Gene Trb3 (Human)
Trb3
Sequence
Protein domains of Trb3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Trb3.AA | Trbl | 73-315 | 62 | 7.89999999999e-194 | 617.75 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 73-315 Range on HMM: 1-256/256 Sequence Identity: 62% (160 aa) LLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRT-------------HGDMHSLVRSRHRIPEPEA .|||.||...|.|.||.||.||.|||.|.|.. ..|.||..||.|.|..|..||..|.|..|.||.|| ||||||.||.|.|..|.|| CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA AVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHY |.||.||..|.|||||||.|||||||.||||.|.||.||.||.|||||..||.||||||||.|||||.||||....||||||||.|||||.|.|||.|.| ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY PFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL ||.||||..||.|||||....|..||..||||.||||||||.||.||..||||||. PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF |
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| Kinase | Trb3.AA | CAMK | 140-315 | 19 | 1.3e-54 | 174.02 | In-house | 143-425 (425) | Show / Hide |
Range on Protein: 140-315
Range on HMM: 143-425/425
Sequence Identity: 19% (55 aa)
THG----DMHSLVRSR---------------HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER---------------KKLVLENLED
. | |. . .... .|..| ||. .|||.. |...||.|. | ||||. . |... .. .
SGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF
SCVLTG-----------------------PDDSLWDKHACPAYVG-PEILSSR------------ASYSGKAADVWSLGVALFTMLAGHYPFQDS-----
...... ... ... .|.|. ||.|.. | |...|.||.|| |..|| |..||...
ANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEI
--------EPVLLFGKIRRGAYALPAG------------------------LSAPARCLVRCLLRREPAERLTATGILLHPWL
.. || ||..| | | .|. ...|.|..|...| .|.|.. .| |||.
CEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | Trb3.AA | SgK495 | 143-313 | 36 | 1.9e-33 | 101.0 | In-house | 1-171 (171) | Show / Hide |
Range on Protein: 143-313 Range on HMM: 1-171/171 Sequence Identity: 36% (63 aa) DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAA . | |. | |. ..| . || .| ||||| | . . .. . | | | | |. |||. |..|| | | || . NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH-QITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGRP-YRGKPS DVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAG--LSAPARCLVRCLLRREPAERLTATGILLHP |.| ||| ||||| | .|| || | || ||. | .| | ||.| || .| .||||| .. DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV |
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| Kinase | Trb3.AA | MELK | 142-315 | 32 | 1.6e-32 | 108.26 | In-house | 82-254 (254) | Show / Hide |
Range on Protein: 142-315 Range on HMM: 82-254/254 Sequence Identity: 32% (59 aa) GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKH---AC---PAYVGPEILSSRA |.| . ...|. | |. ..|||. |.|. | | |||| ..| . . ||. | | | |.| | ||| ||... . GEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGL---CAKT---KGRKDYHNLQTCCGSPAYAAPELIQGK- SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL .| | |||||.|. |.... | ||.| ... || .| | | || .. |.| .| .| |. .| |||. QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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| Kinase | Trb3.AA | CAMKL | 223-315 | 34 | 2.3e-28 | 87.49 | In-house | 197-297 (297) | Show / Hide |
Range on Protein: 223-315 Range on HMM: 197-297/297 Sequence Identity: 34% (36 aa) PAYVGPEILSS-RASYSGKAADVWSLGVALFTMLAGHYPFQDSEPV-------LLFGKIRRGAYALP--AGLSAPARCLVRCLLRREPAERLTATGILLH |.| |||... .| |...|.||.|| |..|. |..|| | .|. ||..| | | .| ..| | | .| . | .| |. |. | PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH PWL ||. PWM |
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| Kinase | Trb3.AA | GIN4 | 142-315 | 30 | 7.6e-28 | 85.68 | In-house | 119-293 (293) | Show / Hide |
Range on Protein: 142-315 Range on HMM: 119-293/293 Sequence Identity: 30% (54 aa) GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKA |.. .. .. ..|| || |||. .. || ... |||| . |. ... . | . . | | | ||| . . | | | GELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLL-DHKYNRIKIADFG-MAALETDNKLLETSCGSPHYAAPEIVMGIP-YHGFA ADVWSLGVALFTMLAGHYPFQDS--EPVLLFGKIRRGAYALPAG--LSAPARCLVRCLLRREPAERLTATGILLHPWL .|||| || || .| || ||.. | |. .| | .|. .| |. |.| .| .| |.. || || . SDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI |
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| Kinase | Trb3.AA | AMPK | 223-315 | 39 | 1.9e-27 | 78.58 | In-house | 163-254 (254) | Show / Hide |
Range on Protein: 223-315 Range on HMM: 163-254/254 Sequence Identity: 39% (37 aa) PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL | | ||. |.. | | |.|| || |. || | || |.. |. ||. | | .|. || |. |....|. | .|.| | |||. PCYAAPEMISGKL-YCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | Trb3.AA | RSK | 224-315 | 33 | 3.6e-26 | 92.82 | In-house | 173-278 (278) | Show / Hide |
Range on Protein: 224-315 Range on HMM: 173-278/278 Sequence Identity: 33% (36 aa) AYVGPEILS---SRASYSGKAADVWSLGVALFTMLAGHYPFQD---SEPVLLFGKIRRGA--YALP--AGLSAPARCLVRCLLRREPAERLT-----ATG .|. ||.| . .. ||.|.||||| ...||.|. ||| . . .. .|..| .| . ||..|. |.| .| |.|. ||. | EYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE ILLHPWL |. |||. IKQHPWF |
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| Kinase | Trb3.AA | MARK | 223-315 | 40 | 5.5e-26 | 82.06 | In-house | 169-262 (262) | Show / Hide |
Range on Protein: 223-315 Range on HMM: 169-262/262 Sequence Identity: 40% (38 aa) PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSE--PVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWL |.| |||.... | |...|.||||| |..|. |..|| .. . |. ||.|| | | .|. .| |.. || | || |.. |. |||. PPYMAPEIFLKK-PYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | Trb3.AA | TSSK | 224-315 | 31 | 9.4e-21 | 64.83 | In-house | 193-289 (289) | Show / Hide |
Range on Protein: 224-315 Range on HMM: 193-289/289 Sequence Identity: 31% (31 aa) AYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQD--SEPVLLFGKIR-RGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWL ||. |||| .. |..|..||||.|| |..|. |. || | |.. . .. ... . |. ..|. .. |.| .|. .| .|.... |. |.|. AYAAPEILRGIP-YDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKV-CFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| S_TKc | Trb3.AA | S_TKc | 71-315 | 22 | 1.2e-19 | 72.48 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 71-315 Range on HMM: 1-231/231 Sequence Identity: 22% (63 aa) YVLLEPE---EGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHG---DMHSLVRSRHR------IPEPE | .|.. |. |.. | || .. .|. . . .. .. . |... . .| . || .. | |.... ..| | .|| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H AAVLFRQMATALAHCHQHGLVLRDLK----------------LCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAA |. ...|.. ||..||.|| . |||| |.|.. | |. ||.| .|..... ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL----GYGKCKC DVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILL-------HPWL |.||.|. |. ||.| ||. .. ..| ||. | .|. ..| .|...|..|.|| .| |||. DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Trb3.AA | Pkinase | 223-315 | 22 | 1.7e-18 | 66.52 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 223-315 Range on HMM: 175-293/293 Sequence Identity: 22% (27 aa) PAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS------EPVLLFGKIRRGAYALPAGLS---------------------APARCLVRCL | |. ||.. ..| |...|.||.|. |. || |. ||... .. .. .|... . . . ... ..... PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LRREPAERLTATGILLHPWL |.. |..|.||. || |||. LCKDPKKRPTAEQILQHPWF |
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| Kinase | Trb3.AA | CAMKL | 142-185 | 36 | 9.2e-12 | 33.66 | In-house | 106-155 (297) | Show / Hide |
Range on Protein: 142-185 Range on HMM: 106-155/297 Sequence Identity: 36% (18 aa) GD--MHSLVRSR----HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL |. .. .... |.||.|| .|||. |...||.|| | ||.|. GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP |
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| Kinase | Trb3.AA | TSSK | 141-185 | 37 | 1.8e-11 | 33.88 | In-house | 101-151 (289) | Show / Hide |
Range on Protein: 141-185 Range on HMM: 101-151/289 Sequence Identity: 37% (19 aa) HGDMHSLVRSR------HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL |||. . .. | ...|..| .||||. |...|| |. | ||||. HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC |
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| Kinase | Trb3.AA | MARK | 142-185 | 32 | 1.6e-10 | 30.81 | In-house | 87-132 (262) | Show / Hide |
Range on Protein: 142-185 Range on HMM: 87-132/262 Sequence Identity: 32% (15 aa) GDMHSLVRSR--HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL |.... .... .|..|.|| ..|||. |. ||... | ||.|. GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP |
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| Kinase | Trb3.AA | AMPK | 150-185 | 38 | 1.5e-07 | 18.52 | In-house | 93-128 (254) | Show / Hide |
Range on Protein: 150-185 Range on HMM: 93-128/254 Sequence Identity: 38% (14 aa) SRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKL .. |..| ||. .| |. .. ||.|. | ||||. KHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP |
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| Kinase | Trb3.AA | Pkinase | 141-185 | 24 | 1e-06 | 24.79 | Pfam | 84-136 (293) | Show / Hide |
Range on Protein: 141-185 Range on HMM: 84-136/293 Sequence Identity: 24% (13 aa) HG----DMHSLVR--SRHRI--PEPEAAVLFRQMATALAHCHQHGLVLRDLKL .| | ..... .. .. .| |. ..|.. .|..||..| . ||||. GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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| Kinase | Trb3.AA | RSK | 147-185 | 34 | 0.002274 | 8.61 | In-house | 92-132 (278) | Show / Hide |
Range on Protein: 147-185 Range on HMM: 92-132/278 Sequence Identity: 34% (14 aa) LVRSRHR--IPEPEAAVLFRQMATALAHCHQHGLVLRDLKL | . .| . | ||.. ... . |. | ||.| . ||||. LQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP |
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