Gene TRKC (Human)

TRKC

Species: Human
Alias: TRKC, gp145(trkC), NTRK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 15q26,

Classification

Group: TK
Family: Trk

Sequence

Name Sequence Type Origin Length Description Download
TRKC.NA RNA Sugen Kinome 2860 None Fasta, JSON
TRKC.AA Protein Sugen Kinome 839 None Fasta, JSON
TRKC.kin_dom Protein Kinase Domain Sugen Kinome 286 None Fasta, JSON

Protein domain

Protein domains of TRKC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT TRKC.AA LRRNT 31-58 29 4.5e-07 28.92 Pfam 1-31 (31) Show / Hide 
Range on Protein: 31-58
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ACPANCVCS--KTEINCRRPDDGNLFPL-LE
.||..|.|.  .|...|.... .| .|  | 
QCPRPCHCHHDHTHVYCSDRNLTNHVPRDLP
LRRNT TRKC.AA LRRNT 31-63 21 1e-06 29.16 SMART 1-38 (38) Show / Hide 
Range on Protein: 31-63
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

ACPANCVCS---KTEINCRRPDDG-NLFPL-LEGQDSG
.||..|.|.    |...|...  . | .|. . .. . 
QCPRPCHCHPDFHTHVYCDDRNLTWNEVPRDIPPDTTY
LRR_1 TRKC.AA LRR_1 104-126 25 7.041011 3.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 104-126
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

GLQKLTIKN-S--GL-RSIQPRAFAKN
 ||.| . .     | ..|.|..| . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 TRKC.AA LRR_1 128-150 29 0.001299 16.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 128-150
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLRYINLSS-N--RLT-TLSWQLFQTL
.|....||. |  .|| ...   |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRRCT TRKC.AA LRRCT 160-208 27 2.9e-13 51.31 SMART 1-55 (55) Show / Hide 
Range on Protein: 160-208
Range on HMM: 1-55/55
Sequence Identity: 27% (15 aa)

NFFNCSCDIRWMQLWQEQ--GEAKLNSQ-NLYCINADGSQL-PLFRMN--ISQCD
| .||.|..||.|.|..|   .. . .| ...| . .  .  |||...   ..|.
NPWNCDCHLRWFQRWLQQQHNRHVQDPQSDMRCASPEHMRGQPLFHYLHSDFKCP
IG TRKC.AA IG 216-302 23 3.3e-11 44.5 SMART 1-58 (58) Show / Hide 
Range on Protein: 216-302
Range on HMM: 1-58/58
Sequence Identity: 23% (21 aa)

HVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN--GFTLTCIAENVVGMSNA--SVALTVY
   .||.||.....||  |      . |                        ||. ||. ||   . | .| |.   |.  .  .. |||.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 TRKC.AA IGc2 222-291 31 5.9e-05 22.41 SMART 1-56 (56) Show / Hide 
Range on Protein: 222-291
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

REGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG
.||.....||  .|.| |.. |.    |...           .   ||. ||| || | . ||.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP-----------WNWTLTIKNVTPEDSG-YYTCYARNPWG
I-set TRKC.AA I-set 210-243 32 0.000205 17.49 Pfam 1-34 (92) Show / Hide 
Range on Protein: 210-243
Range on HMM: 1-34/92
Sequence Identity: 32% (11 aa)

PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW
|...    ...|.||. |  .|. .|.| |.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSW
I-set TRKC.AA I-set 283-301 42 0.341636 6.56 Pfam 74-92 (92) Show / Hide 
Range on Protein: 283-301
Range on HMM: 74-92/92
Sequence Identity: 42% (8 aa)

TCIAENVVGMSNASVALTV
||.|.| .| . ... |||
TCVATNSFGEAECTAELTV
I-set TRKC.AA I-set 325-352 44 7e-06 22.55 Pfam 24-52 (92) Show / Hide 
Range on Protein: 325-352
Range on HMM: 24-52/92
Sequence Identity: 44% (13 aa)

VRGNPPPTLHWLHNGQPLRE-SKIIHVEY
|.|.|||.  |...|||||. |. ... |
VTGDPPPQVSWFKDGQPLRPDSDRHQMTY
I-set TRKC.AA I-set 374-392 42 1.327141 4.56 Pfam 71-89 (92) Show / Hide 
Range on Protein: 374-392
Range on HMM: 71-89/92
Sequence Identity: 42% (8 aa)

GNYTLIAKNPLGTANQTIN
| || .|.|..|.|  |..
GKYTCVATNSFGEAECTAE
Kinase TRKC.AA Trk 538-824 77 1.7e-220 738.79 In-house 1-275 (275) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-275/275
Sequence Identity: 77% (224 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAM
||||.||||||||||||||||||.|..|||.||||.|||.. .|||||||||||||||||.|||||||||.|.|||.|||||||||||||.||.||||||
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM

ILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS-TDYYRLFNPSGNDFCIWCEVGGHTMLPIRW
.....|||||.|.|...|||.||.||||||||.|||||||||.||||||||.||.|||||||||||||| |||||              ||.||||||||
CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYR--------------VGHHTMLPIRW

MPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL
||||||||||||.|||||||||..||.||||||||.||||.||||||.|||. |||||.||.||||.||||||||||||.|||.|..|.
MPPESIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase TRKC.AA TyrKc 538-824 42 1.4e-139 470.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-280/280
Sequence Identity: 42% (135 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNL--QHEHIVKFYGVCGDG-------DPLIMVFEYMKHGDLNKF
|.|...|||||||.|.... .        . |||| ||. .   |.|| |||.....|  .|..||..|||| ..       .|| .|.|||.||||...
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST-------DYYRLFNPSGNDFC
||.|.|.               | ....|... |||.|| ||.|....|||||.||||||.|. |||.|||.|||.|.        ||||          
LRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYR----------

IWCEV----GGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ-----LSNTEVIECITQGRVLERPRV--------CPKEVYDVML
    .    ||.||||||||.||.|.|.||||.|||||||| .|||||||.||.       .||.||||.. ||. ...|          ||.|.|..|.
----KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

GCWQREPQQRLNIKEIYKIL
 ||...| .| . .||....
QCWHEDPEDRPTFSEIHECF
Kinase TRKC.AA Pkinase_Tyr 538-824 43 3.7e-137 465.13 Pfam 1-270 (270) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-270/270
Sequence Identity: 43% (130 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA---RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDP--LIMVFEYMKHGDLNKFLR
|.. ..|||||||.|......  .| ..|. |||| ||. .      |.|| |||.....| .|..||..||||  .|.|  ...|.|||.|||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHT
.|               |. | ....|... |||.|| ||.|....|||||.|||||. |. |||.|||..||.|..||| .             ..|..
KHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-Y------------RKRGGG

MLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP-WFQLSNTEVIECI-TQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL
.|||.||.||.|.|.||||.|||||||| .|||||||.|| .  .||.||.| |  .|. ...|. ||.|.||.|. ||. .|..|   .||. .|
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TRKC.AA TK 538-824 26 3.2e-119 401.54 In-house 1-486 (486) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

IVLKRELGEGAFG---KVFLAECYNLSP--------------------TKDKMLVAVKALK---DPTLAARKD--------------FQREAELLTN--L
|.| ..||||.||   .|...| ....|                    .. |. |||| ||   . . ....|              . .|.... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHEHIVKFYGVCGDG------------DPLIMVFEYMKHGD----LNKFLRAHGPDAMILVDGQPRQAKGE-----------------------------
.|..||..|||| .|             |...| |||.|||    | ..||.. |...   |. ..|  ..                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGLSQMLHIASQIASGMVYLASQ------HFVHRDLATRNCLVGANLL-----------VKIGDFGMS-
                               | . |.| .. |||.|| ||.|.      .|||||||.|||||| |.            .||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDVYS-TDYYRLFNPSGNDFCIWCEVGG--------------HTMLPIRWMPPESIM---------YRKFTTESDVWSFGVILWEIFTYGKQP
       ||.|| .||||  ......   |                    ..||||||.||...         |.||||.|||||||| .|||||||..|
QGSGVLARDIYSDDDYYRKSSYGTGRPM-W----PFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP

WFQ-LSN---------TEVIECITQG--------------RVLERPRVCP--------------KEVYDVMLGCWQREPQQRLNIKEIYKIL
.   .||         .||.|....|                ...|  ||              .|.||.|. ||...|..| . ..... |
YYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TRKC.AA Musk 538-824 44 4e-108 358.44 In-house 1-282 (282) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-282/282
Sequence Identity: 44% (132 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA-RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA
|.  |..|||||| || |    | |  . ..|||| |||   .   .|||||| ..    |  |||  |||  | |. . ||||  |||| ||..  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

MILVDGQPRQ------AKGELGLSQM--LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGG
      | |       . | ..|. .  | .| ||| || ||    ||||||||||||.. .  ||| |||.|| .|. |||.     .||.        
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYK---GHENDH--------

HTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL
    ||||||||||.| .||.|||||..||.||||| |. ||.. ..  |||  | || .|  |  || .|| .|  |||..|  |   ..| ...
---IPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase TRKC.AA Ror 538-814 44 2.4e-104 352.94 In-house 1-265 (308) Show / Hide 
Range on Protein: 538-814
Range on HMM: 1-265/308
Sequence Identity: 44% (125 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA
.    ||||..||||.  . . . . .  |.||.|..|.  . | ..||..|..|   |.|  ||.  |||    |. |.|||| ||||  ||  . | .
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

MILVD---GQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLP
   ..   .  |  |  |  .  |||| |||.|| ||.| ||||||||.||||||  . ||| ||| .||.|| ||||.               .  ..|
D--HGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQ--------------HKSWMP

IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR
||||.||.||| ||...||.|||||.||||. || ||.   || |||| | .  .|. |  ||  .|  |  ||   |  |
IRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRR
Kinase TRKC.AA InsR 538-826 39 1.5e-101 341.88 In-house 1-278 (278) Show / Hide 
Range on Protein: 538-826
Range on HMM: 1-278/278
Sequence Identity: 39% (117 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKM--LVAVKALKD-PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP
||| ||.|.|.||.| .    .. |        .|.| ... ...  | .|  ||.   .  . |.|. .|||  | |   | | |..|||  .||.. |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DAMILVDGQPRQ-AKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLP
..       ...  .    |.||.  |..|..|| |||.  ||||||| |||.| . . |||||||| ||.| .||||.              ||  |||
EEEF--NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRK--------------GGKGMLP

IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI-TQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHA
.|||.|||.   .||| ||||||||.|||. | | ||   ||| .| . |   | ||..|  ||. ....|  |||  |. |   ..| ..|  
VRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TRKC.AA DDR 538-824 39 4.8e-89 302.14 In-house 1-306 (306) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-306/306
Sequence Identity: 39% (125 aa)

IVLKRELGEGAFGKVFLAECYNLS-------PTK----DKMLVAVKALKD-PTLAARKDFQREAELLTNLQ-HEHIVKFYGVCGDGDPLIMVFEYMKH-G
 . .  .||| || | | |  ..        .      . .||||| |.   . .||.|| .|.  .  .  |  ||.  |||   .|. |. |||   |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNKFLRAHGPDAMILVDGQ---PRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFG--MSRDVYSTDYYRLFNPSGN
||| |. .| .    | . .       |  .  .. ..|. |||||| ||.|  |||||||||||||| .. .|| |||  |||  || ||||       
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYR-------

DFCIWCEVGG-----HTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVY-DVML
       | |        .||||| .|||.  |||| ||||.||| .||.|.  . ||. ||..  ||| .     .||.  .| .|..||.|.| . |.
-------VEGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMC

GCWQREPQQRLNIKEIYKIL
 ||.|...||   .|| | |
RCWRRDQSQRPSFEEIHKFL
Kinase TRKC.AA Src 538-824 36 5.6e-88 298.58 In-house 1-255 (255) Show / Hide 
Range on Protein: 538-824
Range on HMM: 1-255/255
Sequence Identity: 36% (106 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAM
| |.|.||.| || |. .  .|     ... |||| ||  |  . ..|..||.....|.||..|. | || ...|   | |||.|| | ..|..      
IKLCRKLGQGQFGEVWMG-YWN-----GNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------

ILVDGQPRQAKGE-LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS--TDYYRLFNPSGNDFCIWCEVGGHTMLPI
        . .|  | | | . .| |.|.|| || |. ..||||| || ||| |...|..|||  | .     | |                    ..||
--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARH--------------GAKFPI

RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKIL
.|. || | |..||. |||||||. |.||.|||. |    .| ||.... .|  . .|. ||.|.|. .|| ||...|.||   . ... |
KWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TRKC.AA UTK 538-711 35 8.4e-57 192.85 In-house 1-194 (296) Show / Hide 
Range on Protein: 538-711
Range on HMM: 1-194/296
Sequence Identity: 35% (71 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK--DPTLAARK---DFQREAE---LLTNLQ-HEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKF
. | |.||.|||| |..|.  . |.   .|.||||...  ...  ..    || .||    .. ... |.......||| .. |...| |||. ||| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN-------LLVKIGDFG---MSRDVY---------STDY
|| |.|...        ..   | | |.|. |..||.|| ||.|..||||||| |||||...       ...||.|||   |||.|.         ...|
LRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

YR
|.
YM
Kinase TRKC.AA Fer 645-825 32 9.1e-55 184.95 In-house 101-283 (283) Show / Hide 
Range on Protein: 645-825
Range on HMM: 101-283/283
Sequence Identity: 32% (64 aa)

RQAKGE-LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-NLLVK--IGDFGMSRD--VYSTDYY--RLFNPSGNDFCIWCEVGGHTMLPIRW
.  |.. . . . . .. |.|.|| || |.. .|||.| ||||... .. .|  | ||||||.  .| .||.                    ....||||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE----------------KACKVPIRW

MPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ----LSNTEV----IECITQ-GRVLERPRVCPKEVYDVML-GCWQREPQQRLNIKEIYKILH
..||.. .. .....||||||| .||||| |..|..     . .|.|    .. |.. |. .  |  .|.|.. .|.  |||..| .| . |||...|.
LAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase TRKC.AA S_TKc 538-827 22 4.5e-53 183.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 538-827
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKH--GDLNKFLRAHGPD
  . |..|.||||||...   .     .. .||.| .|       ....|| ..| . .|..|||.|.|. | | | ||.||. .  ||| .... .|. 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

AMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIR
    .          .   .  ... ||.... |. |....||||   | |.     .||.|||..| .                        .      
GLRFP----------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPW

WMPPESIMYRKFTT-ESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK------ILHAL
.|.|| .   .... ..|.||.|.||.| .. |. |.    . ...  .            ..|. | . .|.|..|..|. . |. .      .   .
YMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TRKC.AA TK-Unique 538-705 35 4e-49 167.55 In-house 1-184 (294) Show / Hide 
Range on Protein: 538-705
Range on HMM: 1-184/294
Sequence Identity: 35% (66 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKM-LVAVKALK-DPTLAARKDFQREAELLTNLQ-HEHIVKFYGVCGDGD-PLIMVFEYMKHGDLNKFLRAHG
.......|||||| |. .|  ... . ||   ||||.|| . |.  ..|| .|.... .|  |..||...|.| . | |  ...||.  |.| ..||  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PD--AM-------ILVDGQPRQAKGE-LGLSQMLHIASQIASGMVYLAS--QHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY
|.           . ..  |..   | . . ...|.| |||.|| ||||  ...|||||..||.|.. .. .||.||||.||||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVY
Kinase TRKC.AA UTK 730-824 39 2.9e-40 135.45 In-house 199-296 (296) Show / Hide 
Range on Protein: 730-824
Range on HMM: 199-296/296
Sequence Identity: 39% (39 aa)

TMLPIRWMPPESIMYR-KFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQG--RVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL
...||||| ||.. .. .||| |||||||| .|||.|.|..|.  .|| .|.. .. |  . ...|. || .||..|. ||. .|| | ....... .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TRKC.AA TK-Unique 731-824 42 6.1e-38 128.45 In-house 197-294 (294) Show / Hide 
Range on Protein: 731-824
Range on HMM: 197-294/294
Sequence Identity: 42% (42 aa)

MLPIRWMPPESIM--YRKF-TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVC-PKEVYDVMLGCWQREPQQRLNIKEIYKIL
..|||||.|||.   .. . ||.||||||||..|||||.|..|  ........|||..|  ...|  | ..|.| .|  |||.||..| .. .| ..|
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TRKC.AA Pkinase 538-702 26 8.7e-32 113.48 Pfam 1-160 (293) Show / Hide 
Range on Protein: 538-702
Range on HMM: 1-160/293
Sequence Identity: 26% (48 aa)

IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD--FQR--EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG----DLNKFL
....| .|.|.||.|     |     ..  .|||| .| ..    ||    |  |.... .|.|..||..|... |.| . ||.||. .|    ||  ..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RAHGPDAMILVDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV----KIGDFGMSR
..              ...| .     .  ... ||..|. |. |. ..||||   |.|.  |  .    ||.||| ..
ST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase TRKC.AA Fer 538-630 33 4.3e-26 85.92 In-house 1-101 (283) Show / Hide 
Range on Protein: 538-630
Range on HMM: 1-101/283
Sequence Identity: 33% (34 aa)

IVLKRELGEGAFGKVFLA--ECYNLSPTKDKM---LVAVKAL--KDPTLAARKDFQREAELLTN-LQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL
..|.  |||||||.|...  . . . ...       |.|| .   |.| . .|.| .|| .. | ..| ..||||||| |  |.  |.|....|.| ..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

R
.
K
Kinase TRKC.AA Pkinase 734-824 17 1.2e-16 59.93 Pfam 175-293 (293) Show / Hide 
Range on Protein: 734-824
Range on HMM: 175-293/293
Sequence Identity: 17% (21 aa)

IRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQL----SNTEVIECITQGRVLERPRVCP-----------------------KEVYDVMLG
...|.|| |. ... ....|.||.|.||.| .. |. |. .     .  . ...| . .  . .. .|                       .|  |.. .
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWQREPQQRLNIKEIYKI--L
|... |..|.....| .   .
CLCKDPKKRPTAEQILQHPWF