Gene TXK (Human)

TXK

Species: Human
Alias: TXK, PTK4, RLK, TKL, PSCTK5, MGC22473, BTKL
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4p11,

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
TXK.NA RNA Sugen Kinome 2914 None Fasta, JSON
TXK.AA Protein Sugen Kinome 527 None Fasta, JSON
TXK.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of TXK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 TXK.AA SH3 85-141 39 1.1e-16 62.64 SMART 1-58 (58) Show / Hide 
Range on Protein: 85-141
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

IQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDR-LGNEGLIPSNYVTENK
 .|.||||. ...|  | ... . ...||| ...|||.| .  |.||..|||||.| .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 TXK.AA SH3_1 88-134 32 3.1e-16 57.71 Pfam 1-49 (49) Show / Hide 
Range on Protein: 88-134
Range on HMM: 1-49/49
Sequence Identity: 32% (16 aa)

KALYDFLPREPCNLALRRAEEYLILEKYNP-HWWKARDRLGN-EGLIPS
.||||. ...|  | ... ... ..|| .  .|||.|.  .. ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH2 TXK.AA SH2 150-231 38 3.2e-42 125.78 Pfam 1-81 (81) Show / Hide 
Range on Protein: 150-231
Range on HMM: 1-81/81
Sequence Identity: 38% (32 aa)

WYHRNITRNQAEHLLRQ-ESKEGAFIVRDSR-HLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYH
|||..|.|..||.||.. . ..|.|.||.|. . |.||.||. . .   .  .|||.|...| |..|...|| |.|..||....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 TXK.AA SH2 148-237 40 8.2e-35 122.89 SMART 1-87 (87) Show / Hide 
Range on Protein: 148-237
Range on HMM: 1-87/87
Sequence Identity: 40% (38 aa)

YEWYHRNITRNQAEHLLRQE-SKEGAFIVRDSRH-LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAE--RHAFQSIPELIWYHQHNAAG
..||| ||.| .||.||...  ..|.|.||||..  |.|..||. .        .|||.|..||.|..|..|  |. |.|. ||. ..|||. |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase TXK.AA Tec 271-522 72 1.7e-214 718.88 In-house 1-254 (254) Show / Hide 
Range on Protein: 271-522
Range on HMM: 1-254/254
Sequence Identity: 72% (185 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEM--LL
|.|.||.|||||||||||.||....||||.|.|||||||||||||||||||||.|||||||||.|..|.|||||.||.|||||||||.|....|.|  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

SVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFE
..|||.||||.||||...||||||||||||...|.||.||||||||||||.|.||.|.|||.||.||||| ...||||||||.|||||||||..||||.|
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

NKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTE
|.||..|||..|.|.|||||||..|.||..||.|||||||.||||..|||..||
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase TXK.AA Pkinase_Tyr 271-520 47 6.30000000001e-147 498.24 Pfam 1-270 (270) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-270/270
Sequence Identity: 47% (127 aa)

LAFIKEIGSGQFGVVHLGEWR-----SHIQVAIKAINEGSMSE----EDFIEEAKVMMKL-SHSKLVQLYGVCI-QRKP--LYIVTEFMENGCLLNYLRE
. |.|..|.|.||.|..|.|.      .|.||.| ..||.|.|    |||..|||.|..| .| ..|.|||||. |..|  .|||.|.|..|.||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYV-LDDEY-VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSF
.   |..|  ..||. |..|..||||||....||||||||||||... .|||.|||..|..  ||.| ... |.|.|||| .||.. ..|...|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEVFTEGKMP-FENKSNLQVVEAI-SEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAV
||||||.|| |..| ... || .|.|.|  .| |. .|...|  ||..| .|||..|| ||||.|...  
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TXK.AA TyrKc 271-520 42 1.8e-136 460.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKL--SHSKLVQLYGVCIQR-------KPLYIVTEFMENGCLLNYLRENKGK
. ..|..|.|.||.|..|.|.  ||||.| ..|..  .|||..||..|.||  .|  .|.|||||.|        .||.||.|.|..|.|..|||....|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDD--------EYVSSF--GAK--FPIKWSPPEVFLFNKYSSKSDV
|  . ||| | .|..|||||.....||||||||||||..  .|||||||..|.. ||         |...   |.|  .||.| .||.. ..|...||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGVLMWEVFTEGKMPFEN-----KSNLQVVEAISEGFRLYRPHL--------APMSIYEVMYSCWHEKPEGRPTFAELLRAV
|||||.|||.|| |..| ..     .|| .|.| . .|.|. .|.         .|  .|..| .||||.|| ||||.|. .  
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TXK.AA Src 271-520 45 5.5e-122 411.56 In-house 1-255 (255) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-255/255
Sequence Identity: 45% (116 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLR-ENKGK-LRKEMLL
. .....|.|||| |  | |. ...||.| . .|.|| |.| .||..| ||.| |||||| || | .| |||||.|..|.|| ||. . .|. |. . |.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

SVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVL--DDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMP
.    . |||.|||.. |||||||||| ||. . ..|. |||  | .   ||||... ||||||||  || ....... ||||||||.|..|..| |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

FENKSNLQVVEAISEGFRLYRPHLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAV
 .  .| .|..... |.|. .||  | ..|| .|  |||..|| ||||. |    
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TXK.AA TK 271-520 23 2.9e-117 394.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

LAFIKEIGSGQFG---VVHLGEWRSH--------------------------IQVAIKAINEG-SMSEEDFIE--------------EAKVMMKLS----
. ..|..|.||||   .|..||||..                          ..||.| . || .||.|.|..              || .|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSKLVQLYGVCIQR------------KPLYIVTEFMENGC----LLNYLRENKGK--------------------------------------------
 |  .|.||||| |             .|..||.|.|..|.    |..|||....|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRKEMLLSVCQDICEGMEYLERN------GYIHRDLAARNCLVSSTCI-----------VKISDFGMT-
                               |  . ||  |..|..|||||...      ...|||||||||||..  .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RYV-LDDEYVSSF------------------------GAKFPIKWSPPEVFL---------FNKYSSKSDVWSFGVLMWEVFTEG-KMPFENK
       |..  ||.|...                         |.|.||.| .||...         ..|...|||||||||||||.|| | ... .. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------LQVVEAISEG--------------FRLYRPHLAP--------------MSIYEVMYSCWHEKPEGRPTFAELLRAV
||          .|.| . .|              .|. .| ..|                .|..| .|||..|| ||||..|... 
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TXK.AA SFK-Src 271-524 44 3.9e-110 327.69 In-house 1-259 (259) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-259/259
Sequence Identity: 44% (114 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLS
 .  |  |||||| |  | |    .||.|    |.||.| | .|| || || | .|.||| ||    |.||.|| | .| || ||.| .|. ||   |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

VCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVL-DDE-YVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPF
   ..  || ||| . ..|||||||| ||    ..|. |||| | .  ||| |    ||||||||  ||  . |..| ||||||||.|| |. | | .|.
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

ENKSNLQVVEAISE--GFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIA
.  .|  |.  .    | |.  |   |   |..|  || ..|. ||||  |.    .  
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase TXK.AA Src-Unclassified 271-520 38 1.1e-100 340.81 In-house 1-284 (284) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-284/284
Sequence Identity: 38% (110 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEG---SMSEEDFI--------EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENK
.  ....| |||| | .| ||  . ||.|   .|    || | |         .||..| |..| .||.||.|| | .| ||.||.| || || .|||  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKLRKEMLL-------------SVCQDICEGMEYLERNGYIHRDLAARNCLVSSTC-----IVKISDFGMT--RYVLDDEYVSSFGAKFPIKWSPPEVFL
|..    ..             ..   .  ||.||| ..|.|||||||| |.         .||. |||    . . ||.|.   ||.||.||  || |.
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRP--HLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAV
  . | ||||||.|.| ||..| |. |     |  |.| .. |.|. .|  |. | .||| .|  |||. |. ||||  |    
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase TXK.AA SrcB 271-522 45 6.2e-97 328.33 In-house 1-251 (251) Show / Hide 
Range on Protein: 271-522
Range on HMM: 1-251/251
Sequence Identity: 45% (116 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLS
| ..| .|.|||| | .| .. |..||.|.. .|.|| | |..|| || .| | .||.|| |  .  |.||.||.|..|||| .|. ..| ||  . |. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

VCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFEN
.   | ||| |.||  |||||| | | ||| | . || |||. | . |.||    ||||||||  ||   |  .  ||||||||.|. |. | |..|.  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

KSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTE
..| .|......|.|. ||   |  .|..|  ||.|.|| |||| . |..| .
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTF-DYLQSVLD
Kinase TXK.AA UTK 271-520 34 5.2e-96 325.26 In-house 1-296 (296) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-296/296
Sequence Identity: 34% (101 aa)

LAFIKEIGSGQFGVVHLGEWR------SHIQVAIKAINEGSM---SEE---DFIEEAK---VMMKLS-HSKLVQLYGVCIQRKPLYIVTEFMENGCLLNY
... ...|.|.||.||.....         .||.|. .....   ..|   ||.|||.   .|.... | ....|.||| | .|..||||.|||| |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRENKG-------KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSST-------CIVKISDFG---MTRYVL---------DDEYVSSFG-AK
|| ..         |... .|. . || .||.||.. |..||||||||||| .         ..||.|||   |.|.|          ...|. . .  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWSPPEVFLFN-KYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEG--FRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAV
 ||.|  ||..  . ....|||||||||..||..| |..|... || ||......|   |. .|.  |...|..| .|||  |. ||.| .|. ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TXK.AA SrcA 271-521 45 7.3e-96 303.41 In-house 1-250 (250) Show / Hide 
Range on Protein: 271-521
Range on HMM: 1-250/250
Sequence Identity: 45% (114 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLS
.. .. .| |.|| | .| |    .|||| .  | || | |.|||..| || | |||||| | .   |.|||||.|  | || .|....|| |.   |  
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAV-VSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

VCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFEN
.   . ||| |.||  |||||| | | ||    | || |||. | . |.|| .  ||||||||  ||  |. ..  ||||||||.|. |. | |..|.  
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

KSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVT
  |  |.| . .|...  |   | |..|.|  ||.  || |||| | | .  
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTF-EYLQSFL
Kinase TXK.AA Abl 271-520 45 5.2e-94 314.02 In-house 1-252 (252) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-252/252
Sequence Identity: 45% (114 aa)

LAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLL
.   . .| ||.| |  | |. |   ||.|.. | .|  ..|..|| .| .. |  |||| ||| .  | ||.|||| .| ||.|||| .. .|   .||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

SVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFE
 .   |  ||.|||.. .||||||||||||.   |||. |||..| . || |    ||||||||  ||   .||.||||||| ||||.||. | |  |. 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

NKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAV
     .| . . .|.|. ||.  | ..||.|  ||. ..  ||.|.|. .|.
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase TXK.AA Frk 271-524 43 6.2e-93 315.06 In-house 1-260 (260) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-260/260
Sequence Identity: 43% (114 aa)

LAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLR--ENKG-KLRKEML
. .|...|||||| |  | |   . ||.| .  |.|  .||. ||..| || |.||.||| ||   .|.||.|| |..| |..||.  ..|| ... ..|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR-YVLDDE--YVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGK
. .   .  || |||   |||||||||| ||    |.|| |||. |  . |.|  | |  ||.|||||  ||    ||.. ||||||||.|. |. | |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIA
||.    | .|.. ...|.|. .|   |  .||.|  |||..|. ||||  |   . .  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TXK.AA S_TKc 271-524 24 7.6e-53 182.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

LAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMEN--GCLLNYLRENKGK-----L
  ....||.| ||.|... ... . .|||| |.      |... | ....|  |  .|.||.|.   . ||.|.|....  | |. |.......     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS-KSDVWSFGVLMWEVFT
   .  .... ||...||. ..| |||||   | |...   .||.|||. | .                . .|||.   .|.  |.|.||.|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

EGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLR-----AVTEIA
 |. ||.     .. . |            . .  . .  |..  || |||  |.|.     .  .  
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TXK.AA Pkinase 271-520 22 1.7e-43 154.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIE-----EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENG----CLLNYLR-ENK
. ... |||| ||.| .. ...  ..||.| |.  . ...  ..     |...| .|.|   |.||...  .. .|.|.|..|.|     |  |.. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL--RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV----KISDFGMTR---YVLDDEYVSSFGAKFPIKWSPPEVFL-FNKYSSKSDV
|..    . . ...  |..|.||. ..| |||||   |.|..... .    ||.|||  .   |  .  . .  |  .   . .||| .  ..|..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGVLMWEVFTEGKMPFENK------SNLQVVEAISE-GFRLYRPHLAP-------------------MSIYEVMYSCWHEKPEGRPTFAELLRA--V
||.|....|... |. || ..      . .|... | .  ..  .| . .                    .  .....|.. .|. |||....|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF