG RSYRFMVMERLGIDLQKISG-QNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGH ..||||||.|.|.||||| |||. |...|||||..||||||||.||||||||||||||.|||. ||||||||.||||.|||||||.|.||.|.||..| EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCH NGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLK--DPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFL |||.||||.|||||.| |||||.|||||||..||.|.|||...|. ||..||.||....|..|....|..|....||||.... NGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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Kinase | VRK2.AA | CK1 | 29-309 | 25 | 1.3e-83 | 284.05 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 29-309 Range on HMM: 1-339/339 Sequence Identity: 25% (87 aa) WVLGKKIGSGGFG-LIYLAFP---TNKPEK----DARHVVKVEYQ-ENGPLFSELKFYQRVAKKDCIKKWIE------RKQLD-YLGIPLFYGSGLTEFK | ..||||.|||| ||.... .... . . . ..||| ..|........||...|. ..||| . .. .. .|.| . . .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE GRSYRFMVMERLGIDLQKISG---Q-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY--------------KNPDQVYLADYGLSY-RY .. |..|||..|| .|... . |. | ..|.|...|.||..|||.|.. ..| |||..|...|. .. .|||. |.|.. .| DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY CPNGNHK----------QYQENPR----KGHNG-TIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK--LPWEQNLKDPVA-----VQTAKTNLLDEL .....|. |. . .. ||. | |....|...|.|. ..|| |.. ..|... || |. ||| ||.||. |. .| . || RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPW-QNMKDEMKPKDHQVEKMKYEFIDEK PQSV-LKWAPSGS----SCCEIAQFLVCAHSLAYDEKPNYQAL . |. .. .. .. . | ... .|| |...|.|... KMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | VRK2.AA | CK1-Unclassified | 29-255 | 34 | 9.9e-29 | 81.93 | In-house | 1-220 (244) | Show / Hide |
Range on Protein: 29-255 Range on HMM: 1-220/244 Sequence Identity: 34% (81 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEY--QENGPLFSELKFYQRVAKKD-CIKKWIERKQLDYLGIPLFYGSGLTEFKG--RSYRFMVMER ...|||.| || ||.. .|. .. .|.| ... |. | |..|.. . | .||| | . .. . | .|||. YRVIEKIGQGSFGEIYKC--INMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNC-DNF------I-KGIPKMY----WCGQEEQGDYNIMVMDL LGIDLQKISGQNG-TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG--YKNPDQVYLADYGLSYRYC---PNGNHKQYQENPRKGHNGTIEFT || .| .. . | ||| .. |.. .||.|.. ..| ||| | | | || .|||. |.||| || .|.| .|.|| |. || .. LGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYREN--KNLTGTARYA SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLK |. ||.|. ||| | | |||... | |.||| ||.| SINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW-QNIK |
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Kinase | VRK2.AA | TTBKL | 29-313 | 25 | 9.9e-28 | 90.75 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 29-313 Range on HMM: 1-288/288 Sequence Identity: 25% (81 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLG------IPLFYGSGLTEFKGRSYRFMVME |. |.||.|||| .|.. .. ... | ..|.| ..| ...|...| .| . | | .| ...|| .. .|.||||. WMIVKMIGEGGFGQVYHVWDMKDKKDCA--AMKEE-------------KNRLEGGDSRMK-MEVHVLMKLQPNGSPHFPKCHCSGKRK----DYNFMVMT RLGIDLQKIS--GQNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYK---NPD--QVYLADYGLSYRYC-PNGNH-------KQYQENP .| .||.. .|. | ..|.. .||. |..| ..|.. ..| |.| .| .||. ... ||| |.|.. .| ..|. | . | LCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRP RK-----GHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAP----SGSSCCEIAQFLVCAHS |. . ||. ..|...| . ..| | . | . .|| ||| .|..|. . .| |..||. . | | . |..|.... | .| RNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPW-TNMEDKMEIEHMKKNMKDED---LFKDMPRDHDCPSEFCKFMKHL---RS LAYDEKPNYQALKKIL | | . |.|. . ... LRYYDRPDYEMIYECF |
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Kinase | VRK2.AA | CK1-D | 116-309 | 34 | 7.7e-27 | 91.63 | In-house | 69-261 (261) | Show / Hide |
Range on Protein: 116-309 Range on HMM: 69-261/261 Sequence Identity: 34% (69 aa) YRFMVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNG--NHKQYQENPRKGHN | |||. || | . . | ||| |. |. .|||| ....| ||| | |.| | . ||. |.||. || | | || | YNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYREN--KNLT GTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQAL || . |. |.|. ||| |.| ||| .. . | ||| | || | . | . . | |. | .|.. ...| .|.||.| | GTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW-QGLK--AATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | VRK2.AA | CK1 | 29-255 | 32 | 8e-27 | 89.49 | In-house | 1-220 (271) | Show / Hide |
Range on Protein: 29-255 Range on HMM: 1-220/271 Sequence Identity: 32% (78 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKV--EYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKG--RSYRFMVMERL .|.|||.| || |||. ... |.. .|. . ... | | |.|.. .. | ||| | . . . | .|||. | YRVGRKIGQGSFGDIYLGINMTNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNC-DN-------QCHGIPHMY----WCGQEEQGDYNIMVMDLL GIDLQ---KISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRY--CPNGNHKQYQENPRKGHNGTIEFT | .| .. .. . | ||| .. |.. .||.|.. ..| ||| | | | |. .|||. |.||. || ...| .|.|| |. || .. GPSLEDLFNFCNRKFSLK--TVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYREN--KNLTGTARYA SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLK |. .| |. ||| | | |||... | |.||| |.|| SINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW-QGLK |
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Kinase | VRK2.AA | CK1-A | 112-309 | 30 | 1e-24 | 84.18 | In-house | 65-261 (261) | Show / Hide |
Range on Protein: 112-309 Range on HMM: 65-261/261 Sequence Identity: 30% (60 aa) KGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKG ... | |||. || | . . | ||| | |. .||.|| ..| ||| | |.| . ...| |.||. .| . .. . | CEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKN HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQAL ||. . |..|| |. ||| |.| .||.|. . ||||| | .| . . | . | |. . | . .. . .| ..|.|.| | LTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPW-QGMK--AMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | VRK2.AA | TTBK | 116-309 | 30 | 4.4e-16 | 53.36 | In-house | 70-257 (257) | Show / Hide |
Range on Protein: 116-309 Range on HMM: 70-257/257 Sequence Identity: 30% (60 aa) YRFMVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQENPRK--G . .|||. .| | . |.| || |.||. .|. .| ||. . | ||| | .| .. ..|. |.|| .| | . ||. | FNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYT---NACGEVRPPREVAG HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQAL ||. . | ||. . |. | | | . . | ||| .|| | | . || |. |. ||. .|| | ..|.|| . FRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRK-IKDKDQVGEMKEKYDHRM---LLKHCPH-----EFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | VRK2.AA | CK1-G | 142-257 | 33 | 1.6e-14 | 45.56 | In-house | 97-214 (266) | Show / Hide |
Range on Protein: 142-257 Range on HMM: 97-214/266 Sequence Identity: 33% (40 aa) TVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG---YKNPDQVYLADYGLS--YRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL ||... | |.. .||.|. . . .|.| | | | |.. ... |.|. |. . . | | | .| || . | | | ||| | | | TVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--HKSLTGTARYMSINTHLGREQSRRDDMEAL GYCMLRWLCGKLPWEQNLKDP | . | |.||| | || . GHMFMYFLRGSLPW-QGLKAD |
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Kinase | VRK2.AA | Worm6 | 116-250 | 26 | 2.1e-13 | 44.77 | In-house | 77-221 (279) | Show / Hide |
Range on Protein: 116-250 Range on HMM: 77-221/279 Sequence Identity: 26% (39 aa) YRFMVMERLGIDLQKISGQN--GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY------KNPDQVYLADYGLSY--RYCPNGNHKQYQEN ....||. .| .|. . . | .| |...| .|. .| | . ..| |.|..| | .. ..|. |.|.. .|| .|| . . FNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRW PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW .. | || . .| .||| ..|. |.| | |. ...|.||| TACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPW |
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Kinase | VRK2.AA | S_TKc | 29-313 | 14 | 5.8e-11 | -16.19 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-313 Range on HMM: 1-231/231 Sequence Identity: 14% (46 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER---KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLG . ...|||.|.|| |.. .. . . .|. .. . |. |. . | .|.. . .. .|||| .. YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCD I---DLQKISGQNGT------FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEF || .. ..|. | .. . ... |||.|.. .| |.| .|.|| .. ..| ||. .. . || .. GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWY TSLDAHKGVALSR-RSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEK---PNYQALK-- . .. ..|. .| .. |||. |.. . . . . . | . | .| . .||. MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE ------KIL . WDIKCHPWF |
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Kinase | VRK2.AA | Worm6 | 29-63 | 37 | 3.6e-07 | 22.12 | In-house | 1-34 (279) | Show / Hide |
Range on Protein: 29-63 Range on HMM: 1-34/279 Sequence Identity: 37% (13 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE | ..||||.|||| .|.. . . .| . ..|.| WKVTKKIGEGGFGAVYKVEDKSDKKK-KQFAMKCE |
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Kinase | VRK2.AA | CK1-D | 29-45 | 58 | 0.000255 | 10.96 | In-house | 1-17 (261) | Show / Hide |
Range on Protein: 29-45 Range on HMM: 1-17/261 Sequence Identity: 58% (10 aa) WVLGKKIGSGGFGLIYL . .|.||||| || ||. YRIGRKIGSGSFGDIYH |
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Kinase | VRK2.AA | TyrKc | 29-298 | 17 | 0.000406 | -156.05 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 29-298 Range on HMM: 1-280/280 Sequence Identity: 17% (57 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVA----KKDCIKKWIER-----KQL--DYLGIPLFYGSGLTE---FKGR .||||.|.| || .|.. . . || |.|. .. . | ..| . | .|| ... | ITLGKKLGEGAFGEVYKGTWK----------------------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYI SYRFMVME-----RLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG-----NHKQYQE ..||| | |.| .. .. .. |. . . ||.|.. ..| |. | | |.| .. .| .| ||| |. .. ... | EPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLS-RDIYDDDQQGESKDYYRK NPRKGHN--GTIEFTSLDAHKGVALSRRSDV--------EILGYCMLRWLCGKLPWEQN----LKDPVAVQTAKTNLLDELPQS---------VLKWAPS .|| . | ... . . . ||| ||. | |. |.. ... ... |. . |.. . KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY-------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI GSSCCEI-----AQFLVCAHSL ..|.. | . . . MKQCWHEDPEDRPTFSEIHECF |
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Kinase | VRK2.AA | TTBK | 29-44 | 68 | 0.000623 | 9.82 | In-house | 1-16 (257) | Show / Hide |
Range on Protein: 29-44 Range on HMM: 1-16/257 Sequence Identity: 68% (11 aa) WVLGKKIGSGGFGLIY | |||| |||| || WKVVKKIGGGGFGEIY |
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Kinase | VRK2.AA | CK1-A | 29-66 | 39 | 0.001313 | 8.42 | In-house | 1-35 (261) | Show / Hide |
Range on Protein: 29-66 Range on HMM: 1-35/261 Sequence Identity: 39% (15 aa) WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE . | .||||| || |||. ... | | .|.| .. YRLVRKIGSGSFGDIYLGINITNGEEVA---IKMESNK |
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Kinase | VRK2.AA | Pkinase | 150-190 | 34 | 0.001313 | 13.84 | Pfam | 117-159 (293) | Show / Hide |
Range on Protein: 150-190 Range on HMM: 117-159/293 Sequence Identity: 34% (15 aa) MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQ---VYLADYGLS .| |||.|.. .| |.| .|.|. .|.. | ..| ||. ILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLA |
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Kinase | VRK2.AA | CK1 | 286-307 | 36 | 0.001425 | 8.4 | In-house | 250-271 (271) | Show / Hide |
Range on Protein: 286-307 Range on HMM: 250-271/271 Sequence Identity: 36% (8 aa) CEIAQFLVCAHSLAYDEKPNYQ .| |..| . .| ..|||.|. NEFAMYLNYCRQLHFEEKPDYM |
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Kinase | VRK2.AA | CK1-G | 287-309 | 30 | 0.00214 | 7.27 | In-house | 244-266 (266) | Show / Hide |
Range on Protein: 287-309 Range on HMM: 244-266/266 Sequence Identity: 30% (7 aa) EIAQFLVCAHSLAYDEKPNYQAL ..|..| . .| ..|.| | | QFATYLRYVRRLDFFECPDYDYL |
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Kinase | VRK2.AA | CK1-G | 29-45 | 47 | 0.003373 | 6.59 | In-house | 1-17 (266) | Show / Hide |
Range on Protein: 29-45 Range on HMM: 1-17/266 Sequence Identity: 47% (8 aa) WVLGKKIGSGGFGLIYL . ||||| | || ... YRVGKKIGCGNFGELFE |
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Kinase | VRK2.AA | Pkinase | 29-46 | 50 | 0.008344 | 11.0 | Pfam | 1-18 (293) | Show / Hide |
Range on Protein: 29-46 Range on HMM: 1-18/293 Sequence Identity: 50% (9 aa) WVLGKKIGSGGFGLIYLA ...|.|||||.|| |.. YHIGRKIGSGSFGCVYKC |
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Kinase | VRK2.AA | Worm6 | 297-309 | 23 | 0.425164 | 0.11 | In-house | 267-279 (279) | Show / Hide |
Range on Protein: 297-309 Range on HMM: 267-279/279 Sequence Identity: 23% (3 aa) SLAYDEKPNYQAL ...| ..|.|. . QYSYWDRPDYKFI |