Gene TTBK1 (Human)
TTBK1
Sequence
Protein domains of TTBK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | TTBK1.AA | TTBK | 34-289 | 83 | 1.3e-220 | 739.18 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-257/257 Sequence Identity: 83% (215 aa) WKVLKKIGGGGFGEIYEAMDLLTR-ENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL |||.||||||||||||||.|.... |.||.||||||||||||||||||||||||.||||||||||||.||||.||||||.|||||||.||||.|.||||| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEF |||.|||.|||.||||||||||||||||||||.|||.||||||||||||||||..|.|||||.||||||||||||.|||.|||||||||||||||||||| RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF AVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLI ..|||||||||||.|||..||||.|||||||.|.|||.|.|||.||.|...|||||| VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | TTBK1.AA | CK1 | 34-289 | 34 | 1.6e-125 | 423.32 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-339/339 Sequence Identity: 34% (116 aa) WKVLKKIGGGGFG-EIYEA-----MDLLTR-----ENVALKVESAQQPKQ-VLKMEVAVLKKL---------------------QGKDHVCRFIGCGRNE ||| ||||.|||| .||.. .|. . | .|.|||.... .| ..||.....|. .|. |.|... .|... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED K-FNYVVMQLQGRNLADLRR--SQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPS------------TYRKCYMLDFGLAR-QYT . .||.||.| |.|| |||. .... |...|.|... |.||..| .|. ||.||||||.||.||| .| ..|. ||.|||.|| .|. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR NTTGDV------------RPPRN---VAGFRG-TVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ--LPWRKIKDKEQ-----VGMIKEKYEHRMLL . |.. ||||. .|||| |.||.|.|.|...|.||.|||||.||||.|. .|. |||...||... |.. |... ..... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM ------------KHMPSEFHLFLDHIASLDYFTKPDYQLI ...|.|| ....| ||.|...|||. | STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | TTBK1.AA | Worm6 | 34-289 | 41 | 6.2e-113 | 381.49 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-279/279 Sequence Identity: 41% (115 aa) WKVLKKIGGGGFGEIYEAMDLLTREN--VALKVES--AQQPKQVLKMEVAVLKKLQGKD--HVCRFIGCGRNEK--FNYVVMQLQGRNLADLRRSQPRGT |||.|||| |||| .|.. | . .. .|.|.|. .. ..|.||||..|||.. . |.|... .|. .. |||.||.| |.||.|||. .| . WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRL----PSTYRKCYMLDFGLAR--QYTNTTGDVRPPR-NVAGFRGTVRYASVNAHKNREMGR |...|.|... | ||.|| |..||.|||.||.||. || ... ||||||..| .| |. ...|.|| ...|||||||||....||..|..| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR HDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK--YEH-----RMLLKHMPS-EFHLFLDHIASLDYFTKPDYQLI ||. | |||.||. ||.||||..||. .|. .|.. .. ||... | || .| | ...|...|||. | KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | TTBK1.AA | TTBKL | 34-293 | 38 | 1e-111 | 377.46 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 34-293 Range on HMM: 1-288/288 Sequence Identity: 38% (111 aa) WKVLKKIGGGGFGEIYEAMDLLT-RENVALKVESAQQPK--QVLKMEVAVLKKLQ--GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGT-FT |.. |.||.||||..|...|. . . |.|.|. .. . ...|||| ||.||| |. |.......|.....|..||.| |.|| |||. |.. |. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPST---YRKCYMLDFGLARQYTNTTGDV-----------RPPRN---VAGFRGTVRYASVNA .|..|.| |.|... .|..||.|||.||.|...| .. | | .|||.|||| . |. |.||| |.||||.||.|.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKH------MPSEFHLFLDHIASLDYFTKPDYQLIMSVF | .| ||||||||..||..|...| |||. ..||.... |.. . | | .|||| | |. ||.| |||. |. .| HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | TTBK1.AA | CK1 | 34-287 | 35 | 2.7e-66 | 226.54 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 34-287 Range on HMM: 1-271/271 Sequence Identity: 35% (96 aa) WKVLKKIGGGGFGEIYEAMDLLTREN---VALKVESAQQPKQVLKMEVAVLKKLQG------KDHVCRFIGCGRN--EKFNYVVMQLQGRNLADLRRSQP .| .||| | ||.||..... | .. || |.|.. . . |. |. ..| ||| .. . . ||.. ...|..|| | |..| || YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYT-NTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDD | |.| |.| .. |... || .|. .|.|||||| || ||| ..|. ||||| .| |. | |. .. ||.||||.|.| .| .| || R-KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD LWSLFYMLVEFAVGQLPWRKIKDK------EQVGMIKEKYEHRMLLKH-MPSEFHLFLDHIASLDYFTKPDYQ . || |.|. |. |.||| .| . |. ...| .. . .| | |.||. .| .. .|... ||||. MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | TTBK1.AA | CK1-Unclassified | 34-256 | 38 | 7.6e-66 | 193.32 | In-house | 1-229 (244) | Show / Hide |
Range on Protein: 34-256 Range on HMM: 1-229/244 Sequence Identity: 38% (91 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD-------HVCRFIGCGRNEK--FNYVVMQLQGRNLADLRRSQPRG .|..||| | |||||..... | |.||.|.|.. . |. |. ... ||. .. . . ||..|. .|..|| | |..| || . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFN-MCNR TFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYT--NTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDL |.| |.| .. |... || .|. .|.|||||| || ||.| . ..|. ||||. | || | |. .. || ||||.|||. | .| ||| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL WSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYE || | |. |. |.||| || ... ||||| ESLGYVLIYFLKGSLPWQNIKANNK----KEKYE |
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Kinase | TTBK1.AA | CK1-D | 34-289 | 37 | 1.9e-52 | 180.53 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-261/261 Sequence Identity: 37% (98 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLR ... .|||.| ||.|| .. | | ||.|.|... |..| . | .|| . . ||.. .| .||.| | | || | | | | | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR-KFSLKTVLM LGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTT-GDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEF |. |.. || ||. |.|||||| || || | |..|||||..| . | | || ||||.| |. | | ||| || |.|. | LADQMICRIEYIHCRNFIHRDIKPDNFLMG-LGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF AVGQLPWRKIK---DKEQVGMIKEK---YEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLI . | ||| .| ... | || . | | .|||| .... .| . |||| . NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | TTBK1.AA | CK1-A | 34-289 | 35 | 2e-51 | 177.13 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-261/261 Sequence Identity: 35% (93 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLR .....||| | ||.|| .. . |.||.|.||.. | | | . ||| . . |.. .| .||.| | | || | ||. | | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR-RFTMKTVLM LGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVR-PPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEF | |.. || .| .|.|||||| || || . | ...|||||..| | |. ||.||||.||| | | ||. |. |... | LADQMIMRIEYVHEKNFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF AVGQLPWRKIK---DKEQVGMIKEKYEH---RMLLKHMPSEFHLFLDHIASLDYFTKPDYQLI |.||| .| | . | || .| | .|.|| ... .. .| . .||| . NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | TTBK1.AA | CK1-G | 34-289 | 33 | 1.9e-41 | 138.2 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 34-289 Range on HMM: 1-266/266 Sequence Identity: 33% (90 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLS ..| |||| | |||..| ... | || | | . |. | | | |. .| | || |.| || | | | || | .|.. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCG---KYNIMVMDLLGPSLEDLFDWCDR-KFSVK TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPS-TYRKCYMLDFGLARQYTN-TTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFY |.. . .|... .|..|| . ||.|| || || . . .. .. |||.|.|| |. | | || || |.| | || | ||. .| TVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGH MLVEFAVGQLPWR-----KIKDK-EQVGMIKEKYEHRMLLKH--MPSEFHLFLDHIASLDYFTKPDYQLI | | |.||| | . . .|. | | |.. .| .| .| . .||.| .||| . MFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | TTBK1.AA | Dual | 34-293 | 26 | 2.9e-38 | 126.19 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 34-293 Range on HMM: 1-282/282 Sequence Identity: 26% (76 aa) WKVLKKIGGGGFGEIYEAMDLLT----RENVALKVESAQQPKQVL--KMEVAVLKKLQG---------KDHVCRFIGCGRNE--KFNYVVMQLQGRNLAD ||| . .| |||...| . . ..||.|| | | | |. | .| . .. |. | | | .|.|| . | | . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTN-TTGDVRPPRNVAGFRGTVRYASVNAHKNRE || | .. .. . | |..| ||.|.|||.|||.||. | | . ||.||...| | .. .|..| . |. |||. . .. IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG-LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKD MGRHDDLWSLFYMLVE-FAVGQ-LPWRKIKDKEQVGMIKEKYEHRMLLK---HMPSEFHLFLDHIASLDYFTKPDYQLIMSVF || ||| . ||. . . ..||| | . |. . . | | .. .. . .. | . ||| .. QGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | TTBK1.AA | S_TKc | 34-308 | 20 | 7.9e-23 | 83.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 34-308 Range on HMM: 1-231/231 Sequence Identity: 20% (60 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGR---NLADLRRSQPRGT----F ...|.||| |.||. | . . | . ||.|. . . .. |...||| . ......... .. .. |.|| . . .| |. ....|. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF TLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGR-HDDLWSL . .. .. .||.. .| .|| |..|||.||.| . . |||||||. | || | . |. | ||. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC FYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKER---GIAE-------NEAF .| |...|. |.. |. |. .| ... ..|. .. ..| . . . | GCILYEMLCGYPPFP------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | TTBK1.AA | Pkinase | 34-160 | 25 | 1.4e-22 | 80.93 | Pfam | 1-139 (293) | Show / Hide |
Range on Protein: 34-160 Range on HMM: 1-139/293 Sequence Identity: 25% (36 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM------EVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRN--LADLR----RSQ .....||| |.||. |.... |.. ||.|. . . | .. |....|.| . ....|.... .... |.|| . . ..|| . . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W PRGTF--TLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNF .|.| . . . .|||. .| .|| |..|||.||.|. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI |
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Kinase | TTBK1.AA | TyrKc | 34-293 | 19 | 8.3e-09 | -80.27 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-293 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKL-QGKDHVCRFIGCGRNE-------KFNYVVMQL-QGRNLADLRRSQPRG . .||.| | |||.|... ..|| |. . .. . | ...|| ... |..|. . . . ..|| . . .| | |. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK TFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNT--TGDVRPPRNVA----GFR--GTVRYASVNAHKNREM ..... | || . | .|| .. |||. | |. . ||||.| .. .| .. .. | . .| . . . .. -LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF GRHDDLWSLFYMLVE-FAVGQLPWRK-----IKDKEQVGMIKEKYEHRMLLK-------HMPSEFHLFLDHIASLDYFTKPDYQLIMSVF | || .. | | || |. ....| . .|. | . ..|.| . | | . | . | TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | TTBK1.AA | Pkinase | 176-240 | 27 | 2e-06 | 24.18 | Pfam | 155-213 (293) | Show / Hide |
Range on Protein: 176-240 Range on HMM: 155-213/293 Sequence Identity: 27% (18 aa) DFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHK-NREMGRHDDLWSLFYMLVEFAVGQLPWR |||||.|. . . .| || .|.. .. ... |. | ||. .| |.. |..|.. DFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP |