Gene VRK1 (Human)
VRK1
Sequence
Protein domains of VRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | VRK1.AA | VRK | 37-303 | 63 | 1.9e-212 | 685.87 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 37-303 Range on HMM: 1-284/284 Sequence Identity: 63% (180 aa) WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP-SDNGPLFTELKFYQRAAKPEQIQKWIRTRK------------LKYLGVPKYWGSGLHDKNG |..|.|||||||||||||..|.......||..|||.|| ..|||||||..||||||||||||||....| |..||.|..||.|.||.|| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG KSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH ..||||.|.|||.||||||| .|..|||.||||||..|.||.|||.||.|||||||||.|.||.. |||||||||||||||||||.|.|..|||||.||| EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCH DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK--DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM .||.||||.|||.|.|||||.|||||||||..||.|.|||.|.|. ||..|.|.|.....||...|.||||.|....||.||| NGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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Kinase | VRK1.AA | CK1 | 37-320 | 24 | 2.1e-85 | 290.07 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 37-320 Range on HMM: 1-339/339 Sequence Identity: 24% (84 aa) WKVGLPIGQGGFG-CIYLADMN--SSESVG---SDAPCVVKVEPSD-NGPLFTELKFYQRAAKPEQIQKWIR----TRKLKY---LGVPKYWGSGLHDKN |||. .||.|||| .||..... .... . .. ...|||| . .|........||. .|.....|| . . |... .|.| . | .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE GKSYRFMIMDRFGSDLQKIYE---ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY--------------KNPDQVYLVDYGLAY-RY .. |..|.|...| .|... . . ..|| ||.|.. ...|. |||.|.. ..| |||..|... . .. .|||..|.|.| .| DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY CPEGVHK----------EYKEDP----KRCHDG-TIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGH--LPWEDNLK-----DPKYVRDSKIRYRENI .. . |. .... . |. . | |....||..|.|. ..|| ||. ..|..| || |. ||| . . |.. |.. | .. . RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEK ASLMDKCFPEKN-----KPGEIAKYMETVKLLDYTEKPLYENL .. . .. | | |.|. .. |.| ..| ||.. KMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | VRK1.AA | CK1-A | 122-320 | 33 | 7.6e-32 | 109.74 | In-house | 65-261 (261) | Show / Hide |
Range on Protein: 122-320 Range on HMM: 65-261/261 Sequence Identity: 33% (68 aa) NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLA--YRYCPEGVHKEYKEDPK ..| | |.|| | | .. .||. |||| | .. .||.||. ..| ||| | |. . ...|.|.||| || | .|.|| CEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYRED-- RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYE . ||. . ||.|| |. ||| |.| .||.|. . |.||| | . || . ... | | | | . ||. .. | . |.| | KNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC---KGFPAEFCMYMNYCRNLRFEEQPDYM NL | YL |
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Kinase | VRK1.AA | CK1-D | 126-320 | 33 | 4.3e-30 | 103.28 | In-house | 69-261 (261) | Show / Hide |
Range on Protein: 126-320 Range on HMM: 69-261/261 Sequence Identity: 33% (65 aa) YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGT | |.|| | | .. ..|| |||| |.. .. .|||| ....| ||| | |. | . ||..|.||| || |. .. || YNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGT IEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL . || | |. ||| ||| ||| .. . | ||| | . .| . .. . | | | | ..||. .. | . .|| | | ARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLC---KGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | VRK1.AA | CK1-G | 126-320 | 31 | 6e-26 | 84.86 | In-house | 70-266 (266) | Show / Hide |
Range on Protein: 126-320 Range on HMM: 70-266/266 Sequence Identity: 31% (64 aa) YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQVYLVDYGLA--YRYCPEGVHKEYKEDPKRC | |.|| | | .. .|| |||.... ... .||.|.|. . .|.| | | |.. ....|.|.| |. . . | | | .. YNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--HKS HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE----DNLKDPKYVRDSKIRYRENIASLMDK-CFPEKNKPGEIAKYMETVKLLDYTEKP || . || | | ||| |.| || . | |.||| ||.| .| . . . . || |.. ||| ..|.|.. | ||. |.| LTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKE-RYQKIGDTKRKTNIEDLCQNNAFPE-----QFATYLRYVRRLDFFECP LYENL |. | DYDYL |
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Kinase | VRK1.AA | CK1-Unclassified | 126-261 | 40 | 6.2e-25 | 70.53 | In-house | 78-216 (244) | Show / Hide |
Range on Protein: 126-261 Range on HMM: 78-216/244 Sequence Identity: 40% (57 aa) YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN--YKNPDQVYLVDYGLAYRYC---PEGVHKEYKEDPKRC | .|.|| |..| .. ..|| |||| . ... .||.|.. ..| ||| | | || .|||..|.||. || .| | .|.| .. YNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRE--NKN HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW || ..|| || |. ||| ||| |||..| | |.||| LTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW |
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Kinase | VRK1.AA | CK1 | 126-261 | 37 | 1e-24 | 82.17 | In-house | 79-216 (271) | Show / Hide |
Range on Protein: 126-261 Range on HMM: 79-216/271 Sequence Identity: 37% (53 aa) YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY--KNPDQVYLVDYGLAYRYC-PE-GVHKEYKEDPKRCH | .|.|| | .| . . ..|| |||| . ... .||.|.. ..| ||| | | |. .|||..|.||| || .. . | .|.| .. YNIMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRE--NKNL DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW || ..|| .| |. ||| |.| |||... | |.||| TGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW |
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Kinase | VRK1.AA | TTBKL | 124-324 | 25 | 2.2e-17 | 55.33 | In-house | 72-288 (288) | Show / Hide |
Range on Protein: 124-324 Range on HMM: 72-288/288 Sequence Identity: 25% (56 aa) KSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK---NPD--QVYLVDYGLAYRYC-PEGVH----K |.|.||.| | .||... . . ||. |.. .. ..|. | ..|.. ..| |.| .| . |. ... |||.|.|.| .| ..| . KDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIH EYKEDPKRCHD--------GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM | | .| . ||. ..|...|.. .| || . | .| . | |||. |..|.. . | . |. ... .. | | .| | ENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWT-NMEDKMEIEHMKKNM--KDEDLFKDMPRDHDCPSEFCKFM ETVKLLDYTEKPLYENLRDIL .... |.| . | || .. .. KHLRSLRYYDRPDYEMIYECF |
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Kinase | VRK1.AA | Worm6 | 126-320 | 22 | 1.4e-13 | 45.37 | In-house | 77-279 (279) | Show / Hide |
Range on Protein: 126-320 Range on HMM: 77-279/279 Sequence Identity: 22% (47 aa) YRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY------KNPDQVYLVDYGLAY--RYCPEGV--HKEY- .....| .| .|. . .. . ..|| | |.... |. .| | . ..| |.|..| . .. ..|..|.|.. .|| .| .. FNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRW KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPG-EIAKYMETVKLLDYT .. . | || . .. .|.| .|. |.| | |. ...| ||| ..||.. | . | . | .. . | ..| . . | | . |. . ..| TACGFR---GTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWR-HMKDHDHVEKHKKWCRRRTRAPMMRMFFG-PCPKEEFNDIMDYIDQYSYW EKPLYENL ..| |... DRPDYKFI |
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Kinase | VRK1.AA | S_TKc | 37-342 | 13 | 3.7e-11 | -13.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 37-342 Range on HMM: 1-231/231 Sequence Identity: 13% (44 aa) WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG .... .||.|.||. |.. .. .. . .|. . |.|.. |. .| . . |. .. . .. .|.|. . YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCD S---DLQKIYEANAKR-----FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEF || .. . . .. |. .. . |.. |||.|.| .| |.| .|.||. .. . | ||| .. | || .. GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------------TTFC--GTPWY TSIDAHNGVAPSR-RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ . .. . | .| ... |.| |.. ... ...|. . ..|.. . MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------------QMQMMFKKIG--------------------------SPEAKDFIRK GLKA-----IGSKDDGK-------LDLS |. .. . . CLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | VRK1.AA | TTBK | 223-320 | 30 | 1.7e-07 | 22.57 | In-house | 169-257 (257) | Show / Hide |
Range on Protein: 223-320 Range on HMM: 169-257/257 Sequence Identity: 30% (30 aa) GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL ||. . || || |. || | | .. . | ||| .|| | | .| . |.. | | |. .|. .| |.| ..| | . GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWR-KIKDKDQVGEMKEKY--DHRMLLKHC------PHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | VRK1.AA | TTBK | 149-204 | 39 | 5.7e-07 | 20.7 | In-house | 94-151 (257) | Show / Hide |
Range on Protein: 149-204 Range on HMM: 94-151/257 Sequence Identity: 39% (23 aa) FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN--LLLNYKNPDQVYLVDYGLAYRY || | |.| . ||. .| ||. . | ||| || . .| .. ..|..|.||| .| FSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQY |
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Kinase | VRK1.AA | Worm6 | 37-54 | 55 | 7e-05 | 13.84 | In-house | 1-18 (279) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/279 Sequence Identity: 55% (10 aa) WKVGLPIGQGGFGCIYLA |||. .||.|||| .|.. WKVTKKIGEGGFGAVYKV |
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Kinase | VRK1.AA | TTBK | 37-52 | 68 | 0.00011 | 12.52 | In-house | 1-16 (257) | Show / Hide |
Range on Protein: 37-52 Range on HMM: 1-16/257 Sequence Identity: 68% (11 aa) WKVGLPIGQGGFGCIY ||| ||.|||| || WKVVKKIGGGGFGEIY |
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Kinase | VRK1.AA | TyrKc | 37-303 | 13 | 0.000339 | -154.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 37-303 Range on HMM: 1-280/280 Sequence Identity: 13% (46 aa) WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR-TRKLKYLG-----VPKYWGSGLHDKN-----GKS . | .| | || .|.. .. .. ||. .| .. .| | .. || . . | .... . ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG-----VHKEYKE----D . | | ||.. .. .... |. |. .. | . ||.|.. ..| |. | | |.. .. .| | ||. |. .. .. |. . MIVMEYMPHG-DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKG PK--------------RC-------------------------HDGTIE--FTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK | . . | |. . ..... | .| . .| . . GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMS--------------------F- IRYRENIASLMDKCFPEKNKP----GEIAKYM . . . ..| .| |. . || ... VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | VRK1.AA | CK1 | 37-54 | 61 | 0.000515 | 9.94 | In-house | 1-18 (271) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/271 Sequence Identity: 61% (11 aa) WKVGLPIGQGGFGCIYLA .|| |||| || |||. YRVGRKIGQGSFGDIYLG |
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Kinase | VRK1.AA | CK1-Unclassified | 37-54 | 50 | 0.000658 | 7.44 | In-house | 1-18 (244) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/244 Sequence Identity: 50% (9 aa) WKVGLPIGQGGFGCIYLA .|. |||| || ||.. YRVIEKIGQGSFGEIYKC |
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Kinase | VRK1.AA | CK1 | 293-318 | 37 | 0.001192 | 8.67 | In-house | 245-271 (271) | Show / Hide |
Range on Protein: 293-318 Range on HMM: 245-271/271 Sequence Identity: 37% (10 aa) KN-KPGEIAKYMETVKLLDYTEKPLYE |. | | | |.. .. |.. ||| |. KGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | VRK1.AA | TTBKL | 37-59 | 34 | 0.001209 | 8.26 | In-house | 1-23 (288) | Show / Hide |
Range on Protein: 37-59 Range on HMM: 1-23/288 Sequence Identity: 34% (8 aa) WKVGLPIGQGGFGCIYLADMNSS |.. ||.|||| .|.. . .. WMIVKMIGEGGFGQVYHVWDMKD |
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Kinase | VRK1.AA | Pkinase | 124-201 | 28 | 0.00405 | 12.11 | Pfam | 72-159 (293) | Show / Hide |
Range on Protein: 124-201 Range on HMM: 72-159/293 Sequence Identity: 28% (25 aa) KSYRFMIMDRF-GS----DLQKIYE-ANAKRF--SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ---VYLVDYGLA |.. |.|. | || . . . ..| | ... . || |||.|.. .| |.| .|.|.. .|.. | . | ||| KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLA |
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Kinase | VRK1.AA | CK1-G | 37-53 | 41 | 0.031116 | 3.27 | In-house | 1-17 (266) | Show / Hide |
Range on Protein: 37-53 Range on HMM: 1-17/266 Sequence Identity: 41% (7 aa) WKVGLPIGQGGFGCIYL ..|| || | || ... YRVGKKIGCGNFGELFE |
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Kinase | VRK1.AA | CK1-D | 37-62 | 37 | 0.034871 | 3.31 | In-house | 1-27 (261) | Show / Hide |
Range on Protein: 37-62 Range on HMM: 1-27/261 Sequence Identity: 37% (10 aa) WKVGLPIGQGGFGCIYL-ADMNSSESV ...| || | || ||. ..... | | YRIGRKIGSGSFGDIYHGTNIQTNEEV |
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Kinase | VRK1.AA | CK1-A | 37-54 | 44 | 0.040409 | 3.08 | In-house | 1-18 (261) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/261 Sequence Identity: 44% (8 aa) WKVGLPIGQGGFGCIYLA ... .|| | || |||. YRLVRKIGSGSFGDIYLG |
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Kinase | VRK1.AA | Pkinase | 37-54 | 44 | 0.058859 | 8.0 | Pfam | 1-18 (293) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/293 Sequence Identity: 44% (8 aa) WKVGLPIGQGGFGCIYLA ...| .||.|.||| |.. YHIGRKIGSGSFGCVYKC |