Gene Trb2 (Human)
Trb2
Sequence
Protein domains of Trb2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Trb2.AA | Trbl | 66-308 | 68 | 2.3e-205 | 654.83 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 66-308 Range on HMM: 1-256/256 Sequence Identity: 68% (176 aa) LLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERS-------------YGDMHSFVRTCKKLREEEA .|||.||.||..|.|.|.|.|..||||.|.||||.|.|.|||..|..|..|.|.||||.|||.||||. .|||||.||..|.|.|||| CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA ARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRY ||||.|...||||||..|.||||||||.|.|||||||...||||||..|..|.||||.||||||||||||||.|.|||||||||.||||||||||||||| ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY PFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF ||||.||..||.|||||||.|||.|||||.||||..||||||||.|.|.||.|||| PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF |
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| Kinase | Trb2.AA | CAMK | 75-308 | 18 | 1.4e-66 | 213.31 | In-house | 10-425 (425) | Show / Hide |
Range on Protein: 75-308
Range on HMM: 10-425/425
Sequence Identity: 18% (75 aa)
VFRAVHLHSG------------EELVCKVFDIS-------------------------------CYQESLAPCFCLSA---------HSNINQITEIILG
|....| ... .. .|. | . .. . ... | || .. |..
VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED
-------------------ETKAYVFF---ERSYG-----DMHSFV--RTC-------------KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK
... | .. | | |. ... ..| ... |.||.|.| ||.|||..||. . | ||||.
PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPEN
FIFKDEER---------------TRVKLESLEDAYILRG-----------------------DDDSLSDKHGCPAYVS-PEILNTSG------------S
. | .. .|. | .... ... ... |.|.|.. ||.|| .|
ILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKP
YSGKAADVWSLGVMLYTMLVGRYPFHDI-------------EPSSLFSKIRRGQFN-IPETLSP-----------------------KAKCLIRSILRRE
| |...|.||.||.||.||.|..|| . ... || ||..|... .|. .|| .|.|||..|...
YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVD
PSERLTSQEILDHPWF
|..|.| ...|.|||.
PEKRMTIEQCLNHPWM
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| Kinase | Trb2.AA | MELK | 110-308 | 33 | 5.6e-40 | 134.12 | In-house | 56-254 (254) | Show / Hide |
Range on Protein: 110-308 Range on HMM: 56-254/254 Sequence Identity: 33% (67 aa) HSNINQITEIILGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDS | .| |. .| | | .. .| . |.| .. ..| |||. .| || ||.|. | | |||| ..|... . .. | | | HQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHN LSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF | | ||| ||... .| | |||||.|..||....| || | . .. || .| .. |. |||..| |.| .| .| |. ...|.||| LQTCCGSPAYAAPELIQGK-QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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| Kinase | Trb2.AA | CAMKL | 216-308 | 34 | 2.7e-36 | 113.23 | In-house | 197-297 (297) | Show / Hide |
Range on Protein: 216-308 Range on HMM: 197-297/297 Sequence Identity: 34% (36 aa) PAYVSPEILNT-SGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPS-------SLFSKIRRGQFNIP--ETLSPKAKCLIRSILRREPSERLTSQEILDH |.| .|||.. .| |...|.||.||.||.|..|..|| | . |. ||..| ...| .| .. |||..| . |..| | ..|. | PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH PWF ||. PWM |
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| Kinase | Trb2.AA | Ciliate-E2-Unclassified | 134-308 | 21 | 2e-34 | 116.79 | In-house | 105-352 (352) | Show / Hide |
Range on Protein: 134-308
Range on HMM: 105-352/352
Sequence Identity: 21% (54 aa)
YGDMHSFVRTCKK-----------------LREEEAA-----RLFYQIASAVAHCHDGG-LVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGD----
.||.. . . .|| . |..|. ..|.|| .. ..| . . ||.|. .|... . ..|. . .. . .
GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD
-----------DDSLSDKHGCPAYV----SPEILNTSGSYSG--KAADVWSLGVMLYTMLVGRYPFHDIEPSS----------------LFSKIRRGQFN
.. .... | | | .||.| . . ...|.||||| || || |.||| | . |...| ....
TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ
IPE--------TLSPKAKCLIR----SILRREPSERLTSQEILDHPWF
.|. ..||.|| .|. ..| |..|.| ..|| ||||
FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | Trb2.AA | AMPK | 214-308 | 44 | 5.5e-34 | 98.32 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 214-308 Range on HMM: 161-254/254 Sequence Identity: 44% (42 aa) GCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF | | | .||. .. | | |.|| || || || |. || | . ..|. ||. |.. ||. |||.|| ||...|. | .|.| ..| |||| GSPCYAAPEMI-SGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | Trb2.AA | MARK | 214-308 | 41 | 6.3e-33 | 105.1 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 214-308 Range on HMM: 167-262/262 Sequence Identity: 41% (40 aa) GCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFH--DIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF | |.| .|||.. . | |...|.||||| ||.|..|..|| ... |. ||.||.. || .|.... ||...| |.|| | .||. |||. GTPPYMAPEIFL-KKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| S_TKc | Trb2.AA | S_TKc | 64-308 | 25 | 1.2e-32 | 115.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 64-308 Range on HMM: 1-231/231 Sequence Identity: 25% (68 aa) YLLLEPL-EGD--HVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLS-AHSNINQITEIILGETKAYVFFERSYG---DMHSFVRTCKK------LREE | .|... .| |....| ..|.. .|. . . . .|. | || .. ... .. |...| | |.... . ... . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- EAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVG .|....|||..|...||. | . |||| . . ..|. | .| . | | |..||.| .|.....|.||.|..|| ||.| HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG RYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILD-------HPWF . ||. .. .| ||. || || .|| .|...|..|.| |.| |||| YPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Trb2.AA | RSK | 214-308 | 36 | 3.4e-31 | 109.97 | In-house | 170-278 (278) | Show / Hide |
Range on Protein: 214-308 Range on HMM: 170-278/278 Sequence Identity: 36% (40 aa) GCPAYVSPEILN---TSGSYSGKAADVWSLGVMLYTMLVGRYPFHD---IEPSSLFSKIRRGQ--FNIP--ETLSPKAKCLIRSILRREPSERLT----- . .|. ||.|. | .. ||.|.||||| .|.||.|. ||. .. .. .|..|. ...| ..||. || ||| | |.|. ||. YTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD SQEILDHPWF .||..|||| AEEIKQHPWF |
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| Kinase | Trb2.AA | Ciliate-E2 | 216-308 | 29 | 1.8e-30 | 101.82 | In-house | 251-365 (365) | Show / Hide |
Range on Protein: 216-308 Range on HMM: 251-365/365 Sequence Identity: 29% (36 aa) PAYVSPEILNTSGSY-------SGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP------------------ETLSPKAKCLIRS--- | |..||||| . . ....|.|||||.|| || |..|| . .| .....| . .|...| ||. PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK -ILRREPSERLT-SQEILDHPWF .| ..|..|.| ..||.|||| RMLQKDPEKRITGWEQILNHPWF |
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| Kinase | Trb2.AA | TSSK | 217-308 | 34 | 1.2e-28 | 91.18 | In-house | 193-289 (289) | Show / Hide |
Range on Protein: 217-308 Range on HMM: 193-289/289 Sequence Identity: 34% (34 aa) AYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHD--IEPSSLFSKIR-RG-QFNI--PETLSPKAKCLIRSILRREPSERLTSQEILDHPWF ||..|||| . |..|..||||.|| ||.|..|. || | .. . .. .. .| . ...|. .| |||..|. .|..|....||. |.| AYAAPEIL-RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | Trb2.AA | Pkinase | 216-308 | 26 | 2.7e-28 | 101.11 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 216-308 Range on HMM: 175-293/293 Sequence Identity: 26% (32 aa) PAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDI------EPSSLFSKIRRGQFNIPETLS---------------------PKAKCLIRSI | |..||... .|.| |...|.||.|..|| || || || . .. .. .|..... .. . . .| .|... PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LRREPSERLTSQEILDHPWF |.. |..|.| ..|| |||| LCKDPKKRPTAEQILQHPWF |
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| Kinase | Trb2.AA | CAMKL | 110-178 | 30 | 5.3e-11 | 31.21 | In-house | 74-155 (297) | Show / Hide |
Range on Protein: 110-178 Range on HMM: 74-155/297 Sequence Identity: 30% (25 aa) HSNINQITEIILGETK------AYVFFERSYGD---MHSFV--RTCKK--LREEEAARLFYQIASAVAHCHDGGLVLRDLKL | || .. |.| ... | . | | .. .. . ... . |.|| |.| || |||..||. | | ||.|. HPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP |
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| Kinase | Trb2.AA | AMPK | 110-178 | 35 | 7.8e-11 | 28.46 | In-house | 58-128 (254) | Show / Hide |
Range on Protein: 110-178 Range on HMM: 58-128/254 Sequence Identity: 35% (25 aa) HSNINQITEII-LGETKAYVFFERS-YGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL | .| | |.| .| ... | |. ... ..| |.||.|.| || |.| ||. . | ||||. HPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP |
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| Kinase | Trb2.AA | TSSK | 135-178 | 36 | 8.8e-11 | 31.6 | In-house | 102-151 (289) | Show / Hide |
Range on Protein: 135-178 Range on HMM: 102-151/289 Sequence Identity: 36% (18 aa) GDMHSFVRTC------KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL ||. ..... . |.||.| ..| |..|||..||. . | ||||. GDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC |
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| Kinase | Trb2.AA | MARK | 135-178 | 41 | 8.9e-09 | 25.0 | In-house | 87-132 (262) | Show / Hide |
Range on Protein: 135-178 Range on HMM: 87-132/262 Sequence Identity: 41% (19 aa) GDMHSFVRTC--KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL |....... .| |||| |.| || ||| ||. . | ||.|. GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP |
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| TyrKc | Trb2.AA | TyrKc | 64-308 | 16 | 8.4e-07 | -112.67 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 64-308 Range on HMM: 1-280/280 Sequence Identity: 16% (47 aa) YLLLEPL-EGDH--VFRAVHLHSGEELVCKVFDISCYQESL---APCFCLS--AHSNINQITEIILGE-------TKAYVFFE-RSYGDMHSFVRTCKK- |.. | || |.... .. |. .. .| . | | | || .. ... . .. .| ..|| ... | ... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRV------KLESLEDAYILRGDDDSLSDKHGCP-----AYVSPEILNTSGSYSGKAA | .. .|||. .. |. ... ||| | ... . .. . .|. ..| . . . |. .|| . | .. . LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT-TKS DVWSLGVMLYTML-VGRYPFHD-----IEPSSLFSKIRRGQFNIPETL---------SPKAKCLIRSILRREPSERLTSQEILDHPWF |||| ||... .. | | . .... .. ....| . ... .... ...|..| | .|| | | DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | Trb2.AA | Pkinase | 135-178 | 26 | 3e-06 | 22.95 | Pfam | 85-136 (293) | Show / Hide |
Range on Protein: 135-178 Range on HMM: 85-136/293 Sequence Identity: 26% (14 aa) G----DMHSFVR--TCKKL--REEEAARLFYQIASAVAHCHDGGLVLRDLKL | | ..... ... |.|. . .|||......||. | . ||||. GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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| Kinase | Trb2.AA | Ciliate-E2 | 145-178 | 20 | 7.4e-05 | 12.58 | In-house | 140-189 (365) | Show / Hide |
Range on Protein: 145-178 Range on HMM: 140-189/365 Sequence Identity: 20% (10 aa) KKLREEEAARLFYQIAS---------------AVAHCHDGG-LVLRDLKL |.. |.|......||.. |. ..| . . ||.|. KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP |
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| Kinase | Trb2.AA | RSK | 147-178 | 40 | 0.000898 | 10.1 | In-house | 101-132 (278) | Show / Hide |
Range on Protein: 147-178 Range on HMM: 101-132/278 Sequence Identity: 40% (13 aa) LREEEAARLFYQIASAVAHCHDGGLVLRDLKL . |.||. ...|..|| | |. | . ||||. FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP |
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